中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

146 records (took 0.018 seconds)

    N-(3-(4-Substituted-1-piperiding1)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists
    101.
    发明申请
    N-(3-(4-Substituted-1-piperiding1)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists 审中-公开
    N-（3-（4-取代-1-哌啶-1-基）-1-苯基丙基）取代磺酰胺作为N​​K-3受体拮抗剂

    公开(公告)号：US20070117847A1

    公开(公告)日：2007-05-24

    申请号：US11635942

    申请日：2006-12-08

    Applicant: Mark Chambers ,  Philip Jones ,  Helen Szekeres

    Inventor： Mark Chambers ,  Philip Jones ,  Helen Szekeres

    IPC: A61K31/454 ,  C07D409/14

    CPC classification number: C07D401/04 ,  A61K31/454 ,  A61K31/497 ,  C07D211/58 ,  C07D401/14 ,  C07D409/14

    Abstract: The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises administering to that subject a therapeutically effective amount of a compound of formula I: wherein, generally, Q is R1 is benzyl, phenyl, thiophene or imidazolyl optionally substituted with C1-4alkyl or halogen, such as methyl, fluorine or bromine; R2 is hydrogen or C1-4alkyl such as methyl; R3 is phenyl; R4 is hydrogen; R5 is hydrogen or C1-6alkylcarbonyl such as methylcarbonyl; X is —SO2— or —C(O)N(R2)SO2— where R2 is preferably hydrogen; Y is a bond, CH2 or Z1 where Z1 is —N(Rf)— in which Rf is C1-6alkylcarbonyl such as ethylcarbonyl; and R6 is phenyl, pyrazolyl, pyridyl, pyrimidinyl or benzimidazolonyl optionally substituted with one or two groups chosen from C1-6alkyl and benzyl, such as methyl, ethyl and benzyl; or a pharmaceutically acceptable salt thereof.

    Abstract translation: 本发明提供治疗患有诸如精神分裂症的受试者的方法，所述疾病包括施用NK-3拮抗剂，其包括向该受试者施用治疗有效量的式I化合物：其中 通常，Q是R 1是苄基，苯基，噻吩或任选被C 1-4烷基或卤素取代的咪唑基，例如甲基，氟或溴; R 2是氢或C 1-4烷基，例如甲基; R 3是苯基; R 4是氢; R 5是氢或C 1-6烷基羰基，例如甲基羰基; X是-SO 2 - 或-C（O）N（R 2）SO 2 - ，其中R 2 O / >优选为氢; Y是键，CH 2或Z 1，其中Z 1是-N（R f）， - 其中R 1是C 1-6烷基羰基，例如乙基羰基; R 6是苯基，吡唑基，吡啶基，嘧啶基或苯并咪唑烷基，任选地被一个或两个选自C 1-6烷基和苄基的基团取代，例如甲基，乙基和 苄基; 或其药学上可接受的盐。

    Soft restraining system
    103.
    发明申请
    Soft restraining system 审中-公开
    软约束系统

    公开(公告)号：US20050240132A1

    公开(公告)日：2005-10-27

    申请号：US10250409

    申请日：2001-08-29

    Applicant: Philip Jones ,  Alan Hickling ,  Ruth Hickling

    Inventor： Philip Jones ,  Alan Hickling ,  Ruth Hickling

    IPC: A61F5/37 ,  A61F5/00

    CPC classification number: A61F5/37

    Abstract: A device for restraining a miscreant includes a bell shaped tubular body adapted to envelop the torso of a miscreant. Openings at each end allow the body to be passed over the head to surround the torso of the miscreant. Restraining straps are each adapted to encircle one half of the tubular body. Each end of each of the straps may be locked at two diametrically opposed locations on the body. To deploy the device, it is held generally above the head of the miscreant and pulled downwardly over his head and torso. When the upper opening has passed the head of the miscreant to encircle his neck, one free end of each strap is pulled manually to cause lockable tightening thereof around the body of the device, thereby restraining the miscreant.

    Abstract translation: 用于限制歹徒的装置包括适于包围歹徒的躯干的钟形管形体。 在每一端的开口允许身体穿过头部以围绕歹徒的躯干。 约束带各自适合于环绕管状体的一半。 每个带子的每个端部可以锁定在身体上的两个直径相对的位置处。 为了部署设备，它通常保持在歹徒的头上，并向下拉到他的头部和躯干上。 当上部开口已经穿过歹徒的头部以包围他的脖子时，每个带子的一个自由端被手动地拉动，以使其围绕装置的身体可锁定紧固，从而限制歹徒。

    Method for determining handover in a multicellular communications system
    105.
    发明授权
    Method for determining handover in a multicellular communications system 失效
    用于确定多小区通信系统中的切换的方法

    公开(公告)号：US06192245B1

    公开(公告)日：2001-02-20

    申请号：US08973882

    申请日：1998-03-02

    Applicant: Philip Jones ,  Howard Thomas ,  Keith Essam ,  Andrew Le Fleming

    Inventor： Philip Jones ,  Howard Thomas ,  Keith Essam ,  Andrew Le Fleming

    IPC: H04Q720

    CPC classification number: H04W36/04

    Abstract: A method for determining a handover for a mobile station (1) in a multicellular communication system having a serving cell (3), a plurality of neighboring cells (4,5), and at least one control cell where the cells include at least one macrocell (2) and a plurality of microcells. The method includes the steps of comparing the received signal of the control cell with a parameter value.

    Abstract translation: 一种用于在具有服务小区（3），多个相邻小区（4,5）以及至少一个控制小区的多小区通信系统中确定移动站（1）的切换的方法，其中所述小区包括至少一个 宏小区（2）和多个微小区。 该方法包括将控制单元的接收信号与参数值进行比较的步骤。

    Operating head with phased fluid delivery
    106.
    发明授权
    Operating head with phased fluid delivery 失效
    操作头与分流输送

    公开(公告)号：US4852947A

    公开(公告)日：1989-08-01

    申请号：US123140

    申请日：1987-11-20

    Applicant: Philip Jones

    Inventor： Philip Jones

    IPC: B23Q1/00 ,  E21C35/23

    CPC classification number: E21C35/23 ,  B23Q1/0018

    Abstract: Operating head assembly, e.g. cutter head of a coal or other mining machine having provision for feeding a supply of water or other fluid to the head during operation has provision for phasing the fluid delivery to limit it to the zone about the head in which the cutting action is taking place dependent on the direction of movement of the head. Delivery jets of the head are fed through individual valve units (22) each having an independently operable hydraulic or other actuator (28), the power input thereto being controlled by apertured timing faces (36, 38) on co-acting parts of the head (11) and body (10), power feed through the timing faces being controlled e.g. in correspondence to the position of change-over valve (44, 46) operating in response to controls which direct movement of the head. In an alternative construction the valve units are actuated mechanically by a camming formation which can be indexed depending on the direction of movement.

    Abstract translation: 操作头组件，例如 具有用于在操作期间向头部供应水或其它流体的煤或其他采矿机的切割头具有用于定量流体输送以将其限制在围绕头部进行切割动作的区域相关的区域 在头部运动的方向上。 头部的输送射流通过各自具有可独立操作的液压或其它致动器（28）的单个阀单元（22）进给，其输入的功率由位于头部的协同作用部分上的有孔正时面（36,38）控制 （11）和主体（10），通过正时面的动力馈送被控制，例如 对应于转向阀（44,46）的位置，该转换阀响应于引导头部移动的控制而操作。 在替代结构中，阀单元通过凸轮结构机械地致动，该凸轮结构可根据运动方向进行分度。

Patent Agency Ranking