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公开(公告)号:US5468756A
公开(公告)日:1995-11-21
申请号:US241631
申请日:1994-05-12
申请人: Fumio Suzuki , Takeshi Kuroda , Shigeto Kitamura , Kenji Ohmori
发明人: Fumio Suzuki , Takeshi Kuroda , Shigeto Kitamura , Kenji Ohmori
IPC分类号: A61K31/435 , A61K31/4375 , A61P11/08 , A61P29/00 , A61P37/08 , C07D471/14 , C07D471/00 , A61K31/44
CPC分类号: C07D471/14
摘要: Disclosed are imidazonaphthyridine derivatives represented by formula (I) ##STR1## wherein: R.sup.1 represents lower alkyl or substituted or unsubstituted aryl; andX--Y--Z represents ##STR2## wherein R.sup.2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C (R.sup.5)H--(CH.sub.2).sub.n --R.sup.4 (wherein R.sup.4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 independently represents hydrogen or lower alkyl; R.sup.5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R.sup.3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryland pharmaceutically acceptable salts thereof.The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.
摘要翻译: 公开了由式(I)表示的咪唑并吡啶衍生物其中:R1表示低级烷基或取代或未取代的芳基; 并且XYZ表示其中R2表示氢,低级烷基,烯基,芳烯基或-C(R5)H-(CH2)n-R4(其中R4表示取代或未取代的芳基,取代或未取代的吡啶基,取代或未取代的呋喃基 羟基取代的低级烷基,低级烷酰氧基,吗啉代,低级烷酰基,羧基,低级烷氧基羰基,环烷基,羟基,低级烷氧基,卤素或NR6R7,其中R6和R7独立地表示氢或低级烷基; R5表示氢,低级烷基或苯基; n表示0〜3的整数)。 并且R 3表示氢,巯基,羟基,低级烷基或芳基及其药学上可接受的盐。 这些化合物显示有效的抗炎,抗过敏和支气管扩张活性。
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公开(公告)号:US5342841A
公开(公告)日:1994-08-30
申请号:US29069
申请日:1993-03-10
申请人: Fumio Suzuki , Junichi Shimada , Akira Karasawa , Hideaki Mizumoto , Hiroshi Kase , Hiromi Nonaka
发明人: Fumio Suzuki , Junichi Shimada , Akira Karasawa , Hideaki Mizumoto , Hiroshi Kase , Hiromi Nonaka
IPC分类号: C07D473/06 , A61K31/52 , C07D473/02
CPC分类号: C07D473/06
摘要: A xanthine derivative of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are substituted or unsubstituted alicyclic alkyl; m1 and m2 are the same or different and represent an integer of 0 to 2; and Q represents ##STR2## (in which R.sup.3 and R.sup.4 are the same or different and are substituted or unsubstituted alicyclic alkyl) or ##STR3## (in which n is 0 or 1, and Y is a single bond or alkylene); or a pharmaceutically acceptable salt thereof is disclosed.This derivative has diuretic activity and renal protecting activity.
摘要翻译: 式(I)的黄嘌呤衍生物:其中R1和R2相同或不同,为取代或未取代的脂环族烷基; m1和m2相同或不同,表示0〜2的整数。 和Q表示
(其中R 3和R 4相同或不同,是取代或未取代的脂环族烷基)或 (其中n为0或1,Y为单键或亚烷基)。 或其药学上可接受的盐。 该衍生物具有利尿活性和肾脏保护活性。 -
公开(公告)号:US5281610A
公开(公告)日:1994-01-25
申请号:US993920
申请日:1992-12-18
申请人: Fumio Suzuki , Takashi Kawakita , Takeshi Kuroda , Kenji Ohmori , Hiroshi Nakajima , Toshikazu Kamiya , Tatsuya Tamaoki
发明人: Fumio Suzuki , Takashi Kawakita , Takeshi Kuroda , Kenji Ohmori , Hiroshi Nakajima , Toshikazu Kamiya , Tatsuya Tamaoki
IPC分类号: C07D471/14 , A61K31/435 , C07D471/22
CPC分类号: C07D471/14 , Y10S514/88
摘要: Disclosed is a pyrazolonaphthyridine compound represented by the formula: ##STR1## wherein R.sup.1 is represents hydrogen, lower alkyl, aralkyl, or substituted or unsubstituted aryl, R.sup.2 represents hydrogen, lower alkyl, thienyl, substituted or unsubsutituted aryl, hydroxy or amino, or a pharmaceutically acceptable salt thereof.The compound possesses antiinflammatory effect, immunosuppressive effect, broncho-dilatory effect and hair growth-stimulative effect.
