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公开(公告)号：US20170157858A1
公开(公告)日：2017-06-08
申请号：US15123183
申请日：2016-07-07
Inventor： Sang Hwa LEE
CPC classification number: B33Y70/00 , A61F2/28 , A61F2/2803 , A61F2/30942 , A61F2002/2835 , A61F2002/30948 , A61F2002/30952 , A61F2002/30962 , A61F2240/002 , B29C64/386 , B29C67/00 , B29K2067/00 , B29K2995/006 , B33Y50/00 , B33Y50/02 , B33Y80/00
Abstract: Provided is a technique of manufacturing a scaffold for jaw bone or bone reconstruction, by which a scaffold is fast and accurately manufactured to be placed instantly after treatment and simultaneously a scaffold is manufactured to be stably placed in an irregular recipient site or a wide region such as a tumor. A method of manufacturing a block type scaffold include generating a three-dimensional (3D) image of a scaffold to be placed in a recipient site for bone reconstruction by using a medical image file (DICOM file) of CT image data, dividing the 3D image of the scaffold into a plurality of block images, and manufacturing the scaffold by outputting the 3D image of the scaffold by using a 3D printer, wherein a plurality of 3D objects corresponding to the plurality of block images are output to be separable from one another.
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公开(公告)号：US20170112506A1
公开(公告)日：2017-04-27
申请号：US14759230
申请日：2015-04-30
Inventor： Jae Jun KIM
CPC classification number: A61B17/1631 , A61B17/00234 , A61B17/1613 , A61B17/1622 , A61B2017/00398 , A61B2017/00415
Abstract: Disclosed is a medical motor drill having an angle adjusting function. The medical motor drill includes a main body, a shaft connected to the main body, a drill unit connected to the shaft so as to be bendable relative to the shaft, the drill unit including a motor configured to receive power from the main body and a drill blade configured to be rotated by the motor, a drive force transmission unit configured to bend the drill unit relative to the shaft, and an angle adjustment unit connected to the drive force transmission unit to adjust a bending degree of the drill unit. The medical motor drill has advantages of enabling drilling over a wide range in a state in which a drill manipulation position is fixed and of enabling adjustment in the angle of the drill unit that is located distant from a user manipulation position.
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103.发明申请VOXEL TYPE BLOCK PHANTOM FOR A MULTIFUNCTIONAL RADIATION MEASUREMENT APPARATUS 有权用于多功能辐射测量装置的VOXEL型块体公开(公告)号：US20170043186A1
公开(公告)日：2017-02-16
申请号：US15118625
申请日：2015-01-29
Inventor： DO KUN YOON , JOO YOUNG JUNG , TAE SUK SUH
IPC: A61N5/10
CPC classification number: A61N5/1075 , A61N2005/1076
Abstract: The present invention relates to a voxel-type block phantom for a multifunctional radiation measurement apparatus. A phantom, for adjusting an amount of radiation, has solid pixel blocks, having a radiation measuring device equipped therein and different media and densities from one another, assembled on top of one another so as to be assembled into a 3-dimensional voxel, wherein the phantom is formed by placing a solid block which is appropriate for a density that corresponds to each pixel of the 3-dimensional voxel. An inspector can personally and instantly customize a phantom that is appropriate for a subject to be measured and thus can obtain an accurate measurement value.
Abstract translation: 本发明涉及一种用于多功能辐射测量装置的体素型块体模。 用于调节辐射量的体模具有固体像素块，其中装备有辐射测量装置，并且彼此不同的介质和密度彼此组装，以便组装成三维体素，其中 通过放置适合于对应于三维体素的每个像素的密度的固体块来形成体模。 检查员可以亲自定制适合被测量对象的体模，从而可以获得准确的测量值。
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104.发明授权Composition for treating immune diseases containing daurinol compound as active ingredient 有权用于治疗含有牛油醇化合物作为活性成分的免疫疾病的组合物公开(公告)号：US09526717B2
公开(公告)日：2016-12-27
申请号：US14913082
申请日：2014-08-22
Inventor： Mi-La Cho , Dong-Yun Shin , Min-Jung Park , Seon-Yeong Lee , Eun Ji Yang , Eun Kyung Kim , Hye-Jin Son , Eun-Jung Lee , Jae-Kyung Kim , Sung-Hee Lee
IPC: A61K31/365 , A61K36/75
CPC classification number: A61K31/365 , A61K36/75
Abstract: The daurinol compound according to the present invention exhibits excellent therapeutic effects on arthritis and inflammatory bowel diseases by having an excellent activity in inhibiting the generation of IL-17 and TNF-α, which are inflammatory cytokines causing inflammation, and can alleviate transplant rejection by inhibiting the proliferation of alloreactive T cells and increasing regulatory T cells; therefore, the daurinol compound according to the present invention can be used as a pharmaceutical composition capable of treating and preventing immune diseases. In addition, being a natural substance derived from the Mongolian medicinal plant Haplophyllum dauricum or Haplophyllum cappadocicum, the daurinol compound according to the present invention does not cause cytotoxicity and thus may be used as a composition for a functional health food capable of preventing and remedying immune diseases.
