公开(公告)号：US20060196277A1

公开(公告)日：2006-09-07

申请号：US11276571

申请日：2006-03-06

申请人： Mark Allen ,  Michael Ellis ,  Jason Kroh ,  Donald Miller

发明人： Mark Allen ,  Michael Ellis ,  Jason Kroh ,  Donald Miller

IPC分类号： G01F1/58

CPC分类号： G01R23/12 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/05 ,  A61B5/076 ,  A61B2560/0219 ,  A61B2560/0223 ,  G01D21/00 ,  G01F15/066 ,  G01R23/145

摘要： The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal.

公开(公告)号：US20050096175A9

公开(公告)日：2005-05-05

申请号：US10418509

申请日：2003-04-16

申请人： Donald Miller

发明人： Donald Miller

IPC分类号： B62M11/00 ,  F16H15/28 ,  F16H61/664 ,  F16H15/26

CPC分类号： B62M11/00 ,  F16H15/28 ,  F16H61/664

摘要： A continuously variable transmission is disclosed for use in rotationally or linearly powered machines and vehicles. The single axle transmission provides a simple manual shifting method for the user. An additional embodiment is disclosed which shifts automatically dependent upon the rotational speed of the wheel. Further, the practical commercialization of traction roller transmissions requires improvements in the reliability, ease of shifting, function and simplicity of the transmission. The disclosed transmission may be used in vehicles such as automobiles, motorcycles, and bicycles. The transmission may, for example, be driven by a power transfer mechanism such as a sprocket, gear, pulley or lever, optionally driving a one way clutch attached at one end of the main shaft.

公开(公告)号：US20050053607A1

公开(公告)日：2005-03-10

申请号：US10683480

申请日：2003-10-09

申请人： Paula Bates ,  Donald Miller ,  John Trent ,  Xiaohua Xu

发明人： Paula Bates ,  Donald Miller ,  John Trent ,  Xiaohua Xu

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61P35/00 ,  C07K14/47 ,  C12N15/113 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/574 ,  A61K39/395 ,  A61K33/24

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K39/39558 ,  A61K45/06 ,  A61N5/10 ,  C07K14/47 ,  C12N15/113 ,  C12Q1/6886 ,  G01N33/5005 ,  G01N33/57492

摘要： Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.

摘要翻译： 通过利用通常核定位的蛋白质核仁素的表面表达来治疗肿瘤和癌症的方法。

公开(公告)号：US4445719A

公开(公告)日：1984-05-01

申请号：US298712

申请日：1981-09-02

申请人： Donald Miller ,  Clark A. Bowers

发明人： Donald Miller ,  Clark A. Bowers

IPC分类号： B63C7/20 ,  B66C1/62 ,  B66C1/66

CPC分类号： B63C7/20 ,  B66C1/62

摘要： A release mechanism is provided for a structural member, such as a cylindal object recovery device, wherein the structural member has top and bottom sides. The release mechanism includes a block which is attachable to the structural member so as to extend thereabove. A piston is mounted in the block and is moveable vertically between up and down positions. At least one rod is connected to the piston and extends vertically downwardly beyond the bottom side of the structural member so as to be capable of moving the piston to the upward position when forcibly engaged by the object. A U-shaped holder is fitted over the block with each leg of the holder having a recess. A pair of pistons is laterally mounted in the U-shaped block in an opposing relationship, and each piston is moveable between inward and outward positions. Each lateral piston is engageable with the holder within the holder recess in the outward position so as to retain the U-shaped holder to the block, and each lateral piston clears the respective holder recess in the inward position so as to release the U-shaped holder from the block. A rod is connected to each lateral piston and extends inwardly within the block for engagement and disengagement with the vertical piston as the vertical piston moves from its down position to its up position. A spring arrangement is provided for biasing each lateral piston toward the inward position. Each rod maintains the respective lateral piston in its outward holder engaging position when the lateral piston rod is in engagement with the vertical piston. Further, each rod allows the respective lateral piston to be spring biased to its inward disengaged position with respect to the holder when the lateral piston rod is disengaged from the vertical piston. With this arrangement forcible engagement of the bottom of the vertical rod with the cylindrical object will cause the vertical piston to move upwardly and allow the lateral pistons to move inwardly to release the U-shaped holder from the block and the structural member.

