公开(公告)号：US20060278581A1

公开(公告)日：2006-12-14

申请号：US11465952

申请日：2006-08-21

申请人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

发明人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

IPC分类号： B01D61/00

CPC分类号： B01D63/16 ,  A61M1/16 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  B01D61/145 ,  B01D61/18 ,  B01D61/28 ,  B01D63/06 ,  B01D65/08 ,  B01D2321/2033 ,  B01D2321/2041 ,  B01D2321/205

摘要： Systems and methods convey the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface. At least one of the inner and outer surfaces carries a membrane that consists essentially of either a hemofiltration membrane or a hemodialysis membrane. The systems and methods cause relative movement between the inner and outer surfaces about the axis at a selected surface velocity, taking into account the size of the gap. The relative movement of the two surfaces creates movement of the blood within the gap, which creates vortical flow conditions that induce transport of cellular blood components from the membrane while plasma water and waste material are transported to the membrane for transport across the membrane. Shear-enhanced transport of waste materials and blood plasma water results.

摘要翻译： 系统和方法通过限定在围绕轴线的内表面和与内表面同心的外表面之间的间隙传送血液。 内表面和外表面中的至少一个带有基本上由血液滤过膜或血液透析膜组成的膜。 系统和方法考虑到间隙的大小，引起内表面和外表面之间围绕轴线以所选表面速度的相对运动。 两个表面的相对运动产生血液在间隙内的移动，这产生了涡旋流动条件，其诱导细胞血液成分从膜的运输，而等离子体水和废物被输送到膜以便跨过膜运输。 剪切加强了废料和血浆水的运输。

公开(公告)号：US07182867B2

公开(公告)日：2007-02-27

申请号：US11043370

申请日：2005-01-26

申请人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

发明人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

IPC分类号： B01D63/16 ,  B01D61/14 ,  B01D63/00 ,  B01D61/00

CPC分类号： B01D63/16 ,  A61M1/16 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  B01D61/145 ,  B01D61/18 ,  B01D61/28 ,  B01D63/06 ,  B01D65/08 ,  B01D2321/2033 ,  B01D2321/2041 ,  B01D2321/205

摘要： Systems and methods convey the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface. At least one of the inner and outer surfaces carries a membrane that consists essentially of either a hemofiltration membrane or a hemodialysis membrane. The systems and methods cause relative movement between the inner and outer surfaces about the axis at a selected surface velocity, taking into account the size of the gap. The relative movement of the two surfaces creates movement of the blood within the gap, which creates vortical flow conditions that induce transport of cellular blood components from the membrane while plasma water and waste material are transported to the membrane for transport across the membrane. Shear-enhanced transport of waste materials and blood plasma water results.

摘要翻译： 系统和方法通过限定在围绕轴线的内表面和与内表面同心的外表面之间的间隙传送血液。 内表面和外表面中的至少一个带有基本上由血液滤过膜或血液透析膜组成的膜。 系统和方法考虑到间隙的大小，引起内表面和外表面之间围绕轴线以所选表面速度的相对运动。 两个表面的相对运动产生血液在间隙内的移动，这产生了涡旋流动条件，其诱导细胞血液成分从膜的运输，而等离子体水和废物被输送到膜以便跨过膜运输。 剪切加强了废料和血浆水的运输。

公开(公告)号：US20090218277A1

公开(公告)日：2009-09-03

申请号：US12399545

申请日：2009-03-06

申请人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

发明人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

IPC分类号： B01D17/038

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  B04B5/0442 ,  B04B2005/045

摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

摘要翻译： 使用分离装置和方法来使用用于围绕轴线旋转的分离通道。 这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。 入口将流体输送到通道中。 屏障位于内外侧壁部分的通道中间。 第一流动路径在屏障的上游侧和下游侧之间连通。 收集区域可以位于屏障的下游，用于与第一流动路径通信。 通道的外侧壁部分可以位于其上游部分的径向外侧。 屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。 第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

