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94 条记录 (耗时 0.054 秒)

    Polypeptides that bind an anti-tissue factor antibody and uses thereof
    91.
    发明申请
    Polypeptides that bind an anti-tissue factor antibody and uses thereof 审中-公开
    结合抗组织因子抗体的多肽及其用途

    公开(公告)号：US20060177446A1

    公开(公告)日：2006-08-10

    申请号：US11290770

    申请日：2005-11-29

    申请人： Charles Eigenbrot ,  Yu-Ju Meng ,  Daniel Kirchhofer ,  Leonard Presta

    发明人： Charles Eigenbrot ,  Yu-Ju Meng ,  Daniel Kirchhofer ,  Leonard Presta

    IPC分类号： A61K39/395 ,  C07K16/22

    CPC分类号： C07K16/4258 ,  C07K16/4241 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention relates to antibodies and polypeptides useful in blocking the binding of antibodies to anti-tissue factor, decreasing the activity of the anti-tissue factor antibodies and/or neutralizing the activity of an anti-tissue factor antibody. The present invention also relates to nucleic acids encoding the antibodies and polypeptides and compositions comprising the antibodies or polypeptides or nucleic acid molecules. The present invention provides methods of treating a hypercoagulable state or an inflammatory disease using the antibodies and polypeptides of this invention and other methods of using said antibodies and polypeptides.

    摘要翻译： 本发明涉及可用于阻断抗体与抗组织因子结合的抗体和多肽，降低抗组织因子抗体的活性和/或中和抗组织因子抗体的活性。 本发明还涉及编码抗体和多肽的核酸以及包含抗体或多肽或核酸分子的组合物。 本发明提供使用本发明的抗体和多肽以及使用所述抗体和多肽的其它方法治疗高凝状态或炎性疾病的方法。

    Inhibitors of vascular endothelial growth factor activity, their uses and processes for their production
    94.
    发明授权
    Inhibitors of vascular endothelial growth factor activity, their uses and processes for their production 有权
    血管内皮生长因子活性抑制剂，其用途及其制备方法

    公开(公告)号：US06383486B1

    公开(公告)日：2002-05-07

    申请号：US09348886

    申请日：1999-07-01

    申请人： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    发明人： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    IPC分类号： A61K39395

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K16/2863 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/31

    摘要： The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

    摘要翻译： 本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体 蛋白质结合VEGF并拮抗其内皮细胞增殖和血管生成活性。 本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，携带这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法 具有不希望的血管形成。