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171 条记录 (耗时 0.023 秒)

    Conjugate compounds containing aza-macro-cycles and processes for their preparation
    101.
    发明授权
    Conjugate compounds containing aza-macro-cycles and processes for their preparation 失效
    含有杂环 - 周期的共轭化合物及其制备方法

    公开(公告)号：US5684135A

    公开(公告)日：1997-11-04

    申请号：US451306

    申请日：1995-05-26

    申请人： David Parker ,  Nigel Robert Arnold Beeley ,  Thomas Andrew Millican

    发明人： David Parker ,  Nigel Robert Arnold Beeley ,  Thomas Andrew Millican

    IPC分类号： A61K49/06 ,  C07D257/02 ,  C07F9/6524 ,  C07K17/06

    CPC分类号： A61K49/06 ,  C07D257/02 ,  C07F9/6524

    摘要： ##STR1## Conjugate compounds are described comprising a compound of formula (1), wherein A is a group --Alk
    3 -- or --Alk
    3 N(R
    4 )Alk
    1 --, Alk
    2 , Alk
    3 and Alk
    4 which may be the same or different is each a C
    1-4 alkylene chain optionally substituted by one or more C
    1-6 alkyl groups; and R
    1 , R
    2 , R
    3 and R
    4 , which may be the same or different, is each a hydrogen atom or a group--AlkR
    5 where Alk is an optionally substituted straight or branched C
    1-6 alkyl group and R
    5 is a hydrogen atom or a --CO
    2 H, --CONR
    6 R
    7 (where R
    6 and R
    7 , which may be the same or different is each a hydrogen atom or an alkyl group) or --P(X
    1 )(X
    2 R
    8 )L group where X
    1 and X
    2 is each an oxygen or sulphur atom. R
    8 is a hydrogen atom or an alkyl group and L is an aliphatic, aromatic, or heteroaromatic group or a linker group with the proviso that at least one of R
    1 , R
    2 , R
    3 and R
    4 is a group AlkP(X
    1 )(X
    2 R
    8 )L where L is a linker group; and a metal complexes and/or salts thereof, coupled to a protein, peptide or carbohydrate. The conjugates are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours.

    摘要翻译： （1）描述了包含式（1）化合物的共轭化合物，其中A是可以相同或不同的基团-Alk3-或-Alk3N（R4）Alk1，Alk2，Alk3和Alk4，各自可以相同或不同 任选被一个或多个C 1-6烷基取代的C 1-4亚烷基链; 并且可以相同或不同的R 1，R 2，R 3和R 4各自为氢原子或AlkR 5基团，其中Alk为任选取代的直链或支链C 1-6烷基，R 5为氢原子或 - CO 2 H，-CONR 6 R 7（其中R 6和R 7可以相同或不同，各自为氢原子或烷基）或-P（X1）（X2R8）L基团，其中X1和X2各自为氧或硫原子。 R8是氢原子或烷基，L是脂族，芳族或杂芳族基团或连接基团，条件是R1，R2，R3和R4中的至少一个是AlkP（X1）（X2R8）L 其中L是连接基团; 和与蛋白质，肽或碳水化合物偶联的金属络合物和/或其盐。 缀合物可用于成像和治疗异常细胞疾病，例如治疗肿瘤。

    Tetra-aza macrocycles, processes for their preparation and their use in magnetic resonance imaging
    102.
    发明授权
    Tetra-aza macrocycles, processes for their preparation and their use in magnetic resonance imaging 失效
    四氮杂大环化合物，其制备方法及其在磁共振成像中的应用

    公开(公告)号：US5653960A

    公开(公告)日：1997-08-05

    申请号：US311721

    申请日：1994-09-23

    申请人： David Parker ,  Nigel Robert Arnold Beeley

    发明人： David Parker ,  Nigel Robert Arnold Beeley

    IPC分类号： A61K49/00 ,  A61K49/06 ,  C07D257/02 ,  C07F20060101 ,  C07F9/30 ,  C07F9/32 ,  C07F9/6524 ,  A61B5/055 ,  C07D255/00 ,  C07D255/02

