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    Method and apparatus for optimization and assessment of response to extra-systolic stimulation (ESS) therapy
    4.
    发明授权
    Method and apparatus for optimization and assessment of response to extra-systolic stimulation (ESS) therapy 失效
    用于优化和评估对收缩期刺激（ESS）治疗的反应的方法和装置

    公开(公告)号：US07970466B2

    公开(公告)日：2011-06-28

    申请号：US10680494

    申请日：2003-10-07

    申请人： Lawrence J. Mulligan ,  D. Curtis Deno ,  John E. Burnes ,  Nirav V. Sheth

    发明人： Lawrence J. Mulligan ,  D. Curtis Deno ,  John E. Burnes ,  Nirav V. Sheth

    IPC分类号： A61N1/00 ,  A61B5/04

    CPC分类号： A61N1/3627 ,  A61N1/36514 ,  A61N1/36578

    摘要： A method and apparatus for optimizing and assessing the response to extra-systolic stimulation (ESS) are provided. An optimization/monitoring parameter is calculated as a function of potentiation ratio, PR, and recirculation fraction, RF, derived from measurements of myocardial contractile function during and after ESS. PR may be computed as the ratio of the contractile function on post-extra-systolic beats during ESS to baseline contractile function. RF may be computed as the slope of a linear regression performed on a plot of the contractile function for a post-extra-systolic beat versus the contractile function for the previous post-extra-systolic beat after ESS is ceased. The ESI resulting in a maximum optimization/monitoring parameter, preferably computed as the product of PR and RF, is determined as the optimal ESI. The operating ESI may be automatically adjusted, and/or PR and RF data may be stored for monitoring purposes.

    摘要翻译： 提供了一种用于优化和评估对收缩期刺激（ESS）的反应的方法和装置。 根据ESS期间和之后的心肌收缩功能测量得出，优化/监测参数作为增强比PR和再循环分数RF的函数计算。 PR可以计算为ESS期间收缩功能对收缩后收缩期与基线收缩功能的比值。 RF可以被计算为在ESS停止之后针对收缩后收缩压的收缩功能图与先前的收缩后节拍后的收缩功能的曲线进行的线性回归的斜率。 产生最大优化/监测参数的ESI，优选地计算为PR和RF的乘积，被确定为最佳ESI。 可以自动调整操作ESI，并且可以存储和/或PR和RF数据用于监视目的。