公开(公告)号：US09765091B2

公开(公告)日：2017-09-19

申请号：US13809581

申请日：2011-07-11

Applicant: Christelle Bolea ,  Sylvain Celanire ,  Lam Tang ,  Nigel J. Liverton ,  Philip Jones

Inventor： Christelle Bolea ,  Sylvain Celanire ,  Lam Tang ,  Nigel J. Liverton ,  Philip Jones

IPC: C07D513/12 ,  A61K31/4162 ,  A61K31/429 ,  A61K31/55 ,  A61K45/06 ,  C07D513/04 ,  C07D513/14 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/506 ,  A61B5/00 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61K9/20 ,  A23L5/00

CPC classification number: C07D513/12 ,  A23L5/00 ,  A61B5/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/06 ,  A61K9/10 ,  A61K9/2059 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/55 ,  A61K45/06 ,  C07D513/04 ,  C07D513/14 ,  A61K2300/00

Abstract: The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.

公开(公告)号：US09729224B2

公开(公告)日：2017-08-08

申请号：US12016688

申请日：2008-01-18

Applicant: Carlo Luschi ,  Simon Huckett ,  Steve Allpress ,  Philip Jones

Inventor： Carlo Luschi ,  Simon Huckett ,  Steve Allpress ,  Philip Jones

IPC: H04B7/04 ,  H04B7/08 ,  H04B7/02

CPC classification number: H04B7/0874 ,  H04B7/02 ,  H04B7/04

Abstract: Wireless receivers are described for receiving signals from a transmitter. A receiver can include a plurality of antennas each for receiving a version of a signal via a different propagation channel and providing that version to a respective input. Signal processing means can be included and configured to operate diversity processing of a supplied number of said inputs for use in performing detection of said signal. The receiver can include channel parameter estimation means, configured to estimate one or more channel parameters on the propagation channels. The receiver can also include selection means configured to select only a subset of said inputs to implement a specific dimensionality of the receiver diversity processing, in dependence on the one or more channel parameters indicative of channel conditions on said propagation channels. The diversity processing can be linear or non-linear. Related methods and software implementations and computer program products are also described.

公开(公告)号：US09127059B2

公开(公告)日：2015-09-08

申请号：US13391619

申请日：2010-08-20

Applicant: Julian Alexander Barden ,  Neil Brewis ,  Philip Jones ,  Steven Grant

Inventor： Julian Alexander Barden ,  Neil Brewis ,  Philip Jones ,  Steven Grant

IPC: C07K16/28

CPC classification number: C07K16/28 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

Abstract translation: 本发明涉及用于结合P2X7受体的抗原结合位点，抗原结合位点由通式1定义：FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

公开(公告)号：US08851418B2

公开(公告)日：2014-10-07

申请号：US13569528

申请日：2012-08-08

Applicant: Andrija Ekmed{hacek over (z)}ić ,  Mario Straccia ,  Philip Jones

Inventor： Andrija Ekmed{hacek over (z)}ić ,  Mario Straccia ,  Philip Jones

IPC: B64C25/10 ,  B64C25/14 ,  B64C25/20 ,  B64C25/04

CPC classification number: B64C25/04

Abstract: A landing gear attachment apparatus (100) has a landing gear side bearing retention arrangement (104) connected to an aircraft side attachment apparatus (102), held together by a series of fuse pins. The interaction between a fuse pin carrier and a trunnion block varies the amount of load required to separate the landing gear from the fuselage depending on the direction of the load.

