公开(公告)号：US08624528B2

公开(公告)日：2014-01-07

申请号：US12707533

申请日：2010-02-17

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K1/08 ,  H05H15/00

CPC classification number: A61N5/10 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates generally to treatment of solid cancers. More particularly, the invention relates to enhancing synchrotron acceleration cycle usage efficiency by adjusting the synchrotron's acceleration cycle to correlate with a patient's respiration rate where efficiency refers to the duty cycle or the percentage of acceleration cycles used to deliver charged particles to the tumor. The system senses patient respiration and controls timing of negative ion beam formation, injection of charged particles into a synchrotron, acceleration of the charged particles, and extraction to yield delivery of the particles to the tumor at a predetermine period of the patient's respiration cycle. Independent control of charged particle energy and intensity is maintained during the timed irradiation therapy. Multi-field irradiation ensures efficient delivery of Bragg peak energy to the tumor while spreading ingress energy about the tumor.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地，本发明涉及通过调节同步加速器的加速循环来增强同步加速循环的使用效率，以与患者的呼吸速率相关联，其中效率是指用于将带电粒子递送到肿瘤的占空比或加速循环的百分比。 该系统感测患者呼吸并控制负离子束形成的时间，将带电粒子注入同步加速器，加速带电粒子和提取以在患者呼吸周期的预定时间段内将颗粒递送至肿瘤。 在定时照射治疗期间，保持对带电粒子能量和强度的独立控制。 多场照射可以有效地将布拉格峰值能量递送到肿瘤，同时扩散肿瘤周围的进入能量。

公开(公告)号：US08614554B2

公开(公告)日：2013-12-24

申请号：US13447187

申请日：2012-04-14

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H7/00

CPC classification number: H05H13/04 ,  H05H7/04

Abstract: The invention comprises a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, flat surface incident magnetic field surfaces, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子束放射治疗一起使用的带电粒子束加速，提取和/或靶向方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了转动磁体，边缘聚焦磁体，集中磁场磁体，绕组和控制线圈，平面入射磁场表面和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减少 即使在从同步加速器提取质子的过程中，所需磁场的尺寸也能直接降低所需的工作功率，并允许同步加速器中质子的持续加速。

公开(公告)号：US08399866B2

公开(公告)日：2013-03-19

申请号：US13197480

申请日：2011-08-03

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/10 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle beam extraction method and apparatus optionally used in conjunction with charged particle beam radiation therapy of cancerous tumors. The system uses a radio-frequency (RF) cavity system to induce oscillation of a charged particle stream. Sufficient amplitude modulation of the charged particle stream causes the charged particle stream to hit a material, such as a foil element of a set of foils. The foil decreases the energy of the charged particle stream, which decreases a radius of curvature of the charged particle stream in the synchrotron sufficiently to allow a physical separation of the reduced energy charged particle stream from the original charged particle stream where thickness of a selected foil is a function of energy of circulating charged particles. The physically separated charged particle stream is then removed from the system by use of an applied field and deflector.

Abstract translation: 本发明包括带电粒子束提取方法和装置，可选地与癌肿瘤的带电粒子束放射治疗一起使用。 该系统使用射频（RF）空腔系统来诱导带电粒子流的振荡。 带电粒子流的足够的幅度调制使得带电粒子流撞击一组材料，例如一组箔的箔元件。 箔片降低了带电粒子流的能量，这减少了同步加速器中的带电粒子流的曲率半径，从而允许将还原能带电粒子流与原始带电粒子流物理分离，其中选定箔片的厚度 是循环带电粒子的能量的函数。 然后通过使用施加的场和偏转器将物理分离的带电粒子流从系统中移除。

公开(公告)号：US08378321B2

公开(公告)日：2013-02-19

申请号：US12554913

申请日：2009-09-06

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: H05H13/04 ,  A61B6/04 ,  A61B6/4028 ,  A61B6/4092 ,  A61N5/1049 ,  A61N2005/1087 ,  H05H7/08 ,  H05H7/12

Abstract: The invention comprises a laying, semi-vertical, or seated patient positioning, alignment, and/or control method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. Patient positioning constraints are used to maintain the patient in a treatment position, including one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are movable and/or under computer control for rapid positioning and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract translation: 本发明包括与癌症肿瘤的多轴带电粒子或质子束放射治疗结合使用的铺设，半垂直或就座的患者定位，对准和/或控制方法和装置。 患者定位限制用于将患者维持在治疗位置，包括以下中的一个或多个：座椅支撑件，背部支撑件，头部支撑件，手臂支撑件，膝盖支撑件和脚部支撑件。 一个或多个定位限制是可移动的和/或在计算机控制下，用于病人的快速定位和/或固定。 系统可选地使用位于与粒子束癌治疗系统的质子束路径基本相同的路径中的X射线束。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制质子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

公开(公告)号：US08378311B2

公开(公告)日：2013-02-19

申请号：US13196395

申请日：2011-08-02

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K1/08 ,  H05H15/00

CPC classification number: A61N5/10 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle cancer therapy system or synchrotron system using one or more switches to introduce a corresponding one or more resistors into a circuit linking a power supply to a magnet or an inductor during an applied power recovery phase between acceleration cycles of the synchrotron, which reduces time of reduction in power from an active applied power to a power suitable for use with a subsequent injection of charged particles into the synchrotron.

