公开(公告)号：US07881789B2

公开(公告)日：2011-02-01

申请号：US11832552

申请日：2007-08-01

申请人： Joseph M. Pastore ,  Steven D. Girouard ,  Bruce H. KenKnight ,  Qingsheng Zhu ,  Jiang Ding

发明人： Joseph M. Pastore ,  Steven D. Girouard ,  Bruce H. KenKnight ,  Qingsheng Zhu ,  Jiang Ding

IPC分类号： A61N1/368

CPC分类号： A61N1/3622 ,  A61N1/3627 ,  A61N1/3684

摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

摘要翻译： 心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。 在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

公开(公告)号：US07813799B2

公开(公告)日：2010-10-12

申请号：US10952345

申请日：2004-09-28

申请人： Scott M. Freeberg ,  Michael J. Lyden ,  Qingsheng Zhu

发明人： Scott M. Freeberg ,  Michael J. Lyden ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3712

摘要： Methods and systems involve adjusting an energy used for safety pacing based on the capture threshold. The safety pacing energy may be adjusted prior to a capture threshold test. During the capture threshold test, backup safety paces are delivered using the adjusted pacing energy. Following suspension of automatic capture verification, the device may enter a suspension mode. During the suspension mode, safety pacing pulses are delivered using a pacing energy adjusted based on capture threshold.

摘要翻译： 方法和系统包括根据捕获阈值调整用于安全起搏的能量。 可以在捕获阈值测试之前调整安全起搏能量。 在捕获阈值测试期间，使用调整的起搏能量传送备用安全步伐。 在停止自动捕获验证之后，设备可能进入暂停模式。 在悬架模式下，使用基于捕获阈值调整的起搏能量来传送安全起搏脉冲。

公开(公告)号：US20090187228A1

公开(公告)日：2009-07-23

申请号：US12415660

申请日：2009-03-31

申请人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

发明人： Geng Zhang ,  Jungkuk Kim ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3712 ,  A61N1/3716

摘要： A cardiac electrical stimulation system that enhances the ability of the system to automatically detect whether an electrical stimulus results in heart capture or contraction. The cardiac electrical stimulation system may be utilized, for example, as a cardiac pacer or as a cardioverter defibrillator. The cardiac electrical stimulation system includes an electrical stimulation circuit that attenuates polarization voltages or “afterpotential” which develop at the heart tissue/electrode interface following the delivery of a stimulus to the heart tissue, which thereby allows the stimulation electrodes to be utilized to sense an evoked response to the electrical stimulus. The cardiac electrical stimulation system utilizes the stimulation electrodes to sense an evoked response, thereby eliminating the necessity for an indifferent electrode to sense an evoked response. The present invention allows accurate detection of an evoked response of the heart, to thereby determine whether each electrical stimulus results in capture.

摘要翻译： 心脏电刺激系统，其增强系统自动检测电刺激是否导致心脏捕获或收缩的能力。 心脏电刺激系统可以用作例如心脏起搏器或心律转复除颤器。 心脏电刺激系统包括电刺激电路，该电刺激电路衰减在向心脏组织递送刺激之后在心脏组织/电极界面处发展的极化电压或“后电位”，从而允许刺激电极用于感测 诱发对电刺激的反应。 心脏电刺激系统利用刺激电极来感测诱发反应，从而消除无关电极感应诱发反应的必要性。 本发明允许精确检测心脏的诱发反应，从而确定每个电刺激是否导致捕获。

公开(公告)号：US20090187226A1

公开(公告)日：2009-07-23

申请号：US12412608

申请日：2009-03-27

申请人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

发明人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

IPC分类号： A61N1/362

CPC分类号： A61N1/371 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/3962

摘要： A method and apparatus are disclosed for treating a condition of a patient's heart includes placing a first electrode and/or a second electrode in a right ventricle of the heart. In one example, a reference electrode is placed within the patient and internal or external to the heart. A pacing signal is generated including a first signal component, a second signal component and a reference component with the first and second signal components having opposite polarity and with both of the first and second components having a potential relative to the reference component. The pacing signal and the placement of the electrodes are selected to alter a contraction of a left ventricle of the heart.

