公开(公告)号：US5755736A

公开(公告)日：1998-05-26

申请号：US895342

申请日：1997-07-16

申请人： Jeffrey M. Gillberg ,  Walter H. Olson

发明人： Jeffrey M. Gillberg ,  Walter H. Olson

IPC分类号： A61N1/362

CPC分类号： A61N1/3622 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7264

摘要： An implantable anti-tachyarrhythmia device which delivers anti-tachyarrhythmia therapies to a patient's heart in response to detection of tachyarrhythmias. The device defines first criteria indicating the presence of atrial tachycardia and second criteria indicating the presence of atrial fibrillation, and compares the time elapsed since the either the first or second criteria were initially met to a defined time duration. In response to the defined duration having passed and either of the first or second criteria being met, the device triggers delivery of an appropriate anti-tachyarrhythmia therapy. The timer is reset on detection of termination of atrial tachyarrhythmia, but not on failure of the first and second criteria to be met. The first and second criteria are defined such that they can not be concurrently met.

公开(公告)号：US09364162B2

公开(公告)日：2016-06-14

申请号：US12772578

申请日：2010-05-03

申请人： Jian Cao ,  Jeffrey M. Gillberg

发明人： Jian Cao ,  Jeffrey M. Gillberg

IPC分类号： A61N1/37 ,  A61B5/00 ,  A61B5/0464 ,  A61N1/362

CPC分类号： A61B5/0464 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/7217 ,  A61N1/3622 ,  A61N1/37 ,  A61N1/3718

摘要： In general, this disclosure is directed to signal processing based methods to reject oversensing due to electromagnetic interference or other noise without compromising tachyarrhythmia detection sensitivity. A method comprises sensing a signal indicative of cardiac activity, detecting a cardiac event based on the signal, determining a count of fluctuations of the signal within a window between the detected cardiac event and a next cardiac event, and determining whether noise is present in the signal based on the count.

摘要翻译： 通常，本公开涉及基于信号处理的方法，以抵消由于电磁干扰或其他噪声引起的过度感染，而不会影响快速性心律失常检测灵敏度。 一种方法包括感测指示心脏活动的信号，基于该信号检测心脏事件，确定检测到的心脏事件与下一个心脏事件之间的窗口内的信号波动的计数，以及确定是否存在噪声 信号基于计数。

公开(公告)号：US09101772B2

公开(公告)日：2015-08-11

申请号：US12633893

申请日：2009-12-09

申请人： Karen J. Kleckner ,  Kathleen A. Prieve ,  Jeffrey M. Gillberg ,  Ren Zhou ,  Kenneth M. Anderson ,  D. Curtis Deno ,  Glenn C. Zillmer ,  Ruth N. Klepfer ,  Vincent E. Splett ,  David E. Euler ,  Lawrence J. Mulligan ,  Edwin G. Duffin ,  David A. Igel ,  John E. Burnes

发明人： Karen J. Kleckner ,  Kathleen A. Prieve ,  Jeffrey M. Gillberg ,  Ren Zhou ,  Kenneth M. Anderson ,  D. Curtis Deno ,  Glenn C. Zillmer ,  Ruth N. Klepfer ,  Vincent E. Splett ,  David E. Euler ,  Lawrence J. Mulligan ,  Edwin G. Duffin ,  David A. Igel ,  John E. Burnes

IPC分类号： A61N1/365 ,  A61N1/368 ,  A61N1/362 ,  A61N1/36 ,  A61N1/39

CPC分类号： A61N1/3627 ,  A61N1/36114 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/3684 ,  A61N1/3962

摘要： A method of stimulation therapy and an apparatus for providing the therapy which addresses cardiac dysfunction including heart failure. The therapy employs atrial pacing pulses delivered to a heart after the atrial refractory period and timed so that they will not cause a ventricular contraction. These atrial pacing are timed to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.

