公开(公告)号：US07962210B2

公开(公告)日：2011-06-14

申请号：US12468648

申请日：2009-05-19

申请人： Douglas R. Daum ,  Qingsheng Zhu ,  Bruce H. KenKnight

发明人： Douglas R. Daum ,  Qingsheng Zhu ,  Bruce H. KenKnight

IPC分类号： A61N1/362

CPC分类号： A61N1/37217 ,  A61N1/3625 ,  A61N1/3627 ,  A61N1/37247

摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.

摘要翻译： 一种可植入医疗装置，例如心脏起搏器或植入式心律转复除颤器，具有以患者所说话语的形式接收通信的能力。 声学换能器结合在该装置内，连同相关联的滤波电路使声音通信能够用于影响装置的操作或被记录以供稍后播放。

公开(公告)号：US07953486B2

公开(公告)日：2011-05-31

申请号：US11225712

申请日：2005-09-13

申请人： Douglas R. Daum ,  Geng Zhang ,  Qingsheng Zhu ,  Gerrard M. Carlson ,  Julio Spinelli

发明人： Douglas R. Daum ,  Geng Zhang ,  Qingsheng Zhu ,  Gerrard M. Carlson ,  Julio Spinelli

IPC分类号： A61N1/365

CPC分类号： A61N1/365

摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.

摘要翻译： 与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。 最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。 最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。 在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率 到起搏器。

公开(公告)号：US20110105933A1

公开(公告)日：2011-05-05

申请号：US13004543

申请日：2011-01-11

申请人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

发明人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

IPC分类号： A61B5/02

CPC分类号： A61B7/04 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/04014 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/1118 ,  A61B5/742 ,  A61B7/023 ,  G06F19/00

摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

摘要翻译： 用于输出心音的装置包括可植入系统和外部系统。 可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。 外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。 可植入系统还可以包括用于检测心脏电信号的传感器。 在这种情况下，还输出表示心电信号的输出。

公开(公告)号：US07904155B2

公开(公告)日：2011-03-08

申请号：US11549676

申请日：2006-10-16

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

摘要翻译： 公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。 可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。 加速度计响应于心室壁位置的运动产生信号。 然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。 可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。 可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

公开(公告)号：US07881789B2

公开(公告)日：2011-02-01

申请号：US11832552

申请日：2007-08-01

申请人： Joseph M. Pastore ,  Steven D. Girouard ,  Bruce H. KenKnight ,  Qingsheng Zhu ,  Jiang Ding

发明人： Joseph M. Pastore ,  Steven D. Girouard ,  Bruce H. KenKnight ,  Qingsheng Zhu ,  Jiang Ding

IPC分类号： A61N1/368

CPC分类号： A61N1/3622 ,  A61N1/3627 ,  A61N1/3684

摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

摘要翻译： 心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。 在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

公开(公告)号：US07813799B2

公开(公告)日：2010-10-12

申请号：US10952345

申请日：2004-09-28

申请人： Scott M. Freeberg ,  Michael J. Lyden ,  Qingsheng Zhu

发明人： Scott M. Freeberg ,  Michael J. Lyden ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3712

摘要： Methods and systems involve adjusting an energy used for safety pacing based on the capture threshold. The safety pacing energy may be adjusted prior to a capture threshold test. During the capture threshold test, backup safety paces are delivered using the adjusted pacing energy. Following suspension of automatic capture verification, the device may enter a suspension mode. During the suspension mode, safety pacing pulses are delivered using a pacing energy adjusted based on capture threshold.

摘要翻译： 方法和系统包括根据捕获阈值调整用于安全起搏的能量。 可以在捕获阈值测试之前调整安全起搏能量。 在捕获阈值测试期间，使用调整的起搏能量传送备用安全步伐。 在停止自动捕获验证之后，设备可能进入暂停模式。 在悬架模式下，使用基于捕获阈值调整的起搏能量来传送安全起搏脉冲。

公开(公告)号：US20090187228A1

公开(公告)日：2009-07-23

申请号：US12415660

申请日：2009-03-31

申请人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

发明人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3712 ,  A61N1/3716

摘要： A cardiac electrical stimulation system that enhances the ability of the system to automatically detect whether an electrical stimulus results in heart capture or contraction. The cardiac electrical stimulation system may be utilized, for example, as a cardiac pacer or as a cardioverter defibrillator. The cardiac electrical stimulation system includes an electrical stimulation circuit that attenuates polarization voltages or “afterpotential” which develop at the heart tissue/electrode interface following the delivery of a stimulus to the heart tissue, which thereby allows the stimulation electrodes to be utilized to sense an evoked response to the electrical stimulus. The cardiac electrical stimulation system utilizes the stimulation electrodes to sense an evoked response, thereby eliminating the necessity for an indifferent electrode to sense an evoked response. The present invention allows accurate detection of an evoked response of the heart, to thereby determine whether each electrical stimulus results in capture.

