公开(公告)号：US08637024B2

公开(公告)日：2014-01-28

申请号：US13294652

申请日：2011-11-11

Applicant: David Ho ,  Yaoxing Huang ,  Craig Pace ,  Ruijiang Song ,  Qing Fang

Inventor： David Ho ,  Yaoxing Huang ,  Craig Pace ,  Ruijiang Song ,  Qing Fang

IPC: A61K39/00 ,  A61K39/42 ,  A61K39/395 ,  A61K38/00

CPC classification number: C07K16/2812 ,  C07K16/1063 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: Disclosed herein are fusion antibodies created to provide both an antigen-binding site that targets the CD4 receptor and an antigen-binding site that targets the HIV envelope. The fusion antibodies disclosed herein provide improved potency and breadth against HIV as compared to monospecific antibodies, and additionally provide high barrier against viral resistance. Also disclosed are pharmaceutical formulations and therapeutic methods utilizing such fusion proteins.

Abstract translation: 本文公开了产生以提供靶向CD4受体的抗原结合位点和靶向HIV包膜的抗原结合位点的融合抗体。 与单特异性抗体相比，本文公开的融合抗体提供了针对HIV的改进的效力和广度，并且另外提供了抗病毒抗性的高屏障。 还公开了使用这种融合蛋白的药物制剂和治疗方法。

公开(公告)号：US20120264759A1

公开(公告)日：2012-10-18

申请号：US13377031

申请日：2010-06-08

Applicant: Chunlin Tao ,  Qinwei Wang ,  David Ho ,  Laxman Nallan ,  Tulay Polat ,  Xiaowen Sun ,  Neil Desai

Inventor： Chunlin Tao ,  Qinwei Wang ,  David Ho ,  Laxman Nallan ,  Tulay Polat ,  Xiaowen Sun ,  Neil Desai

IPC: A61K31/53 ,  A61P35/00 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P27/02 ,  A61P37/02 ,  A61P29/00 ,  A61P37/06 ,  C07D403/04 ,  A61P19/02

CPC classification number: C07D417/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12

Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.

Abstract translation: 本发明提供了三嗪化合物及其用于调节蛋白激酶和治疗由所述蛋白激酶介导的疾病的方法。

公开(公告)号：US20120196860A1

公开(公告)日：2012-08-02

申请号：US13376814

申请日：2010-06-09

Applicant: Chunlin Tao ,  Qinwei Wang ,  Laxman Nallan ,  Tulay Polat ,  David Ho ,  Neil Desai

Inventor： Chunlin Tao ,  Qinwei Wang ,  Laxman Nallan ,  Tulay Polat ,  David Ho ,  Neil Desai

IPC: A61K31/5377 ,  C07D409/14 ,  A61K31/53 ,  C07D413/14 ,  C07D403/14 ,  C07D401/14 ,  A61P35/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P19/02 ,  A61P27/02 ,  A61P37/06 ,  A61P29/00 ,  A61P17/02 ,  A61P11/00 ,  C07D405/14

CPC classification number: A61K31/53 ,  A61K31/496 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

Abstract: The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.

Abstract translation: 本发明提供三嗪衍生物，并进一步提供使用这些化合物调节蛋白激酶和治疗由蛋白激酶介导的疾病和病症的方法。

公开(公告)号：US20110268656A1

公开(公告)日：2011-11-03

申请号：US12959340

申请日：2010-12-02

Applicant: David Ho ,  Tove Olafsen ,  Arye Lipman

Inventor： David Ho ,  Tove Olafsen ,  Arye Lipman

IPC: A61K51/10 ,  A61P37/02 ,  A61K39/395 ,  A61P35/00 ,  C07K16/32 ,  A61K49/00

CPC classification number: C07K16/3069 ,  A61K51/1072 ,  C07K2317/24 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/77 ,  C07K2317/90

Abstract: In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided.

