公开(公告)号：US20090187226A1

公开(公告)日：2009-07-23

申请号：US12412608

申请日：2009-03-27

申请人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

发明人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

IPC分类号： A61N1/362

CPC分类号： A61N1/371 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/3962

摘要： A method and apparatus are disclosed for treating a condition of a patient's heart includes placing a first electrode and/or a second electrode in a right ventricle of the heart. In one example, a reference electrode is placed within the patient and internal or external to the heart. A pacing signal is generated including a first signal component, a second signal component and a reference component with the first and second signal components having opposite polarity and with both of the first and second components having a potential relative to the reference component. The pacing signal and the placement of the electrodes are selected to alter a contraction of a left ventricle of the heart.

摘要翻译： 公开了一种用于治疗患者心脏状况的方法和装置，包括将第一电极和/或第二电极放置在心脏的右心室中。 在一个示例中，将参考电极放置在患者体内并在心脏内部或外部。 生成包括第一信号分量，第二信号分量和参考分量的起搏信号，其中第一和第二信号分量具有相反的极性，并且第一和第二分量都具有相对于参考分量的电势。 选择起搏信号和放置电极以改变心脏左心室的收缩。

公开(公告)号：US07512440B2

公开(公告)日：2009-03-31

申请号：US11300611

申请日：2005-12-13

申请人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

发明人： Daniel Felipe Ortega ,  Alberto German Giniger ,  Qingsheng Zhu ,  J. Edward Shapland

IPC分类号： A61N1/362

CPC分类号： A61N1/371 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/3962

摘要： A method and apparatus are disclosed for treating a condition of a patient's heart includes placing a first electrode and a second electrode in a right ventricle of the heart. A reference electrode is placed within the patient and internal or external to the heart. A pacing signal is generated including a first signal component, a second signal component and a reference component with the first and second signal components having opposite polarity and with both of the first and second components having a potential relative to the reference component. The first component is transmitted to the first electrode. The second component is transmitted to the second electrode. The reference electrode is connected to the reference component which may be an electrical ground. The pacing signal and the placement of the electrodes are selected to alter a contraction of a left ventricle of the heart.

摘要翻译： 公开了一种用于治疗患者心脏状况的方法和装置，包括将第一电极和第二电极放置在心脏的右心室中。 参考电极放置在患者体内并在心脏内部或外部。 生成包括第一信号分量，第二信号分量和参考分量的起搏信号，其中第一和第二信号分量具有相反的极性，并且第一和第二分量都具有相对于参考分量的电势。 第一部件被传输到第一电极。 第二部件被传送到第二电极。 参考电极连接到可以是电接地的参考部件。 选择起搏信号和放置电极以改变心脏左心室的收缩。

公开(公告)号：US20090005832A1

公开(公告)日：2009-01-01

申请号：US12147356

申请日：2008-06-26

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/37

CPC分类号： A61N1/3627

摘要： Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by generating pulses for delivery to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, an implantable pulse generator includes circuitry for generating pacing profiles, with signals of opposite polarities, specifically selected for delivery on electrodes at a site near the septal wall of a right ventricle of the heart.

摘要翻译： 工具和方法特别适合于某些心脏状况，包括使用导管将右心室和左心室从右心室中的引线起搏，例如为了促进用于再同步的机械和/或电同步收缩。 某些方面涉及起搏和/或作图，通过产生用于递送到心脏部位的脉搏，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/ 压力或其组合。 在一个实施例中，可植入脉冲发生器包括用于产生具有相反极性的信号的起搏曲线的电路，其具体选择用于在靠近心脏右心室隔壁的位置处的电极上传送。

公开(公告)号：US20080215108A1

公开(公告)日：2008-09-04

申请号：US12152099

申请日：2008-05-12

申请人： Qingsheng Zhu ,  Julio C. Spinelli

发明人： Qingsheng Zhu ,  Julio C. Spinelli

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3684

摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.

摘要翻译： 心律管理系统检测水肿。 响应于检测到的水肿发作，其启动或调整心脏再同步治疗和/或心脏收缩调节（CCM）治疗。

公开(公告)号：US07366567B2

公开(公告)日：2008-04-29

申请号：US11088231

申请日：2005-03-23

申请人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

发明人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

IPC分类号： A61N1/365

CPC分类号： A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

公开(公告)号：US20080045852A1

公开(公告)日：2008-02-21

申请号：US11926425

申请日：2007-10-29

申请人： John Hatlestsad ,  Qingsheng Zhu ,  Jeffrey Stahmann

发明人： John Hatlestsad ,  Qingsheng Zhu ,  Jeffrey Stahmann

IPC分类号： A61B5/08

CPC分类号： A61B5/0809 ,  A61B5/0816 ,  A61B5/1071 ,  A61B5/1116 ,  A61B5/1135 ,  A61B5/4806 ,  A61B5/6831 ,  A61B5/6846 ,  A61B5/686 ,  A61N1/36542

