公开(公告)号：US20110160557A1

公开(公告)日：2011-06-30

申请号：US12732403

申请日：2010-03-26

申请人： Can Cinbis ,  H. Toby Markowitz

发明人： Can Cinbis ,  H. Toby Markowitz

IPC分类号： A61B5/04

CPC分类号： A61B5/0028 ,  A61B5/0031 ,  A61B2034/2053 ,  A61B2560/0271 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37241 ,  A61N1/3756

摘要： A system and method are described for testing communication through a patient during implantation using telemetry coupling electrodes on a delivery catheter. In one example, at least two telemetry coupling electrodes may be placed on or within a delivery catheter to test conductive communication with external body electrodes during implantation. In some instances, the telemetry coupling electrodes of the delivery catheter may approximate the spacing of telemetry electrodes on an IMD. In this manner, testing conductively coupled communication with telemetry coupling electrodes of the catheter may be used to mimic the telemetry electrodes on the IMD and determine a target position and/or orientation of an electrode or electrodes of the IMD for successful conductive communication through the body.

摘要翻译： 描述了一种用于在植入期间通过患者使用传送导管上的遥测耦合电极来测试通信的系统和方法。 在一个示例中，至少两个遥测耦合电极可以放置在输送导管上或内部，以在植入期间测试与外部身体电极的导电连通。 在一些情况下，输送导管的遥测耦合电极可以接近IMD上遥测电极的间距。 以这种方式，测试与导管的遥测耦合电极的导电耦合通信可以用于模拟IMD上的遥测电极，并且确定IMD的电极或电极的目标位置和/或取向以通过身体成功地导电连通 。

公开(公告)号：US20110066198A1

公开(公告)日：2011-03-17

申请号：US12845830

申请日：2010-07-29

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

IPC分类号： A61N1/36

CPC分类号： A61B5/14551 ,  A61B5/1459 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36557 ,  A61N1/3925 ,  A61N1/3956

摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.

摘要翻译： 一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器 发射由邻近光学传感器的组织体积散射的光，以产生对应的检测到的光强度输出信号;耦合到传感器的控制模块，以响应于递送治疗来控制传感器的光发射;以及耦合到治疗传递的控制器 模块和传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于所述组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能 趋势。

公开(公告)号：US20100317940A1

公开(公告)日：2010-12-16

申请号：US12797800

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/1455

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.

摘要翻译： 用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测 通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用 光检测器输出信号。

公开(公告)号：US07787947B2

公开(公告)日：2010-08-31

申请号：US11394477

申请日：2006-03-31

申请人： Sourav Bhunia ,  Walter H. Olson ,  Can Cinbis

发明人： Sourav Bhunia ,  Walter H. Olson ,  Can Cinbis

IPC分类号： A61N1/00

CPC分类号： A61B5/14542 ,  A61B5/1459 ,  A61N1/3621 ,  A61N1/36557 ,  A61N1/3956

摘要： A medical device identifies a hemodynamically unstable arrhythmia based upon optical hemodynamic sensor signals. The optical hemodynamic sensor includes a light source for transmitting light corresponding to first and second wavelengths through a blood perfused tissue of a patient and a light detector for generating optical signals corresponding to an intensity of the detected light at the first and second wavelengths. At a low motion period for the patient, optical signals are obtained from the optical hemodynamic sensor and are analyzed to determine a baseline motion level for the patient. Subsequent signals obtained from the optical hemodynamic sensor are compared to the baseline motion levels, with only those signals corresponding to periods where motion does not exceed the baseline level of motion being further analyzed to determine if they are consistent with a hemodynamically unstable arrhythmia.

