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公开(公告)号：US4350271A
公开(公告)日：1982-09-21
申请号：US180353
申请日：1980-08-22
申请人： James B. Eckenhoff
发明人： James B. Eckenhoff
CPC分类号： A61K9/0004 , A61M31/002
摘要： A fluid dispenser that operates by absorbing water is disclosed. The dispenser includes a rigid water permeable housing; a water insoluble, water swellable composition that fills a segment of the space within the housing, a lipophilic fluid charge that fills the remainder of the space within the housing and that is immiscible in the water-swellable composition, and an outlet through the housing that communicates with the fluid charge. In operation the water swellable composition absorbs water, expands, and in piston-like fashion displaces the fluid charge from the dispenser via the outlet.
摘要翻译： 公开了一种通过吸收水进行操作的流体分配器。 分配器包括刚性透水壳体; 填充壳体内的空间的一部分的水不溶性水膨胀性组合物，填充该壳体内的空间的其余部分并且在水溶胀性组合物中不混溶的亲脂性流体装置，以及通过该壳体的出口 与流体充电连通。 在操作中，水可溶胀组合物吸收水，膨胀，并且以活塞状的方式通过出口将来自分配器的流体进料置换。
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公开(公告)号：US4340048A
公开(公告)日：1982-07-20
申请号：US246595
申请日：1981-03-28
申请人： James B. Eckenhoff
发明人： James B. Eckenhoff
CPC分类号： A61M5/14248 , A61J1/06 , A61M5/145
摘要： A self-driven hypodermic injector that injects an injectable pharmaceutical composition at a constant baseline rate and may be manipulated to supplement the baseline rate with one or more pulses of the composition. The injector consists of a tubular housing with one fixed basal end wall that carries a hollow small gauge needle and one axially moveable end wall; an axially slideable water imbibing assembly mounted transversely in the housing lumen that divides the lumen into a pharmaceutical composition-containing compartment contiguous to the basal end wall and a water-containing compartment. In operation the subassembly imbibes water from the water-containing compartment and expands into the pharmaceutical-containing compartment to displace the pharmaceutical therefrom at the baseline rate. Pulses are effected by depressing the axially moveable end wall which in turn slides the subassembly toward the fixed end wall thereby exerting pressure on the pharmaceutical composition and increasing the injection rate.
摘要翻译： 一种自驱动的皮下注射器，其以恒定的基线速率注射可注射药物组合物，并且可以被操纵以用该组合物的一个或多个脉冲来补充基线速率。 注射器由具有一个固定的基底端壁的管状壳体组成，其具有中空的小规格针和一个可轴向移动的端壁; 轴向可滑动的吸水组件，其横向地安装在所述壳体腔中，其将所述内腔分成与所述基底端壁和含水隔间相邻的含药物组合物隔间。 在操作中，该组件吸收来自含水隔室的水并膨胀成含药物隔室，以基线速率从其中置换药物。 通过按压可轴向移动的端壁来实现脉冲，该端壁又将子组件滑向固定端壁，从而对药物组合物施加压力并增加注射速率。
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公开(公告)号：US06682522B2
公开(公告)日：2004-01-27
申请号：US10310742
申请日：2002-12-04
申请人： John P. Carr , James B. Eckenhoff
发明人： John P. Carr , James B. Eckenhoff
IPC分类号： A61K948
CPC分类号： A61K9/0004
摘要： An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule having a beneficial agent reservoir, an osmotic agent which expands on contact with fluid imbibed through a permeable membrane retained by the implant capsule, a delivery port, and a valve for opening and closing the delivery port. When the osmotic agent expands, a pressure is exerted against a separating member positioned between the beneficial agent reservoir and the osmotic agent. The separating member moves within the capsule, thereby forcing the valve to move a distance such that the beneficial agent can exit the reservoir through the delivery port.
摘要翻译： 用于受控输送有益药剂的渗透递送系统包括具有有益药剂储存器的植入物胶囊，渗透剂，其与通过由植入物胶囊保留的可渗透膜吸收的流体接触而扩张，输送口和用于打开的阀 并关闭送货口。 当渗透剂膨胀时，对位于有益剂储存器和渗透剂之间的分离构件施加压力。 分离构件在胶囊内移动，从而迫使阀移动一定距离，使得有益剂可以通过输送口离开储存器。
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公开(公告)号：US5431919A
公开(公告)日：1995-07-11
申请号：US81743
申请日：1993-06-23
申请人： Fred Maruyama , John P. Carr , James B. Eckenhoff
发明人： Fred Maruyama , John P. Carr , James B. Eckenhoff
CPC分类号： A61K9/0004
摘要： The present invention is concerned with improving the delivery of a drug from a ruminal delivery device to give a consistent delivery of drug to the ruminal environment. Thus, the invention is directed to an improved ruminal drug delivery device comprising a semipermeable membrane having an exit orifice and defining a compartment, the compartment containing a swellable osmotic agent expandable member, a drug to be dispensed, a density element and, optionally, a partition layer between the osmotic expandable member and the drug formulation, wherein the improvement comprises an essentially gas-impermeable barrier means that separates the density element from the other components within the delivery device for isolating gases evolved from the density element from the other components within the delivery device. The invention is also directed to methods and articles for providing a consistent delivery of drug from a ruminal drug delivery device.
摘要翻译： 本发明涉及改善药物从瘤胃递送装置的递送以使药物向瘤胃环境的一致递送。 因此，本发明涉及一种改进的瘤胃药物递送装置，其包括具有出口孔并限定隔室的半透膜，所述隔室含有可溶胀渗透剂可膨胀构件，待分配药物，密度元件和任选地 渗透可膨胀构件和药物制剂之间的分隔层，其中改进包括基本上气体不可渗透的阻挡装置，其将密度元件与输送装置内的其它成分分离，用于将密度元素放出的气体与其中的其它成分分离 送货装置 本发明还涉及用于提供来自瘤胃药物递送装置的药物的一致递送的方法和制品。
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105.发明授权Density element and method of manufacture thereof to achieve a particular transverse rupture strength 失效密度元件及其制造方法以达到特定的横向断裂强度
公开(公告)号：US5372776A
公开(公告)日：1994-12-13
申请号：US204916
申请日：1994-03-02
申请人： John R. Peery , James B. Eckenhoff
发明人： John R. Peery , James B. Eckenhoff
CPC分类号： B22F3/10 , A61K9/0068
摘要： A density element (12) for use in ruminal delivery devices (10) which is manufactured by partial sintering in such a manner as to fragment upon contact with the many parts in rendering machinery without damage to the blades. The density element (12) has density of at least about 1.5 gm/cm.sup.3 and a transverse rupture strength greater than about 3000 psi no greater than about 30,000 psi. The part is sintered under conditions which do not permit full weld bond strength to be obtained and may thereafter be heat treated or impregnated with an inert hydrophobic material to increase corrosion resistance.
摘要翻译： 一种用于瘤胃输送装置（10）的密度元件（12），其通过部分烧结制造，以在与机器中的许多部件接触而碎裂而不损坏叶片的情况下分裂。 密度元件（12）具有至少约1.5gm / cm 3的密度和大于约3000psi的横向断裂强度不大于约30,000psi。 该部件在不能获得完全焊接接合强度的条件下烧结，然后可以用惰性疏水材料进行热处理或浸渍以提高耐腐蚀性。
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公开(公告)号：US5234693A
公开(公告)日：1993-08-10
申请号：US939247
申请日：1992-09-02
CPC分类号： A61K9/0004
摘要： This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces. The invention provides a fluid-imbibing delivery device comprising a housing enclosing an internal compartment, said housing having a first wall section that substantially restricts the passage of fluid into the delivery device, i.e. is substantially fluidimpermeable, and that contains a beneficial agent; a second wall section that permits the passage of fluid into the delivery device, i.e. is fluid-permeable, and that contains at least one expandable driving member; and exit means; with a protective sleeve means extending from the first wall section of the housing to cover and protect the second wall section of the housing and the junction of the first and second sections. The protective sleeve is preferably configured to provide substantially no resistance to flow of fluid vapor through the fluid-permeable second wall section.
摘要翻译： 本发明涉及活性剂递送装置。 更具体地，本发明涉及一种输送装置，其包括用于保护输送装置免受瞬时机械力的套筒。 本发明的输送装置是坚固的并且耐瞬态机械力。 本发明提供一种流体吸收递送装置，其包括封闭内部隔室的壳体，所述壳体具有基本上限制流体进入输送装置的第一壁部分，即基本上不透液体，并且含有有益剂; 允许流体进入输送装置的第二壁部分，即流体可渗透的，并且其包含至少一个可膨胀的驱动构件; 出口手段; 具有从壳体的第一壁部分延伸以覆盖并保护壳体的第二壁部分和第一和第二部分的连接处的保护套筒装置。 保护套管优选地构造成基本上不提供通过流体可渗透的第二壁部分的流体蒸汽的流动阻力。
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公开(公告)号：US5227167A
公开(公告)日：1993-07-13
申请号：US842939
申请日：1992-02-27
CPC分类号： A61M31/002 , A61K9/0004
摘要： The invention provides a dispensing device comprising a loading dose (first agent delivery means) for short-term and continuous delivery of an agent having a high potency, retained together with a long-term dispensing device (second agent delivery means) capable of a long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent may be delivered to the environment of use over time. A rapid initial delivery of beneficial agent is followed by continuous and prolonged delivery of agent.
摘要翻译： 本发明提供了一种分配装置，其包括用于短期和连续输送具有高效力的药剂的负荷剂量（第一药剂递送装置），其与能够长时间的长期分配装置（第二药剂递送装置）一起保持 - 连续递送代理。 第一和第二药剂递送装置的组合提供了一种装置，其中基本上恒定剂量的有益药剂可随时间递送到使用环境中。 快速初始交付有益药剂之后是持续和长期的药剂输送。
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公开(公告)号：US5180591A
公开(公告)日：1993-01-19
申请号：US551720
申请日：1990-07-11
IPC分类号： A61M5/148 , A61K20060101 , A61K9/00 , A61K9/22 , A61M31/00
CPC分类号： A61K9/0004
摘要： This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces. The invention provides a fluid-imbibing delivery device comprising a housing enclosing an internal compartment, said housing having a first wall section that substantially restricts the passage of fluid into the delivery device, i.e. is substantially fluid-impermeable, and that contains a beneficial agent; a second wall section that permits the passage of fluid into the delivery device, i.e. is fluid-permeable, and that contains at least one expandable driving member; and exit means; with a protective sleeve means extending from the first wall section of the housing to cover and protect the second wall section of the housing and the junction of the first and second sections. The protective sleeve is preferably configured to provide substantially no resistance to flow of fluid or fluid vapors through the fluid-permeable second wall section.
摘要翻译： 本发明涉及活性剂递送装置。 更具体地，本发明涉及一种输送装置，其包括用于保护输送装置免受瞬时机械力的套筒。 本发明的输送装置是坚固的并且耐瞬态机械力。 本发明提供了一种流体吸收递送装置，其包括封闭内部隔室的壳体，所述壳体具有基本上限制流体进入输送装置的第一壁部分，即基本上不流体渗透，并且包含有益剂; 允许流体进入输送装置的第二壁部分，即流体可渗透的，并且其包含至少一个可膨胀的驱动构件; 出口手段; 具有从壳体的第一壁部分延伸以覆盖并保护壳体的第二壁部分和第一和第二部分的连接处的保护套筒装置。 保护套管优选地构造成基本上不提供通过流体可渗透的第二壁部分的流体或流体蒸气的流动阻力。
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公开(公告)号：US5000957A
公开(公告)日：1991-03-19
申请号：US329917
申请日：1989-03-28
CPC分类号： A61K9/0068 , A61K9/0004 , A61M31/002
摘要： A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhancing the amount of the beneficial agent dispensed from the system positioned between the thermo responsive composition and the means for occupying space.
摘要翻译： 公开了一种分配系统，其包括围绕管腔的壁。 所述内腔包括（1）包含有益剂的热响应组合物，（2）用于占据所述内腔中用于从所述分配系统推动所述热响应组合物的空间的装置，和（3）用于增强分配的有益剂量的装置 从位于热敏组合物和用于占据空间的装置之间的系统。
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公开(公告)号：US4892778A
公开(公告)日：1990-01-09
申请号：US054714
申请日：1987-05-27
CPC分类号： A61M31/002 , A61K9/0004 , Y10S428/913 , Y10T428/24992 , Y10T428/31504 , Y10T428/31511 , Y10T428/31909 , Y10T428/31978
摘要： A dispenser is enclosed for delivering a beneficial agent to an enviroment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.
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