    CPC分类号： A61K49/06 ,  C07D257/02 ,  C07F9/6524 ,  Y10S514/836

    摘要： ##STR1## Metal complex of tetra-aza macrocycles of formula (1) wherein Alk
    1 , Alk
    2 , Alk
    3 and Alk
    4 , which may be the same or different, is each a C
    1-4 alkylene chain optionally substituted by one or more optionally substituted C
    1-6 alkyl groups; and R
    1 , R
    2 , R
    3 and R
    4 which may be the same or different is each a hydrogen atom or a group AlkR
    5 where Alk is an optionally substituted straight or branched C
    1-6 alkyl group and R
    5 is a hydrogen atom or a --CO
    2 H,--CONR
    6 R
    7 [where R
    6 and R
    7 , which may be the same or different, is each a hydrogen atom or a C
    1-6 alkyl group] or --P(X
    1 )(X
    2 R
    8 )R
    9 group where X
    1 and X
    2 , which may be the same or different is each an oxygen or sulphur atom, R
    8 is a hydrogen atom or an alkyl group and R
    9 is an aliphatic, aromatic or heteroaromatic group, with the proviso that at least two of R
    1 , R
    2 , R
    3 and R
    4 is a group -AlkP(X
    1 )(X
    2 R
    8 )R
    9 or one or R
    1 , R
    2 , R
    3 and R
    4 is a group -AlkP(X
    1 )(X
    2 R
    8 )R
    9 and at least one of the remaining groups R
    1 , R
    2 , R
    3 and R
    4 is a group -AlkCO
    2 H or -AlkCONR
    6 R
    7 , or a salt thereof, for use as contrast agents in nuclear magnetic resonance imaging are described.

    摘要翻译： （1）式（1）的四氮杂大环的金属络合物，其中Alk1，Alk2，Alk3和Alk4可以相同或不同，各自为任选被一个或多个任选取代的C 1-4亚烷基链 C 1-6烷基; 可以相同或不同的R 1，R 2，R 3和R 4各自为氢原子或AlkR 5基团，其中Alk为任选取代的直链或支链C 1-6烷基，R 5为氢原子或-CO 2 H，-CONR 6 R 7 [其中R6和R7可以相同或不同，各自为氢原子或C1-6烷基]或-P（X1）（X2R8）R9基团，其中X1和X2可以相同或不同 每个为氧或硫原子，R8为氢原子或烷基，R9为脂族，芳族或杂芳族基团，条件是R1，R2，R3和R4中的至少两个为基团-AlkP（X1） （X2R8）R9或一个或R1，R2，R3和R4是基团-AlkP（X1）（X2R8）R9，并且其余基团R1，R2，R3和R4中的至少一个是基团-AlkCO2H或-AlkCONR6R7， 或其盐，用作核磁共振成像中的造影剂。

    Electrodeposition of nickel-iron alloys
    103.
    发明授权
    Electrodeposition of nickel-iron alloys 失效
    镍 - 铁合金的电沉积

    公开(公告)号：US4089754A

    公开(公告)日：1978-05-16

    申请号：US816247

    申请日：1977-07-18

    申请人： Robert Arnold Tremmel ,  Roy Wilbur Herr

    发明人： Robert Arnold Tremmel ,  Roy Wilbur Herr

    IPC分类号： C12P19/56 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P31/04 ,  A61P35/00 ,  C07H15/252 ,  C25D3/56

    CPC分类号： C25D3/562

    摘要： An aqueous bath suitable for the electrodeposition of a bright iron-nickel electrodeposit onto a substrate susceptible to corrosion comprising iron ions, nickel ions, a bath soluble primary nickel brightener containing a sulfo-oxygen group, a bath soluble complexing agent, and an auxiliary bath soluble nickel brightener containing a sulfo-oxygen group, said auxiliary brightener having the general formula:R--SO.sub.2 --R.sub.1 --S--R.sub.2 --SO.sub.3.sup.- M.sup.+,whereinR is an aliphatic hydrocarbon moiety having 1 to 4 carbon atoms, or aryl,R.sub.1 and R.sub.2 are aliphatic hydrocarbon moieties of from 1 to 4 carbon atoms,R and R.sub.1 may be linked together to form an organic radical when R is aliphatic, andM.sup.+ is hydrogen, sodium potassium, lithium or ammonium.