摘要翻译： 刺激疗法的方法和用于提供包括心力衰竭在内的心脏功能障碍的治疗的装置。 该疗法使用心房起搏脉搏在心房不应期后输送到心脏并且定时，使得它们不会引起心室收缩。 这些心房起搏的时间是为了获得对心肌力学（功效）的有益影响，同时保持心律失常诱导的极低水平的风险。 这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。

公开(公告)号：US08768459B2

公开(公告)日：2014-07-01

申请号：US13561967

申请日：2012-07-30

申请人： Subham Ghosh ,  Jeffrey M. Gillberg

发明人： Subham Ghosh ,  Jeffrey M. Gillberg

IPC分类号： A61N1/00

CPC分类号： A61N1/3702 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3962

摘要： One or more embodiments of the present disclosure relates to a method and/or system for classifying and/or treating heart rhythms. The present disclosure involves sensing electrical signals associated with depolarizations of a patient's heart. The sensed electrical signals are converted to digital values and storing the digital values. Normalizing solely a maximum and a minimum value of the stored digital values associated with a depolarization of the patient's heart without normalizing other stored digital values of the depolarization is another aspect of the present disclosure. The maximum and minimum values associated with the depolarization are compared to maximum and minimum values associated with a template derived from signals indicative of a heart depolarization of known type. A determination is made as to whether a match exists between the maximum and minimum values associated with the depolarization to the maximum and minimum values associated with a template.

摘要翻译： 本公开的一个或多个实施方案涉及用于分类和/或治疗心律的方法和/或系统。 本公开涉及感测与患者心脏的去极化相关联的电信号。 感测的电信号被转换成数字值并存储数字值。 仅对与患者心脏去极化相关联的存储数字值的最大值和最小值进行归一化，而不对其他存储的去极化数字值进行归一化，这是本发明的另一方面。 将与去极化相关联的最大值和最小值与与从指示已知类型的心脏去极化的信号衍生的模板相关联的最大值和最小值进行比较。 确定在与去极化相关联的最大值和最小值与与模板相关联的最大值和最小值之间是否存在匹配。

公开(公告)号：US08694097B2

公开(公告)日：2014-04-08

申请号：US12826880

申请日：2010-06-30

申请人： Jian Cao ,  Jeffrey M. Gillberg

发明人： Jian Cao ,  Jeffrey M. Gillberg

IPC分类号： A61N1/04

CPC分类号： A61N1/3704 ,  A61B5/7203 ,  A61N1/3962

摘要： An implantable medical device uses an implantable sensor for acquiring a physiological signal that is received by a digital signal processor. The digital signal processor is a multi-channel signal processor including a first signal processing channel having a first sensitivity for sensing the physiological signal and a second signal processing channel having a second sensitivity different than the first sensitivity for sensing the physiological signal.

摘要翻译： 可植入医疗装置使用可植入传感器来获取由数字信号处理器接收的生理信号。 数字信号处理器是包括具有用于感测生理信号的第一灵敏度的第一信号处理通道和具有与用于感测生理信号的第一灵敏度不同的第二灵敏度的第二信号处理通道的多通道信号处理器。

公开(公告)号：US20130109985A1

公开(公告)日：2013-05-02

申请号：US13285872

申请日：2011-10-31

申请人： Jeffrey M. Gillberg ,  Scott A. Hareland ,  Leonard P. Radtke ,  David G. Schaenzer ,  John D. Wahlstrand

发明人： Jeffrey M. Gillberg ,  Scott A. Hareland ,  Leonard P. Radtke ,  David G. Schaenzer ,  John D. Wahlstrand

IPC分类号： A61B5/0402

CPC分类号： A61B5/7221 ,  A61B5/0464 ,  A61B5/7203 ,  A61B2560/0266

摘要： A system includes a memory and a processing module. The memory includes a primary sensing vector and N alternate sensing vectors. The processing module determines a ranking value for each of the N alternate sensing vectors. Each ranking value is indicative of the integrity of a cardiac electrical signal acquired via the corresponding alternate sensing vector. The processing module senses cardiac events using the primary sensing vector, detects a reduction in the integrity of a cardiac electrical signal acquired via the primary sensing vector, and selects one of the N alternate sensing vectors in response to detecting a reduction in the integrity of the cardiac electrical signal acquired via the primary sensing vector. The selection is based on the ranking value associated with the one of the N alternate sensing vectors. The processing module then senses cardiac events using the selected one of the N alternate sensing vectors.