Abstract translation: 本发明包括使用一个或多个开关的带电粒子癌症治疗系统或同步加速器系统，以在相同的加速器的加速循环期间的施加的功率恢复阶段期间将相应的一个或多个电阻器引入到将电源连接到磁体或电感器的电路中 ，其将功率从主动施加功率降低到适用于随后将带电粒子注入同步加速器中的功率的时间减少。

公开(公告)号：US08374314B2

公开(公告)日：2013-02-12

申请号：US13100102

申请日：2011-05-03

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K5/10 ,  A61N5/10

CPC classification number: A61N5/1049 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1097

Abstract: The invention comprises an X-ray system that is orientated to provide X-ray images of a patient in the same orientation as viewed by a proton therapy beam, is synchronized with patient respiration, is operable on a patient positioned for proton therapy, and does not interfere with a proton beam treatment path. Preferably, the synchronized system is used in conjunction with a negative ion beam source, synchrotron, and/or targeting method apparatus to provide an X-ray timed with patient respiration and performed immediately prior to and/or concurrently with particle beam therapy irradiation to ensure targeted and controlled delivery of energy relative to a patient position resulting in efficient, precise, and/or accurate noninvasive, in-vivo treatment of a solid cancerous tumor with minimization of damage to surrounding healthy tissue in a patient using the proton beam position verification system.

Abstract translation: 本发明包括X射线系统，该X射线系统被定向以提供与质子治疗束相同的取向的患者的X射线图像，与患者呼吸同步，可对位于质子治疗的患者进行操作，并且 不干扰质子束处理路径。 优选地，同步系统与负离子束源，同步加速器和/或靶向方法装置结合使用以提供与患者呼吸定时并在颗粒束治疗照射之前和/或同时进行的X射线，以确保 靶向和受控的相对于患者位置的能量传递，导致使用质子束位置验证系统以最小化对患者周围健康组织的损伤的最小化对固体癌性肿瘤的有效，精确和/或准确的非侵入性，体内治疗 。

公开(公告)号：US08373145B2

公开(公告)日：2013-02-12

申请号：US12542155

申请日：2009-08-17

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/10 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子束放射治疗一起使用的带电粒子束加速，提取和/或靶向方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了旋转磁体，边缘聚焦磁体，集中磁场磁体，绕组和控制线圈以及提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接直接减小所需磁场的尺寸 降低了所需的操作功率，并且即使在从同步加速器提取质子的过程中也允许同步加速器中质子的持续加速。

公开(公告)号：US08309941B2

公开(公告)日：2012-11-13

申请号：US12561675

申请日：2009-09-17

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H7/10

CPC classification number: H05H13/04 ,  A61N5/1049 ,  A61N2005/1087

Abstract: The invention comprises a patient respiration monitoring and/or control method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The respiration monitoring system uses thermal and/or force sensors to determine where a patient is in a respiration cycle in combination with a feedback signal control delivered to the patient to inform the patient when breath control is required. The resulting breath control is timed with charged particle delivery to the tumor to enhance accuracy, precision, and/or efficiency of tumor treatment.

Abstract translation: 本发明包括与癌症肿瘤的多轴带电粒子或质子束放射治疗结合使用的患者呼吸监测和/或控制方法和装置。 呼吸监测系统使用热和/或力传感器来确定患者在呼吸循环中的位置，并结合传送给患者的反馈信号控制，以在需要呼吸控制时通知患者。 所得到的呼吸控制与带电颗粒递送到肿瘤的时间同步以提高肿瘤治疗的准确性，精确度和/或效率。

公开(公告)号：US08288742B2

公开(公告)日：2012-10-16

申请号：US12558504

申请日：2009-09-12

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/1049 ,  A61N5/10 ,  A61N5/1082 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a patient positioning method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The patient positioning system is used to translate the patient and/or rotate the patient into a zone where the proton beam can scan the tumor using a targeting system. The patient positioning system is optionally used in conjunction with systems used to constrain movement of the patient, such as semi-vertical, sitting, or laying positioning systems.

Abstract translation: 本发明包括与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用的患者定位方法和装置。 患者定位系统用于翻译患者和/或将患者旋转到质子束可以使用靶向系统扫描肿瘤的区域。 患者定位系统可选地与用于限制患者的运动的系统结合使用，例如半垂直，坐着或铺设定位系统。

公开(公告)号：US20120248325A1

公开(公告)日：2012-10-04

申请号：US13481923

申请日：2012-05-28

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K5/08 ,  A61B6/04 ,  A61N5/00

CPC classification number: H05H7/10 ,  A61N5/1048 ,  A61N5/1067 ,  A61N2005/1087 ,  H01J3/04 ,  H01J3/14 ,  H05H13/04

Abstract: The invention comprises a patient positioning method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The patient positioning system is used to translate the patient and/or rotate the patient into a zone where the proton beam can scan the tumor using a targeting system. The patient positioning system is optionally used in conjunction with systems used to constrain movement of the patient, such as semi-vertical, sitting, or laying positioning systems.

Abstract translation: 本发明包括与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用的患者定位方法和装置。 患者定位系统用于翻译患者和/或将患者旋转到质子束可以使用靶向系统扫描肿瘤的区域。 患者定位系统可选地与用于限制患者的运动的系统结合使用，例如半垂直，坐着或铺设定位系统。