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公开(公告)号：US06508808B1
公开(公告)日：2003-01-21
申请号：US09748099
申请日：2000-12-21
申请人： John P. Carr , James B. Eckenhoff
发明人： John P. Carr , James B. Eckenhoff
IPC分类号： A61K948
CPC分类号： A61K9/0004
摘要： An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule having a beneficial agent reservoir, an osmotic agent which expands on contact with fluid imbibed through a permeable membrane retained by the implant capsule, a delivery port, and a valve for opening and closing the delivery port. When the osmotic agent expands, a pressure is exerted against a separating member positioned between the beneficial agent reservoir and the osmotic agent. The separating member moves within the capsule, thereby forcing the valve to move a distance such that the beneficial agent can exit the reservoir through the delivery port.
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公开(公告)号：US5462741A
公开(公告)日：1995-10-31
申请号：US234457
申请日：1994-04-28
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A fluid-activated delivery device is disclosed comprising a housing defining an internal compartment, a beneficial agent formulation in the compartment, exit means in the housing for delivering the beneficial agent formulation from the delivery device, and wherein the formulation comprises an active agent in an amount of 50 wt % or greater blended with a glyceride or a mixture of glycerides of a fatty acid.
摘要翻译： 公开了一种流体激活的输送装置，其包括限定内部隔室的壳体，隔室中的有益剂制剂，壳体中的出口装置，用于将有益剂制剂从输送装置输送，并且其中所述制剂包含活性剂， 与甘油酯或脂肪酸的甘油酯的混合物共混的量为50重量％以上。
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公开(公告)号：US06682522B2
公开(公告)日：2004-01-27
申请号：US10310742
申请日：2002-12-04
申请人： John P. Carr , James B. Eckenhoff
发明人： John P. Carr , James B. Eckenhoff
IPC分类号： A61K948
CPC分类号： A61K9/0004
摘要： An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule having a beneficial agent reservoir, an osmotic agent which expands on contact with fluid imbibed through a permeable membrane retained by the implant capsule, a delivery port, and a valve for opening and closing the delivery port. When the osmotic agent expands, a pressure is exerted against a separating member positioned between the beneficial agent reservoir and the osmotic agent. The separating member moves within the capsule, thereby forcing the valve to move a distance such that the beneficial agent can exit the reservoir through the delivery port.
摘要翻译： 用于受控输送有益药剂的渗透递送系统包括具有有益药剂储存器的植入物胶囊，渗透剂，其与通过由植入物胶囊保留的可渗透膜吸收的流体接触而扩张，输送口和用于打开的阀 并关闭送货口。 当渗透剂膨胀时，对位于有益剂储存器和渗透剂之间的分离构件施加压力。 分离构件在胶囊内移动，从而迫使阀移动一定距离，使得有益剂可以通过输送口离开储存器。
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公开(公告)号：US5431919A
公开(公告)日：1995-07-11
申请号：US81743
申请日：1993-06-23
申请人： Fred Maruyama , John P. Carr , James B. Eckenhoff
发明人： Fred Maruyama , John P. Carr , James B. Eckenhoff
CPC分类号： A61K9/0004
摘要： The present invention is concerned with improving the delivery of a drug from a ruminal delivery device to give a consistent delivery of drug to the ruminal environment. Thus, the invention is directed to an improved ruminal drug delivery device comprising a semipermeable membrane having an exit orifice and defining a compartment, the compartment containing a swellable osmotic agent expandable member, a drug to be dispensed, a density element and, optionally, a partition layer between the osmotic expandable member and the drug formulation, wherein the improvement comprises an essentially gas-impermeable barrier means that separates the density element from the other components within the delivery device for isolating gases evolved from the density element from the other components within the delivery device. The invention is also directed to methods and articles for providing a consistent delivery of drug from a ruminal drug delivery device.
摘要翻译： 本发明涉及改善药物从瘤胃递送装置的递送以使药物向瘤胃环境的一致递送。 因此，本发明涉及一种改进的瘤胃药物递送装置，其包括具有出口孔并限定隔室的半透膜，所述隔室含有可溶胀渗透剂可膨胀构件，待分配药物，密度元件和任选地 渗透可膨胀构件和药物制剂之间的分隔层，其中改进包括基本上气体不可渗透的阻挡装置，其将密度元件与输送装置内的其它成分分离，用于将密度元素放出的气体与其中的其它成分分离 送货装置 本发明还涉及用于提供来自瘤胃药物递送装置的药物的一致递送的方法和制品。
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公开(公告)号：US5368863A
公开(公告)日：1994-11-29
申请号：US6448
申请日：1993-01-21
CPC分类号： A61K9/0068 , A61K9/0004
摘要： The present invention is directed to an improvement in a delivery device, the device comprising a wall that surrounds an internal lumen or compartment which contains a beneficial agent or medicament formulation, an expandable driving member and an optional density member, and having an exit means, and wherein the improvement comprises prehydrating the delivery device as a means for advancing the beginning or startup of agent delivery from the delivery system to give earlier release of beneficial agent to the environment of use. An embodiment of the invention concerns a fluid reservoir in contact with the expandable driving member to provide prehydration of the device.
