公开(公告)号：US5977385A

公开(公告)日：1999-11-02

申请号：US115984

申请日：1998-07-15

Applicant: Michael T. Flavin ,  Ze-Qi Xu ,  Albert Khilevich ,  David Zembower ,  John D. Rizzo ,  Shuyuan Liao ,  Aye Mar ,  Lin Lin ,  Vilayphone Vilaychack ,  Darko Brankovic ,  Sergey Dzekhster ,  Jinjun Liu

Inventor： Michael T. Flavin ,  Ze-Qi Xu ,  Albert Khilevich ,  David Zembower ,  John D. Rizzo ,  Shuyuan Liao ,  Aye Mar ,  Lin Lin ,  Vilayphone Vilaychack ,  Darko Brankovic ,  Sergey Dzekhster ,  Jinjun Liu

IPC: A61K45/06 ,  C07D311/16 ,  C07D493/04 ,  C07D493/14 ,  C07D493/00

CPC classification number: C07D493/04 ,  A61K45/06 ,  C07D311/16 ,  C07D493/14

Abstract: A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

公开(公告)号：US5859050A

公开(公告)日：1999-01-12

申请号：US926307

申请日：1997-09-05

Applicant: Michael T. Flavin ,  Ze-Qi Xu ,  Albert Khilevich ,  David Zembower ,  John D. Rizzo ,  Lin Lin

Inventor： Michael T. Flavin ,  Ze-Qi Xu ,  Albert Khilevich ,  David Zembower ,  John D. Rizzo ,  Lin Lin

IPC: A61K45/06 ,  C07D311/16 ,  C07D493/04 ,  C07D493/14 ,  A61K31/35

CPC classification number: C07D493/04 ,  A61K45/06 ,  C07D311/16 ,  C07D493/14

Abstract: A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

公开(公告)号：US5734513A

公开(公告)日：1998-03-31

申请号：US627293

申请日：1996-04-03

Applicant: Chien-Jui Wang ,  James Lee ,  Lance M. Lan ,  Lin-Lin Chen ,  Tai Yuan Wang ,  Chien-Ping Kung ,  Junejei Huang ,  Wei-Chung Chao ,  Dao-Yang Huang

Inventor： Chien-Jui Wang ,  James Lee ,  Lance M. Lan ,  Lin-Lin Chen ,  Tai Yuan Wang ,  Chien-Ping Kung ,  Junejei Huang ,  Wei-Chung Chao ,  Dao-Yang Huang

IPC: G02B25/00 ,  G02B3/08 ,  G02B27/22 ,  G09G3/00

CPC classification number: G02B25/002

Abstract: A foldable screen display for displaying screen images is disclosed which comprises: (a) at least two sub-displays; (b) a hinging member for pivotally connecting the sub-displays together on a side-by-side manner; (c) a magnifying optical element provided on top of each of the sub-displays, the magnifying optical element providing a magnifying power of between about 1.05 and about 1.3 so as to cause images displayed on the sub-displays to be perceived by a user as if they were from a single display; and (d) a membrane covering both of the sub-displays and the hinging member, the membrane being made of a transparent and resilient material. In a preferred embodiment, the magnifying optical element is a zone plate type magnifying optical element and is constructed to provide a magnifying power approximately equalling to one plus the ratio between the width of the hinging member and the width of sub-display. The foldable screen display provides the advantages of being able to reduce the size of the display without compromising user's desire for maximum viewing comfort; therefore, it is an excellent device for use in making personal digital assistants, electronic books, electronic Rolodex.RTM., pen-based computers, portable TV, etc.