摘要翻译： 心脏电刺激系统，其增强系统自动检测电刺激是否导致心脏捕获或收缩的能力。 心脏电刺激系统可以用作例如心脏起搏器或心律转复除颤器。 心脏电刺激系统包括电刺激电路，该电刺激电路衰减在向心脏组织递送刺激之后在心脏组织/电极界面处发展的极化电压或“后电位”，从而允许刺激电极用于感测 诱发对电刺激的反应。 心脏电刺激系统利用刺激电极来感测诱发反应，从而消除无关电极感应诱发反应的必要性。 本发明允许精确检测心脏的诱发反应，从而确定每个电刺激是否导致捕获。

公开(公告)号：US20090187226A1

公开(公告)日：2009-07-23

申请号：US12412608

申请日：2009-03-27

申请人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

发明人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

IPC分类号： A61N1/362

CPC分类号： A61N1/371 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/3962

摘要： A method and apparatus are disclosed for treating a condition of a patient's heart includes placing a first electrode and/or a second electrode in a right ventricle of the heart. In one example, a reference electrode is placed within the patient and internal or external to the heart. A pacing signal is generated including a first signal component, a second signal component and a reference component with the first and second signal components having opposite polarity and with both of the first and second components having a potential relative to the reference component. The pacing signal and the placement of the electrodes are selected to alter a contraction of a left ventricle of the heart.

摘要翻译： 公开了一种用于治疗患者心脏状况的方法和装置，包括将第一电极和/或第二电极放置在心脏的右心室中。 在一个示例中，将参考电极放置在患者体内并在心脏内部或外部。 生成包括第一信号分量，第二信号分量和参考分量的起搏信号，其中第一和第二信号分量具有相反的极性，并且第一和第二分量都具有相对于参考分量的电势。 选择起搏信号和放置电极以改变心脏左心室的收缩。

公开(公告)号：US07512440B2

公开(公告)日：2009-03-31

申请号：US11300611

申请日：2005-12-13

申请人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

发明人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

IPC分类号： A61N1/362

CPC分类号： A61N1/371 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/3962

摘要： A method and apparatus are disclosed for treating a condition of a patient's heart includes placing a first electrode and a second electrode in a right ventricle of the heart. A reference electrode is placed within the patient and internal or external to the heart. A pacing signal is generated including a first signal component, a second signal component and a reference component with the first and second signal components having opposite polarity and with both of the first and second components having a potential relative to the reference component. The first component is transmitted to the first electrode. The second component is transmitted to the second electrode. The reference electrode is connected to the reference component which may be an electrical ground. The pacing signal and the placement of the electrodes are selected to alter a contraction of a left ventricle of the heart.

摘要翻译： 公开了一种用于治疗患者心脏状况的方法和装置，包括将第一电极和第二电极放置在心脏的右心室中。 参考电极放置在患者体内并在心脏内部或外部。 生成包括第一信号分量，第二信号分量和参考分量的起搏信号，其中第一和第二信号分量具有相反的极性，并且第一和第二分量都具有相对于参考分量的电势。 第一部件被传输到第一电极。 第二部件被传送到第二电极。 参考电极连接到可以是电接地的参考部件。 选择起搏信号和放置电极以改变心脏左心室的收缩。

公开(公告)号：US07479107B2

公开(公告)日：2009-01-20

申请号：US11258432

申请日：2005-10-25

申请人： Qingsheng Zhu ,  Julio Spinelli

发明人： Qingsheng Zhu ,  Julio Spinelli

IPC分类号： A61B5/00

CPC分类号： A61B5/14539 ,  A61B5/0008 ,  A61B5/024 ,  A61B5/076 ,  A61B5/145

摘要： An implanted heart monitor includes sensors that measure various aspects of the heart failure patient's heart. A remote heart monitoring system connects the implanted heart monitor to a care provider, such as a physician. The data provided by the implanted heart monitor permits the care provider to obtain valuable data on the heart in order to make health care decisions affecting the heart failure patient's treatment. In many cases, the measurement of core body temperature and other patient data will enable the care provider to alter the patient's treatment to address the patient's condition. The implanted heart monitor can communicate over a wireless communication link with an external monitor. The implanted heart monitor may be implemented as part of a pacing device (i.e., pace maker) or may be a separate unit devoted to monitoring functions. The external monitor communicates with a monitoring station over a communication link. The monitoring station can operate as a centralized data collection unit, collecting data from multiple external monitors and multiple implanted heart monitors. Various other aspects of a heart failure patient's heart and/or body can be monitored, such as heart rate, blood pH levels, blood CO2 levels, and any other indications of the heart failure patient's activity. Various predetermined thresholds may be set to trigger alarms and/or data reports.

摘要翻译： 植入心脏监测器包括测量心力衰竭患者心脏的各个方面的传感器。 远程心脏监测系统将植入的心脏监测器连接到护理提供者，例如医师。 由植入式心脏监测器提供的数据允许护理提供者在心脏上获得有价值的数据，以便使医疗保健决定影响心力衰竭患者的治疗。 在许多情况下，核心体温和其他患者数据的测量将使护理人员能够改变患者的治疗以解决病人的状况。 植入的心脏监测器可以通过无线通信链路与外部监视器进行通信。 植入心脏监视器可以被实现为起搏装置（即，起搏器）的一部分，或者可以是专用于监视功能的单独单元。 外部监视器通过通信链路与监控站进行通信。 监控站可以作为集中数据采集单元运行，从多个外部监视器和多个植入心脏监视器收集数据。 可以监测心力衰竭患者的心脏和/或身体的各种其他方面，例如心率，血液pH值，血液二氧化碳水平以及心力衰竭患者活动的任何其他指征。 可以设置各种预定阈值以触发报警和/或数据报告。