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    Tissue heating and ablation systems and methods using self-heated electrodes
    92.
    发明授权
    Tissue heating and ablation systems and methods using self-heated electrodes 失效
    组织加热和消融系统和使用自热电极的方法

    公开(公告)号：US6022346A

    公开(公告)日：2000-02-08

    申请号：US480138

    申请日：1995-06-07

    申请人： Dorin Panescu ,  Sidney D. Fleischman ,  David K. Swanson

    发明人： Dorin Panescu ,  Sidney D. Fleischman ,  David K. Swanson

    IPC分类号： A61B18/12 ,  A61B18/14 ,  A61N1/40 ,  A61B17/39

    CPC分类号： A61B18/1206 ,  A61B18/1492 ,  A61N1/403 ,  A61B18/1402 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00791 ,  A61B2018/00803

    摘要： Systems and methods using an electrode able to transmit heating or ablation energy into tissue include first and second sensing elements associated with the electrode for measuring first and second temperatures. The electrode also includes a heating element in thermal conductive contact with the electrode for heating the electrode. The systems and methods sequentially activate the heating element and sense temperatures without transmitting tissue heating or ablation energy, and then transmit heating or ablation energy and sense temperatures without activating the heating element, to derive from the sensed temperatures a prediction of maximum tissue temperature.

    摘要翻译： 使用能够将加热或消融能量传递到组织中的电极的系统和方法包括与用于测量第一和第二温度的电极相关联的第一和第二感测元件。 电极还包括与用于加热电极的电极导热接触的加热元件。 系统和方法顺序地激活加热元件并且感测温度而不传递组织加热或消融能量，然后传递加热或消融能量并感测温度而不激活加热元件，从感测的温度导出最大组织温度的预测。

    Systems and methods for matching electrical characteristics and propagation velocities in cardiac tissue
    93.
    发明授权
    Systems and methods for matching electrical characteristics and propagation velocities in cardiac tissue 失效
    用于匹配心脏组织中电特性和传播速度的系统和方法

    公开(公告)号：US5833621A

    公开(公告)日：1998-11-10

    申请号：US589799

    申请日：1996-01-22

    申请人： Dorin Panescu ,  David K. Swanson

    发明人： Dorin Panescu ,  David K. Swanson

    IPC分类号： A61B5/05 ,  A61B5/053 ,  A61N1/05 ,  A61B5/04

    CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61N1/056

    摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods also sense the timing of local depolarization events in the tissue in which impedance is sensed and derive therefrom the propagation velocities of the sensed depolarization events. The systems and methods match the derived tissue electrical characteristics with the derived propagation velocities in spatial relation to the electrodes to characterize the morphology of the contacted heart tissue. This matching provides precise differentiation between regions of infarcted heart tissue and healthy heart tissue.

    摘要翻译： 系统和方法使用三个或更多个间隔开的电极检查心脏组织形态，其中至少两个电极位于心脏内与心内膜组织接触。 所述系统和方法将电流透过位于所选择的电极对之间的心脏组织的区域，每对电极中的至少一个位于心脏内。 系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。 系统和方法还感测组织中的局部去极化事件的定时，其中阻抗被感测并从其导出感测去极化事件的传播速度。 系统和方法将衍生的组织电特征与与电极空间关系的导出传播速度相匹配，以表征所接触的心脏组织的形态。 这种匹配提供梗塞心脏组织和健康心脏组织的区域之间的精确分化。

    Systems for examining the electrical characteristics of cardiac tissue while minimizing contact with blood within the heart
    95.
    发明授权
    Systems for examining the electrical characteristics of cardiac tissue while minimizing contact with blood within the heart 失效
    用于检查心脏组织的电学特征同时最小化与心脏内的血液接触的系统

    公开(公告)号：US5732698A

    公开(公告)日：1998-03-31

    申请号：US571682

    申请日：1995-12-13

    申请人： David K. Swanson ,  Dorin Panescu

    发明人： David K. Swanson ,  Dorin Panescu

    IPC分类号： A61B5/042 ,  A61B5/053 ,  A61B18/00 ,  A61B18/14 ,  A61B5/0408 ,  A61N1/05

    CPC分类号： A61B5/6855 ,  A61B5/0422 ,  A61B5/0536 ,  A61B5/6858 ,  A61B18/00 ,  A61B18/1492 ,  A61B2562/0209 ,  A61B2562/043

    摘要： Systems for examining heart tissue morphology deploy one or more electrodes into the heart in contact with endocardial tissue. The systems transmit electrical current from the electrodes in paths through the contacted endocardial tissue. Based upon these current transmissions, the systems derive the electrical characteristics of tissue lying in the path. This electrical characteristic can be directly correlated to tissue morphology. The systems maximize surface contact with endocardial tissue, while minimizing contact with the surrounding blood pool, to obtain accurate tissue electrical characteristic measurements.