    摘要翻译： 一种适用于将亮铁镍电沉积物电沉积到容易受腐蚀的基材上的水浴，包括铁离子，镍离子，含有磺基氧基的溶解性可溶性初级镍增白剂，浴溶性络合剂和辅助浴 含有磺基氧基团的可溶性增白剂，所述辅助增白剂具有以下通式：

    Emergency locator system for locating and retrieving sunken vessels
    105.
    发明授权
    Emergency locator system for locating and retrieving sunken vessels 失效
    用于定位和检索沉没船的紧急定位系统

    公开(公告)号：US4040135A

    公开(公告)日：1977-08-09

    申请号：US633922

    申请日：1975-11-20

    申请人： Ruben Robert Arnold

    发明人： Ruben Robert Arnold

    IPC分类号： B63C7/26 ,  B63B21/52

    CPC分类号： B63C7/26

    摘要： An emergency locator system for locating and retrieving sunken vessels and vessels in distress comprising in combination a base, a buoyant float releasably mounted thereon and a long line connecting the base and float. The base is adapted to be mounted on an external surface of a vessel in spaced apart relationship thereto to permit fluid to circulate between the vessel surface and the base. The base comprises a hydrostatic pressure sensing-diaphragm activated float holding and trigger release assembly. The diaphragm is located on a lower surface of the base adjacent the vessel surface when the base is mounted on the vessel. The base has U-shaped grapple cables attached to it and the grapple cable ends may also be attached to the vessel beneath the mounted base. The float is adapted to be releasably mounted on the base and upon the base float being subjected to a pre-selected external pressure the float is released and floats to the water surface being connected to the base by a long locator line. The float has provisions for a dye marker embedded therein and a signaling system mounted on a top surface thereof or it may be provided without either of these or just one of them at the option of the user.

    摘要翻译： 一种紧急定位系统，用于定位和检索遇难的凹陷船只和船只，其中包括基座，可释放地安装在其上的浮力浮子和连接底座和浮子的长线。 基座适于以与其间隔的关系安装在容器的外表面上，以允许流体在容器表面和底座之间循环。 底座包括一个静水压力感应隔膜激活的浮动保持和触发器释放组件。 当基座安装在容器上时，隔膜位于邻近容器表面的基座的下表面上。 基座具有连接到其上的U形抓斗电缆，并且抓斗电缆端部也可以附接到安装的底座下面的容器。 浮子适于可释放地安装在基座上，并且在基座浮子受到预先选择的外部压力的作用下，浮子被释放并浮动到通过长定位线连接到基座的水面上。 浮子具有嵌入其中的染料标记的装置和安装在其顶表面上的信号系统，或者可以在用户可选的情况下提供它们中的任何一个或仅一个。

    Variable Difficulty Balance Board for Standing Desk and Fitness Use
    106.
    发明申请
    Variable Difficulty Balance Board for Standing Desk and Fitness Use 审中-公开

    公开(公告)号：US20200238135A1

    公开(公告)日：2020-07-30

    申请号：US16777679

    申请日：2020-01-30

    申请人： Robert Arnold Stehlik

    发明人： Robert Arnold Stehlik

    IPC分类号： A63B26/00 ,  A63B22/18 ,  A63B22/16 ,  A63B21/00

    摘要： A variable difficulty balance board for standing desk and fitness use is provided. The balance board facilitates the conditioning and rehabilitation of the nerves, bones, muscles, and joints of the body by limiting the range of motion and biomechanical forces around the longitudinal and lateral axes. The balance board comprises a deck, a fulcrum receiver, and a fulcrum insert. The fulcrum insert is press-fit into a fulcrum cavity of the fulcrum receiver. The fulcrum insert extends outward from the fulcrum receiver and provides an area where the balance board can pivot. The fulcrum insert may be replaced by the user such that it may occupy either a first orientation or a second orientation within the fulcrum cavity. The first orientation and the second orientation configures the fulcrum insert such that it provides a lateral or longitudinal axis of balance relative to the deck, respectively.

    Golf swing alignment and aiming system
    109.
    发明授权
    Golf swing alignment and aiming system 有权

    公开(公告)号：US09636564B1

    公开(公告)日：2017-05-02

    申请号：US14726215

    申请日：2015-05-29

    申请人： Robert Arnold

    发明人： Robert Arnold

    IPC分类号： A63B69/36

    CPC分类号： A63B69/3641 ,  A63B69/3623 ,  A63B69/3667 ,  A63B2071/0694 ,  A63B2210/50

    摘要： A golf swing alignment and swing-aiming device is disclosed. An embodiment of the device includes a main elongated member, an aim arm that is pivotally connected to the main elongated member, an aiming strip that is pivotally connected to the aim arm, and a ball positioning arm that is pivotally connected to the main member at a location near the second end of the main member. The device collapses so that it can fit inside a club sheath in a golf bag, and can be unfolded to allow the user to position the aiming strip in a parallel arrangement with the main member, so that the aiming strip can be used to guide the swing of a golf club while positioning one's feet along the main member.