公开(公告)号：US20110076765A1

公开(公告)日：2011-03-31

申请号：US12890014

申请日：2010-09-24

申请人： Jian-Qiang Fan ,  Satoshi Ishii ,  Naoki Asano

发明人： Jian-Qiang Fan ,  Satoshi Ishii ,  Naoki Asano

IPC分类号： C12N5/071

CPC分类号： A61K31/445 ,  A61K31/70 ,  A61K31/7008 ,  C07D451/06 ,  C12N9/2465

摘要： Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.

摘要翻译： 通过以有效增加酶的活性的量施用葡糖脑苷脂酶的竞争性抑制剂，在哺乳动物细胞中增强与戈谢病相关的酶的活性的方法。 用于该方法的优选化合物是亚氨基糖和相关化合物。 特别地，N-烷基脱氧野尻霉素的C8-12-烷基衍生物，异佛胺化合物和钙半胱氨酸化合物对增强葡糖脑苷脂酶活性是有效的。

公开(公告)号：US07666611B2

公开(公告)日：2010-02-23

申请号：US10542217

申请日：2003-12-17

申请人： Takao Shimizu ,  Satoshi Ishii ,  Kyoko Noguchi

发明人： Takao Shimizu ,  Satoshi Ishii ,  Kyoko Noguchi

IPC分类号： G01N33/53 ,  C12Q1/00

CPC分类号： G01N33/76 ,  C07K14/705 ,  G01N2333/726

摘要： It is intended to provide a novel receptor of LPA and a method of screening a drug such as an LPA receptor antagonist using the same. Use as a lysophosphatidic acid (LPA) receptor comprising a G protein-coupled protein p2y9. More specifically, use of the G protein-coupled protein p2y9 as a lysophosphatidic acid (LPA) receptor. A method of screening an agonist or an antagonist to the LPA receptor as described above by using the receptor.

摘要翻译： 旨在提供LPA的新型受体和使用其来筛选药物如LPA受体拮抗剂的方法。 用作包含G蛋白偶联蛋白质p2y9的溶血磷脂酸（LPA）受体。 更具体地，使用G蛋白偶联蛋白质p2y9作为溶血磷脂酸（LPA）受体。 通过使用受体来筛选上述LPA受体的激动剂或拮抗剂的方法。

公开(公告)号：US07277251B2

公开(公告)日：2007-10-02

申请号：US11266129

申请日：2005-11-02

申请人： Satoshi Ishii ,  Masato Taniguchi ,  Tetsuo Ueda ,  Noboru Yoshida

发明人： Satoshi Ishii ,  Masato Taniguchi ,  Tetsuo Ueda ,  Noboru Yoshida

IPC分类号： G11B21/02

CPC分类号： G11B5/6064 ,  G11B5/54 ,  G11B5/607 ,  G11B21/12 ,  G11B21/22

摘要： Embodiments of the invention perform a stable data write operation at a low operating ambient temperature and promptly perform a write command process within a magnetic recording apparatus that employs a load/unload design. In one embodiment, write heads unloaded on a ramp are completely preheated before magnetic disks reach their rated rotation speed. This preheat operation takes time T1. After completion of write head preheating, the write heads are loaded from the ramp. This loading operation takes time T2. Since time T1 and time T2 do not sequentially elapse, it is possible to prevent a write operation from being rendered unstable by thermal protrusion while expediting a write command process.

摘要翻译： 本发明的实施例在低操作环境温度下执行稳定的数据写入操作，并且在采用加载/卸载设计的磁记录装置内及时执行写命令处理。 在一个实施例中，在磁盘达到其额定转速之前，在斜坡上卸载的写头被完全预热。 此预热操作需要时间T 1。 在写入头预热完成之后，写入头从斜坡加载。 此加载操作需要时间T 2。 由于时间T 1和时间T 2不顺序地经过，所以可以防止写入操作在加速写入命令处理时由于热突起而变得不稳定。

公开(公告)号：US07148840B2

公开(公告)日：2006-12-12

申请号：US10999974

申请日：2004-12-01

申请人： Yoshikazu Dooi ,  Satoshi Ishii ,  Hiroyuki Yatsuka ,  Nobukazu Shima ,  Masaki Hitotsuya

发明人： Yoshikazu Dooi ,  Satoshi Ishii ,  Hiroyuki Yatsuka ,  Nobukazu Shima ,  Masaki Hitotsuya

IPC分类号： G01S13/38 ,  G01S13/10 ,  G01S13/32 ,  G01S13/93

CPC分类号： G01S13/582 ,  G01S7/02 ,  G01S13/08 ,  G01S13/87 ,  G01S13/931 ,  G01S2013/9321 ,  G01S2013/9375 ,  G01S2013/9378

摘要： A radar apparatus comprises: a transmitter unit having a high-frequency oscillating unit whose oscillation frequency is variable, and a pulse amplitude modulating unit for amplitude-modulating a pulse of a transmission high-frequency signal output from the high-frequency oscillating unit with a first control pulse signal; a receiver unit having a gating unit for controlling ON/OFF of an input of a received high-frequency signal with a second control pulse signal; and a controlling and signal processing unit for controlling the transmitter unit and the receiver unit, and for switching a first operation mode for making the apparatus function as an FM-CW radar, and a second operation mode for making the apparatus function as a pulse radar.

