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    Imidazole and benzimidazole derivatives useful as histamine H3 antagonists
    93.
    发明授权
    Imidazole and benzimidazole derivatives useful as histamine H3 antagonists 失效
    可用作组胺H3拮抗剂的咪唑和苯并咪唑衍生物

    公开(公告)号：US07482468B2

    公开(公告)日：2009-01-27

    申请号：US11334932

    申请日：2006-01-19

    申请人： Robert G. Aslanian ,  Wing C. Tom ,  Xiaohong Zhu

    发明人： Robert G. Aslanian ,  Wing C. Tom ,  Xiaohong Zhu

    IPC分类号： C07D403/10 ,  C07D403/14 ,  C07D221/04

    CPC分类号： C07D491/10 ,  C07D233/84 ,  C07D235/26 ,  C07D235/28 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

    摘要： Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: n is 2-5; R is R3-aryl, R3-heteroaryl, R3-cycloalkyl, R3-heterocycloalkyl, alkyl, haloalkyl, —OR4, —SR4 or —S(O)1-2R5; R1 and R2 are H or optionally substituted phenyl or optionally substituted and X is —O— or —S—; or R1 and R2, together with the carbon atoms to which they are attached form optionally substituted and X is —O—, —S— or —NR7—; Z is and the remaining variables are as defined in the specification; also disclosed are pharmaceutical compositions comprising the compounds of formula I; also disclosed are methods of treating allergy, allergy-induced airway responses, congestion, obesity and metabolic syndrome using the compounds of Formula I, as well as combinations with other drugs useful for treating those diseases.

    摘要翻译： 公开了下式的化合物或其药学上可接受的盐或溶剂化物，其中：n为2-5; R是R 3 - 芳基，R 3 - 杂芳基，R 3 - 环烷基，R 3 - 杂环烷基，烷基，卤代烷基，-OR 4，-SR 4或-S（O）1-2R 5; R1和R2是H或任选取代的苯基或任选取代的，X是-O-或-S-; 或R 1和R 2与它们所连接的碳原子一起形成任选被取代，X是-O - ， - S-或-NR 7 - ; Z是，其余变量如规范中所定义; 还公开了包含式I化合物的药物组合物; 还公开了使用式I化合物治疗过敏，过敏诱发的气道反应，充血，肥胖和代谢综合征的方法，以及与用于治疗这些疾病的其它药物的组合。

    1-[[1-[(2-Amino-6-methyl-4-pyridinyl)methyl]-4-fluoro-4-piperidinyl]carbonyl]-4-[2-(2-pyridinyl)-3H-imidazo[4,5-b]pyridin-3-yl]piperidine
    94.
    发明授权
    1-[[1-[(2-Amino-6-methyl-4-pyridinyl)methyl]-4-fluoro-4-piperidinyl]carbonyl]-4-[2-(2-pyridinyl)-3H-imidazo[4,5-b]pyridin-3-yl]piperidine 失效
    1 - [[1 - [（2-氨基-6-甲基-4-吡啶基）甲基] -4-氟-4-哌啶基]羰基] -4- [2-（2-吡啶基）-3H-咪唑并[4 ，5-b]吡啶-3-基]哌啶

    公开(公告)号：US07332604B2

    公开(公告)日：2008-02-19

    申请号：US11523489

    申请日：2006-09-19

    申请人： Manuel de Lera Ruiz ,  Robert G. Aslanian ,  Michael Y. Berlin ,  Kevin D. McCormick

    发明人： Manuel de Lera Ruiz ,  Robert G. Aslanian ,  Michael Y. Berlin ,  Kevin D. McCormick

    IPC分类号： C07D498/02

    CPC分类号： C07D471/04

    摘要： The present invention discloses the compound of Formula I and pharmaceutically acceptable salts and solvates thereof. The invention also relates to pharmaceutical compositions comprising the Compound of Formula I and its use in treating obesity, metabolic syndrome, diabetes, hepatic lipidosis or nonalcoholic fatty liver disease. The invention also relates to the use of a combination of the Compound of Formula I with additional therapeutic agents for treating obesity, metabolic syndrome, diabetes, hepatic lipidosis or nonalcoholic fatty liver disease.

    摘要翻译： 本发明公开了式I化合物及其药学上可接受的盐和溶剂化物。 本发明还涉及包含式I化合物及其在治疗肥胖，代谢综合征，糖尿病，肝脏脂质沉积或非酒精性脂肪性肝病中的用途的药物组合物。 本发明还涉及式I化合物与用于治疗肥胖，代谢综合征，糖尿病，肝脏脂质沉积或非酒精性脂肪性肝病的其它治疗剂的组合的用途。