Abstract translation: 公开了一种用于显示屏幕图像的可折叠屏幕显示器，其包括：（a）至少两个子显示器; （b）用于将副显示器以并排的方式一起枢转地连接的铰接构件; （c）设置在每个子显示器的顶部的放大光学元件，放大光学元件提供约1.05和约1.3之间的放大倍数，以使得显示在子显示器上的图像被用户感知 好像他们是从一个单一的展示; 和（d）覆盖副显示器和铰链构件的膜，该膜由透明和弹性材料制成。 在优选实施例中，放大光学元件是区域型放大光学元件，并且被构造成提供大致等于一加上铰链构件的宽度与副显示器的宽度之间的比率的放大倍率。 可折叠屏幕显示器提供了能够在不影响用户对最大观看舒适度的期望的情况下减小显示器的尺寸的优点; 因此，它是用于制作个人数字助理，电子书，电子Rolodex TM，笔式电脑，便携式电视等的优秀设备。

公开(公告)号：USD390720S

公开(公告)日：1998-02-17

申请号：US64229

申请日：1996-12-24

Applicant: Jui-Lin Lin

Designer： Jui-Lin Lin

公开(公告)号：USD381837S

公开(公告)日：1997-08-05

申请号：US55833

申请日：1996-06-03

Applicant: Jui-Lin Lin

Designer： Jui-Lin Lin

公开(公告)号：USD1058973S1

公开(公告)日：2025-01-21

申请号：US29951912

申请日：2024-07-11

Applicant: Lin Lin

Designer： Lin Lin

公开(公告)号：US20180178371A1

公开(公告)日：2018-06-28

申请号：US15390940

申请日：2016-12-27

Applicant: Lin Lin Weng

Inventor： Lin Lin Weng

IPC: B25H3/02 ,  B65D25/28

CPC classification number: B25H3/028

Abstract: A dynamic toolbox that is capable of being disassembled has two pull-out side tool racks and two pop-out lift-racks. The toolbox is configured with multiple triangular apertures that provide sufficient supporting strength but eliminate unnecessary material weight.

公开(公告)号：US09662076B2

公开(公告)日：2017-05-30

申请号：US13292429

申请日：2011-11-09

Applicant: Lei Jia ,  Lin Lin

Inventor： Lei Jia ,  Lin Lin

IPC: A61B6/08 ,  A61B6/04

CPC classification number: A61B6/0492 ,  A61B6/08

Abstract: A collimation system for a medical apparatus includes a collimation component having a laser emitting device, at least one photographing device, and a computing device. The laser emitting device is configured to the emit a laser beam to irradiate on a landmark on a body surface of a patient, the at least one photographing device is configured to take a photograph of a laser irradiation spot, and the computing device is configured to obtain a position of the laser irradiation spot by performing computation on images obtained by the at least one photographing device. The system further includes a moving component provided on the medical apparatus and configured to move to a target position for performing diagnosis or treatment. The medical apparatus automatically is configured to locate the moving component based on the position of the irradiation spot obtained from the computation.

公开(公告)号：US20170076040A1

公开(公告)日：2017-03-16

申请号：US15124796

申请日：2015-03-14

Applicant: Tim Hui-Ming Huang ,  Chun-Liang Chen ,  Jeseph Liu ,  Chiou-Miin Wang ,  Ian M. Thompson ,  Chun-Lin Lin

Inventor： Tim Hui-Ming Huang ,  Chun-Liang Chen ,  Joseph Liu ,  Chiou-Miin Wang ,  Ian M. Thompson ,  Chun-Lin Lin

IPC: G06F19/26 ,  C12Q1/68

CPC classification number: G16B45/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57434

Abstract: Certain embodiments are directed to methods of measuring single cell levels of biomarkers associated with prostate cancer.

Abstract translation: 某些实施方案涉及测量与前列腺癌相关的生物标志物的单细胞水平的方法。

公开(公告)号：US09558221B2

公开(公告)日：2017-01-31

申请号：US14079060

申请日：2013-11-13

Applicant: Joseph Weizhen Hu ,  Mei-Lin Lin ,  Blaine C. French

Inventor： Joseph Weizhen Hu ,  Mei-Lin Lin ,  Blaine C. French

IPC: G06F7/00 ,  G06F17/30 ,  G06F13/14

CPC classification number: G06F17/30312

Abstract: Multi-pass parallel merging in a database includes identifying characteristics of non-final pages during database query operations. A phase of page consolidation is triggered based on the identified characteristics and a final page is stored.

Abstract translation: 数据库中的多遍并行合并包括在数据库查询操作期间识别非最终页面的特征。 基于所识别的特征触发页面合并阶段，并存储最终页面。