公开(公告)号：US20170112780A1

公开(公告)日：2017-04-27

申请号：US15399828

申请日：2017-01-06

申请人： TEIKOKU SEIYAKU CO., LTD

发明人： Tomohiro ISHIMA ,  Mamoru NARUSE ,  Hideo KANEDA ,  Kazuo KANAI ,  Takashi SEKINE ,  Shinichi OTA ,  Tomonari YOSHIMURA

IPC分类号： A61K9/70 ,  A61K31/4178 ,  A61K47/22 ,  A61F13/02 ,  A61K47/10 ,  A61K47/38 ,  A61K31/4174 ,  A61M35/00 ,  A61K9/00 ,  A61K47/32

CPC分类号： A61K9/7061 ,  A61F13/02 ,  A61F13/105 ,  A61F2013/00906 ,  A61K9/0014 ,  A61K31/00 ,  A61K31/4174 ,  A61K31/4178 ,  A61K45/06 ,  A61K47/10 ,  A61K47/22 ,  A61K47/32 ,  A61K47/38 ,  A61M35/00

摘要： Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

公开(公告)号：US09517331B2

公开(公告)日：2016-12-13

申请号：US13578168

申请日：2011-02-09

申请人： Mitsutoshi Yaegashi ,  Akihiro Hasui ,  Hiroyuki Kubo

发明人： Mitsutoshi Yaegashi ,  Akihiro Hasui ,  Hiroyuki Kubo

IPC分类号： A61N1/30 ,  A61N1/04

CPC分类号： A61N1/0428

摘要： An iontophoresis patch is equipped with a donor gel and a reference gel which are disposed to contact an external conductor, for example, the skin of a patient and thereby output current from a current-carrying device to the external conductor. The iontophoresis patch includes: a donor portion having the donor gel containing a medical agent to be penetrated into the external conductor; a reference portion having a reference gel, mounted with the current-carrying device on the surface on the side opposite to the reference gel, and disposed on the external conductor apart from the donor portion; and an electrode film for supplying current from the current-carrying device to the donor gel and the reference gel.

摘要翻译： 离子电渗贴片配备有供体凝胶和参考凝胶，其被设置为接触外部导体，例如患者的皮肤，从而将电流从载流装置输出到外部导体。 离子电渗贴片包括：供体部分，其具有供体凝胶，其含有要渗入外导体的药剂; 具有参考凝胶的参考部分，其在与参考凝胶相反的一侧的表面上安装有载流装置，并且设置在远离供体部分的外部导体上; 以及用于从载流装置向供体凝胶和参考凝胶提供电流的电极膜。

公开(公告)号：US09271944B2

公开(公告)日：2016-03-01

申请号：US13583940

申请日：2011-03-11

申请人： Kazuha Tani

发明人： Kazuha Tani

IPC分类号： A61K9/70 ,  A61K31/192 ,  A61K47/10

CPC分类号： A61K47/10 ,  A61K9/7023 ,  A61K9/7061 ,  A61K31/192

摘要： Provided is a water-based patch that contains ketoprofen as an active ingredient, provides high transdermal absorbability of the ketoprofen, and has high safety and high storage stability. The water-based patch contains the ketoprofen, an amine, and polyethylene glycol. In the water-based patch, the added amount of the ketoprofen in a paste is 0.1 to 5% by weight, the added amount of the amine in the paste is 0.5 to 10% by weight, and the added amount of the polyethylene glycol in the paste is 5 to 30% by weight. Particularly, in the water-based patch, diisopropanolamine is used as the amine.

摘要翻译： 提供含有酮洛芬作为活性成分的水性贴剂，提供了酮洛芬的高透皮吸收性，并具有高安全性和高储存稳定性。 水性贴剂含有酮洛芬，胺和聚乙二醇。 在水性贴剂中，糊剂中酮洛芬的添加量为0.1〜5重量％，糊剂中胺的添加量为0.5〜10重量％，聚乙二醇的添加量为 糊剂为5〜30重量％。 特别地，在水性贴片中，使用二异丙醇胺作为胺。