Abstract translation: 根据本发明的丹酚醇化合物通过在抑制作为引起炎症的炎性细胞因子的IL-17和TNF-α的产生中具有优异的活性而对关节炎和炎症性肠病具有优异的治疗效果，并且可以通过抑制 同种异体反应性T细胞的增殖和增加的调节性T细胞; 因此，根据本发明的丹酚醇化合物可以用作能够治疗和预防免疫疾病的药物组合物。 此外，作为来自蒙古药用植物Haplophyllum dauricum或Haplophyllum cappadocicum的天然物质，根据本发明的daurinol化合物不引起细胞毒性，因此可以用作能够预防和补救免疫的功能性保健食品的组合物 疾病
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105.发明申请COMPOSITION FOR PREVENTING OR TREATING B-CELL LYMPHOMA COMPRISING IL-21 EXPRESSING MESENCHYMAL STEM CELLS 审中-公开用于预防或治疗包含IL-21表达间充质干细胞的B细胞淋巴瘤的组合物公开(公告)号：US20160008435A1
公开(公告)日：2016-01-14
申请号：US14671626
申请日：2015-03-27
Inventor： Seok Goo CHO , Nayoun KIM
Abstract: Provided is a pharmaceutical composition for preventing or treating B-cell lymphoma including IL-21 expressing mesenchymal stem cells, and a treating method using the same.
Abstract translation: 提供了用于预防或治疗包括IL-21表达间充质干细胞的B细胞淋巴瘤的药物组合物及其使用方法。
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Patent Agency Ranking
公开(公告)号：US20150320305A1
公开(公告)日：2015-11-12
申请号：US14709748
申请日：2015-05-12
Inventor： Hang-Bong KANG
CPC classification number: A61B3/08 , A61B3/0041 , A61B3/0075
Abstract: The invention relates to an apparatus for measuring stereovision comprising: a frame body having a space therein; a 3D display unit which is arranged on the upper part of the frame body and which display a 3D image downwards through the space; a reflective mirror which is arranged on the lower part of the frame body and which reflects the 3D image displayed from the 3D display unit in a forward direction; an eyepiece which is arranged between the 3D display unit and the reflective mirror on the rear part of the frame body and through which a 3D image is seen; a half mirror by which the 3D image reflected forward by the reflective mirror is penetrated and reflected and which is rotatably installed on the frame body to adjust a reflection angle upward or downward; a stage which is arranged in front of the half mirror, a plurality of protrusion degree markers having a predetermined protrusion degree being arranged on the bottom surface successively with a predetermined distance, a target being installed on the stage to move forward, backward, left and right; and a target driving unit which moves the target forward, backward, left and right; wherein a reflection angle of the half mirror is adjusted such that an imaginary image of an object having a protrusion degree of 0 in the 3D image reflected on the half mirror is located above the protrusion degree marker having a protrusion degree of 0, the imaginary image being seen through the eyepiece; and wherein the target driving unit is controlled such that the target corresponds to an imaginary image of an object of a 3D image having a particular protrusion degree, whereby the stereovision of a tester is evaluated based on a protrusion degree marker to which the target is adjacent among the protrusion degree markers.
Abstract translation: 本发明涉及一种用于测量立体视觉的装置，包括：框架体，其中具有空间; 3D显示单元，其布置在框体的上部，并且通过该空间向下显示3D图像; 反射镜，其布置在所述框体的下部，并且反射从所述3D显示单元向前方显示的3D图像; 布置在3D显示单元和框体后部的反射镜之间的目镜，通过该目镜可以看到3D图像; 由反射镜向前反射的3D图像被穿透和反射并且可旋转地安装在框架体上以向上或向下调整反射角的半反射镜; 布置在半反射镜前面的台阶，具有预定突起度的多个突出度标记，其连续地以预定距离布置在底面上，目标安装在台面上以向前，向后，向左和向前移动; 对; 以及目标驱动单元，其使所述目标向前，向后，向左和向右移动; 其中，半反射镜的反射角被调整为使得在半反射镜上反射的3D图像中具有突出度为0的物体的假想图像位于突出度为0的突出度标记之上，虚像 通过目镜被看见; 并且其中所述目标驱动单元被控制成使得所述目标对应于具有特定突出度的3D图像的对象的假想图像，由此基于所述目标相邻的突出度标记来评估测试器的立体视觉 突出度标记之间。
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公开(公告)号：US09089564B2
公开(公告)日：2015-07-28
申请号：US14325107
申请日：2014-07-07
Inventor： Dong Heon Shin , Tae Yoon Kim
CPC classification number: A61K38/446 , C12N9/0089 , C12Y115/01001
Abstract: A method for treating an angiogenesis-mediated eye disease, includes administering to a subject in need thereof an effective amount of EC-SOD protein, or a vector having a polynucleotide encoding the EC-SOD protein, to treat angiogenesis-mediated eye diseases.