公开(公告)号：US07095363B2

公开(公告)日：2006-08-22

申请号：US10809461

申请日：2004-03-26

申请人： Satoshi Ishii ,  Yoshikazu Dooi ,  Hiroyuki Yatsuka ,  Tetsuo Seki

发明人： Satoshi Ishii ,  Yoshikazu Dooi ,  Hiroyuki Yatsuka ,  Tetsuo Seki

IPC分类号： G01S13/08

CPC分类号： G01S13/348 ,  G01S13/18 ,  G01S13/282 ,  G01S13/931

摘要： A pulse radar apparatus uses different frequencies, for example, frequencies one of which is a multiple or a submultiple of the other for a signal which becomes a reference of a control pulse for controlling a gate operation for a reception signal and a signal which becomes a base of generation of a transmission pulse. As a result, even if noise is caused by the gate operation, its influence can be removed in the processing of reception signals having different frequencies.

摘要翻译： 脉冲雷达装置使用不同的频率，例如，对于作为用于控制接收信号的门控操作的控制脉冲的参考信号和成为接收信号的信号，其中一个频率是另一个频率的倍数或者其他频率的信号， 产生传输脉冲的基础。 结果，即使由门操作引起噪声，也可以在具有不同频率的接收信号的处理中消除其影响。

公开(公告)号：US06952509B2

公开(公告)日：2005-10-04

申请号：US09956047

申请日：2001-09-20

申请人： Satoshi Ishii

发明人： Satoshi Ishii

IPC分类号： G02B5/18 ,  G02B6/02 ,  G02B6/34 ,  H01S3/06 ,  H01S3/067 ,  H04B10/2507 ,  H04B10/2519 ,  H04B10/2525 ,  H04J14/00 ,  H04J14/02

CPC分类号： G02B6/2932 ,  G02B6/29374 ,  G02B6/29394

摘要： In the WDM optical transmission, optical signals propagated through an optical transmission line are supplied to a circulator of a wavelength dispersion compensator. The optical signals supplied to an input terminal of the circulator are transmitted to an input and output terminal of the circulator, and inputted to fiber gratings of the reflection type. The optical signals having a specified wavelength is reflected by one of the fiber gratings, again inputted to the input and output terminal of the circulator, and transmitted to the output terminal of the same. Since the incident optical signals are reflected by the fiber gratings situated at different positions, there arises the difference in the time spent in traveling to and from the fiber grating between the optical signals. Accordingly, the wavelength dispersions of the optical signals can be compensated by suitably selecting the positions of the fiber gratings.

摘要翻译： 在WDM光传输中，通过光传输线传播的光信号被提供给波长色散补偿器的循环器。 提供给循环器的输入端的光信号被传送到循环器的输入和输出端，并输入到反射型光纤光栅。 具有指定波长的光信号由光纤光栅之一反射，再次输入到环行器的输入和输出端，并传送到其输出端。 由于入射光信号被位于不同位置处的光纤光栅反射，所以在光信号之间往返于光纤光栅所花费的时间出现差异。 因此，可以通过适当选择光纤光栅的位置来补偿光信号的波长色散。

公开(公告)号：US20050185312A1

公开(公告)日：2005-08-25

申请号：US11064698

申请日：2005-02-23

申请人： Tetsuo Ueda ,  Kazuyuki Ishibashi ,  Satoshi Ishii ,  Masaaki Noguchi

发明人： Tetsuo Ueda ,  Kazuyuki Ishibashi ,  Satoshi Ishii ,  Masaaki Noguchi

IPC分类号： G11B21/21 ,  G11B5/60 ,  G11B20/18 ,  G11B21/02 ,  G11B27/36

CPC分类号： G11B5/6005 ,  G11B5/40 ,  G11B5/6029 ,  G11B21/21

摘要： Embodiments of the invention are directed to detecting an abnormality in head flying height. In one embodiment, an AGC controller establishes the gain of the reproduced signal through gain adjustment using the servo AGC of the servo signal. A digital filter performs filtering processing by use of the obtained gain data g and the gain data of previous sectors. A comparative judgment section obtains filtered gain data G from the digital filter and compares the gain data G with a reference value CRITERIA to determine whether the flying height is normal or abnormal. If the gain G is larger than the reference value CRITERIA, then the data write operation is inhibited. The filter parameters of the digital filter are programmable parameters which can be set and changed.