Abstract translation: 在一个实施方案中，提供了结合PSMA的微单体。 小体抗体单体由包含N末端至C末端的核苷酸序列编码，可以结合PSMA，人造铰链序列和人IgG CH3序列的scFv序列。 在另一个实施方案中，提供了结合PSMA的CysDB单体。 CysDB单体可以由包含从N末端到C末端的可以结合PSMA和半胱氨酸尾部的scFv序列的核苷酸序列编码。 在其它实施方案中，提供了用于诊断或治疗与受试者中的PSMA表达相关的癌症的方法。

公开(公告)号：US20090223101A1

公开(公告)日：2009-09-10

申请号：US12379913

申请日：2009-03-04

Applicant: Jianguo Wang ,  Steven Tseng ,  David Ho

Inventor： Jianguo Wang ,  Steven Tseng ,  David Ho

IPC: A47G1/24

CPC classification number: A47G1/142 ,  H04N1/00127 ,  H04N1/00562 ,  H04N2201/0063 ,  H04N2201/0089

Abstract: A rotary positioning structure is disclosed for a frame. The frame comprises a housing and a spindle hole disposed on the rear of the housing. The rotary positioning structure comprises elastic members and a rotary stand. Each of the elastic members comprises a tenon and the elastic members are arranged on a circular path surrounding the spindle hole. The rotary stand comprises a rotary shaft and a groove. When the rotary shaft is inserted into the spindle hole, the groove engages with the tenon so that the housing is supported in a first upright position by the rotary stand; also after said rotary shaft is inserted into said spindle hole and then the rotary stand is pivoted on the rotary shaft, the groove engages with another tenon of the elastic members so that the housing is supported in a second upright position by the rotary stand.

Abstract translation: 公开了一种用于框架的旋转定位结构。 框架包括设置在壳体后部的壳体和心轴孔。 旋转定位结构包括弹性构件和旋转架。 每个弹性构件包括榫头，弹性构件布置在围绕心轴孔的圆形路径上。 旋转支架包括旋转轴和凹槽。 当旋转轴插入到主轴孔中时，凹槽与榫头接合，使得壳体由旋转支架支撑在第一直立位置; 在所述旋转轴插入所述心轴孔中之后，旋转支架在旋转轴上枢转的同时，凹槽与弹性构件的另一榫接合，从而通过旋转支架将壳体支撑在第二直立位置。

公开(公告)号：US07564212B2

公开(公告)日：2009-07-21

申请号：US11419355

申请日：2006-05-19

Applicant: Yun Li ,  Guoqiang Tang ,  David Ho

Inventor： Yun Li ,  Guoqiang Tang ,  David Ho

IPC: H02J7/00

CPC classification number: H02J7/355

Abstract: A mobile communication device is provided. The mobile communication device includes a processing unit, a battery unit, a solar cell unit, an electronic switch circuit and an analog to digital converter (ADC). In the mobile communication device, the solar cell unit receives a light and thus a luminance and transforms the luminance into an analog voltage. The ADC is configured to convert the analog voltage into a digital voltage. The processing unit is used to transmit a control voltage according to the digital voltage. In response to the control signal, the electronic switch circuit is controlled to turn the solar cell unit on or off and the solar cell unit provides all, a portion or none of a working current required for the processing unit according to the action of the electronic switch circuit. In addition, a luminance value may be generated according to the light received by the solar cell unit so that a user may be aware of the light quality of the ambient environment, thereby preventing himself/herself from reading under a poor light source environment thus protecting his/her eyesight from being damaged.

Abstract translation: 提供了一种移动通信设备。 移动通信设备包括处理单元，电池单元，太阳能电池单元，电子开关电路和模数转换器（ADC）。 在移动通信装置中，太阳能电池单元接收光并因此接收亮度，并将亮度变换为模拟电压。 ADC配置为将模拟电压转换为数字电压。 处理单元用于根据数字电压发送控制电压。 响应于控制信号，控制电子开关电路以打开或关闭太阳能电池单元，并且太阳能电池单元根据电子装置的动作提供处理单元所需的工作电流的全部，一部分或全部 开关电路。 此外，可以根据太阳能电池单元接收到的光产生亮度值，使得用户可以意识到周围环境的光质量，从而防止在较差的光源环境下自己读取，从而保护 他/她的视力受损。

公开(公告)号：US20080192012A1

公开(公告)日：2008-08-14

申请号：US11896421

申请日：2007-08-31

Applicant: Ching-Sung Chang ,  David Ho ,  Steven Tseng ,  An-Ping Yang

Inventor： Ching-Sung Chang ,  David Ho ,  Steven Tseng ,  An-Ping Yang

IPC: G06F3/02

CPC classification number: H01H13/84 ,  G06F3/0219 ,  H01H2219/044 ,  H01H2225/022 ,  H01H2231/022 ,  H04M1/23

Abstract: An input device constructed in a carrier electronic apparatus comprises a letter button module and a number button module. The letter button module has a plurality of letter buttons to represent different letters respectively, and the number button module has a plurality of number buttons to represent different numbers respectively. The number buttons are separated from the letter buttons by being located in the intervals formed by adjacent rows of the letter buttons. The size, form, and color of the number buttons are different to those of the letter buttons.

