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112 条记录 (耗时 0.029 秒)

    Angiogenesis inhibitor
    103.
    发明授权
    Angiogenesis inhibitor 失效
    血管生成抑制剂

    公开(公告)号：US4975422A

    公开(公告)日：1990-12-04

    申请号：US368232

    申请日：1989-06-19

    申请人： Tamotsu Kanoh ,  Kenichi Matsunaga ,  Kenichi Saito ,  Takayoshi Fujii

    发明人： Tamotsu Kanoh ,  Kenichi Matsunaga ,  Kenichi Saito ,  Takayoshi Fujii

    IPC分类号： A61K36/07 ,  A61K36/06 ,  A61K38/00 ,  A61P9/00 ,  A61P27/02 ,  A61P35/00 ,  C07K14/375

    CPC分类号： C07K14/375 ,  A61K38/00

    摘要： The present invention discloses an angiogenesis inhibitor containing as an active ingredient protein-polysaccharides produced by extraction of mycelia or fruit bodies obtained from culture of a Basidiomycete belonging to a genus Coriolus.The protein-polysaccharide contains about 18 to about 38% by weight of protein, being free from protein-polysaccharides having molecular weight of less than 5,000.More in detail, said protein-polysaccharides of the present invention contain 3 to 6% of nitrogen, a polysaccharide portion thereof, as the main fraction, is composed of .beta.-D-glucan and this glucan portion has branched structures containing 1.fwdarw.3, 1.fwdarw.4 and 1.fwdarw.6 bonds, wherein the protein-component amino acids are mostly acidic amino acids of aspartic acid and glutamic acid, and neutral amino acids of valine and leucine, while the basic amino acids of lysine and alginine are small in content, and the protein-polysaccharide is soluble in water but hardly soluble in methanol, pyridine, chloroform, benzene and hexane and starts to be gradually decomposed at about 120.degree. C.

    Novel nucleic acid-containing glycoprotein
    105.
    发明授权
    Novel nucleic acid-containing glycoprotein 失效
    新型含核酸的糖蛋白

    公开(公告)号：US4663438A

    公开(公告)日：1987-05-05

    申请号：US715816

    申请日：1985-03-25

    申请人： Chikao Yoshikumi ,  Takayoshi Fujii ,  Takao Furusho ,  Kenichi Matsunaga ,  Minoru Ohara ,  Akira Kobayashi

    发明人： Chikao Yoshikumi ,  Takayoshi Fujii ,  Takao Furusho ,  Kenichi Matsunaga ,  Minoru Ohara ,  Akira Kobayashi

    IPC分类号： C12P21/00 ,  A61K36/07 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/37 ,  C07K14/375 ,  C07K14/41 ,  C12N1/00 ,  C12P1/06 ,  C12P9/00 ,  C07K15/14

    CPC分类号： C07K14/375 ,  A61K38/00

    摘要： Disclosed herein is a nucleic acid-containing glycoprotein having molecular weight of 5,000 to 300,000 as determined by ultracentrifugal method; the weight ratio of protein moiety thereof determined by Lowry-Folin's method to saccharide moiety thereof determined by phenol-sulfuric acid method of in the range of 50/50 to 80/20; N-terminal amino acid thereof consisting essentially of tyrosine, leucine or alanine; leucine-phenylalanine-valine as amino acid sequence at C-terminal thereof; the elementary composition consisting essentially of 35.2 to 49.3% of C, 4.8 to 8.0% of H, 4.3 to 12.3% of N, trace to 2.5% of S, trace to 1.2% of P and the balance of O; the isoelectric point of in the range of pH 2.5 to 5.0; and nucleic acid as a component.

    摘要翻译： 本文公开了通过超速离心法测定的分子量为5,000〜300,000的含核酸的糖蛋白; 通过Lowry-Folin法测定的蛋白质部分的重量比通过酚 - 硫酸法测定的糖部分在50/50至80/20范围内; 其N-末端氨基酸主要由酪氨酸，亮氨酸或丙氨酸组成; 亮氨酸 - 苯丙氨酸 - 缬氨酸作为C末端的氨基酸序列; 基本组成基本上由C的35.2至49.3％，H的4.8至8.0％，N的4.3至12.3％，S的2.5％，P的1.2％和O的余量组成。 等电点在2.5〜5.0的范围内; 和核酸作为组分。