公开(公告)号：US09119861B2

公开(公告)日：2015-09-01

申请号：US13516014

申请日：2010-12-14

申请人： Akiko Katayama ,  Katsuyuki Inoo

发明人： Akiko Katayama ,  Katsuyuki Inoo

IPC分类号： A61K31/5415 ,  A61P29/00 ,  A61K31/245 ,  A61K9/70

CPC分类号： A61K31/5415 ,  A61K9/7053 ,  A61K31/245 ,  A61K2300/00

摘要： An adhesive patch is provided in which piroxicam is formulated as a non-steroidal anti-inflammatory analgesic. In particular, provided is a piroxicam-containing transdermally absorbable adhesive patch in which an absorption promoter to piroxicam is formulated to achieve high anti-inflammatory and analgesic effects without inhibiting releasing of these drugs. The piroxicam-containing transdermally absorbable adhesive patch contains piroxicam as a medicinal component and oxybuprocaine or a pharmaceutically acceptable salt thereof as an absorption promoter. In the piroxicam-containing transdermally absorbable adhesive patch, the content of piroxicam is from 0.1% to 5% by weight to the total weight of a drug-containing plaster and the content of oxybuprocaine or the pharmaceutically acceptable salt thereof is from 1% to 30% by weight to the total weight of the drug-containing plaster.

摘要翻译： 提供了一种胶粘贴剂，其中吡罗昔康被配制成非甾体抗炎止痛剂。 特别地，提供了含有喜树毒素的透皮吸收性粘合贴剂，其中将吡罗昔康的吸收促进剂配制成达到高抗炎和止痛作用而不抑制这些药物的释放。 含有喜树碱的透皮吸收性粘合剂贴剂含有作为药物成分的吡罗昔康和作为吸收促进剂的氧麻黄碱或其药学上可接受的盐。 在含有喜树毒素的透皮吸收性贴剂中，炎痛喜树碱的含量相对于含药膏体的总重量为0.1〜5重量％，并且奥布卡因或其药学上可接受的盐的含量为1〜30 相对于含药膏药的总重量的重量百分比。

公开(公告)号：US08840922B2

公开(公告)日：2014-09-23

申请号：US13503198

申请日：2010-10-18

申请人： Satoshi Kawakami ,  Masahiro Yamaji

发明人： Satoshi Kawakami ,  Masahiro Yamaji

IPC分类号： A61K9/70 ,  A61K31/445

CPC分类号： A61K31/445 ,  A61K9/7053

摘要： Provided is a donepezil-containing transdermal absorption formulation that can sustainably administer donepezil for a long period of time, and can provide both a rapid increase in the blood level of donepezil and donepezil sustained release properties. The donepezil-containing transdermal absorption formulation is a transdermal absorption formulation produced by dissolving donepezil, which is the active ingredient, in an adhesive patch base that contains a hydrophobic polymer and an absorption promoter. The absorption promoter is one kind or two or more kinds selected from lauryl alcohol, triethyl citrate, isopropyl myristate, cetyl lactate, oleyl alcohol, sorbitan monooleate, polyethylene glycol monostearate, lauromacrogol, N-methyl-2-pyrrolidone, and triacetin.

摘要翻译： 提供多奈哌齐的透皮吸收制剂，其可以长期可持续地施用多奈哌齐，并且可以提供多奈哌齐和多奈哌齐持续释放性质的血液水平的快速增加。 含多奈哌齐的透皮吸收制剂是通过将多奈哌齐作为活性成分溶解在含有疏水性聚合物和吸收促进剂的粘合剂贴片基中制成的透皮吸收制剂。 吸收促进剂是选自月桂醇，柠檬酸三乙酯，肉豆蔻酸异丙酯，乳酸鲸蜡酯，油醇，脱水山梨糖醇单油酸酯，聚乙二醇单硬脂酸酯，月桂醇，N-甲基-2-吡咯烷酮和三醋精中的一种或两种以上。

公开(公告)号：US20140171555A1

公开(公告)日：2014-06-19

申请号：US14233681

申请日：2012-07-18

申请人： Kazuha Tani ,  Takashi Kamakura

发明人： Kazuha Tani ,  Takashi Kamakura

IPC分类号： C09J133/02

CPC分类号： C09J133/02 ,  A61K9/7061

摘要： Provided is a water-based plaster in which the gel strength is maintained to an appropriate level in a step of producing the water-based plaster, and particularly in a spreading step and an aging step, and a final preparation can exhibit an optimal adhesiveness for adhering to the skin. In the water-based plaster, a water-based adhesive base containing a water-soluble polymer as a main ingredient contains a higher fatty acid which is a liquid at room temperature and a viscosity of 1,000 (mPa·s, 20° C.) or more as a crosslinking modifier. The higher fatty acid is isostearic acid, and the contained amount thereof is 1 to 10% by weight.

