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公开(公告)号:US10294201B2
公开(公告)日:2019-05-21
申请号:US15895685
申请日:2018-02-13
申请人: Dermira, Inc.
IPC分类号: C07D207/12 , C07C309/73 , C07C303/22 , C07C201/12 , C07C309/30 , B01D9/00 , C07C63/24 , C07C67/08 , C07C69/608 , C07F11/00
摘要: Provided herein are methods for the production of glycopyrronium tosylate and glycopyrronium tosylate compositions. Also provided herein are compositions useful in the production of glycopyrronium tosylate. Additionally provided herein are glycopyrronium tosylate compositions. Glycopyrronium tosylate is useful for the treatment of, among other conditions, hyperhidrosis.
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公开(公告)号:US20190144371A1
公开(公告)日:2019-05-16
申请号:US16099438
申请日:2017-05-01
申请人: ZEON CORPORATION
发明人: Kei SAKAMOTO , Kumi OKUYAMA
摘要: Disclosed is a method of producing a compound which includes: obtaining a reaction product which contains a monoester compound represented by the following formula (I) and 1,4-cyclohexanedicarboxylic acid dichloride and/or 1,4-cyclohexanedicarboxylic acid, by reacting in an organic solvent a hydroxy compound represented by the formula Q-OH (where Q represents organic group which may have a substituent) with 1,4-cyclohexanedicarboxylic acid dichloride and/or 1,4-cyclohexanedicarboxylic acid; and mixing the reaction product with an acidic aqueous solution, where A represents hydroxyl group or chlorine atom and Q is as defined above.
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公开(公告)号:US10266478B2
公开(公告)日:2019-04-23
申请号:US15547382
申请日:2016-01-29
发明人: Yogesh Ramesh Nevare , Susheela Bhaskar Idage , Bhaskar Bhairavnath Idage , Swaminathan Sivaram
摘要: The present invention relates to a novel process for the preparation of a linear monomer alkyl lactyl lactate by a simple esterification reaction of acid with ester in presence of suitable catalysts or reagents. The present invention further relates to a process for the preparation of poly acid from alkyl lactyl lactate by using suitable catalyst.
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公开(公告)号:US10239818B2
公开(公告)日:2019-03-26
申请号:US15513716
申请日:2015-09-21
申请人: BASF SE
发明人: Armin Schraut , Martin Kaller , Rob Bronneberg , Jasmin Stammer , Martin Das , Gerrit Harnischmacher
摘要: The present invention relates to a process for preparing a terephthalic diester by reacting terephthalic acid with at least one alcohol, wherein terephthalic acid is suspended in the alcohol in a dispersing tank, the preliminary suspension is passed from the dispersing tank into a reactor and converted in the presence of an esterification catalyst, a reaction suspension is drawn off from a region between the upper region and the lower region of the reactor, a first stream of the reaction suspension is recycled into the upper region of the reactor and a second stream of the reaction suspension is introduced into the lower region of the reactor, and the reaction suspension is thus mixed, wherein the stream drawn off and/or the first stream is passed through a heat exchanger outside the reactor and heated; and water of reaction is distilled off together with the vapor as alcohol-water azeotrope, the vapor is at least partly condensed, the condensate is separated into an aqueous phase and an organic phase and the organic phase is at least partly recycled into the reaction system.
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公开(公告)号:US20190084921A1
公开(公告)日:2019-03-21
申请号:US16146499
申请日:2018-09-28
发明人: Fanghui Tang , Chi Ma , Qiang Jia
IPC分类号: C07C213/00 , C07C213/02 , C07C219/06 , C07C67/24 , C07C67/08 , C07C69/63 , C07C215/08
CPC分类号: C07C213/00 , C07C67/08 , C07C67/24 , C07C213/02 , C07C219/06 , C07C69/63 , C07C215/08
摘要: The present invention relates to a preparation method of 4-isopropylamino-1-butanol, in which using cheap and readily available tetrahydrofuran and acetic acid solution of hydrogen bromide as starting materials to prepare a novel intermediate of 4-isopropylamino-1-acetoxyl butane and further obtain the target product. The present invention has advantages of convenient process operations, mild reaction conditions, economical and environment-friendly benefits, and suitability for industrial production to obtain the product with high purity and high yield.
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公开(公告)号:US10233293B2
公开(公告)日:2019-03-19
申请号:US15815266
申请日:2017-11-16
IPC分类号: C08G77/38 , C08J3/24 , C07C41/01 , C07C67/08 , C07C29/147 , C07C319/12 , C07C67/00 , C07C67/02 , C07C67/10
摘要: A process includes forming a bio-derived crosslinking material from biorenewable aconitic acid. The process includes initiating a chemical reaction to form a bio-derived crosslinking material that includes multiple functional groups. The chemical reaction includes converting each carboxylic acid group of a biorenewable aconitic acid molecule to one of the multiple functional groups.
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公开(公告)号:US20190047938A1
公开(公告)日:2019-02-14
申请号:US16076644
申请日:2017-09-05
申请人: LG CHEM, LTD.
发明人: Hyun Kyu KIM , Mi Yeon LEE , Yun Ki CHO , Jeong Ju MOON , Joo Ho KIM , Seok Ho JEONG
摘要: The present invention relates to a plasticizer composition and a resin composition including the same, and can provide a plasticizer composition in which three types of terephthalate-based materials and three types of cyclohexane 1,4-diester-based materials are mixed, and by which environmental friendliness can be secured, mechanical properties such as tensile strength and an elongation rate, physical properties such as migration properties and volatile loss can be improved to levels equal to or higher than those of existing products, and effects of improving processability and plasticizing efficiency can be expected, and a resin composition including the same.
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公开(公告)号:US20190031593A1
公开(公告)日:2019-01-31
申请号:US16072032
申请日:2017-04-11
IPC分类号: C07C67/54 , C07C51/265 , C07C67/03 , C07C67/08
CPC分类号: C07C67/54 , C07C51/265 , C07C63/331 , C07C67/03 , C07C67/08 , C07C69/76 , C08K5/12 , C07C63/333
摘要: This disclosure relates to methods for producing purified aromatic esters useful as plasticizers, to the purified aromatic esters, and to polymer compositions containing the purified esters. The purified aromatic esters can be produced by esterifying carboxylic acid with methyl or ethyl alcohol, separating the resulting methyl or ethyl esters from the carboxylic acid and any byproduct impurities, and then transesterifying the methyl or ethyl esters with C4 to C14 alcohol to produce the purified aromatic esters. Additionally, precipitation, filtration, and wash steps can be employed to purify the carboxylic acid, the methyl or ethyl alcohol, and/or the aromatic esters.
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公开(公告)号:US20190023680A1
公开(公告)日:2019-01-24
申请号:US16024368
申请日:2018-06-29
IPC分类号: C07D311/80 , C07C45/67 , C07C45/41 , C07C67/08 , C07C45/68 , C07C29/143 , C07C29/132 , C07C69/533 , C07C49/248
摘要: Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.
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公开(公告)号:US20190002651A1
公开(公告)日:2019-01-03
申请号:US16124546
申请日:2018-09-07
IPC分类号: C08J3/24 , C08G77/38 , C07C67/10 , C07C67/02 , C07C319/12 , C07C29/147 , C07C67/08 , C07C41/01 , C07C67/00
摘要: A process includes forming a bio-derived crosslinking material from biorenewable aconitic acid. The process includes initiating a chemical reaction to form a bio-derived crosslinking material that includes multiple functional groups. The chemical reaction includes converting each carboxylic acid group of a biorenewable aconitic acid molecule to one of the multiple functional groups.
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