公开(公告)号：US6128112A

公开(公告)日：2000-10-03

申请号：US962252

申请日：1997-10-31

申请人： Daniel Nelson Harres

发明人： Daniel Nelson Harres

IPC分类号： H04B10/158 ,  H04L25/49 ,  H04B10/08

CPC分类号： H04B10/697 ,  H04L25/4904

摘要： The method and associated apparatus of the present invention decodes digital signals by appropriately weighting the respective noise portions of the two phase segments generated by the detector, such as an APD in an optical communications system, such that the digital signal can be reliably decoded despite the presence of multiplicative noise induced by the detector. The detector detects a digitally encoded communications carrier signal having a waveform defining first and second portions. The detector then generates an electrical signal in response to the digitally encoded communications carrier signal. The electrical signal has two phase segments, namely, one phase segment corresponding to the first portion of the digitally encoded communications carrier signal and another phase segment corresponding to the second portion of the digitally encoded communications carrier signal. Each phase segment also includes a respective noise portion. The optical decoding method and apparatus determines a weighting factor based upon the respective noise portions of the two phase segments. Thereafter, at least one phase segment is weighted by the weighting factor. For example, the noisier phase segment can be attenuated by the weighting factor. A decoder can then identify the logic level of the digital signal based upon the two phase segments as weighted by the weighting factor.

摘要翻译： 本发明的方法和相关装置通过适当地加权由诸如光通信系统中的APD的检测器产生的两个相位段的各个噪声部分来对数字信号进行解码，使得数字信号可以被可靠地解码，尽管 存在由检测器引起的乘法噪声。 检测器检测具有定义第一和第二部分的波形的经数字编码的通信载波信号。 然后，检测器响应于数字编码的通信载波信号产生电信号。 电信号具有两个相位段，即对应于数字编码的通信载波信号的第一部分的一个相位段和对应于数字编码的通信载波信号的第二部分的另一个相位段。 每个相位段还包括相应的噪声部分。 光解码方法和装置基于两个相位段的相应噪声部分确定加权因子。 此后，至少一个相位段被加权因子加权。 例如，噪声相位段可以通过加权因子衰减。 然后，解码器可以基于由加权因子加权的两个相位段来识别数字信号的逻辑电平。

公开(公告)号：US6031150A

公开(公告)日：2000-02-29

申请号：US476900

申请日：1995-06-07

申请人： Joseph Bryan ,  Lydia Aguilar Bryan ,  Daniel Nelson

发明人： Joseph Bryan ,  Lydia Aguilar Bryan ,  Daniel Nelson

IPC分类号： A01K67/027 ,  A61K38/00 ,  C07H21/04 ,  C07K14/705 ,  C07K16/44 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/566 ,  G01N33/577 ,  C12N5/00

CPC分类号： C12N15/8509 ,  C07K14/705 ,  C12Q1/6883 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  A61K38/00 ,  C12Q2600/156 ,  C12Q2600/166 ,  Y10S435/81

摘要： The present invention is directed to a method of detecting persistent hyperinsulinemic hypoglycemia of infancy comprising obtaining a sample comprising patient nucleic acids from a patient tissue sample; amplifying sulfonylurea receptor specific nucleic acids from said patient nucleic acids to produce a test fragment; obtaining a sample comprising control nucleic acids from a control tissue sample; amplifying control nucleic acids encoding wild type sulfonylurea receptor to produce a control fragment; comparing the test fragment with the control fragment to detect the presence of a sequence difference in the test fragment, wherein a difference in said test fragment indicates persistent hyperinsulinemic hypoglycemia of infancy. A diagnostic kit and primers for the detection of persistent hyperinsulinemic hypoglycemia of infancy are also within the scope of the present invention.

摘要翻译： 本发明涉及一种检测婴幼儿期高血糖低血糖症的方法，包括从患者组织样品获得包含患者核酸的样品; 从所述患者核酸扩增磺酰脲受体特异性核酸以产生测试片段; 从对照组织样品获得包含对照核酸的样品; 扩增编码野生型磺酰脲受体的对照核酸以产生对照片段; 将测试片段与对照片段进行比较以检测测试片段中序列差异的存在，其中所述测试片段的差异表示婴儿期持续性高胰岛素血症低血糖。 用于检测婴幼儿持续性高胰岛素血症低血糖症的诊断试剂盒和引物也在本发明的范围内。