摘要： Systems and methods obtain information that allows detection of whether a patient suffers from congestion by monitoring a response of the patient to a recumbent position of the patient's body. The patient may be monitored to determine a respiration pattern for a non-recumbent position such as standing and a respiration pattern for a recumbent position such as lying down. The two patterns may be compared, either by a processing device or a physician, to determine a difference in the two respiration patterns. Furthermore, the congestion may be inferred from detecting an amount of time that the patient spends in a recumbent position or from detecting the recumbent angle that the patient obtains, either of which is presumed to indicate whether a recumbent position presents discomfort to the patient due to the presence of congestion.

摘要翻译： 系统和方法获得允许通过监视患者对患者身体的卧位的反应来检测患者是否患有拥塞的信息。 可以监测患者以确定用于躺卧位置的无卧位的呼吸模式，例如躺卧和躺卧位置的呼吸模式。 可以通过处理装置或医师来比较两种模式，以确定两种呼吸模式的差异。 此外，可以通过检测患者在躺卧位置中花费的时间量或从检测患者获得的躺卧角度来推断拥塞，其中任何一个被推定为指示躺卧位置是否由于患者的不适而给患者带来不适 拥堵的存在。

公开(公告)号：US20080015653A1

公开(公告)日：2008-01-17

申请号：US11780405

申请日：2007-07-19

申请人： Krzysztof Siejko ,  Gerrard Carlson ,  William Lincoln ,  Qingsheng Zhu

发明人： Krzysztof Siejko ,  Gerrard Carlson ,  William Lincoln ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36542 ,  A61N1/36578 ,  A61N1/3682 ,  A61N1/3702

摘要： A cardiac rhythm management system provides a phonocardiographic image indicative of a heart's mechanical events related to hemodynamic performance. The phonocardiographic image includes a stack of acoustic sensor signal segments representing multiple cardiac cycles. Each acoustic sensor signal segment includes heart sounds indicative of the heart's mechanical events and representations of the heart's electrical events. The stack of acoustic sensor signal segments are aligned by a selected type of the heart's mechanical or electrical events and are grouped by a cardiac timing parameter for presentation.

摘要翻译： 心律管理系统提供指示与血液动力学性能相关的心脏的机械事件的心音图像。 心音图像包括表示多个心动周期的一组声传感器信号段。 每个声学传感器信号段包括指示心脏的机械事件和心脏电气事件的表示的心脏声音。 声学传感器信号段的堆叠通过所选择的心脏的机械或电气事件的类型对准，并且通过心脏定时参数分组以进行呈现。

公开(公告)号：US07225024B2

公开(公告)日：2007-05-29

申请号：US10677144

申请日：2003-09-30

申请人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

IPC分类号： A61N1/365 ,  A61B5/00

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： A cardiac management implantable device that has an intravascular device body, and one or more chemical sensors coupled with the intravascular device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种具有血管内装置体的心脏管理可植入装置，以及与血管内装置本体结合的一个或多个化学传感器。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

公开(公告)号：US07206634B2

公开(公告)日：2007-04-17

申请号：US10206131

申请日：2002-07-26

申请人： Jiang Ding ,  Yinghong Yu ,  Qingsheng Zhu

发明人： Jiang Ding ,  Yinghong Yu ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/36542 ,  A61N1/36514 ,  A61N1/3682 ,  A61N1/3684

摘要： A cardiac rhythm and function management device configured to automatically adjust stimulation parameters used in delivering cardiac resynchronization therapy. Mechanical contraction intervals are measured using appropriately placed accelerometers and compared with optimum values. The stimulation parameters can then be adjusted accordingly in a manner that moves the mechanical contraction intervals toward their optimum values.

摘要翻译： 心律和功能管理装置被配置为自动调整用于递送心脏再同步治疗的刺激参数。 使用适当放置的加速度计测量机械收缩间隔，并与最佳值进行比较。 然后可以以使机械收缩间隔向其最佳值移动的方式相应地调节刺激参数。

公开(公告)号：US07191000B2

公开(公告)日：2007-03-13

申请号：US09919483

申请日：2001-07-31

申请人： Qingsheng Zhu ,  Julio C. Spinelli

发明人： Qingsheng Zhu ,  Julio C. Spinelli

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3684

摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.

摘要翻译： 心律管理系统检测水肿。 响应于检测到的水肿发作，其启动或调整心脏再同步治疗和/或心脏收缩调节（CCM）治疗。