Abstract translation: 起落架附接装置（100）具有连接到由一系列保险丝销保持在一起的飞机侧连接装置（102）的起落架侧轴承保持装置（104）。 保险丝销托架和耳轴座之间的相互作用根据负载方向改变将起落架与机身分离所需的负载量。

公开(公告)号：US20130252944A1

公开(公告)日：2013-09-26

申请号：US13809583

申请日：2011-07-11

Applicant: Christelle Bolea ,  Sylvain Celanire ,  Lam Tang ,  Philip Jones ,  Nigel J. Liverton ,  Richard Soll ,  Jingchao Dong ,  Zhiyu Lei ,  Fuqing Liu ,  Yanling Kong ,  Yi Ju ,  Haoyong Zhang ,  Jieping Wei ,  Qiaoxin Wei ,  Minxiang Zhang ,  Yunfu Luo

Inventor： Christelle Bolea ,  Sylvain Celanire ,  Lam Tang ,  Philip Jones ,  Nigel J. Liverton ,  Richard Soll ,  Jingchao Dong ,  Zhiyu Lei ,  Fuqing Liu ,  Yanling Kong ,  Yi Ju ,  Haoyong Zhang ,  Jieping Wei ,  Qiaoxin Wei ,  Minxiang Zhang ,  Yunfu Luo

IPC: C07D513/04 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/506 ,  C07D513/14 ,  A61K45/06

CPC classification number: C07D513/12 ,  A23L27/2056 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/06 ,  A61K9/10 ,  A61K9/2059 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/55 ,  A61K45/06 ,  C07D513/04 ,  C07D513/14 ,  A61K2300/00 ,  A23V2200/16 ,  A23V2200/322 ,  A23V2200/328

Abstract: The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.

Abstract translation: 本发明涉及新的式（I）化合物，其中M，A和Y如式（I）所定义; 本发明化合物是代谢型谷氨酸受体的调节剂 - 亚型4（“mGluR4”），其可用于治疗或预防中枢神经系统疾病以及由mGluR4受体调节的其它障碍。 本发明还涉及药物组合物和这些化合物在制备药物中的用途，以及这些化合物用于预防和治疗涉及mGluR4的疾病的用途。

公开(公告)号：US08362030B2

公开(公告)日：2013-01-29

申请号：US12922270

申请日：2009-03-13

Applicant: Raffaele Ingenito ,  Philip Jones ,  Laura Llauger Bufi ,  Jesus Maria Ontoria Ontoria ,  Rita Scarpelli

Inventor： Raffaele Ingenito ,  Philip Jones ,  Laura Llauger Bufi ,  Jesus Maria Ontoria Ontoria ,  Rita Scarpelli

IPC: A61K31/437 ,  C07D471/12

CPC classification number: C07D471/06 ,  C07D471/16

Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.

Abstract translation: 本发明涉及作为聚（ADP-核糖）聚合酶（PARP）的抑制剂的式（I）化合物及其药学上可接受的盐或互变异构体，因此可用于治疗癌症，炎性疾病，再灌注损伤，缺血状况， 中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤，皮肤衰老和紫外线诱发的皮肤损伤，以及用于癌症治疗的化学或放射增敏剂。

公开(公告)号：US08268827B2

公开(公告)日：2012-09-18

申请号：US12739262

申请日：2008-11-14

Applicant: Danila Branca ,  Gabriella Dessole ,  Federica Ferrigno ,  Philip Jones ,  Olaf Kinzel ,  Samuele Lillini ,  Ester Muraglia ,  Giovanna Pescatore ,  Carsten Schultz-Fademrecht

Inventor： Danila Branca ,  Gabriella Dessole ,  Federica Ferrigno ,  Philip Jones ,  Olaf Kinzel ,  Samuele Lillini ,  Ester Muraglia ,  Giovanna Pescatore ,  Carsten Schultz-Fademrecht

IPC: C07D401/00 ,  A60K31/50

CPC classification number: C07D403/10

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐或互变异构体，其是聚（ADP-核糖）聚合酶（PARP）的抑制剂，因此可用于治疗癌症，炎性疾病，再灌注损伤，缺血性疾病 ，中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤，皮肤衰老和紫外线诱发的皮肤损伤，以及用于癌症治疗的化学或放射增敏剂。

