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101 条记录 (耗时 0.091 秒)

    Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors
    91.
    发明申请
    Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors 审中-公开
    吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途

    公开(公告)号：US20060089375A1

    公开(公告)日：2006-04-27

    申请号：US10527866

    申请日：2003-09-12

    申请人： David Allen ,  Diane Coe ,  Caroline Cook ,  Michael Dowle ,  Christophen Edlin ,  Julie Hamblin ,  Martin Johnson ,  Paul Jones ,  Richard Knowles ,  Mika Lindvall ,  Charlotte Mitchell ,  Alison Redgrave ,  Peter Ward

    发明人： David Allen ,  Diane Coe ,  Caroline Cook ,  Michael Dowle ,  Christophen Edlin ,  Julie Hamblin ,  Martin Johnson ,  Paul Jones ,  Richard Knowles ,  Mika Lindvall ,  Charlotte Mitchell ,  Alison Redgrave ,  Peter Ward

    IPC分类号： C07D471/02 ,  A61K31/4745

    CPC分类号： C07D471/04

    摘要： The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl, —CH2CH2OH or —CH2CH2CO2C1-2alkyl; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.

    摘要翻译： 本发明涉及式（I）化合物或其盐：其中：R 1是C 1-4烷基，C 1-3烷基， 氟代烷基，-CH 2 CH 2 OH或-CH 2 CH 2 CO 2， C 1-12烷基; R 2是氢原子（H），甲基或C 1氟代烷基; R 3是任选取代的C 3-8环烷基或任选取代的单不饱和C 5〜5-7环烯基或任选取代的杂环基 子公式（aa），（bb）或（cc）; 其中n 1和n 2独立地为1或2; 并且其中Y是O，S，SO 2或NR 10; 或R 3是双环基（dd）或（ee）：其中X是NR 4 R 5或OR 5a 。 这些化合物是磷酸二酯酶（PDE）抑制剂，特别是PDE4抑制剂。 还提供了式（I）化合物或其药学上可接受的盐在制备用于治疗和/或预防哺乳动物例如人的炎性和/或过敏性疾病的药物中的用途， 例如慢性阻塞性肺疾病（COPD），哮喘或过敏性鼻炎。

    Tracking an image-recording medium using a watermark and associated memory
    97.
    发明申请
    Tracking an image-recording medium using a watermark and associated memory 有权
    使用水印和相关联的内存跟踪图像记录介质

    公开(公告)号：US20050086480A1

    公开(公告)日：2005-04-21

    申请号：US10662220

    申请日：2003-09-12

    申请人： Roger Kerr ,  Timothy Tredwell ,  Christopher DuMont ,  Diane Carroll-Yacoby ,  Paul Jones ,  Peter Stwertka

    发明人： Roger Kerr ,  Timothy Tredwell ,  Christopher DuMont ,  Diane Carroll-Yacoby ,  Paul Jones ,  Peter Stwertka

    IPC分类号： G03B27/475 ,  H04N1/32 ,  H04L9/00

    CPC分类号： G03B27/475

    摘要： A method for tracking a segment of an image-recording medium and an image-recording medium are provided. In a first aspect of the invention what is provided is a method for distributing an image-recording medium. In accordance with the method, an identifying mark is encoded within a recorded image area on the image-recording medium. A tracking memory is associated with the image-recording medium with the tracking memory having information stored therein. The image-recording medium is distributed to users of the image- recording medium and tracking information from the tracking memory is read and stored in a database that associates the users to whom the image-recording medium has been distributed with the identifying mark recorded in the image area.

    摘要翻译： 提供了用于跟踪图像记录介质和图像记录介质的段的方法。 在本发明的第一方面中，提供了一种用于分发图像记录介质的方法。 根据该方法，识别标记被编码在图像记录介质上的记录图像区域内。 跟踪存储器与具有存储有信息的跟踪存储器的图像记录介质相关联。 图像记录介质被分配给图像记录介质的用户，并且将来自跟踪存储器的跟踪信息读取并存储在数据库中，该数据库将图像记录介质已被分发的用户与记录在图像记录介质中的识别标记相关联 图像区域。

    Toothbrush
    99.
    发明授权
    Toothbrush 失效
    牙刷

    公开(公告)号：US06330730B1

    公开(公告)日：2001-12-18

    申请号：US09124266

    申请日：1998-07-29

    申请人： Richard Huw Davies ,  Derek Guy Savill ,  Paul Jones

    发明人： Richard Huw Davies ,  Derek Guy Savill ,  Paul Jones

    IPC分类号： A46B904

    CPC分类号： A46B15/0002

    摘要： A toothbrush incorporating an indicator comprising a pressure indicating material which provides an optical signal without the provision of a power supply. Preferably, the pressure sensitive material is a piezochromic material, such as a liquid crystal cholesterol ester.

    摘要翻译： 一种包含指示器的牙刷，包括提供光信号而不提供电源的压力指示材料。 优选地，压敏材料是压敏变色材料，例如液晶胆固醇酯。

    Foldable bowl
    100.
    发明授权
    Foldable bowl 失效
    可折叠碗

    公开(公告)号：US6019244A

    公开(公告)日：2000-02-01

    申请号：US85734

    申请日：1998-05-27

    申请人： Paul Jones

    发明人： Paul Jones

    IPC分类号： A01K5/01 ,  A01K7/00 ,  B65D6/16 ,  B65D6/36 ,  B65D5/01

    CPC分类号： A01K5/0114 ,  A01K7/00

    摘要： A portable, foldable, leak-proof bowl is provided, suitable for use by hikers and campers to provide drinking water to dogs and other pets. The bowl comprises a flexible hoop capable of being twisted into at least two circles of smaller diameter, a foldable material attached to the hoop so as to define a circular bottom for the bowl, and a side also made of a foldable material, said side being preferably in the form of a cone section tapering toward the top. The bowl folds into a compact, aesthetically pleasing circular packet, and when fasteners holding it in the folded position are released, automatically opens to its ready-to-use bowl-shaped configuration.

    摘要翻译： 提供便携式，可折叠，防漏的碗，适用于徒步旅行者和露营者为狗和其他宠物提供饮用水。 碗包括柔性箍，其能够扭曲成至少两个较小直径的圆圈，附接到箍的可折叠材料，以便限定碗的圆形底部，以及也由可折叠材料制成的侧面，所述侧面是 优选地以朝向顶部渐缩的锥形部分的形式。 碗折叠成一个紧凑的，美观的圆形包装，当将其固定在折叠位置的紧固件被释放时，自动打开成即时使用的碗形配置。