摘要翻译： 医疗设备基于光学血液动力学传感器信号识别血液动力学不稳定的心律失常。 光学血液动力学传感器包括用于通过患者的血液灌注组织透射与第一和第二波长相对应的光的光源，以及用于产生与第一和第二波长的检测光的强度对应的光信号的光检测器。 在患者的低运动周期中，从光学血液动力学传感器获得光学信号，并且被分析以确定患者的基线运动水平。 将从光学血液动力学传感器获得的后续信号与基线运动水平进行比较，只有那些对应于运动未超过基线运动水平的周期的信号进行进一步分析，以确定它们是否与血液动力学不稳定的心律失常一致。

公开(公告)号：US07682316B2

公开(公告)日：2010-03-23

申请号：US11781734

申请日：2007-07-23

申请人： David A. Anderson ,  Can Cinbis

发明人： David A. Anderson ,  Can Cinbis

IPC分类号： A61B5/02

CPC分类号： A61N1/36514 ,  A61B7/003 ,  A61B7/006 ,  A61B7/008 ,  A61B2562/0204 ,  A61N1/36578 ,  A61N1/3702

摘要： An implantable medical device system senses a first signal using a first acoustical sensor adapted to be operatively positioned in a first internal body location for sensing heart sounds in a patient. The system includes a second acoustical sensor adapted to be operatively positioned in a second internal body location for sensing sounds in the patient and generate a second signal that is less responsive to the heart sounds than the first acoustical signal. An implantable medical device including a housing and a processor enclosed in the housing receives the first signal and the second signal and generates a corrected first signal by canceling non-cardiac signals in the first signal using the second signal.

摘要翻译： 植入式医疗设备系统使用适于被操作地定位在第一内部身体位置中的第一声学传感器来感测第一信号，以感测患者心脏的声音。 该系统包括适于可操作地定位在第二内部身体位置中的第二声学传感器，用于感测患者中的声音，并产生比第一声学信号对心音响应较小的第二信号。 包括壳体和封装在壳体中的处理器的可植入医疗装置接收第一信号和第二信号，并且通过使用第二信号消除第一信号中的非心脏信号来产生校正的第一信号。

公开(公告)号：US20080208067A1

公开(公告)日：2008-08-28

申请号：US12039281

申请日：2008-02-28

申请人： Can Cinbis ,  James K. Carney

发明人： Can Cinbis ,  James K. Carney

IPC分类号： A61B5/02

CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

摘要： A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, and generates a blood volume index in response to a light source of the plurality of light sources emitting light at an isobestic wavelength. The blood volume index is then utilized to verify the identifying of the cardiac event.

摘要翻译： 一种用于感测心脏事件的医疗装置，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源以及检测发射光的检测器。 处理器响应于由检测器检测到的发射光来确定多个光测量，并且响应于以异常波长发射光的多个光源的光源产生血液体积指数。 然后利用血容量指数来验证心脏事件的识别。

公开(公告)号：US20080208020A1

公开(公告)日：2008-08-28

申请号：US12039263

申请日：2008-02-28

申请人： Can Cinbis ,  James K. Carney

发明人： Can Cinbis ,  James K. Carney

IPC分类号： A61B5/1455

CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, updates, for each of the plurality of wavelengths, a first normalization coefficient and a second normalization coefficient in response to the detected emitted light, and adjusts the determined plurality of light measurements in response to the first normalization coefficient and the second normalization coefficient.

摘要翻译： 一种用于感测心脏事件的医疗装置，其包括能够发射多个波长的光的多个光源，以及检测器，用于检测发射的光。 处理器响应于由检测器检测到的发射光来确定多个光测量，响应于检测到的发射光，针对多个波长中的每一个更新第一归一化系数和第二归一化系数，并且调整所确定的 响应于第一归一化系数和第二归一化系数的多个光测量。

公开(公告)号：US20070238992A1

公开(公告)日：2007-10-11

申请号：US11344667

申请日：2006-02-01

申请人： William Donofrio ,  Jeffrey Nycz ,  Can Cinbis ,  Matthew Morrison ,  Susan Drapeau ,  Qingshan (Sam) Ye

发明人： William Donofrio ,  Jeffrey Nycz ,  Can Cinbis ,  Matthew Morrison ,  Susan Drapeau ,  Qingshan (Sam) Ye

IPC分类号： A61B8/00

CPC分类号： A61B8/0875 ,  A61B5/076 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6882 ,  A61B7/005 ,  A61B7/006 ,  A61B8/4472 ,  A61B8/56 ,  A61B8/565

摘要： An implantable sensor for detecting changes in tissue density is disclosed. The implantable sensor includes a transducer adapted for detecting indicators of tissue density. The implantable sensor includes memory for storing data corresponding to the tissue density indicators detected by the sensor. A telemetry circuit is configured for transmitting the tissue density data outside of the body.