摘要翻译： 本发明涉及一种输送装置的改进，该装置包括围绕包含有益剂或药物制剂的内腔或隔室的壁，可膨胀的驱动构件和任选的密封构件，并且具有出口装置， 并且其中所述改进包括将所述递送装置预水化，作为用于促进从所述递送系统开始或启动药剂递送的装置，以将有益药剂早期释放到使用环境中。 本发明的一个实施例涉及一种与可膨胀驱动构件接触的流体储存器，以提供装置的预水化。
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公开(公告)号：US5227167A
公开(公告)日：1993-07-13
申请号：US842939
申请日：1992-02-27
CPC分类号： A61M31/002 , A61K9/0004
摘要： The invention provides a dispensing device comprising a loading dose (first agent delivery means) for short-term and continuous delivery of an agent having a high potency, retained together with a long-term dispensing device (second agent delivery means) capable of a long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent may be delivered to the environment of use over time. A rapid initial delivery of beneficial agent is followed by continuous and prolonged delivery of agent.
摘要翻译： 本发明提供了一种分配装置，其包括用于短期和连续输送具有高效力的药剂的负荷剂量（第一药剂递送装置），其与能够长时间的长期分配装置（第二药剂递送装置）一起保持 - 连续递送代理。 第一和第二药剂递送装置的组合提供了一种装置，其中基本上恒定剂量的有益药剂可随时间递送到使用环境中。 快速初始交付有益药剂之后是持续和长期的药剂输送。
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公开(公告)号：US5223266A
公开(公告)日：1993-06-29
申请号：US876734
申请日：1992-04-27
CPC分类号： A61K9/0068 , A61K9/0004
摘要： The present invention is directed to an improvement in a delivery device, the device comprising a wall that surrounds an internal lumen or compartment which contains a beneficial agent or medicament formulation, an expandable driving member and an optional density member, and having an a exit means, and wherein the improvement comprises prehydrating the delivery device as a means for advancing the beginning or startup of agent delivery from the delivery system to give earlier release of beneficial agent to the environment of use. An embodiment of the invention concerns a fluid reservoir in contact with the expandable driving member to provide prehydration of the device.
摘要翻译： 本发明涉及递送装置的改进，该装置包括围绕包含有益剂或药物制剂的内腔或隔室的壁，可膨胀驱动构件和任选的密封构件，并且具有出口装置 ，并且其中所述改进包括将所述输送装置预水化为用于促进从所述递送系统开始或启动药剂递送的装置，以将有益药剂早期释放到使用环境。 本发明的一个实施例涉及一种与可膨胀驱动构件接触的流体储存器，以提供装置的预水化。
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公开(公告)号：US20110230865A1
公开(公告)日：2011-09-22
申请号：US13116970
申请日：2011-05-26
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Bonnie J. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Bonnie J. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
IPC分类号： A61M37/00
CPC分类号： A61M5/14526 , A61K9/0004 , A61K9/0024 , A61K38/09 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
摘要翻译： 本发明涉及一种用于在预定给药期间递送活性剂制剂的装置。 不可渗透的储存器分为水溶胀剂室和活性剂配制室。 来自环境的流体通过半渗透塞吸入水溶胀剂室中，活性剂制剂通过反向扩散调节出口释放。 交付期限达2年。
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公开(公告)号：US06395292B2
公开(公告)日：2002-05-28
申请号：US09848211
申请日：2001-05-04
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
IPC分类号： A61F200
CPC分类号： A61M5/14526 , A61K9/0004 , A61K9/0024 , A61K38/09 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
摘要翻译： 本发明涉及一种用于在预定给药期间递送活性剂制剂的装置。 不可渗透的储存器分为水溶胀剂室和活性剂配制室。 来自环境的流体通过半渗透塞吸入水溶胀剂室中，活性剂制剂通过反向扩散调节出口释放。 交付期限达2年。
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公开(公告)号：US06180129B2
公开(公告)日：2001-01-30
申请号：US08956424
申请日：1997-10-23
IPC分类号： A61K914
CPC分类号： A61K9/0004 , A61M31/002
摘要： A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.
摘要翻译： 公开了用于将有益剂递送到动物的递送系统。 递送系统包括围绕内腔的壁，所述壁包括限制流体进入系统的组合物和允许流体进入系统的组合物。 管腔包括有益剂和可膨胀构件。 递送系统包括用于递送有益剂的出口装置。
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