摘要翻译： 本发明的实施例涉及检测头部飞行高度的异常。 在一个实施例中，AGC控制器通过使用伺服信号的伺服AGC的增益调整来建立再生信号的增益。 数字滤波器通过使用获得的增益数据g和先前扇区的增益数据来执行滤波处理。 比较判断部分从数字滤波器获得滤波后的增益数据G，并将增益数据G与参考值CRITERIA进行比较，以确定飞行高度是正常还是异常。 如果增益G大于参考值CRITERIA，则禁止数据写入操作。 数字滤波器的滤波器参数是可设置和更改的可编程参数。

公开(公告)号：US20050167449A1

公开(公告)日：2005-08-04

申请号：US10511359

申请日：2003-06-10

申请人： Kazunari Hanaoka ,  Satoshi Ishii

发明人： Kazunari Hanaoka ,  Satoshi Ishii

IPC分类号： G01F11/28 ,  G01F13/00 ,  B67D5/06

CPC分类号： G01F13/001 ,  G01F11/282

摘要： A powder body metering apparatus for metering a powder body such as a synthetic resin raw material is structured such that a powder body outlet of a metering container of another metering apparatus is connected to a second opening (50), whereby a powder body transport system is constructed, the powder body within the metering container of the other metering apparatus can be transported to a predetermined place via a metering container (32), by finishing a discharge of the powder body within the metering container (32), thereafter keeping a switch valve (36) in a closed state, filling the powder body in the metering container of the other metering apparatus and thereafter generating a gas stream toward a first opening (49) from the second opening (50), thus the metering container (32) being utilized as a part of a transport pipe.

摘要翻译： 用于计量合成树脂原料等粉末体的粉末体计量装置被构造成使得另一计量装置的计量容器的粉末体出口连接到第二开口（50），由此粉末体输送系统 通过在计量容器（32）内完成粉末体的排放，可以通过计量容器（32）将另一计量装置的计量容器内的粉末体输送到预定的位置，然后保持开关阀 （36）处于关闭状态，将粉末体填充到另一计量装置的计量容器中，然后从第二开口（50）向第一开口（49）产生气流，因此计量容器（32）为 用作运输管道的一部分。

公开(公告)号：US06778129B2

公开(公告)日：2004-08-17

申请号：US10401758

申请日：2003-03-31

申请人： Satoshi Ishii ,  Yoshikazu Dooi ,  Masayuki Kishida

发明人： Satoshi Ishii ,  Yoshikazu Dooi ,  Masayuki Kishida

IPC分类号： G01S1342

CPC分类号： G01S13/584 ,  G01S13/345

摘要： The crossover detection method of a radar apparatus according to the present invention calculates distance/relative velocity information at a multitude of different clock times, using a beat signal; calculates predicted distance/relative velocity information indicating distance/relative velocity, respectively, of a target after a prescribed time has elapsed; calculates predicted distance/relative velocity errors by subtracting the calculated distance/relative velocity information from the calculated predicted distance/relative velocity information, respectively; calculates degree of similarity information, based on the predetermined average predicted distance/relative velocity errors and the calculated predicted distance/relative velocity errors; and determines whether there is crossover, based on the above information.

摘要翻译： 根据本发明的雷达装置的交叉检测方法使用拍子信号来计算多个不同时钟频率的距离/相对速度信息; 在规定时间过去之后，分别计算指示目标的距离/相对速度的预测距离/相对速度信息; 通过从计算出的预测距离/相对速度信息中减去计算出的距离/相对速度信息来计算预测距离/相对速度误差; 基于预定的平均预测距离/相对速度误差和计算出的预测距离/相对速度误差来计算相似度信息度; 并基于上述信息确定是否存在交叉。

公开(公告)号：US06589964B2

公开(公告)日：2003-07-08

申请号：US10172604

申请日：2002-06-14

申请人： Jian-Qiang Fan ,  Satoshi Ishii

发明人： Jian-Qiang Fan ,  Satoshi Ishii

IPC分类号： A61K31445

CPC分类号： A61K31/445 ,  A61K31/70 ,  A61K31/7008 ,  C07D451/06 ,  C12N9/2465

摘要： Method for enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds.

摘要翻译： 通过以有效提高酶的活性的量施用酶的竞争性抑制剂，在哺乳动物细胞中增强与溶酶体储存障碍相关的酶的活性的方法。 用于该方法的优选化合物是亚氨基糖和相关化合物。