摘要翻译: 公开了由下式表示的吡唑并萘啶化合物:其中R 1表示氢,低级烷基,芳烷基或取代或未取代的芳基,R 2表示氢,低级烷基,噻吩基,取代或未取代的芳基,羟基或氨基,或 其药学上可接受的盐。 该化合物具有抗炎作用,免疫抑制作用,支气管扩张作用和毛发生长刺激作用。
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公开(公告)号:US5226758A
公开(公告)日:1993-07-13
申请号:US812621
申请日:1991-12-23
申请人: Kohichi Tanaka , Makoto Tsukada , Fumio Suzuki
发明人: Kohichi Tanaka , Makoto Tsukada , Fumio Suzuki
IPC分类号: H01L21/304 , H01L21/00
CPC分类号: B24B37/345 , H01L21/67023 , Y10S414/137
摘要: A semiconductor wafer handling apparatus and method for transferring a wafer, one of whose faces has been already polished, from a wafer holder, which holds the wafer with the wafer's polished face facing downward, to a wafer cassette submerged in water contained in a water tank; the apparatus includes a wafer receive assembly and a water tank and the wafer receive assembly has a flat surface and is adapted to swing between an up-facing position at which the flat surface faces upward and a down-facing position at which the flat surface faces downward, and the wafer receive assembly is provided with ejection nozzles which eject water with a force sufficient to keep the wafer floating, and the water tank contains a wafer cassette to receive the wafer, and is capable of forcing the wafer which is left to sink in the water to enter the wafer cassette; whereas the method comprises: dropping the wafer from the wafer holder with the polished face facing downward onto a thin water layer formed over the wafer receive assembly; swinging the wafer receive assembly together with the wafer through an angle of about 180.degree. so that the wafer is turned upside down and brought in the water tank, whereupon the wafer sinks through the water with the polished face facing upward; and forcing the wafer to enter the wafer cassette.
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公开(公告)号:US5192769A
公开(公告)日:1993-03-09
申请号:US921720
申请日:1992-07-30
申请人: Fumio Suzuki , Takashi Kawakita , Takeshi Kuroda , Kenji Ohmori , Hiroshi Nakajima , Toshikazu Kamiya , Tatsuya Tamaoki
发明人: Fumio Suzuki , Takashi Kawakita , Takeshi Kuroda , Kenji Ohmori , Hiroshi Nakajima , Toshikazu Kamiya , Tatsuya Tamaoki
摘要: Disclosed is a pyrazolonaphthyridine compound represented by the formula: ##STR1## wherein R.sup.1 is represents hydrogen, lower alkyl, aralkyl, or substituted or unsubstituted aryl, R.sup.2 represents hydrogen, lower alkyl, thienyl, substituted or unsubstituted aryl, hydroxy or amino, or a pharmaceutically acceptable salt thereof.The compound possesses antiinflammatory effect, immunosuppressive effect, broncho-dilatory effect and hair growth-stimulative effect.
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公开(公告)号:US5127079A
公开(公告)日:1992-06-30
申请号:US658869
申请日:1991-02-22
CPC分类号: A61B1/04 , A61B1/00165 , G02B23/26
摘要: An endoscope comprising as an image-transmitting member a multifilament type plastic optical fiber in which 50 to 20,000 islands having a core-sheath structure, a core diameter of 2 to 70 .mu.m and a circular or substantially circular section are arranged in a zigzag-stacked or square-stacked structure in the sea having a circular or substantially circular section, so that the lamination structure of the entire cores has a substantially circular shape in the section of the image-transmitting portion, wherein the same positional relationship of the ends of light-transmitting paths arranged in the section of the optical fiber is maintained on both the ends of the optical fiber, the periphery of the section of the image-transmitting portion of the optical fiber has a circular or substantially circular shape, and an object lens is attached to one end of the image-transmitting member and an image-transmitting light-receiving member is arranged on the other end of the image-transmitting member.
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公开(公告)号:US5068236A
公开(公告)日:1991-11-26
申请号:US486831
申请日:1990-03-01
申请人: Fumio Suzuki , Junichi Shimada , Kazuhiro Kubo , Tetsuji Ohno , Akira Karasawa , Akio Ishii , Hiromi Nonaka
发明人: Fumio Suzuki , Junichi Shimada , Kazuhiro Kubo , Tetsuji Ohno , Akira Karasawa , Akio Ishii , Hiromi Nonaka
IPC分类号: A61K31/52 , A61K31/522 , A61P7/10 , A61P9/08 , A61P9/12 , A61P13/02 , A61P15/00 , C07D473/04 , C07D473/06 , C07D473/08 , C07D473/10 , C07D473/12 , C07D473/20 , C07D473/22
CPC分类号: C07D473/04 , C07D473/06 , C07D473/22
摘要: Novel xanthine compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have a diuretic action, a renal-protecting action and a vasodilative action.The compounds are useful as a diuretic, a renal-protecting agent and an antihypertensive agent.
