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2867 条记录 (耗时 0.036 秒)

    FOOD COMPOSITION FOR SUPPRESSING HEPATIC LIPOGENESIS
    93.
    发明申请
    FOOD COMPOSITION FOR SUPPRESSING HEPATIC LIPOGENESIS 审中-公开

    公开(公告)号：US20200268828A1

    公开(公告)日：2020-08-27

    申请号：US16797211

    申请日：2020-02-21

    申请人： FUJI OIL HOLDINGS INC.

    发明人： Hiroshi INOUE ,  Kumi KIMURA ,  Nobuhiko TACHIBANA

    IPC分类号： A61K38/05 ,  A23L33/18 ,  A61K38/16

    摘要： A peptide having an effect of suppressing hepatic lipogenesis, where a peptide is one or two or more peptides selected from 11 dipeptides (Ala-Gly, His-Asn, His-Ser, His-Thr, His-Trp, Val-Met, Trp-Glu, Trp-Lys, Tyr-Lys, Tyr-Ser and Tyr-Tyr) and 25 tripeptides (Val-Ile-Leu, Gly-Ser-Leu, Val-Leu-Gln, His-Ala-Gln, Arg-Ala-Val, Lys-Leu-Gly, Ile-Val-Ile, Lys-Pro-Ile, Leu-Val-Ile, Leu-Arg-Asp, Gln-Glu-Glu, Ser-Gly-Glu, Arg-Trp-Phe, Asp-Phe-Phe, Asp-Val-Phe, Pro-Phe-Tyr, Phe-Ile-Arg, Asn-Gly-Arg, Ile-Ile-Pro, Ile-Asp-Arg, Ile-His-Arg, Ile-Asp-Arg, Asn-Arg-Val, Ser-Ser-Val and Val-Phe-Val), is provided. The peptide may be used to a food composition for suppressing hepatic lipogenesis and an agent for suppressing hepatic lipogenesis.

    PALATINOSE FOR ENHANCING DIETARY SUPPLEMENT AND PHARMACEUTICAL DELIVERY
    95.
    发明申请
    PALATINOSE FOR ENHANCING DIETARY SUPPLEMENT AND PHARMACEUTICAL DELIVERY 审中-公开

    公开(公告)号：US20200237791A1

    公开(公告)日：2020-07-30

    申请号：US16785498

    申请日：2020-02-07

    申请人： Bruce W. Kneller

    发明人： Bruce W. Kneller

    IPC分类号： A61K31/7016 ,  A61K9/00 ,  A61K38/05 ,  A61K33/00 ,  A61K31/197 ,  A61K31/7076 ,  A61K31/70 ,  A61K45/06 ,  A61K31/566 ,  A61K31/122

    摘要： The present invention is directed to a dietary supplement comprising palatinose or a derivative thereof. The dietary supplement may be a nutritional product, a sports performance product, a weight loss product or a meal replacement product. The present invention is also directed to a method of increasing the absorption of a compound into the bloodstream, cells and tissue comprising administering palatinose, or a derivative thereof, in combination with the compound. The present invention also relates to a diluent for parenteral compounds. The diluent comprises palatinose or a derivative thereof. Another aspect of the present invention is directed to a method of decreasing the recovery time to pre-performance levels of total adenosine triphosphate (ATP) levels in a mammal comprising administering palatinose, or a derivative thereof, to the mammal. The present invention is further directed to a method of supplying a compound to a diabetic patient, burn victim patient or trauma victim patient. The method comprises administering palatinose, or a derivative thereof, in combination with the compound.

    Methods and compositions for treating metabolic reprogramming disorders
    98.
    发明授权
    Methods and compositions for treating metabolic reprogramming disorders 有权

    公开(公告)号：US10568868B2

    公开(公告)日：2020-02-25

    申请号：US15885147

    申请日：2018-01-31

    申请人： THE JOHNS HOPKINS UNIVERSITY

    发明人： Barbara Slusher ,  Jonathan Powell

    IPC分类号： A61K31/223 ,  A61K31/4045 ,  A61K38/05 ,  A61K31/655 ,  A61K39/395 ,  A61K31/22 ,  A61K31/225

    摘要： The disclosure provides methods of treating a condition, disease, or disorder in a subject that involves metabolically reprogrammed cells whose activation, function, growth, proliferation, or survival depends on increased activity of at least one metabolic pathway selected from the group consisting of glutamine metabolism, glycolysis, and fatty acid synthesis, comprising administering to the subject a compound having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON).