公开(公告)号：US20220184113A1

公开(公告)日：2022-06-16

申请号：US17546177

申请日：2021-12-09

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Anushree Chatterjee ,  Thomas R. Aunins ,  Prashant Nagpal

IPC: A61K31/7105 ,  A61K38/10 ,  C12N15/113 ,  A61P31/14

Abstract: The inventive technology generally relates to systems, methods, and compositions for the treatment of viral infections, as well as novel use of antisense technology to rationally design antiviral compositions that can be applied to clinical cases and human infections. In one preferred aspect, the inventive technology includes methods, and compositions to treat COVID-19 in humans through the targeted inhibition of viral genome expression.

公开(公告)号：US20220176141A1

公开(公告)日：2022-06-09

申请号：US17600855

申请日：2020-04-01

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Anthony V. Caparso ,  Richard J. Davis ,  Malik Kahook ,  Naresh Mandava

IPC: A61N2/00 ,  A61N2/02

Abstract: Systems and methods for wireless neural stimulation are presented. A microstimulator comprising a highly magnetic permeable material is implanted in the tissue of a living body. A wearable external controller creates a time-varying magnetic field that extends to the microstimulator in the tissue. The microstimulator re-shapes and boosts the time-varying magnetic field in the area surrounding the microstimulator, causing neural stimulation in the area around the microstimulator. A physician programmer device is also presented that allows a physician to program the wearable external controller.

公开(公告)号：US20220175870A1

公开(公告)日：2022-06-09

申请号：US17541737

申请日：2021-12-03

Applicant: The Regents of the University of Colorado, a body corporate ,  United States of America as Represented by the Administrator of NASA

Inventor： Anushree Chatterjee ,  Afshin Beheshti ,  Sylvain Vincent Costes ,  Thomas R. Aunins ,  Prashant Nagpal

IPC: A61K38/04

Abstract: The inventive technology generally relates to systems, methods, and compositions for the treatment of viral infections, as well as novel use of antisense technology to rationally design antiviral compositions that can be applied to clinical cases and human infections. In one preferred aspect, the inventive technology includes methods, and compositions to treat COVID-19 in humans through the targeted inhibition of host-derived miRNAs.

公开(公告)号：US20220158570A1

公开(公告)日：2022-05-19

申请号：US17436455

申请日：2020-03-04

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Christoph Matthias Keplinger ,  Shane Karl Mitchell ,  Nicholas Alexander Kellaris ,  Philipp Rothemund

IPC: H02N1/00 ,  B32B27/30 ,  B32B27/36 ,  B32B27/08

Abstract: A hydraulically amplified self-healing electrostatic (HASEL) transducer includes a composite, multi-layered structure. In an example, a HASEL transducer includes a dielectric layer including at least one fluid dielectric layer. The dielectric layer includes a first side and a second side opposing the first side. The HASEL transducer further includes a first electrode disposed at the first side of the dielectric layer, a second electrode disposed at the second side of the dielectric layer, a first outer layer disposed at the first electrode opposite the dielectric layer, and a second outer layer disposed at the second electrode opposite the dielectric layer. The first outer layer and second outer layer exhibit different mechanical and electrical properties from the dielectric layer.

公开(公告)号：US20220151478A1

公开(公告)日：2022-05-19

申请号：US17665692

申请日：2022-02-07

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Darren D. Lynn

IPC: A61B1/227 ,  H04M1/02 ,  H04N5/225 ,  A61B1/00 ,  A61B1/04

Abstract: An enhanced optical design for imaging of live human tissue as a supplemental attachment to wireless mobile devices such as smartphones. The improved imaging system includes a series of optical ball lenses coupled to a medical-grade light source to allow universal compatibility to mobile device (e.g., smartphone) cameras. The releasable optical attachment comprises optical enhancement elements allowing universal compatibility without the need of an application or special program to re-orient the image therein permitting less loss of picture acuity and blanket usability to HIPAA-verified smartphone applications used in hospitals and patient's electronic health records. The addition of an external light source and light-redirecting elements negates the need for a smartphone light source or smartphone re-programming to illuminate target.

公开(公告)号：US11336377B1

公开(公告)日：2022-05-17

申请号：US17443647

申请日：2021-07-27

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE ,  Government of the United States of America as represented by the Secretary of Commerce

Inventor： Scott B. Papp ,  Jizhao Zang

IPC: H04B10/58 ,  H04B10/54 ,  H04B10/548

Abstract: A millimeter-wave frequency synthesizer generates a millimeter wave by photomixing two Kerr-soliton microcombs. A single-frequency laser beam is modulated to create first and second pump components having first and second pump frequencies. The first pump component excites a first microresonator to create a first microcomb while the second pump component excites a second microresonator to generate a second microcomb. A pair of comb lines from the two microcombs is detected to generate a low-frequency beat note that is phase-locked by identically tuning the pump frequencies. Another pair of comb lines is detected with a high-speed photodiode to generate the millimeter wave. The frequency of the millimeter wave is based on (i) the difference between the pump frequencies, (ii) the difference between the repetition rates, and (iii) the index of the comb lines that are photomixed to generate the millimeter wave.

公开(公告)号：US20220128878A1

公开(公告)日：2022-04-28

申请号：US17506170

申请日：2021-10-20

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Michael T. STRAND ,  Christopher BARILE ,  Tyler S. HERNANDEZ ,  Andrew L. YEANG ,  Michael D. MCGEHEE

IPC: G02F1/1506 ,  B32B17/10 ,  G02F1/155 ,  G02F1/1343 ,  E06B9/24 ,  C09K9/00

Abstract: Dynamic windows with adjustable tint give users greater control over flow of light and heat. Reversible metal electrodeposition dynamic windows include (i) a transparent or translucent conductive electrode; (ii) an electrolyte solution in contact with the electrode, the electrolyte solution comprising metal cations that are reversibly electrodeposited onto the transparent electrode upon application of a cathodic potential; and (iii) a counter electrode. The electrolyte solution advantageously includes a small amount of an additive (e.g., an inhibitor, an accelerator, a leveler, or an organic or inorganic molecule that similarly serves to enhance the surface morphology of the metal cations during reversible metal electrodeposition onto the transparent electrode). Such enhancement of surface morphology during the reversible electrodeposition of the metal tinting layer over the electrode enhances one or more of color neutrality, transmittance characteristics of visible wavelengths (e.g., ability to achieve a near 0% transmission privacy state), infrared reflectance, or switching speed.

公开(公告)号：US11304996B2

公开(公告)日：2022-04-19

申请号：US17007908

申请日：2020-08-31

Applicant: GLOBEIMMUNE, INC. ,  THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate

Inventor： Donald Bellgrau ,  Thomas H. King

IPC: A61K39/00 ,  A61K36/064 ,  G01N33/573

Abstract: Disclosed are methods of treating individuals with yeast-based immunotherapy who have been preselected as being sensitive to type I interferons, as well as methods for selecting individuals for treatment with yeast-based immunotherapeutic compositions and methods for enhancing or improving an individual's response to yeast-based immunotherapy, based on the individual's sensitivity to type 1 interferons (T1IFNs).

公开(公告)号：US20220115981A1

公开(公告)日：2022-04-14

申请号：US17497414

申请日：2021-10-08

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Moncef Krarti

IPC: H02S20/32 ,  H02S20/23

Abstract: Systems and methods of use of movable shading devices, are disclosed. In some example implementations, the system can include one or more movable shading devices, where the one or more movable shading devices are configured to be selectively moveable, based on control by a programmable controller, with respect to an external surface of a building or house, where the external surface of the building or house includes at least one wall surface and at least one roof surface, to conserve at least one of cooling energy use associated with the building or house and/or heating energy use associated with the building or house.

公开(公告)号：US20220105011A1

公开(公告)日：2022-04-07

申请号：US17432542

申请日：2020-02-21

Applicant: The Regents Of The University Of Colorado, A Body Corporate

Inventor： Devatha P. NAIR ,  Dylan MORI ,  Michael J. SCHURR

IPC: A61K6/69 ,  C07C245/02 ,  C08F265/04

Abstract: Antimicrobial azo compounds include azobenzene monomers having a phenyl ring comprising a hydroxyl substituent group. The azobenzene monomers can be reacted with a polymeric material to form an antimicrobial coating that prevents growth of persistent biofilms. In some implementations, the azobenzene monomers can be used to coat the surface of a dental resin-based composite to prevent the formation secondary caries. In some implementations, the azobenzene coating can be used to disperse microbial biofilms through a photofluidization process (rapid photoisomerization) in addition to biochemically preventing formation of the microbial biofilm.