公开(公告)号：US20120178748A1

公开(公告)日：2012-07-12

申请号：US13347541

申请日：2012-01-10

Applicant: John Emmerson CAMPBELL ,  Philip JONES ,  Michael Charles HEWITT

Inventor： John Emmerson CAMPBELL ,  Philip JONES ,  Michael Charles HEWITT

IPC: A61K31/5383 ,  A61K31/519 ,  A61K31/437 ,  C07D498/14 ,  C07D487/04 ,  C07D471/04 ,  C07D491/147 ,  A61P3/04 ,  C07D471/14 ,  A61P25/00 ,  A61P3/00 ,  A61P25/18 ,  A61P25/28 ,  A61P25/22 ,  A61P25/24 ,  A61P25/16 ,  A61P25/20 ,  A61P3/10 ,  A61K31/4985

CPC classification number: C07D519/00 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5383 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04

Abstract: Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

Abstract translation: 本文提供了杂芳基化合物，其合成方法，包含该化合物的药物组合物及其用途。 在一个实施方案中，本文提供的化合物可用于治疗，预防和/或治疗各种疾病，例如CNS障碍和代谢紊乱，包括但不限于例如神经障碍，精神病，精神分裂症，肥胖症， 和糖尿病。

公开(公告)号：US08026265B2

公开(公告)日：2011-09-27

申请号：US12086812

申请日：2006-12-21

Applicant: Philip Jones ,  Jesus Maria Ontoria Ontoria ,  Rita Scarpelli ,  Raffaele Ingenito ,  Carsten Schultz-Fademrecht

Inventor： Philip Jones ,  Jesus Maria Ontoria Ontoria ,  Rita Scarpelli ,  Raffaele Ingenito ,  Carsten Schultz-Fademrecht

IPC: A61K31/415 ,  C07D233/00

CPC classification number: C07D233/64 ,  C07D401/12

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful for treating neurodegenerative diseases, mental retardation, schizophrenia, inflammatory diseases, restenosis, immune disorders, diabetes, cardiovascular disorders and asthma.

Abstract translation: 本发明涉及式（I）的化合物及其药学上可接受的盐和互变异构体。 本发明化合物是组蛋白脱乙酰酶（HDAC）的抑制剂，可用于治疗包括癌症在内的细胞增殖性疾病。 它们也可用于治疗神经变性疾病，精神发育迟滞，精神分裂症，炎性疾病，再狭窄，免疫疾病，糖尿病，心血管疾病和哮喘。

公开(公告)号：US07901261B1

公开(公告)日：2011-03-08

申请号：US12421832

申请日：2009-04-10

Applicant: Jose Rosas Zarich ,  Matthew Philip Jones

Inventor： Jose Rosas Zarich ,  Matthew Philip Jones

IPC: B63B35/81

CPC classification number: B63B35/7936 ,  B63B35/812

Abstract: A board assembly for kitesurfing and/or kiteboarding includes an elongated board for traversing a supporting surface while a person is riding the board and apparatus for changing the orientation of the person's feet relative to the different ends of the board. Such apparatus includes a deck that is rotatably attached to the board, foot receptacles coupled to the deck and a device for facilitating rotation of the deck between different stationary positions relative to the different ends of the board while the board is traversing the supporting surface. The device for facilitating rotation temporarily locks the deck in one of the stationary positions upon the deck having been rotated to the one of stationary positions. The device for facilitating rotation responds to motion of the person's feet by causing the deck to be released from retention in the stationary positions.

Abstract translation: 用于冲浪和/或风筝冲浪的板组件包括一个细长板，用于在人骑着板时横过支撑表面，并且用于改变人脚相对于板的不同端部的取向的装置。 这种装置包括可旋转地附接到板的甲板，联接到甲板的脚部容器和用于在板横穿支撑表面时相对于板的不同端部在不同的固定位置之间转动甲板的装置。 用于促进旋转的装置临时将甲板锁定在甲板已经旋转到固定位置之一的固定位置之一上。 用于促进旋转的装置通过使甲板从静止位置的保持力释放而响应于人的脚的运动。