摘要翻译： 公开了一种用于治疗患者心脏状况的方法和装置，包括将第一电极和/或第二电极放置在心脏的右心室中。 在一个示例中，将参考电极放置在患者体内并在心脏内部或外部。 生成包括第一信号分量，第二信号分量和参考分量的起搏信号，其中第一和第二信号分量具有相反的极性，并且第一和第二分量都具有相对于参考分量的电势。 选择起搏信号和放置电极以改变心脏左心室的收缩。

公开(公告)号：US07512440B2

公开(公告)日：2009-03-31

申请号：US11300611

申请日：2005-12-13

申请人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

发明人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

IPC分类号： A61N1/362

CPC分类号： A61N1/371 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/3962

摘要： A method and apparatus are disclosed for treating a condition of a patient's heart includes placing a first electrode and a second electrode in a right ventricle of the heart. A reference electrode is placed within the patient and internal or external to the heart. A pacing signal is generated including a first signal component, a second signal component and a reference component with the first and second signal components having opposite polarity and with both of the first and second components having a potential relative to the reference component. The first component is transmitted to the first electrode. The second component is transmitted to the second electrode. The reference electrode is connected to the reference component which may be an electrical ground. The pacing signal and the placement of the electrodes are selected to alter a contraction of a left ventricle of the heart.

摘要翻译： 公开了一种用于治疗患者心脏状况的方法和装置，包括将第一电极和第二电极放置在心脏的右心室中。 参考电极放置在患者体内并在心脏内部或外部。 生成包括第一信号分量，第二信号分量和参考分量的起搏信号，其中第一和第二信号分量具有相反的极性，并且第一和第二分量都具有相对于参考分量的电势。 第一部件被传输到第一电极。 第二部件被传送到第二电极。 参考电极连接到可以是电接地的参考部件。 选择起搏信号和放置电极以改变心脏左心室的收缩。

公开(公告)号：US07479107B2

公开(公告)日：2009-01-20

申请号：US11258432

申请日：2005-10-25

申请人： Qingsheng Zhu ,  Julio Spinelli

发明人： Qingsheng Zhu ,  Julio Spinelli

IPC分类号： A61B5/00

CPC分类号： A61B5/14539 ,  A61B5/0008 ,  A61B5/024 ,  A61B5/076 ,  A61B5/145

摘要： An implanted heart monitor includes sensors that measure various aspects of the heart failure patient's heart. A remote heart monitoring system connects the implanted heart monitor to a care provider, such as a physician. The data provided by the implanted heart monitor permits the care provider to obtain valuable data on the heart in order to make health care decisions affecting the heart failure patient's treatment. In many cases, the measurement of core body temperature and other patient data will enable the care provider to alter the patient's treatment to address the patient's condition. The implanted heart monitor can communicate over a wireless communication link with an external monitor. The implanted heart monitor may be implemented as part of a pacing device (i.e., pace maker) or may be a separate unit devoted to monitoring functions. The external monitor communicates with a monitoring station over a communication link. The monitoring station can operate as a centralized data collection unit, collecting data from multiple external monitors and multiple implanted heart monitors. Various other aspects of a heart failure patient's heart and/or body can be monitored, such as heart rate, blood pH levels, blood CO2 levels, and any other indications of the heart failure patient's activity. Various predetermined thresholds may be set to trigger alarms and/or data reports.