Abstract translation: 一种治疗血管生成介导的眼睛疾病的方法包括向有需要的受试者施用有效量的EC-SOD蛋白或具有编码EC-SOD蛋白的多核苷酸的载体来治疗血管生成介导的眼睛疾病。
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公开(公告)号：US08980841B2
公开(公告)日：2015-03-17
申请号：US14325077
申请日：2014-07-07
Inventor： Dong Heon Shin , Tae Yoon Kim
CPC classification number: A61K38/446 , A61K38/00 , C12N9/0089 , C12Y115/01001
Abstract: A method for treating a disease, particularly asthma and anaphylactic shock, comprises administering to a subject in need thereof an effective amount of an EC-SOD protein or a vector having a polynucleotide encoding thereof.
Abstract translation: 治疗疾病，特别是哮喘和过敏性休克的方法包括向有需要的受试者施用有效量的EC-SOD蛋白或具有编码其多核苷酸的载体。
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109.发明申请KIT FOR MONITORING IMMUNE STATUS AFTER TRANSPLANT AND METHOD FOR MONITORING IMMUNE STATUS USING SAME 有权用于监测移植后的免疫状态的工具箱和使用其监测免疫状态的方法公开(公告)号：US20150051108A1
公开(公告)日：2015-02-19
申请号：US14536359
申请日：2014-11-07
Inventor： Mi-La CHO , Chul-Woo YANG , Jong-Young CHOI , Joo-Yeon JHUN , Hee-Yeon KIM , Jae-Kyeong BYUN , Ye-Been YIM , Byung-Ha CHUNG , Kyoung-Woon KIM
IPC: G01N33/50 , G01N33/569
CPC classification number: G01N33/5091 , G01N33/56966 , G01N33/56972 , G01N33/56977 , G01N33/6866 , G01N33/6869 , G01N2333/57 , G01N2800/245
Abstract: The present invention relates to a method and a kit for monitoring an immune status after transplant. The kit for monitoring an immune status after transplant and the method for monitoring an immune status of an individual after transplant as provided in the present invention make it easy and accurate to determine an immune status in the individual after transplant and thus have an effect of reducing overuse of an immunosuppressive agent prescribed after transplant and also have an effect of conveniently managing an immune status of each patient.
Abstract translation: 本发明涉及用于监测移植后免疫状态的方法和试剂盒。 本发明提供的用于监测移植后免疫状态的试剂盒和用于监测移植后个体的免疫状态的方法使得容易且准确地确定移植后个体的免疫状态，从而具有减少的作用 过度使用移植后规定的免疫抑制剂，并且还具有方便地管理每个患者的免疫状态的效果。
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110.发明申请公开(公告)号：US20140336220A1
公开(公告)日：2014-11-13
申请号：US14256708
申请日：2014-04-18
Inventor： Mi-La Cho , Jun-Ki Min , Joo-Yeon Jhun , Jae-Kyeong Byun , Hye-Jwa Oh
IPC: A61K31/4704
CPC classification number: A61K31/4704 , A23L33/10 , A23V2002/00 , A61K9/0019 , A23V2200/332
Abstract: The present disclosure relates to a composition and a health functional food for preventing or treating obesity comprising a rebamipide compound or its pharmaceutically acceptable salt as an active component. It is confirmed that when a rebamipide compound of the present disclosure is administered to a mouse model induced with obesity, it shows excellent effects of reducing weight, reducing adipocyte, and reducing a total cholesterol content in the body, as compared with a non-administered control group, and also, it shows an excellent effect of suppressing differentiation of cytotoxic Th17 cells that generate and secrets inflammatory cytokine and an excellent effect of improving activity of regulatory T cells (Treg) capable of suppressing a function of abnormally activated immune cells and controlling an inflammatory reaction. Thus, the rebamipide compound can be used for producing a medicine and a functional food which can effectively treat obesity caused by abnormality of immune modulation.
Abstract translation: 本发明涉及用于预防或治疗肥胖症的组合物和健康功能性食品，其包含雷巴米特化合物或其药学上可接受的盐作为活性成分。 证实当将本公开的雷巴派特化合物施用于由肥胖引起的小鼠模型时，与非给药相比，其显示出优异的减肥重量，减少脂肪细胞和降低体内总胆固醇含量的效果 对照组，也显示出抑制细胞毒Th17细胞产生和分泌炎性细胞因子的分化的优异效果，并且具有改善能够抑制异常活化的免疫细胞功能的调节性T细胞（Treg）活性的优异效果，并控制 炎症反应。 因此，瑞巴派特化合物可用于制备能有效治疗由免疫调节异常引起的肥胖的药物和功能性食品。
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