摘要翻译： 系统包括存储器和处理模块。 存储器包括主感测矢量和N个备选感测矢量。 处理模块确定N个备选感测向量中的每一个的排序值。 每个排序值表示通过相应的替代感测矢量获取的心脏电信号的完整性。 处理模块使用主感测向量感测心脏事件，检测通过主感测向量获取的心电信号的完整性的降低，并且响应于检测到所述N个备选感测向量的完整性的降低而选择N个备选感测向量中的一个 通过主感测矢量获得的心电信号。 选择是基于与N个备选感测向量之一相关联的排名值。 处理模块然后使用所选择的N个备选感测向量之一来感测心脏事件。

公开(公告)号：US20120303084A1

公开(公告)日：2012-11-29

申请号：US13569523

申请日：2012-08-08

申请人： Karen J. Kleckner ,  Kathleen A. Prieve ,  Jeffrey M. Gillberg ,  Ren Zhou ,  Kenneth M. Anderson ,  D. Curtis Deno ,  Glenn C. Zillmer ,  Ruth N. Klepfer ,  Vincent E. Splett ,  David E. Euler ,  Lawrence J. Mulligan ,  Edwin G. Duffin ,  David A. Igel ,  John E. Burnes

发明人： Karen J. Kleckner ,  Kathleen A. Prieve ,  Jeffrey M. Gillberg ,  Ren Zhou ,  Kenneth M. Anderson ,  D. Curtis Deno ,  Glenn C. Zillmer ,  Ruth N. Klepfer ,  Vincent E. Splett ,  David E. Euler ,  Lawrence J. Mulligan ,  Edwin G. Duffin ,  David A. Igel ,  John E. Burnes

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36114 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/3684 ,  A61N1/3962

摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.

摘要翻译： 据信上述方法和装置对于患有心力衰竭，包括心脏功能障碍，慢性HF等的患者以及本文所述的所有变体以及包括本发明的本领域技术人员已知的那些的患者特别有益 被指示。 应当理解，本发明提供监测和治疗各种急性和慢性心脏功能障碍的可能性。 本发明提供了用于通过所述神经支配的心肌底物递送治疗心脏血液动力学功能障碍的系统和方法，在所述神经支配的心肌基质的不应期期间接收电刺激的一个或多个离散脉冲。

公开(公告)号：US20110196247A1

公开(公告)日：2011-08-11

申请号：US12772578

申请日：2010-05-03

申请人： Jian Cao ,  Jeffrey M. Gillberg

发明人： Jian Cao ,  Jeffrey M. Gillberg

IPC分类号： A61B5/0402

CPC分类号： A61B5/0464 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/7217 ,  A61N1/3622 ,  A61N1/37 ,  A61N1/3718

摘要： In general, this disclosure is directed to signal processing based methods to reject oversensing due to electromagnetic interference or other noise without compromising tachyarrhythmia detection sensitivity. A method comprises sensing a signal indicative of cardiac activity, detecting a cardiac event based on the signal, determining a count of fluctuations of the signal within a window between the detected cardiac event and a next cardiac event, and determining whether noise is present in the signal based on the count.