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公开(公告)号:US5058979A
公开(公告)日:1991-10-22
申请号:US242469
申请日:1990-06-21
申请人: Ryozo Yamauchi , Noboru Kawakami , Fumio Suzuki
发明人: Ryozo Yamauchi , Noboru Kawakami , Fumio Suzuki
CPC分类号: G02B6/29332 , G02B6/2552 , G02B6/2835 , G02B2006/2865
摘要: The present invention provides a wide wavelength range optical fiber coupler that to the greatest extent possible, allows optical coupling which is wavelength independent, and thus demonstrates a constant coupling ratio over a wide range of wavelengths. By causing various irregularities to be formed in the fused-elongated region of an optical fiber coupler, thereby leading to the generation of additional modes in addition to the fundamental modes, while at the same time causing multiple mode coupling in which the above mentioned additional modes participate in the coupling of the fundamental modes, it is possible to selectively control the coupling strength at determined wavelengths and thereby achieve optical coupling which is largely wavelength independent and thus demonstrates a relatively constant coupling ratio over a wide range of wavelengths. Furthermore, by causing the strength of coupling between the cores of each component optical fiber to vary along the length of the longitudinal axis of each component optical fiber, it is possible to decrease the degree of sinusoidal variation in the wavelength dependance characteristics of each component optical fiber, thereby making it possible to further achieve optical coupling which is wavelength independent and thus considerably constant over a wide range of wavelengths.
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公开(公告)号:US4992510A
公开(公告)日:1991-02-12
申请号:US394720
申请日:1989-08-16
申请人: Teruhiko Sugimori , Noriyuki Tajiri , Fumio Suzuki , Hideaki Habara , Yutaro Fukuda , Haruki Sato
发明人: Teruhiko Sugimori , Noriyuki Tajiri , Fumio Suzuki , Hideaki Habara , Yutaro Fukuda , Haruki Sato
摘要: Disclosed is method for producing a rubber modified thermoplastic reins which comprises carrying out all or a part of the following setps (I) - (VI):(I) a step of mixing the following (A), (B), (C) and thermoplastic resin (2):(A) a latex of graft rubber polymer (1),(B) an organic agent which is capable of dissolving thermoplastic resin (2) and has a solubility in water of 5% by weight or less at a temperature at which (A), (B), (C) and thermoplastic resin (2) are mixed, amount of the organic agent being 10-600% by weight of polymer (4) which is the sum of graft rubber polymer (1) and thermoplastic resin (2) and(C) a water soluble agent capable of coagulating latex (A), amount of this agent being 10% by weight or less of graft rubber polymer (1),(II) a step of separating and removing aqueous phase from a two-phase mixture obtained in the mixing step (I),(III) a step of mixing the mixture from which the aqueous phase has been removed at step (II) and the whole or a part of thermoplastic resin (3),(IV) a step of removing a part or the whole of organic agent (B) and remaining water from the mixture obtained at step (III) by a thermal means,(V) a step of mixing the remainder of thermoplastic resin (3) in case a part of thermoplastic resin (3) has been mixed at step (III), and(VI) a step of removing the remainder of organic agent (B) in case only a part of organic agent (B) has been removed at step (IV).
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公开(公告)号:US4906764A
公开(公告)日:1990-03-06
申请号:US193775
申请日:1988-05-13
CPC分类号: C07F9/301 , C07F9/3211
摘要: A process for producing a phosphinylamino acid derivative of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group, R.sup.2 is a hydrogen atom, a lower alkyl group, a halo-lower alkyl group or a substituted or unsubstituted phenyl group, and R.sup.3 is a substituted or unsubstituted alkyl group or a substituted or unsubstituted phenyl group, which comprises reacting a compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and/or a compound of the formula: ##STR3## wherein R.sup.1 and R.sup.2 are as defined above, with a compound of the formula:R.sup.3 CONH.sub.2 (IV)wherein R.sup.3 is as defined above, carbon monoxide and hydrogen in the presence of a catalyst containing a metal of group VIII of the Periodic Table.
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