公开(公告)号：US20040166089A1

公开(公告)日：2004-08-26

申请号：US10375705

申请日：2003-02-25

Inventor： Lei Yu ,  Sang Van ,  Shouping Ji ,  Kenji Matsumoto

IPC: A61K031/785 ,  C08G063/48 ,  C08G063/91

CPC classification number: C08G73/0213 ,  A61K47/59 ,  C08G65/002

Abstract: A polymer comprising recurring units represented by formula (I): 1 wherein X is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VZ, where R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl, where V is a labile linker group, and where Z is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, and hexadecaamine dendrimer; and wherein Y is selected from the group consisting of null(CH2)2null, null(CH2)2nullOnull(CH2)2null, null(CH2)2nullOnull(CH2)2nullOnull(CH2)2null, and null(CH2)3nullNHC(O)null(CH2)6nullC(O)NHnull(CH2)3null is useful in nucleic acid delivery applications. Polyacetals of the formula (I) are preferably made by reacting appropriate diols and divinyl ethers. In preferred embodiments, complexes formed between polyacetals of the formula (I) and polynucleotides are useful as transfection reagents.

Abstract translation: 一种包含由式（I）表示的重复单元的聚合物：其中X选自C（O）OR 1，C（O）SR 1，C（O）NR 1 R 2 >和VZ，其中R 1和R 2各自独立地选自氢，C 1至C 10烷基和C 6至C 10芳基，其中V是不稳定的连接基团，并且其中Z被选择 由聚（乙烯亚胺），聚（丙烯亚胺），聚（赖氨酸），PAMAM树枝状聚合物，八胺树枝状聚合物和十六胺树枝状聚合物组成的组中; 并且其中Y选自 - （CH 2）2 - ， - （CH 2）2 -O-（CH 2）2 - ， - （CH 2）2 -O - （CH 2）2 -O - （CH 2）2 - 和 - （CH 2）3 -NHC（O） - （CH 2）6 -C（O）NH-（CH 2）3 - 可用于核酸递送应用。 式（I）的聚缩醛优选通过使适当的二醇和二乙烯基醚反应来制备。 在优选的实施方案中，在式（I）的聚缩醛和多核苷酸之间形成的络合物可用作转染试剂。

公开(公告)号：US20040161403A1

公开(公告)日：2004-08-19

申请号：US10746567

申请日：2003-12-24

Inventor： Xuan S. Zhao ,  Zhongxu Ren ,  Kazunori Emoto

IPC: A61K031/785 ,  C08G063/48

CPC classification number: A61K9/5146 ,  A61K47/34 ,  A61K47/60 ,  A61K47/64 ,  C08G65/329 ,  C08L71/02 ,  C08L2203/02 ,  C08L2205/05 ,  C08L2666/26

Abstract: The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.

Abstract translation: 本发明提供了用于递送各种生物活性剂的多臂嵌段共聚物。 本发明的共聚物含有中心核，多个（3个或更多个）共聚物臂可从中心芯延伸。 每个共聚物臂具有内部多肽片段和外部亲水性聚合物片段。 因此，共聚物的总体结构包括内核区域，其包含中心核心和内部多肽区段，而外核区域本质上是亲水性的。 本发明的多臂共聚物特别可用于递送可以包埋在内芯区内的生物活性剂。

公开(公告)号：US20040147673A1

公开(公告)日：2004-07-29

申请号：US10753779

申请日：2004-01-08

Inventor： Anthony Calabro ,  Richard A. Gross ,  Aniq B. Darr

IPC: C08G063/48 ,  C08G063/91

CPC classification number: A61L27/52 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61L27/14 ,  C08G63/81 ,  C08G73/02 ,  C08J3/075 ,  C08L101/14

Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH. In a preferred embodiment, the macromolecular network is made up of tyramine-substituted hyaluronan molecules that are linked by dityramine bonds to provide a stable, coherent hydrogel with desired physical properties. A method of preparing such a network is also provided.

Abstract translation: 提供二羟基苯基交联的大分子网络，其可用于人造或组织工程应用，例如人造或合成软骨。 通过首先提供多胺或多羧酸盐大分子（沿着分子长度分别具有多个胺或羧酸基团）制备网络，使该高分子与具有游离羧酸基团的羟基苯基化合物反应 多胺或游离的伯胺基，并且通过碳二亚胺介导的反应途径将羟基苯基化合物取代到大分子上以提供羟基苯基取代的大分子。 然后通过在温度和pH值的代谢条件下分别连接到不同的大分子上的两个羟基苯基之间的酶催化的二聚反应将该大分子连接到其它这样的大分子。 在优选的实施方案中，大分子网络由酪胺取代的透明质酸分子组成，其通过二苯胺键连接以提供具有所需物理性质的稳定的，连贯的水凝胶。 还提供了一种制备这种网络的方法。