公开(公告)号：US20070181500A1

公开(公告)日：2007-08-09

申请号：US11734579

申请日：2007-04-12

申请人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

发明人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

IPC分类号： B01D61/00

CPC分类号： B01D63/16 ,  A61M1/16 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  B01D61/145 ,  B01D61/18 ,  B01D61/28 ,  B01D63/06 ,  B01D65/08 ,  B01D2321/2033 ,  B01D2321/2041 ,  B01D2321/205

摘要： Systems and methods convey the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface. At least one of the inner and outer surfaces carries a membrane that consists essentially of either a hemofiltration membrane or a hemodialysis membrane. The systems and methods cause relative movement between the inner and outer surfaces about the axis at a selected surface velocity, taking into account the size of the gap. The relative movement of the two surfaces creates movement of the blood within the gap, which creates vortical flow conditions that induce transport of cellular blood components from the membrane while plasma water and waste material are transported to the membrane for transport across the membrane. Shear-enhanced transport of waste materials and blood plasma water results.

摘要翻译： 系统和方法通过限定在围绕轴线的内表面和与内表面同心的外表面之间的间隙传送血液。 内表面和外表面中的至少一个带有基本上由血液滤过膜或血液透析膜组成的膜。 系统和方法考虑到间隙的大小，引起内表面和外表面之间围绕轴线以所选表面速度的相对运动。 两个表面的相对运动产生血液在间隙内的移动，这产生了涡旋流动条件，其诱导细胞血液成分从膜的运输，而等离子体水和废物被输送到膜以便跨过膜运输。 剪切加强了废料和血浆水的运输。

公开(公告)号：US07494591B2

公开(公告)日：2009-02-24

申请号：US11734579

申请日：2007-04-12

申请人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

发明人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

IPC分类号： B01D61/00 ,  B01D61/14 ,  B01D61/18 ,  B01D61/24 ,  B01D61/28 ,  B01D61/32

CPC分类号： B01D63/16 ,  A61M1/16 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  B01D61/145 ,  B01D61/18 ,  B01D61/28 ,  B01D63/06 ,  B01D65/08 ,  B01D2321/2033 ,  B01D2321/2041 ,  B01D2321/205

摘要： Systems and methods convey the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface. At least one of the inner and outer surfaces carries a membrane that consists essentially of either a hemofiltration membrane or a hemodialysis membrane. The systems and methods cause relative movement between the inner and outer surfaces about the axis at a selected surface velocity, taking into account the size of the gap. The relative movement of the two surfaces creates movement of the blood within the gap, which creates vortical flow conditions that induce transport of cellular blood components from the membrane while plasma water and waste material are transported to the membrane for transport across the membrane. Shear-enhanced transport of waste materials and blood plasma water results.

摘要翻译： 系统和方法通过限定在围绕轴线的内表面和与内表面同心的外表面之间的间隙传送血液。 内表面和外表面中的至少一个带有基本上由血液滤过膜或血液透析膜组成的膜。 系统和方法考虑到间隙的大小，引起内表面和外表面之间围绕轴线以所选表面速度的相对运动。 两个表面的相对运动产生血液在间隙内的移动，这产生了涡旋流动条件，其诱导细胞血液成分从膜的运输，而等离子体水和废物被输送到膜以便跨过膜运输。 剪切加强了废料和血浆水的运输。

公开(公告)号：US20050133448A1

公开(公告)日：2005-06-23

申请号：US11043370

申请日：2005-01-26

申请人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

发明人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

IPC分类号： A61M1/16 ,  A61M1/26 ,  B01D61/18 ,  B01D61/28 ,  B01D63/16 ,  B01D65/08 ,  B01D61/00

CPC分类号： B01D63/16 ,  A61M1/16 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  B01D61/145 ,  B01D61/18 ,  B01D61/28 ,  B01D63/06 ,  B01D65/08 ,  B01D2321/2033 ,  B01D2321/2041 ,  B01D2321/205

摘要： Systems and methods convey the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface. At least one of the inner and outer surfaces carries a membrane that consists essentially of either a hemofiltration membrane or a hemodialysis membrane. The systems and methods cause relative movement between the inner and outer surfaces about the axis at a selected surface velocity, taking into account the size of the gap. The relative movement of the two surfaces creates movement of the blood within the gap, which creates vortical flow conditions that induce transport of cellular blood components from the membrane while plasma water and waste material are transported to the membrane for transport across the membrane. Shear-enhanced transport of waste materials and blood plasma water results.