摘要翻译： 植入心脏监测器包括测量心力衰竭患者心脏的各个方面的传感器。 远程心脏监测系统将植入的心脏监测器连接到护理提供者，例如医师。 由植入式心脏监测器提供的数据允许护理提供者在心脏上获得有价值的数据，以便使医疗保健决定影响心力衰竭患者的治疗。 在许多情况下，核心体温和其他患者数据的测量将使护理人员能够改变患者的治疗以解决病人的状况。 植入的心脏监测器可以通过无线通信链路与外部监视器进行通信。 植入心脏监视器可以被实现为起搏装置（即，起搏器）的一部分，或者可以是专用于监视功能的单独单元。 外部监视器通过通信链路与监控站进行通信。 监控站可以作为集中数据采集单元运行，从多个外部监视器和多个植入心脏监视器收集数据。 可以监测心力衰竭患者的心脏和/或身体的各种其他方面，例如心率，血液pH值，血液二氧化碳水平以及心力衰竭患者活动的任何其他指征。 可以设置各种预定阈值以触发报警和/或数据报告。

公开(公告)号：US20090005832A1

公开(公告)日：2009-01-01

申请号：US12147356

申请日：2008-06-26

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/37

CPC分类号： A61N1/3627

摘要： Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by generating pulses for delivery to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, an implantable pulse generator includes circuitry for generating pacing profiles, with signals of opposite polarities, specifically selected for delivery on electrodes at a site near the septal wall of a right ventricle of the heart.

摘要翻译： 工具和方法特别适合于某些心脏状况，包括使用导管将右心室和左心室从右心室中的引线起搏，例如为了促进用于再同步的机械和/或电同步收缩。 某些方面涉及起搏和/或作图，通过产生用于递送到心脏部位的脉搏，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/ 压力或其组合。 在一个实施例中，可植入脉冲发生器包括用于产生具有相反极性的信号的起搏曲线的电路，其具体选择用于在靠近心脏右心室隔壁的位置处的电极上传送。

公开(公告)号：US20080215108A1

公开(公告)日：2008-09-04

申请号：US12152099

申请日：2008-05-12

申请人： Qingsheng Zhu ,  Julio C. Spinelli

发明人： Qingsheng Zhu ,  Julio C. Spinelli

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3684

摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.

摘要翻译： 心律管理系统检测水肿。 响应于检测到的水肿发作，其启动或调整心脏再同步治疗和/或心脏收缩调节（CCM）治疗。

公开(公告)号：US07366567B2

公开(公告)日：2008-04-29

申请号：US11088231

申请日：2005-03-23

申请人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

发明人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

IPC分类号： A61N1/365

CPC分类号： A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

公开(公告)号：US20080077031A1

公开(公告)日：2008-03-27

申请号：US11985995

申请日：2007-11-19

申请人： Julio Spinelli ,  Qingsheng Zhu

发明人： Julio Spinelli ,  Qingsheng Zhu

IPC分类号： A61B5/0452

CPC分类号： A61N1/37282 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G06Q50/22 ,  G16H40/40

摘要： One embodiment includes a system for prescribing therapeutic treatment for a patient via communications over a network, including an implantable medical device (IMD) to be implanted in the patient to record a patient characteristic, the implantable medical device being programmable and configured to communicate via wireless communications with the IMD and to communicate securely over the network, the medical device programming computer including a user interface. The embodiment includes a server to communicate securely over the network with the medical device programming computer, the server including at least a first expert prescription system comprising at least one physician's prescription and at least one expert-system to compare the at least one patient characteristic to the at least one physician's prescription to issue a parameter to be programmed into the IMD based on the comparison.

摘要翻译： 一个实施例包括一种用于通过网络进行通信来对患者进行治疗性治疗的系统，包括要植入患者中的可植入医疗装置（IMD）以记录患者特征，所述可植入医疗装置是可编程的并且经配置以经由无线 与IMD的通信并且通过网络安全地通信，医疗设备编程计算机包括用户界面。 该实施例包括通过网络与医疗设备编程计算机安全地通信的服务器，该服务器至少包括第一专家处方系统，该第一专家处方系统包括至少一个医师的处方和至少一个专家系统，以将至少一个患者特征与 所述至少一位医生处方根据比较发布要编程到IMD中的参数。