公开(公告)号：US20040122167A1

公开(公告)日：2004-06-24

申请号：US10624588

申请日：2003-07-23

Applicant: KURARAY CO. LTD

Inventor： Takeshi Kusudou ,  Yousuke Kumaki ,  Naoki Fujiwara

IPC: C08F008/00 ,  C08G063/48

CPC classification number: C08F8/28 ,  C08F8/48 ,  Y10T428/3163 ,  Y10T428/31942 ,  C08F16/06

Abstract: The invention provides a polyvinyl acetal having a degree of acetalization of from 45 to 80 mol %, which is obtained through acetalization of a polyvinyl alcohol having a degree of polymerization of from 30 to 1000 and a degree of hydrolysis of from 80.0 to 99.99 mol % and having a specific amount of an ionic group bonded to the terminal thereof via a sulfido bond. The polyvinyl acetal of the invention is useful for binders for ceramic forming and for binders for ink or paint.

Abstract translation: 本发明提供一种缩醛化度为45〜80摩尔％的聚乙烯醇缩醛，其通过聚合度为30〜1000，水解度为80.0〜99.99摩尔％的聚乙烯醇缩醛化而得到， 并且具有通过硫酸键与其末端键合的特定量的离子基团。 本发明的聚乙烯醇缩醛可用于陶瓷成型用粘合剂和用于油墨或油漆的粘合剂。

公开(公告)号：US20040122164A1

公开(公告)日：2004-06-24

申请号：US10661268

申请日：2003-09-12

Inventor： Perry Rosen ,  Kwang H. Nho

IPC: C08G065/00 ,  C08G063/48 ,  C08G063/91

CPC classification number: C08G65/324 ,  C08G65/329 ,  C08G65/331 ,  C08G65/33396 ,  C08L2203/02

Abstract: The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived. New syntheses for preparing such aldehydes are described.

公开(公告)号：US20040120979A1

公开(公告)日：2004-06-24

申请号：US09867924

申请日：2001-05-30

Inventor： Blake J. Roessler ,  James R. Baker JR. ,  Anna U. Bielinska

IPC: C08G063/91 ,  C08G063/48 ,  A61F002/00

CPC classification number: B82Y5/00 ,  A61K47/593 ,  A61K47/595 ,  A61K47/6949 ,  A61K48/00 ,  A61L15/26 ,  A61L15/32 ,  A61L15/44 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2300/802 ,  C08G81/00 ,  C08L101/005

Abstract: The present invention relates to novel compositions and methods for delivering substances to target tissues and cells by contacting the targets with delivery systems associated with membranes (e.g., biocompatible or bioerodable membranes). More particularly, the present invention is directed to dendrimer-based methods and compositions for use in disease therapies, wound healing, and generally, improved gene transfection and compound delivery to target cells and tissues in vitro and in vivo.

Abstract translation: 本发明涉及通过使靶与与膜相关的递送系统（例如生物相容性或生物可侵蚀的膜）接触将物质递送到靶组织和细胞的新型组合物和方法。 更具体地，本发明涉及用于疾病疗法，伤口愈合以及通常在体外和体内改进的基因转染和靶向细胞和组织的化合物递送的基于树枝状大分子的方法和组合物。

公开(公告)号：US20040116599A1

公开(公告)日：2004-06-17

申请号：US10471312

申请日：2004-01-01

Inventor： Fuchang Liu ,  Wenlin Liu ,  Peimin Hou ,  Yuanhao Xu

IPC: C08G063/48

CPC classification number: C09D163/10

Abstract: The invention discloses an acrylic acid-modified epoxy polyester resin and the preparation process thereof. The resin comprises 100 pbw of a copolymer (A) formed from an unsaturated fatty acid-modified polyester and a bisphenol A type epoxy resin, and 20-40 pbw of poly(meth)acrylic acid (ester) (B). The preparation process comprises the following steps: (1) alcoholyzing a drying oil with a polyol; (2) adding successively, to the product from step (1), a dibasic anhydride, a fatty acid containing a conjugated double bond and an epoxy resin, and esterifying to obtain an epoxy polyester; and (3) copolymerizing the epoxy polyester from step (2) and an acrylic monomer. This invention also provides a water-based emulsion containing said resin, and a water-based paint exhibiting excellent antirust property and having low production cost.

