公开(公告)号：US11452872B2

公开(公告)日：2022-09-27

申请号：US16080203

申请日：2017-02-27

Applicant: GALVANI BIOELECTRONICS LIMITED ,  CASE WESTERN RESERVE UNIVERSITY

Inventor： Alessandra Giarola ,  Yee-Hsee Hsieh ,  Stephen J. Lewis ,  Arun Sridhar

IPC: A61N1/36 ,  A61B5/08 ,  A61B5/00 ,  A61N1/05 ,  A61N1/00 ,  A61N1/18

Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.

公开(公告)号：US20220233856A1

公开(公告)日：2022-07-28

申请号：US17619221

申请日：2020-06-17

Applicant: Galvani Bioelectronics Limited

Inventor： Isha Gupta ,  Matteo Donega

IPC: A61N1/36 ,  A61N1/05

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging, shock, acute respiratory distress syndrome (ARDS), severe respiratory distress syndrome (SARS), and coronavirus disease 19 (COVID-19).

公开(公告)号：US11369793B2

公开(公告)日：2022-06-28

申请号：US16328090

申请日：2017-08-25

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  GALVANI BIOELECTRONICS LIMITED

Inventor： Jeffrey Laurence Ardell ,  Kalyanam Shivkumar ,  Arun Sridhar

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/362 ,  A61N1/32

Abstract: Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.

公开(公告)号：US20220193408A1

公开(公告)日：2022-06-23

申请号：US17690974

申请日：2022-03-09

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Marc PEPIN ,  Brian OTIS

IPC: A61N1/36 ,  H02J50/80 ,  H02J50/10 ,  H02J50/20 ,  H02J50/40 ,  A61N1/05 ,  A61N1/372 ,  A61N1/378 ,  H02J7/02 ,  H02J7/34

Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.

公开(公告)号：US20220193400A1

公开(公告)日：2022-06-23

申请号：US17594622

申请日：2020-04-24

Applicant: Faisal ZAIDI ,  GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal ZAIDI

IPC: A61N1/05 ,  A61N1/375

Abstract: A neuromodulation system is described in which electrodes are mounted within a neural interface device configured to include elastic self-pulsatile or IPG-controlled pneumatic/hydraulic collars in a distal end of the system. One or more electrodes are mounted in each collar. Each collar is connected to an implanted pulse generator (IPG) at the proximal end of the neuromodulation system via a lead body that includes pneumatic/hydraulic lines to the collars and electrical wiring to the electrodes. Gas or fluid pressure supplied to each collar can be controlled by one or more precision step motors inside the IPG. Proximal connectors to the lead body have one or more gas or liquid (biocompatible) reservoirs whose pressure is individually or collectively controlled by the one or more precision motors inside the IPG. The IPG can drive one common or multiple independent precision motors lined around each reservoir to drive one or more collars in the neural interface device.

公开(公告)号：US20220023635A1

公开(公告)日：2022-01-27

申请号：US17450308

申请日：2021-10-08

Applicant: Galvani Bioelectronics Limited

Inventor： Brian PEPIN ,  Shiv SABESAN

IPC: A61N1/36 ,  A61N1/05

Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.

公开(公告)号：US20210402194A1

公开(公告)日：2021-12-30

申请号：US17471542

申请日：2021-09-10

Applicant: Greatbatch Ltd. ,  Galvani Bioelectronics Limited

Inventor： Ignacio A. Armesto ,  Luis Daniel Villamil ,  Refet Firat Yazicioglu ,  Kristina Schlegel ,  Kent Leyde

IPC: A61N1/375

Abstract: A device that is implantable in body tissue of a human or animal. The device is comprised of a header comprising at least one terminal adapted for removable connection to a lead and an open ended case closed by a plate to form a housing. The housing is comprised of a surrounding edge wall joined to a first side wall and a second side wall opposed to the first side wall. At least a first suture port extends through the edge wall and the second side wall but not the first side wall at an upper edge region of the housing. A second suture port may extend through the surrounding edge wall and the second side wall but not the first side wall in a similar manner. A third suture port may extend through the header. The three suture ports may define a triangular attachment configuration.

公开(公告)号：USD916688S1

公开(公告)日：2021-04-20

申请号：US29664370

申请日：2018-09-24

Applicant: Galvani Bioelectronics Limited

Designer： Peng Cong ,  Damiano Patron ,  Stephen O'Driscoll

公开(公告)号：US20210093862A1

公开(公告)日：2021-04-01

申请号：US16955393

申请日：2018-12-20

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： MARGRIET VERVOORDELDONK ,  ERIC IRWIN ,  DANIEL JOHN CHEW ,  MATTEO DONEGA ,  CINDY CLEYPOOL ,  ISHA GUPTA

IPC: A61N1/36 ,  A61N1/05

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.

公开(公告)号：US20210085965A1

公开(公告)日：2021-03-25

申请号：US16634626

申请日：2018-07-23

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal ZAIDI ,  Sebastien OUCHOUCHE

IPC: A61N1/05 ,  A61N1/375

Abstract: An extravascular or intravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates formed from a multilumen tubing housing conductors for electrodes positioned in a distal serpentine shaped end of the device. The distal serpentine shaped end includes rows or strips of electrodes or coil electrodes.