    摘要翻译： 用于检查心脏组织形态的系统将一个或多个电极部署到与心内膜组织接触的心脏中。 系统通过穿过所接触的心内膜的路径从电极传输电流。 基于这些当前传输，系统导出位于路径中的组织的电特性。 这种电气特性可以直接与组织形态相关。 系统最大限度地与心内膜组织的表面接触，同时最小化与周围血液池的接触，以获得精确的组织电特征测量。

    System and methods for matching electrical characteristics and propagation velocities in cardiac tissue
    96.
    发明授权
    System and methods for matching electrical characteristics and propagation velocities in cardiac tissue 失效
    用于匹配心脏组织中电特性和传播速度的系统和方法

    公开(公告)号：US5485849A

    公开(公告)日：1996-01-23

    申请号：US189445

    申请日：1994-01-31

    申请人： Dorin Panescu ,  David K. Swanson

    发明人： Dorin Panescu ,  David K. Swanson

    IPC分类号： A61B5/05 ,  A61B5/053 ,  A61N1/05 ,  A61C5/04

    CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61N1/056

    摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods also sense the timing of local depolarization events in the tissue in which impedance is sensed and derive therefrom the propagation velocities of the sensed depolarization events. The systems and methods match the derived tissue electrical characteristics with the derived propagation velocities in spatial relation to the electrodes to characterize the morphology of the contacted heart tissue. This matching provides precise differentiation between regions of infarcted heart tissue and healthy heart tissue.

    摘要翻译： 系统和方法使用三个或更多个间隔开的电极检查心脏组织形态，其中至少两个电极位于心脏内与心内膜组织接触。 所述系统和方法将电流透过位于所选择的电极对之间的心脏组织的区域，每对电极中的至少一个位于心脏内。 系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。 系统和方法还感测组织中局部去极化事件的定时，其中阻抗被感测并从其导出感测的去极化事件的传播速度。 系统和方法将衍生的组织电特征与与电极空间关系的导出传播速度相匹配，以表征所接触的心脏组织的形态。 这种匹配提供梗塞心脏组织和健康心脏组织的区域之间的精确分化。

    Systems and methods for examining the electrical characteristic of cardiac tissue
    98.
    发明授权
    Systems and methods for examining the electrical characteristic of cardiac tissue 失效
    检查心脏组织电学特征的系统和方法

    公开(公告)号：US06256540B1

    公开(公告)日：2001-07-03

    申请号：US08888456

    申请日：1997-07-07

    申请人： Dorin Panescu ,  David K. Swanson ,  Mark S. Mirotznik ,  David S. Schwartzman ,  Kenneth R. Foster

    发明人： Dorin Panescu ,  David K. Swanson ,  Mark S. Mirotznik ,  David S. Schwartzman ,  Kenneth R. Foster

    IPC分类号： A61B504

    CPC分类号： A61B5/6855 ,  A61B5/0422 ,  A61B5/05 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/6858 ,  A61B18/00 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056

    摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.

    摘要翻译： 系统和方法使用三个或更多个间隔开的电极检查心脏组织形态，其中至少两个电极位于心脏内与心内膜组织接触。 所述系统和方法将电流透过位于所选择的电极对之间的心脏组织的区域，每对电极中的至少一个位于心脏内。 系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。 系统和方法使得可以使用多个心内膜电极进行心脏组织的电特征的多次测量。 可以使用多路复用来促进数据处理。 系统和方法还可以鉴定低相对电特征的区域，指示梗死组织，无侵入性手术技术。

    Tissue heating and ablation systems and methods using self-heated electrodes
    100.
    发明授权
    Tissue heating and ablation systems and methods using self-heated electrodes 失效
    组织加热和消融系统和使用自热电极的方法

    公开(公告)号：US06245061B1

    公开(公告)日：2001-06-12

    申请号：US09464952

    申请日：1999-12-15

    申请人： Dorin Panescu ,  Sidney D. Fleischman ,  David K. Swanson

    发明人： Dorin Panescu ,  Sidney D. Fleischman ,  David K. Swanson

    IPC分类号： A01B1739

    CPC分类号： A61B18/1206 ,  A61B18/1402 ,  A61B18/1492 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00791 ,  A61B2018/00803 ,  A61N1/403

    摘要： Systems and methods using an electrode able to transmit heating or ablation energy into tissue include first and second sensing elements associated with the electrode for measuring first and second temperatures. The electrode also includes a heating element in thermal conductive contact with the electrode for heating the electrode. The systems and methods sequentially activate the heating element and sense temperatures without transmitting tissue heating or ablation energy, and then transmit heating or ablation energy and sense temperatures without activating the heating element, to derive from the sensed temperatures a prediction of maximum tissue temperature.

    摘要翻译： 使用能够将加热或消融能量传递到组织中的电极的系统和方法包括与用于测量第一和第二温度的电极相关联的第一和第二感测元件。 电极还包括与用于加热电极的电极导热接触的加热元件。 系统和方法顺序地激活加热元件并且感测温度而不传递组织加热或消融能量，然后传递加热或消融能量并感测温度而不激活加热元件，从感测的温度导出最大组织温度的预测。