摘要翻译： 本发明提供一种在制造水性膏药的步骤中，特别是在铺展步骤和老化步骤中将凝胶强度保持在适当水平的水性石膏，并且最终制剂可以表现出最佳的粘合性 秉承皮肤。 在水性石膏中，以水溶性聚合物为主要成分的水性粘合剂基质含有在室温下为液体的高级脂肪酸，粘度为1,000（mPa·s，20℃） 以上作为交联改性剂。 高级脂肪酸是异硬脂酸，其含量为1〜10重量％。

公开(公告)号：US08741334B2

公开(公告)日：2014-06-03

申请号：US11817210

申请日：2005-02-28

申请人： Masahiro Yamaji ,  Takaya Sugawara

发明人： Masahiro Yamaji ,  Takaya Sugawara

IPC分类号： A61K9/70 ,  A61K31/34 ,  A61F13/00 ,  A01N43/08

CPC分类号： A61K9/7053 ,  A61K9/7076 ,  A61K31/192

摘要： In a plaster for external use for transdermal absorption in which an adhesive layer is laminated on a plastic backing, the adhesive layer contains a styrene-isoprene-styrene block copolymer (SIS), a tackifying resin and a softener which are essential ingredients, and further contains flurbiprofen blended as an active ingredient. The present plaster for external use is a flurbiprofen containing plaster for external use enabling long-term stable release of contained flurbiprofen, and having excellent stability and very high drug releasing property.

摘要翻译： 在用于透皮吸收的外用石膏中，其中粘合剂层层压在塑料背衬上，粘合剂层含有作为必需成分的苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物（SIS），增粘树脂和软化剂，进一步 含有氟比洛芬作为活性成分。 目前用于外用的石膏是含氟比洛芬的外用石膏，能够长期稳定地释放所含的氟比洛芬，具有优异的稳定性和非常高的药物释放性能。

公开(公告)号：USD692153S1

公开(公告)日：2013-10-22

申请号：US29431144

申请日：2012-09-04

申请人： Katsuyuki Inoo

设计人： Katsuyuki Inoo

公开(公告)号：USD692152S1

公开(公告)日：2013-10-22

申请号：US29431138

申请日：2012-09-04

申请人： Katsuyuki Inoo

设计人： Katsuyuki Inoo

公开(公告)号：US20120322840A1

公开(公告)日：2012-12-20

申请号：US13516094

申请日：2010-12-14

申请人： Akiko Katayama ,  Katsuyuki Inoo

发明人： Akiko Katayama ,  Katsuyuki Inoo

IPC分类号： A61K31/42 ,  A61P25/04 ,  A61K31/166 ,  A61P29/00 ,  A61K31/245 ,  A61K31/165

CPC分类号： A61K31/167 ,  A61K9/0014 ,  A61K9/70 ,  A61K31/245 ,  A61K31/42 ,  A61K45/06 ,  A61K2300/00

摘要： A transdermally absorbable preparation in which a basic anti-inflammatory analgesic is formulated is provided to be an external adhesive patch, which has excellent drug releasing without damaging the physical properties of a plaster. The preparation can achieve high releasing of the basic anti-inflammatory analgesic without losing the releasing of the local anesthetic. Specifically provided is a transdermally absorbable adhesive patch, which contains both the basic anti-inflammatory analgesic and the local anesthetic as the absorption promoter for the basic anti-inflammatory analgesic. The basic anti-inflammatory analgesic has the acid dissociation constant (pKa) of 7 or more. The content of the basic anti-inflammatory analgesic is from 0.1% to 10% by weight to the total weight of the drug-containing plaster, and the content of the absorption promoter is from 0.01% to 20% by weight to the total weight of the drug-containing plaster in the transdermally absorbable adhesive patch.

摘要翻译： 将其中配制碱性消炎止痛剂的经皮吸收制剂提供为外用粘合贴剂，其具有优异的药物释放，而不损害石膏的物理性能。 该制剂可以实现基本消炎止痛剂的高释放，而不会失去局部麻醉剂的释放。 具体提供的是经皮可吸收的粘合贴剂，其包含碱性消炎止痛剂和局部麻醉剂作为碱性消炎止痛剂的吸收促进剂。 碱性消炎止痛剂的酸解离常数（pKa）为7以上。 碱性抗炎止痛剂的含量相对于含药膏药的总重量为0.1〜10重量％，吸收促进剂的含量为0.01〜20重量％ 经皮可吸收的贴剂中含药物的石膏。