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    Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors
    1.
    发明申请
    Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors 审中-公开
    吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途

    公开(公告)号：US20060089375A1

    公开(公告)日：2006-04-27

    申请号：US10527866

    申请日：2003-09-12

    申请人： David Allen ,  Diane Coe ,  Caroline Cook ,  Michael Dowle ,  Christophen Edlin ,  Julie Hamblin ,  Martin Johnson ,  Paul Jones ,  Richard Knowles ,  Mika Lindvall ,  Charlotte Mitchell ,  Alison Redgrave ,  Peter Ward

    发明人： David Allen ,  Diane Coe ,  Caroline Cook ,  Michael Dowle ,  Christophen Edlin ,  Julie Hamblin ,  Martin Johnson ,  Paul Jones ,  Richard Knowles ,  Mika Lindvall ,  Charlotte Mitchell ,  Alison Redgrave ,  Peter Ward

    IPC分类号： C07D471/02 ,  A61K31/4745

    CPC分类号： C07D471/04

    摘要： The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl, —CH2CH2OH or —CH2CH2CO2C1-2alkyl; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.

    摘要翻译： 本发明涉及式（I）化合物或其盐：其中：R 1是C 1-4烷基，C 1-3烷基， 氟代烷基，-CH 2 CH 2 OH或-CH 2 CH 2 CO 2， C 1-12烷基; R 2是氢原子（H），甲基或C 1氟代烷基; R 3是任选取代的C 3-8环烷基或任选取代的单不饱和C 5〜5-7环烯基或任选取代的杂环基 子公式（aa），（bb）或（cc）; 其中n 1和n 2独立地为1或2; 并且其中Y是O，S，SO 2或NR 10; 或R 3是双环基（dd）或（ee）：其中X是NR 4 R 5或OR 5a 。 这些化合物是磷酸二酯酶（PDE）抑制剂，特别是PDE4抑制剂。 还提供了式（I）化合物或其药学上可接受的盐在制备用于治疗和/或预防哺乳动物例如人的炎性和/或过敏性疾病的药物中的用途， 例如慢性阻塞性肺疾病（COPD），哮喘或过敏性鼻炎。

    Pet Feeding Apparatus
    6.
    发明申请
    Pet Feeding Apparatus 审中-公开
    宠物喂养器具

    公开(公告)号：US20170006823A1

    公开(公告)日：2017-01-12

    申请号：US14792299

    申请日：2015-07-06

    申请人： Paul Jones

    发明人： Paul Jones

    IPC分类号： A01K5/01

    CPC分类号： A01K1/0356 ,  A01K1/034 ,  A01K5/01 ,  A01K5/0135 ,  A01K5/0225

    摘要： A gravity-fed, animal feeding apparatus is equipped with a funnel, a food chute, and at least one feeding pan. The food chute of the apparatus preferably includes a transport tube configured to extend through a conventional chain-link fence gap via a diamond-shaped fitting, and terminate at the feeding pan disposed on the floor within the fenced pen area. The apparatus is configured to direct dry pet food fed into the funnel disposed on the exterior of the fenced pen area to the feeding pan on the interior of the fence. Gravity causes the food in the funnel to fall into the food chute, passing through the fence, and outputting the food to the feeding pan. The feeding pan is equipped with drainage holes to ensure that the dry food does not get wet, and that water does not collect in the feeding pan.

    摘要翻译： 重力饲养的动物饲养装置配备有漏斗，食物槽和至少一个饲料盘。 该装置的食物槽优选地包括运送管，该输送管构造成经由菱形配件延伸穿过常规的链节栅栏间隙，并终止在设置在围栏笔区域内的地板上的供给盘上。 该装置被构造成将供给到设置在围栏笔区域的外部的漏斗中的干燥宠物食物引导到围栏内部的供给盘上。 重力导致漏斗中的食物落入食物槽中，穿过围栏，并将食物输送到喂食盘。 进料盘配有排水孔，以确保干燥的食物不会变湿，并且水不会在进料盘中收集。

    SYSTEM AND METHOD FOR PROVIDING ENHANCED WEIGHT ALERT NOTIFICATION DURING AUTOMATED PATIENT MANAGEMENT
    8.
    发明申请
    SYSTEM AND METHOD FOR PROVIDING ENHANCED WEIGHT ALERT NOTIFICATION DURING AUTOMATED PATIENT MANAGEMENT 有权
    在自动化患者管理期间提供增强体重警报通知的系统和方法

    公开(公告)号：US20090278696A1

    公开(公告)日：2009-11-12

    申请号：US12432939

    申请日：2009-04-30

    申请人： Par Lindh ,  Donovan Benton Fellows ,  Timothy E. Meyer ,  Paul Jones ,  Kenneth T. Tobacman

    发明人： Par Lindh ,  Donovan Benton Fellows ,  Timothy E. Meyer ,  Paul Jones ,  Kenneth T. Tobacman

    IPC分类号： G08B23/00

    CPC分类号： A61B5/0002 ,  G01G19/4146 ,  G01G19/44 ,  G01G23/3735 ,  G01G23/3742 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3475 ,  G16H50/20

    摘要： A system and method for providing enhanced weight alert notification during automated patient management is presented. A plurality of weight measurements in an automated patient environment from a weight monitoring device for a patient during an observation period is remotely obtained. A raw baseline weight for the patient is determined based on a function of the weight measurements. Irregularities in the weight measurements are identified. The raw baseline weight is processed into a baseline weight by application of a correction coefficient to the irregularities. Weight remotely measured in the automated patient environment for the patient on a substantially regular basis is obtained. Changes in the weight are identified by periodic comparison to the baseline weight. An alert notification is generated in response to the change in weight.

    摘要翻译： 提出了一种在自动化患者管理过程中提供增强重量警报通知的系统和方法。 远程获得在观察期间患者体重监测装置的自动化患者环境中的多个体重测量。 基于体重测量的函数确定患者的原始基线重量。 确定重量测量中的不规则性。 通过对不规则应用校正系数将原始基线权重处理为基线权重。 获得了在患者自动化患者环境中基本上定期地对患者进行远程测量的重量。 通过与基线重量的周期性比较来确定体重的变化。 响应于重量的变化产生警报通知。

    Control of deposition and other processes
    10.
    发明授权
    Control of deposition and other processes 失效
    控制沉积和其他工艺

    公开(公告)号：US07290589B2

    公开(公告)日：2007-11-06

    申请号：US10469738

    申请日：2002-03-05

    申请人： Stephen Richard Duncan ,  Patrick Grant ,  Paul Jones ,  Timothy Rayment

    发明人： Stephen Richard Duncan ,  Patrick Grant ,  Paul Jones ,  Timothy Rayment

    IPC分类号： B22D11/00 ,  B05B7/06

    CPC分类号： C23C4/12

    摘要： Material is incrementally deposited using material directed toward a deposition zone. The scan path of the directed material is controlled according to a path plan derived to reduce derivation from an ideal uniform temperature profile for the deposition during the deposition process. A path plan having angled scan passes that intersect (or overcross one another), for example in a mirrorbox path plan, is preferred.

    摘要翻译： 使用指向沉积区的材料来递增地沉积材料。 定向材料的扫描路径根据导出的路径计划来控制，以减少在沉积过程期间用于沉积的理想均匀温度分布的推导。 具有相交（或彼此跨越）的成角度的扫描遍历的路径计划是优选的，例如在镜像框路径规划中。