公开(公告)号：US20110124604A1

公开(公告)日：2011-05-26

申请号：US12446284

申请日：2007-10-22

申请人： Donald Miller ,  Myron Toews ,  Sanjat Savant ,  Bill Mayhan

发明人： Donald Miller ,  Myron Toews ,  Sanjat Savant ,  Bill Mayhan

IPC分类号： A61K31/661 ,  A61P25/00

CPC分类号： A61K31/661

摘要： A method for enhancing drug delivery to the brain in neurological disorders using lysophosphatidic acid (LPA) and sphingosine I phosphate (S1P) is herein described. Specifically, the permeability properties of LPA and S1P allow for a highly controlled and transient disruption of blood-brain barrier permeability. Thus these phospholipids can be used for delivering a wide variety of therapeutic, prophylactic or diagnostic agents to the brain.

摘要翻译： 本文描述了使用溶血磷脂酸（LPA）和鞘氨醇I磷酸酯（S1P）在神经障碍中增强药物递送至脑的方法。 具体来说，LPA和S1P的渗透性能允许血脑屏障通透性的高度控制和瞬时的破坏。 因此，这些磷脂可用于将多种治疗性，预防性或诊断剂递送至脑。

公开(公告)号：US07595647B2

公开(公告)日：2009-09-29

申请号：US11668601

申请日：2007-01-30

申请人： Jason Kroh ,  Michael Ellis ,  Donald Miller ,  Robert Refermat

发明人： Jason Kroh ,  Michael Ellis ,  Donald Miller ,  Robert Refermat

IPC分类号： G01R27/28 ,  H01B7/00

CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/064 ,  A61B5/07 ,  A61B2560/0219 ,  H01B11/20 ,  H04B5/0043 ,  Y10S128/903

摘要： A coupling loop or antenna is provided that can be used with a system that determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. A cable attached to the coupling loop provides maximum isolation between the energizing signal and the sensor signal by maximizing the distance between the coaxial cables that carry the signals and maintaining the relative positions of the coaxial cables throughout the cable assembly.

摘要翻译： 提供耦合环路或天线，其可以与通过调节激励信号的相位和频率来确定传感器的谐振频率的系统一起使用，直到通电信号的频率与传感器的谐振频率匹配。 连接到耦合回路的电缆通过使承载信号的同轴电缆之间的距离最大化并且保持同轴电缆在整个电缆组件中的相对位置来提供激励信号和传感器信号之间的最大隔离。

公开(公告)号：US20080085795A1

公开(公告)日：2008-04-10

申请号：US11951878

申请日：2007-12-06

申请人： Donald Miller ,  Michael Ross

发明人： Donald Miller ,  Michael Ross

IPC分类号： F16H63/00

CPC分类号： B62J1/28 ,  B62K3/005 ,  B62K3/10 ,  B62K15/006 ,  B62M1/28 ,  F16H9/02 ,  Y10T74/18232 ,  Y10T74/20582 ,  Y10T74/2164

摘要： Drivetrains and frames for vehicles, equipment, machines, etc. Some embodiments of the drivetrains and frames are particularly suited for human powered machines, such as bicycles and exercise equipment. In some embodiments, a drivetrain includes a reciprocating crank coupled to a crank pivot. A lever couples to the crank via a lever pivot positioned on the crank. A lever stop cooperates with a lever guide surface to guide a motion of the lever as the lever pivots about the lever pivot. The lever and/or the crank are operably coupled to a drive pulley, idler pulley, and/or compound pulley. In some embodiments, a drive cable operably couples the lever and/or the crank to the drive pulley, idler pulley, and/or the compound pulley. In one embodiment, one or more pulleys couple to the lever's distal ends. In some embodiments, the drivetrain includes a wheel hub adapted to receive torque from the crank via a drive pulley.

