公开(公告)号：US07888049B2

公开(公告)日：2011-02-15

申请号：US11672440

申请日：2007-02-07

申请人： Christopher M. Shaari

发明人： Christopher M. Shaari

IPC分类号： G01N33/53 ,  G01N31/00

CPC分类号： G01N33/6893 ,  G01N33/53 ,  G01N2800/14 ,  G01N2800/24

摘要： The present invention relates to an assay which can be used on nasal secretions. The assay is used to determine the cause of nasal secretions, for example whether the secretions are due to an allergic reaction or a non-allergic reaction.

摘要翻译： 本发明涉及可用于鼻分泌物的测定法。 该测定用于确定鼻分泌物的原因，例如分泌物是否由于过敏反应或非过敏反应引起。

公开(公告)号：US20100184769A1

公开(公告)日：2010-07-22

申请号：US12664396

申请日：2008-05-31

申请人： Peter SANDNER

发明人： Peter SANDNER

IPC分类号： A61K31/53 ,  C07D487/04 ,  A61P27/16 ,  C12Q1/42

CPC分类号： C12Q1/44 ,  A61K31/53 ,  G01N2333/916 ,  G01N2500/04 ,  G01N2800/14

摘要： The invention provides pharmacological compositions comprising PDE-5 inhibitors for the treatment of hearing impairment i.e. hearing loss and tinnitus. The invention also provides methods of screening for such PDE-5 inhibitors for use in the preparation of medicaments for the treatment of hearing impairment i.e. hearing loss and tinnitus.

摘要翻译： 本发明提供包含PDE-5抑制剂用于治疗听力损伤（即听力损失和耳鸣）的药物组合物。 本发明还提供了筛选用于制备用于治疗听力损害（即听力损失和耳鸣）的药物的这种PDE-5抑制剂的方法。

公开(公告)号：US06951730B2

公开(公告)日：2005-10-04

申请号：US10015521

申请日：2001-12-13

申请人： Parker Small ,  Shih-Wen Huang ,  Ronald Kudla

发明人： Parker Small ,  Shih-Wen Huang ,  Ronald Kudla

IPC分类号： G01N33/50 ,  C12M1/34 ,  C12Q1/28 ,  C12Q1/44 ,  G01N33/52 ,  G01N33/53 ,  G01N33/569 ,  G01N33/68 ,  G01N33/84

CPC分类号： C12Q1/44 ,  G01N33/528 ,  G01N33/56911 ,  G01N33/56983 ,  G01N33/6827 ,  G01N33/6893 ,  G01N33/84 ,  G01N2800/14 ,  G01N2800/24 ,  Y10S435/975 ,  Y10S436/811

摘要： A method for detecting upper respiratory conditions. The method includes implementation of a device upon which are fixed discrete indicators of pH, protein content, nitrite content and/or leukocyte esterase activity.

摘要翻译： 一种检测上呼吸道疾病的方法。 该方法包括实施pH，蛋白质含量，亚硝酸盐含量和/或白细胞酯酶活性的固定的离散指示剂。

公开(公告)号：US06730475B1

公开(公告)日：2004-05-04

申请号：US09579288

申请日：2000-05-25

申请人： Nahid Robertson ,  Cynthia Morton ,  Guy Van Camp ,  Erik Fransen ,  Paul Van de Heyning

发明人： Nahid Robertson ,  Cynthia Morton ,  Guy Van Camp ,  Erik Fransen ,  Paul Van de Heyning

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  C12Q1/6827 ,  C12Q1/6883 ,  G01N2800/14

摘要： The invention features methods of diagnosing and treating Meniere disease. The invention also features kits and probes for diagnosing Meniere disease.

摘要翻译： 本发明具有诊断和治疗梅尼埃病的方法。 本发明还具有用于诊断梅尼埃病的试剂盒和探针。

公开(公告)号：US20020081575A1

公开(公告)日：2002-06-27

申请号：US10015525

申请日：2001-12-13

发明人： Parker Small ,  Shih-Wen Huang ,  Ronald Kudla

IPC分类号： C12Q001/70 ,  C12Q001/44

CPC分类号： C12Q1/44 ,  G01N33/528 ,  G01N33/56911 ,  G01N33/56983 ,  G01N33/6827 ,  G01N33/6893 ,  G01N33/84 ,  G01N2800/14 ,  G01N2800/24 ,  Y10S435/975 ,  Y10S436/811

摘要： A method and device for rapidly, non-invasively and inexpensively differentiating between allergic rhinitis, upper respiratory tract viral infection and bacterial sinusitis, comprising a support strip upon which is fixed discrete indicators of pH, protein content, nitrite content, leukocyte esterase activity, and eosinophil content or other measure of a substance found in allergic secretions, such as TAME esterase, of a sample with which said reagent test strip is contacted. Contact of a nasal secretion with the device of this invention permits differentiation between allergic, bacterial and viral conditions, based on pH, protein content, leukocyte esterase activity, nitrite content, eosinophil content and TAME esterase activity. The invention further provides a novel means for collecting nasal secretions to facilitate differential diagnosis of sinusitis, upper respiratory tract viral infection and allergic rhinitis.