摘要翻译： 通常，本公开涉及基于信号处理的方法，以抵消由于电磁干扰或其他噪声引起的过度感染，而不会影响快速性心律失常检测灵敏度。 一种方法包括感测指示心脏活动的信号，基于该信号检测心脏事件，确定检测到的心脏事件与下一个心脏事件之间的窗口内的信号波动的计数，以及确定是否存在噪声 信号基于计数。

公开(公告)号：US20110022104A1

公开(公告)日：2011-01-27

申请号：US12897485

申请日：2010-10-04

申请人： Todd J. Sheldon ,  Jeffrey M. Gillberg

发明人： Todd J. Sheldon ,  Jeffrey M. Gillberg

IPC分类号： A61N1/368 ,  A61N1/39

CPC分类号： A61N1/3622 ,  A61B5/0468

摘要： AV synchronous, dual chamber pacing systems are disclosed having improved sensing of ectopic ventricular depolarizations or PVCs coincidentally occurring at or shortly following delivery of an A-PACE pulse. A first ventricular sense amplifier that is blanked during and following delivery of an A-PACE pulse is coupled to active and indifferent ventricular pace/sense electrodes defining a ventricular sense vector for sensing natural ventricular depolarizations and declaring a V-EVENT. A far field PVC sense amplifier coupled to a far field PVC sense electrode pair defining a PVC sense vector detects such PVCs while the ventricular sense amplifier is blanked. A PVC declared during the ventricular blanking period by the far field PVC sense amplifier is employed to deliver a VSP pulse upon time-out of a VSP delay, if the VSP function is provided and programmed ON, and/or to halt time-out of an AV delay.

摘要翻译： 公开了AV同步双室起搏系统，其具有改善的异位心室去极化感测或偶然发生在A-PACE脉冲输送或不久之后的PVC。 在A-PACE脉冲输送期间和随后的A-PACE脉冲输送期间被消隐的第一个心室感应放大器与定义用于感测自然心室去极化并宣布V-EVENT的心室感觉矢量的活动和无关心室速度/感觉电极耦合。 耦合到定义PVC感测矢量的远场PVC感测电极对的远场PVC读出放大器检测这种PVC，同时将心室感知放大器消隐。 如果VSP功能被提供和编程为ON，则使用在远场PVC读出放大器的心室消隐期间声明的PVC，以在VSP延迟超时时传送VSP脉冲，和/或停止超时 AV延迟。

公开(公告)号：US07809440B2

公开(公告)日：2010-10-05

申请号：US10359986

申请日：2003-02-06

申请人： Todd J. Sheldon ,  Jeffrey M. Gillberg

发明人： Todd J. Sheldon ,  Jeffrey M. Gillberg

IPC分类号： A61N1/362

CPC分类号： A61N1/3622 ,  A61B5/0468

摘要： AV synchronous, dual chamber pacing systems are disclosed having improved sensing of ectopic ventricular depolarizations or PVCs coincidentally occurring at or shortly following delivery of an A-PACE pulse. A first ventricular sense amplifier that is blanked during and following delivery of an A-PACE pulse is coupled to active and indifferent ventricular pace/sense electrodes defining a ventricular sense vector for sensing natural ventricular depolarizations and declaring a V-EVENT. A far field PVC sense amplifier coupled to a far field PVC sense electrode pair defining a PVC sense vector detects such PVCs while the ventricular sense amplifier is blanked. A PVC declared during the ventricular blanking period by the far field PVC sense amplifier is employed to deliver a VSP pulse upon time-out of a VSP delay, if the VSP function is provided and programmed ON, and/or to halt time-out of an AV delay.

摘要翻译： 公开了AV同步双室起搏系统，其具有改善的异位心室去极化感测或偶然发生在A-PACE脉冲输送或不久之后的PVC。 在A-PACE脉冲输送期间和随后的A-PACE脉冲输送期间被消隐的第一个心室感应放大器与定义用于感测自然心室去极化并宣布V-EVENT的心室感觉矢量的活动和无关心室速度/感觉电极耦合。 耦合到定义PVC感测矢量的远场PVC感测电极对的远场PVC读出放大器检测这种PVC，同时将心室感知放大器消隐。 如果VSP功能被提供和编程为ON，则使用在远场PVC读出放大器的心室消隐期间声明的PVC，以在VSP延迟超时时传送VSP脉冲，和/或停止超时 AV延迟。