Abstract translation: 本发明公开了一种丙烯酸改性环氧聚酯树脂及其制备方法。 该树脂包含100pbw由不饱和脂肪酸改性聚酯和双酚A型环氧树脂形成的共聚物（A）和20-40pbw的聚（甲基）丙烯酸（酯）（B）。 制备方法包括以下步骤：（1）用多元醇对干性油进行醇溶; （2）依次加入来自步骤（1）的产物，二元酸酐，含有共轭双键的脂肪酸和环氧树脂，并酯化得到环氧聚酯; 和（3）使来自步骤（2）的环氧聚酯与丙烯酸单体共聚。 本发明还提供了含有所述树脂的水性乳液和显示出优异的防锈性且生产成本低的水性涂料。

公开(公告)号：US20040096903A1

公开(公告)日：2004-05-20

申请号：US10468264

申请日：2003-12-19

Inventor： William Kenneth Lang ,  Andrew Bruce Holmes ,  Ze-Yi Lim ,  Stuart John Conway ,  Melloney Kate Johns

IPC: G01N033/53 ,  C08G063/48 ,  C08G063/91

CPC classification number: G01N33/92 ,  G01N33/564 ,  G01N33/6854

Abstract: Probes comprising a cardiolipin derivative covalently attached to a solid phase, other than through an allylic oxygen, are described. Methods of making the probes are also described. A cardiolipin analogue which is amino-derivatised at the end of one of the fatty acid side chains is reacted with an activated ester attached to a solid support. The probes are useful for diagnosis of anti-phospholipid antibody syndrome (APS), and for identifying and purifying cardiolipin binding proteins.

Abstract translation: 描述了除了通过烯丙氧以外共价连接到固相的心磷脂衍生物的探针。 还描述了制备探针的方法。 在一个脂肪酸侧链的末端被氨基衍生化的心磷脂类似物与附着在固体支持物上的活化酯反应。 该探针可用于诊断抗磷脂抗体综合征（APS），并用于鉴定和纯化心磷脂结合蛋白。

公开(公告)号：US20040082716A1

公开(公告)日：2004-04-29

申请号：US10471463

申请日：2003-09-08

Inventor： Marie-Pierre Faure ,  Jean-Francois Brisson ,  Ludvik Martinu ,  Jolanta Klemberg-Sapieha ,  Oleg Zabeida

IPC: C08G063/48

CPC classification number: C08J7/123 ,  C08J5/12

Abstract: The present invention relates to a method of making a preformed hydrogel attach to a polymer backing comprising exposing a surface of the backing to an activated gas and depositing the preformed hydrogel on the exposed surface of the backing, and hydrogel products so formed. This hydrogel product can be used as an active ingredient delivery device, a wound cover and a diagnostic tool. It advantageously replaces hydrogel products using chemicals as adhesive agents.

Abstract translation: 本发明涉及使预制的水凝胶连接到聚合物背衬上的方法，其包括将背衬的表面暴露于活化气体，并将预先形成的水凝胶沉积在背衬的暴露表面上，以及如此形成的水凝胶产品。 该水凝胶产品可用作活性成分递送装置，伤口盖和诊断工具。 它有利地替代使用化学品作为粘合剂的水凝胶产品。

公开(公告)号：US20040077786A1

公开(公告)日：2004-04-22

申请号：US10276708

申请日：2003-09-02

Inventor： Patrice Robert ,  Jean-Jacques Flat

IPC: C08L051/04 ,  C08G063/48 ,  B32B027/38

CPC classification number: C08J5/18 ,  C08J2323/06 ,  C08J2323/08 ,  Y10T428/31511

Abstract: The present invention relates to a film comprising copolymers of ethylene and of an unsaturated epoxide and comprising quinones grafted onto these copolymers. The quinones are subsequently reduced (activation) to become oxygen absorbers. According to an advantageous form of the invention, it is possible, in addition to the quinones, to graft a product which results in the appearance of a hydroxyl functional group (proton donor) and optionally introduces other hydroxyl functional groups. This improves the activation of the quinone functional groups. The present invention also relates to structures comprising at least one barrier film to oxygen and at least the preceding film. The present invention also relates to a packaging comprising the preceding structure, in which, starting from the inside of the packaging and proceeding towards the outside, first the oxygen-absorbing film is encountered, followed by the barrier film to oxygen.

Abstract translation: 本发明涉及包含乙烯和不饱和环氧化物的共聚物并包含接枝到这些共聚物上的醌的膜。 随后将醌还原（活化）成为氧吸收剂。 根据本发明的有利形式，除了醌之外，还可以接枝导致羟基官能团（质子供体）出现的产物，并任选引入其它羟基官能团。 这改善了醌官能团的活化。 本发明还涉及包含至少一个氧气阻挡膜和至少前述膜的结构。 本发明还涉及一种包括前述结构的包装，其中从包装内部开始向外部流动，首先遇到氧吸收膜，随后是隔氧膜。