公开(公告)号：US20080075599A1

公开(公告)日：2008-03-27

申请号：US11746482

申请日：2007-05-09

申请人： Donald Miller

发明人： Donald Miller

IPC分类号： F03D3/06

CPC分类号： F03D1/0608 ,  F05B2210/16 ,  Y02E10/721

摘要： A fluid energy converter, such as windmill or a wind turbine, includes a rotor having a front rotatable hub and a back rotatable hub. In some embodiments, a plurality of blades extend from the front hub to the back hub. A suitable blade includes a front section, a tip, and a back section. In one embodiment, the chord of the tip cross section is at an angle relative to the tangent of the rotor radius. The tip chord can be perpendicular to the direction of movement of the fluid. In some cases, the profile of a blade front section, from its root to the tip, forms a concave curve. In one case, the profile of the blade tip, from a junction root to the tip, forms a convex curve. A front section, an apex, and a back section of a blade form a generally parabolic shape.

摘要翻译： 诸如风车或风力涡轮机的流体能量转换器包括具有前部可旋转轮毂和后部可旋转轮毂的转子。 在一些实施例中，多个叶片从前轮毂延伸到后轮毂。 合适的叶片包括前部，尖端和后部。 在一个实施例中，尖端横截面的弦与转子半径的切线成一角度。 尖端弦可以垂直于流体的运动方向。 在一些情况下，叶片前部从其根部到尖端的轮廓形成凹曲线。 在一种情况下，叶片尖端从结根到尖端的轮廓形成凸曲线。 叶片的前部，顶点和后部部分形成大致抛物线形状。

公开(公告)号：US20080073467A1

公开(公告)日：2008-03-27

申请号：US11951838

申请日：2007-12-06

申请人： Donald Miller ,  Michael Ross

发明人： Donald Miller ,  Michael Ross

IPC分类号： B62J1/28 ,  F16C3/04 ,  G05G1/04

CPC分类号： B62J1/28 ,  B62K3/005 ,  B62K3/10 ,  B62K15/006 ,  B62M1/28 ,  F16H9/02 ,  Y10T74/18232 ,  Y10T74/20582 ,  Y10T74/2164

摘要： Drivetrains and frames for vehicles, equipment, machines, etc. Some embodiments of the drivetrains and frames are particularly suited for human powered machines, such as bicycles and exercise equipment. In some embodiments, a drivetrain includes a reciprocating crank coupled to a crank pivot. A lever couples to the crank via a lever pivot positioned on the crank. A lever stop cooperates with a lever guide surface to guide a motion of the lever as the lever pivots about the lever pivot. The lever and/or the crank are operably coupled to a drive pulley, idler pulley, and/or compound pulley. In some embodiments, a drive cable operably couples the lever and/or the crank to the drive pulley, idler pulley, and/or the compound pulley. In one embodiment, one or more pulleys couple to the lever's distal ends. In some embodiments, the drivetrain includes a wheel hub adapted to receive torque from the crank via a drive pulley.

公开(公告)号：US20070287577A1

公开(公告)日：2007-12-13

申请号：US11694119

申请日：2007-03-30

申请人： Donald Miller

发明人： Donald Miller

IPC分类号： F16H13/08

CPC分类号： B62M11/00 ,  F16H15/28 ,  F16H61/664

摘要： A continuously variable transmission is disclosed for use in rotationally or linearly powered machines and vehicles. The single axle transmission provides a simple manual shifting method for the user. An additional embodiment is disclosed which shifts automatically dependent upon the rotational speed of the wheel. Further, the practical commercialization of traction roller transmissions requires improvements in the reliability, ease of shifting, function and simplicity of the transmission. The disclosed transmission may be used in vehicles such as automobiles, motorcycles, and bicycles. The transmission may, for example, be driven by a power transfer mechanism such as a sprocket, gear, pulley or lever, optionally driving a one way clutch attached at one end of the main shaft.

摘要翻译： 公开了一种用于旋转或线性动力的机器和车辆的无级变速器。 单轴传动为用户提供了一种简单的手动换档方法。 公开了另外的实施例，其根据车轮的转速而自动地移动。 此外，牵引辊传动的实际商业化需要提高传动的可靠性，易于移动，功能和简单性。 所公开的变速器可以用于诸如汽车，摩托车和自行车的车辆中。 变速器可以例如由诸如链轮，齿轮，滑轮或杠杆的动力传递机构驱动，可选地驱动附接在主轴一端的单向离合器。