Abstract translation: 构造在载体电子设备中的输入设备包括字母按钮模块和数字按钮模块。 字母按钮模块具有分别代表不同字母的多个字母按钮，并且数字按钮模块具有分别代表不同数字的多个数字按钮。 数字按钮通过位于由字母按钮的相邻行形成的间隔中而与字母按钮分开。 数字按钮的大小，形式和颜色与字母按钮的大小，形式和颜色不同。

公开(公告)号：US20070273656A1

公开(公告)日：2007-11-29

申请号：US11653361

申请日：2007-01-16

Applicant: Jackson Chang ,  David Ho ,  Wei Shen ,  Kaiwu Li

Inventor： Jackson Chang ,  David Ho ,  Wei Shen ,  Kaiwu Li

IPC: G09G5/00

CPC classification number: G06F3/04886

Abstract: A modular keyboard configured for an electronic device having a mechanical portion and a virtual portion. One of the two portions is an alphanumeric keypad and the other portion is a navigation keypad. The alphanumeric keypad is preferably arranged on a lower portion of the body of the electronic device. The virtual keypad is implemented by software and displayed on a touch screen of the electronic device. In one input mode of the electronic device, only a subset of keys the mechanical portion of the modular keyboard is enabled. In another input mode, all keys of the mechanical portion of the keyboard are enabled. In still another input mode, both the mechanical portion and the virtual portion of the modular keyboard are enabled.

Abstract translation: 一种用于具有机械部分和虚拟部分的电子设备的模块化键盘。 两个部分之一是字母数字键盘，另一部分是导航键盘。 字母数字键盘优选地布置在电子设备的主体的下部。 虚拟键盘由软件实现并显示在电子设备的触摸屏上。 在电子设备的一个输入模式中，只有模块键盘的机械部分能够启用键的子集。 在另一个输入模式下，键盘的机械部分的所有键都被使能。 在另一个输入模式中，模块化键盘的机械部分和虚拟部分均能启用。

公开(公告)号：US20070127423A1

公开(公告)日：2007-06-07

申请号：US11412768

申请日：2006-04-27

Applicant: David Ho

Inventor： David Ho

IPC: H04Q7/24

CPC classification number: H04W8/18

Abstract: The present invention discloses a method for providing a client-requested location dependent information for a designated location through a wireless communication system. The method includes a step of detecting a presence of a wireless network client at the designate location by the wireless communication system wherein the wireless communication system includes a data record of client profile to enable a determination if there is such a client-requested location dependent information for the designated location from the user whereby the client-requested location dependent information may be provided to the client at the designated location through the wireless communication system.

Abstract translation: 本发明公开了一种通过无线通信系统为指定位置提供客户请求的位置相关信息的方法。 该方法包括通过无线通信系统检测在指定位置处的无线网络客户端的存在的步骤，其中无线通信系统包括客户机简档的数据记录，以使得能够确定是否存在这样的客户端请求的位置相关信息 对于来自用户的指定位置，通过无线通信系统，可以在指定位置向客户端提供客户请求的位置相关信息。

公开(公告)号：US20070124065A1

公开(公告)日：2007-05-31

申请号：US11535496

申请日：2006-09-27

Applicant: David Ho ,  Wei LIANG

Inventor： David Ho ,  Wei LIANG

IPC: G01C21/32

CPC classification number: G01C21/32

Abstract: A map transmission system and a method thereof are disclosed. The system includes a database, a sender, and a receiver. The database stores at least one map data. The sender generates a map frame data based on the map to be transmitted and converts the map frame data into a vector map data through the database, and then the sender transmits the vector map data to a remote site via a network. The receiver receives the vector map data and displays the vector map data by using a map engine application program.

Abstract translation: 公开了地图传输系统及其方法。 该系统包括数据库，发送者和接收者。 数据库存储至少一个地图数据。 发送方根据要发送的地图生成地图帧数据，并通过数据库将地图帧数据转换为矢量地图数据，然后发送方通过网络将向量地图数据发送到远程站点。 接收器接收矢量地图数据，并使用地图引擎应用程序显示矢量地图数据。