摘要翻译： 公开了一种用于检测组织密度变化的植入式传感器。 可植入传感器包括适于检测组织密度指标的换能器。 可植入传感器包括用于存储对应于由传感器检测的组织密度指示符的数据的存储器。 遥测电路被配置用于将身体外的组织密度数据传输。

公开(公告)号：US20070156190A1

公开(公告)日：2007-07-05

申请号：US11324076

申请日：2005-12-30

申请人： Can Cinbis

发明人： Can Cinbis

IPC分类号： A61N1/00

CPC分类号： A61N1/3925 ,  A61B5/0402 ,  A61B5/7207 ,  A61B5/721 ,  A61N1/3756

摘要： A subcutaneous implantable cardioverter defibrillator (SubQ ICD) includes a housing carrying electrodes for sensing ECG signals and delivering therapy. A sensor detects local motion in the area of the housing and produces a noise signal related to motion artifact noise contained in ECG signals derived from the electrode array. An adaptive noise cancellation circuit enhances ECG signals based on the local motion noise signal. A therapy delivery circuit delivers cardioversion and defibrillation pulses based upon the enhanced ECG signals.

摘要翻译： 皮下植入式心律转复除颤器（SubQ ICD）包括承载电极的壳体，用于感测ECG信号并递送治疗。 传感器检测壳体区域中的局部运动，并且产生与源自电极阵列的ECG信号中包含的运动伪影噪声相关的噪声信号。 自适应噪声消除电路基于局部运动噪声信号来增强ECG信号。 治疗递送电路基于增强的ECG信号提供心脏复律和除颤脉冲。

公开(公告)号：US5479926A

公开(公告)日：1996-01-02

申请号：US401715

申请日：1995-03-10

申请人： Kutay Ustuner ,  Matthew I. Haller ,  Ting-Lan Ji ,  Pai-Chi Li ,  Can Cinbis

发明人： Kutay Ustuner ,  Matthew I. Haller ,  Ting-Lan Ji ,  Pai-Chi Li ,  Can Cinbis

IPC分类号： A61B8/00 ,  G01S7/52 ,  G01S15/89 ,  G06T1/00 ,  H03H17/02

CPC分类号： H03H17/0202 ,  G01S7/52026 ,  G01S7/52046 ,  G01S15/8995 ,  G01S7/5206 ,  G01S7/52071

摘要： A display processor for an ultrasonic imaging system includes a two-dimensional filter to generate a smoothed image signal I.sub.p from a high spatial resolution image signal I.sub.D. I.sub.p is optimized for high contrast resolution and good tissue differentiation, and I.sub.D is optimized for high detail resolution and the display of fine structural details. I.sub.p and I.sub.D are applied as addressing inputs to a look-up table that provides an output image signal I.sub.O that combines both detail resolution of I.sub.D and contrast resolution of I.sub.p. I.sub.O can display detail resolution as brightness and contrast resolution as color. I.sub.O can also be formed as a weighted combination or sum of I.sub.p and I.sub.D.

摘要翻译： 用于超声成像系统的显示处理器包括二维滤波器，以从高空间分辨率图像信号ID生成平滑图像信号Ip。 Ip针对高对比度分辨率和良好的组织分化进行了优化，并针对高细节分辨率和精细结构细节的显示进行了优化。 Ip和ID被用作寻址表的寻址输入，该查询表提供输出图像信号IO，其结合ID的细节分辨率和Ip的对比度分辨率。 IO可以将亮度和对比度分辨率的细节分辨率显示为彩色。 IO也可以形成为Ip和ID的加权组合或总和。