摘要翻译： 系统和方法通过限定在围绕轴线的内表面和与内表面同心的外表面之间的间隙传送血液。 内表面和外表面中的至少一个带有基本上由血液滤过膜或血液透析膜组成的膜。 系统和方法考虑到间隙的大小，引起内表面和外表面之间围绕轴线以所选表面速度的相对运动。 两个表面的相对运动产生血液在间隙内的移动，这产生了涡旋流动条件，其诱导细胞血液成分从膜的运输，而等离子体水和废物被输送到膜以便跨过膜运输。 剪切加强了废料和血浆水的运输。

公开(公告)号：US06863821B2

公开(公告)日：2005-03-08

申请号：US10066311

申请日：2002-02-02

申请人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

发明人： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

IPC分类号： A61M1/16 ,  A61M1/26 ,  B01D61/18 ,  B01D61/28 ,  B01D63/16 ,  B01D65/08 ,  B01D61/00 ,  B01D21/26 ,  B01D61/24

CPC分类号： B01D63/16 ,  A61M1/16 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  B01D61/145 ,  B01D61/18 ,  B01D61/28 ,  B01D63/06 ,  B01D65/08 ,  B01D2321/2033 ,  B01D2321/2041 ,  B01D2321/205

摘要： Systems and methods convey the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface. At least one of the inner and outer surfaces carries a membrane that consists essentially of either a hemofiltration membrane or a hemodialysis membrane. The systems and methods cause relative movement between the inner and outer surfaces about the axis at a selected surface velocity, taking into account the size of the gap. The relative movement of the two surfaces creates movement of the blood within the gap, which creates vortical flow conditions that induce transport of cellular blood components from the membrane while plasma water and waste material are transported to the membrane for transport across the membrane. Shear-enhanced transport of waste materials and blood plasma water results.

公开(公告)号：US07918350B2

公开(公告)日：2011-04-05

申请号：US12399545

申请日：2009-03-06

申请人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

发明人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

IPC分类号： B04B3/00 ,  B04B1/06 ,  B04B1/12 ,  B04B7/10 ,  B01D21/26 ,  B01D45/12

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  B04B5/0442 ,  B04B2005/045

摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

摘要翻译： 使用分离装置和方法来使用用于围绕轴线旋转的分离通道。 这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。 入口将流体输送到通道中。 屏障位于内外侧壁部分的通道中间。 第一流动路径在屏障的上游侧和下游侧之间连通。 收集区域可以位于屏障的下游，用于与第一流动路径通信。 通道的外侧壁部分可以位于其上游部分的径向外侧。 屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。 第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

公开(公告)号：US06849039B2

公开(公告)日：2005-02-01

申请号：US10279765

申请日：2002-10-24

申请人： Kyungyoon Min ,  Richard I. Brown ,  Julie Moriarty

发明人： Kyungyoon Min ,  Richard I. Brown ,  Julie Moriarty

IPC分类号： A61M1/36 ,  A61M1/38 ,  B04B5/04 ,  B01D21/26 ,  B04B11/00

CPC分类号： A61M1/3693 ,  A61M1/3633 ,  A61M1/3696 ,  A61M1/38 ,  A61M2202/0429 ,  A61M2205/128 ,  B04B5/0442 ,  B04B2005/045

摘要： Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.

摘要翻译： 血液分离系统和方法将血液引入低G壁和高G壁之间的环形分离通道，同时围绕轴线旋转分离通道，以将血液分离成血液成分。 环形分隔通道具有环形边界壁。 系统和方法将第一血液成分引导到沿着低G壁的收缩通道。 系统和方法通过与分离通道连通的第一路径去除第一血液成分，所述第一路径通过邻近靠近低G壁的收缩通道的开口。 系统和方法沿着沿着高G壁的轴向方向朝着环形边界壁延伸的表面引导第二血液成分。 所述系统和方法通过第二路径收集第二血液成分，所述第二路径通过与所述环形边界壁轴向间隔开的邻近所述高G壁的表面邻接的开口与所述分离通道连通。