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104 条记录 (耗时 0.059 秒)

    Recombinant antibody against human insulin-like growth factor
    93.
    发明授权
    Recombinant antibody against human insulin-like growth factor 有权
    针对人胰岛素样生长因子的重组抗体

    公开(公告)号：US07498415B2

    公开(公告)日：2009-03-03

    申请号：US10573378

    申请日：2004-09-24

    申请人： Kenya Shitara ,  Kazuyasu Nakamura ,  Yuji Ohki

    发明人： Kenya Shitara ,  Kazuyasu Nakamura ,  Yuji Ohki

    IPC分类号： C07K16/00 ,  C07K16/28

    CPC分类号： C07K16/2896 ,  C07K2317/73

    摘要： It is demanded that pharmaceutical agents for therapeutic treatment of diseases such as cancer, acromegaly and diabetic complications, of which IGF is involved in the progress of the conditions.The present invention provides a recombinant antibody or an antibody fragment thereof which specifically binds to human insulin-like growth factor-I (hereinafter referred to as hIGF-I) and human insulin-like growth factor-II (hereinafter referred to as hIGF-II) to inhibit the biological activities of human IGF-I and human IGF-II, a transformant producing the antibody or the antibody fragment thereof, a process for producing the antibody or the antibody fragment thereof, and a medicament comprising the antibody or the antibody fragment thereof as the active ingredient therein.

    摘要翻译： 要求用于治疗治疗诸如癌症，肢端肥大症和糖尿病并发症的药剂，其中IGF涉及条件的进展。 本发明提供与人胰岛素样生长因子-1（以下称为hIGF-1）和人胰岛素样生长因子-II（以下称为hIGF-II）特异性结合的重组抗体或其抗体片段 ）抑制人IGF-I和人IGF-II的生物活性，产生抗体或其抗体片段的转化体，制备抗体或其抗体片段的方法，以及包含抗体或抗体片段的药物 作为其中的活性成分。

    Cancer metastasis inhibitor
    99.
    发明申请
    Cancer metastasis inhibitor 审中-公开
    癌转移抑制剂

    公开(公告)号：US20060263362A1

    公开(公告)日：2006-11-23

    申请号：US10568714

    申请日：2004-08-20

    申请人： Atsushi Ochiai ,  Kenya Shitara ,  Kazuyasu Nakamura ,  Yuji Ohki

    发明人： Atsushi Ochiai ,  Kenya Shitara ,  Kazuyasu Nakamura ,  Yuji Ohki

    IPC分类号： A61K39/395

    CPC分类号： A61K31/00

    摘要： An object of the present invention is to provide a cancer metastasis inhibitor or, more particularly, a useful pharmaceutical composition for treating of bone metastasis and liver metastasis. In accordance with the invention, a cancer metastasis inhibitor comprising a substance inhibiting the activity of IGF (insulin-like growth factor)-I and IGF-II is an active ingredient is provided. The inhibitor can significantly suppress the metastasis of cancer.

    摘要翻译： 本发明的目的是提供一种癌症转移抑制剂，更具体地，提供一种治疗骨转移和肝转移的有用的药物组合物。 根据本发明，提供了包含抑制IGF（胰岛素样生长因子）-I和IGF-II的活性的物质的癌症转移抑制剂是活性成分。 抑制剂可显着抑制癌症转移。

    Recombinant antibody against human insulin-like growth factor
    100.
    发明申请
    Recombinant antibody against human insulin-like growth factor 有权

    公开(公告)号：US20060240015A1

    公开(公告)日：2006-10-26

    申请号：US10573378

    申请日：2004-09-24

    申请人： Kenya Shitara ,  Kazuyasu Nakamura ,  Yuji Ohki

    发明人： Kenya Shitara ,  Kazuyasu Nakamura ,  Yuji Ohki

    IPC分类号： A61K39/395 ,  C07K16/26

    CPC分类号： C07K16/2896 ,  C07K2317/73

    摘要： It is demanded that pharmaceutical agents for therapeutic treatment of diseases such as cancer, acromegaly and diabetic complications, of which IGF is involved in the progress of the conditions. The present invention provides a recombinant antibody or an antibody fragment thereof which specifically binds to human insulin-like growth factor-I (hereinafter referred to as hIGF-I) and human insulin-like growth factor-II (hereinafter referred to as hIGF-II) to inhibit the biological activities of human IGF-I and human IGF-II, a transformant producing the antibody or the antibody fragment thereof, a process for producing the antibody or the antibody fragment thereof, and a medicament comprising the antibody or the antibody fragment thereof as the active ingredient therein.