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    Intravascular Medical Device
    2.
    发明申请
    Intravascular Medical Device 审中-公开
    血管内医疗器械

    公开(公告)号：US20090198295A1

    公开(公告)日：2009-08-06

    申请号：US12423605

    申请日：2009-04-14

    申请人： Charles L. Dennis ,  George J. Klein ,  Ursula Gebhardt ,  Kenneth M. Anderson ,  Glenn C. Zillmer

    发明人： Charles L. Dennis ,  George J. Klein ,  Ursula Gebhardt ,  Kenneth M. Anderson ,  Glenn C. Zillmer

    IPC分类号： A61N1/39 ,  A61N1/375 ,  A61B17/00

    CPC分类号： A61N1/372 ,  A61N1/37205

    摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.

    摘要翻译： 可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。 系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。 以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。

    Multiple pacing output channels
    3.
    发明授权
    Multiple pacing output channels 有权
    多起搏输出通道

    公开(公告)号：US07184833B2

    公开(公告)日：2007-02-27

    申请号：US10680695

    申请日：2003-10-07

    申请人： Vincent P. Ganion ,  Glenn C. Zillmer

    发明人： Vincent P. Ganion ,  Glenn C. Zillmer

    IPC分类号： A61N1/00 ,  A61B5/04

    CPC分类号： A61N1/3627 ,  A61N1/3684

    摘要： An implantable medical device includes two or more pacing output channels coupled to a single unipolar electrode or bipolar electrode pair. The implantable medical device can control each pacing output channel to deliver pacing pulses via the single electrode or electrode pair at different times and with different amplitudes. In some embodiments, the implantable medical device is used to deliver extra-systolic stimulation therapy. In such embodiments, a first pacing output channel can be controlled to deliver pacing pulses via the electrode or electrode pair with an amplitude sufficient to depolarize a chamber of the heart. A second pacing output channel is controlled to deliver extra-systolic pulses, which can have a lower amplitude than the pacing pulses, via the electrode or electrode pair an extra-systolic interval after sensed or paced depolarizations of the chamber. In some embodiments, the implantable medical device delivers ESS therapy and cardiac resynchronization therapy (CRT).

    摘要翻译： 可植入医疗装置包括耦合到单个单极电极或双极电极对的两个或多个起搏输出通道。 可植入医疗装置可以控制每个起搏输出通道在不同时间和不同振幅下通过单个电极或电极对输送起搏脉冲。 在一些实施例中，可植入医疗装置用于输送收缩期刺激疗法。 在这样的实施例中，可以控制第一起搏输出通道，以经由电极或电极对以足以使心脏腔室去极化的振幅来输送起搏脉冲。 控制第二起搏输出通道，以经由电极或电极对经过感觉或起搏去极化之后的收缩期间隔来传送脉冲，其可以具有比起搏脉冲更低的振幅。 在一些实施例中，可植入医疗装置递送ESS治疗和心脏再同步治疗（CRT）。

    Cardiac pacing modality having improved blanking, timing, and therapy delivery methods for extra-systolic stimulation pacing therapy
    4.
    发明授权
    Cardiac pacing modality having improved blanking, timing, and therapy delivery methods for extra-systolic stimulation pacing therapy 有权
    心脏起搏模式具有改善的消隐，时机和治疗收费刺激起搏治疗方法

    公开(公告)号：US07142916B2

    公开(公告)日：2006-11-28

    申请号：US10692990

    申请日：2003-10-24

    申请人： D. Curtis Deno ,  Vincent E. Splett ,  Jeffrey M. Gillberg ,  Glenn C. Zillmer ,  Ruth N. Klepfer ,  Karen J. Kleckner

    发明人： D. Curtis Deno ,  Vincent E. Splett ,  Jeffrey M. Gillberg ,  Glenn C. Zillmer ,  Ruth N. Klepfer ,  Karen J. Kleckner

    IPC分类号： A61N1/36

    CPC分类号： A61N1/365 ,  A61N1/3627

    摘要： The present invention relates to the secure delivery of an extra-systolic stimulation (ESS) therapy to treat cardiac dysfunction that employs atrial and/or ventricular extra-systoles via pacing-like stimulation of the heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (benefit) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). Further experience with ESS has led to improved implementation methods that depend on better blanking, ESS stimulation timing (of an “extra-systolic interval” or ESI), and ESS therapy delivery options and guidance. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.

    摘要翻译： 本发明涉及一种收缩期刺激（ESS）疗法的安全递送，以治疗心脏功能障碍，其通过心脏起搏样刺激使用心房和/或心室外的心脏。 这些额外的收缩期必须正确定时，以获得对心肌力学（益处）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。 ESS的进一步经验导致改进的实施方法取决于更好的消隐，ESS刺激时间（“收缩期间期”或ESI）和ESS治疗递送选项和指导。 这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。