公开(公告)号：US20100209990A1

公开(公告)日：2010-08-19

申请号：US12681916

申请日：2008-10-08

Applicant: David Gordon ,  Yuval Blat ,  Akbar Nayeem ,  Mark S. Kirby ,  Bin He

Inventor： David Gordon ,  Yuval Blat ,  Akbar Nayeem ,  Mark S. Kirby ,  Bin He

IPC: C12N9/00 ,  C12N15/52 ,  C12N5/02

CPC classification number: C12Y101/01146 ,  C12N9/0006

Abstract: The invention provides gene-targeted non-human animals comprising a genetically modified 11βHSD1 gene encodes a mutant 11βHSD1 polypeptide which is modulated by human 11βHSD1 modulating compounds. The invention further provides cells expressing mutant 11βHSD1 and cells isolated from gene-targeted animals, which cells produce a mutant 11βHSD1. The invention further provides methods of identifying agents that modulate 11βHSD1 activity, and are useful to treat 11βHSD1-related metabolic disorders.

Abstract translation: 本发明提供了基因靶向的非人动物，其包含基因修饰的11和bgr HSD1基因，其编码由人11和HSD1调节化合物调节的突变体11和bgr; HSD1多肽。 本发明还提供表达突变体11和bgr; HSD1的细胞和从基因靶向动物分离的细胞，所述细胞产生突变体11和bgr; HSD1。 本发明还提供了鉴定调节11和HSD1活性的试剂的方法，并且可用于治疗与HSD1相关的代谢紊乱。

公开(公告)号：US20100204983A1

公开(公告)日：2010-08-12

申请号：US12433197

申请日：2009-04-30

Applicant: Kevin Chen-Chuan Chung ,  Zhen Zhang ,  Bin He

Inventor： Kevin Chen-Chuan Chung ,  Zhen Zhang ,  Bin He

IPC: G06F17/27 ,  G06T11/20

CPC classification number: G06F17/271 ,  G06F16/951 ,  G06F17/243 ,  G06F17/2785 ,  Y10S707/99935 ,  Y10S707/99936

Abstract: A computer program product being embodied on a computer readable medium for extracting semantic information about a plurality of documents being accessible via a computer network, the computer program product including computer-executable instructions for: generating a plurality of tokens from at least one of the documents, each token being indicative of a displayed item and a corresponding position; and, constructing at least one parse tree indicative of a semantic structure of the at least one document from the tokens dependently upon a grammar being indicative of presentation conventions.

Abstract translation: 一种计算机程序产品，其体现在计算机可读介质上，用于提取关于可通过计算机网络访问的多个文档的语义信息，所述计算机程序产品包括计算机可执行指令，用于：从至少一个文档生成多个令牌 每个标记指示显示的项目和相应的位置; 并且依赖于表示呈现约定的语法，从令牌构建指示所述至少一个文档的语义结构的至少一个解析树。

公开(公告)号：US20070009572A1

公开(公告)日：2007-01-11

申请号：US11176654

申请日：2005-07-06

Applicant: Bee Mary Chan ,  Jinye Shen ,  Bin He ,  Aiping Zhu ,  Yehai Yan ,  Chee Yue

Inventor： Bee Mary Chan ,  Jinye Shen ,  Bin He ,  Aiping Zhu ,  Yehai Yan ,  Chee Yue

IPC: A61F2/02 ,  B29C45/00

CPC classification number: B29C33/3857 ,  B29C33/424

Abstract: In embodiments of the present invention, a biodegradable/biodegradable polymer film may be used as a scaffold for tissue engineering scaffolds for engineering organized organs, such as vascular grafts, for example. In one embodiment, an ultraviolet (UV) resin made from a diacrylated biodegradable oligomer is molded into a flexible scaffold having cavities and/or channels. Channel/cavity size may be on the order of micrometers and/or nanometers, and thus the walls may have high aspect ratios. Smooth muscle cells may be deposited in the channels and because of the high aspect ratios, the cells may align along the channels/cavities as confluence is reached.

Abstract translation: 在本发明的实施方案中，可生物降解/可生物降解的聚合物膜可用作用于组织工程支架的支架，用于工程组织的器官，例如血管移植物。 在一个实施方案中，由二丙烯酸酯化的可生物降解的低聚物制成的紫外线（UV）树脂被模制成具有空腔和/或通道的柔性支架。 通道/腔尺寸可以在微米级和/或纳米级上，因此壁可具有高纵横比。 平滑肌细胞可以沉积在通道中，并且由于高纵横比，当达到汇合时，细胞可以沿着通道/腔排列。

公开(公告)号：US07047125B1

公开(公告)日：2006-05-16

申请号：US11066244

申请日：2005-02-25

Applicant: Bin He ,  Jeffrey D. Baskett

Inventor： Bin He ,  Jeffrey D. Baskett

IPC: G06G7/70

CPC classification number: F02D41/2477 ,  F02D41/0097 ,  F02D41/1405 ,  F02D41/2432 ,  F02D2041/1433 ,  F02D2200/1004 ,  F02D2200/1006 ,  G01M15/046

Abstract: A system is provided for estimating an operational parameter of a first engine, the first engine including a rotatable crankshaft. The system includes a model for estimating the operational parameter of the first engine as a function of instantaneous crankshaft speed at a plurality of angular positions of the crankshaft of the first engine. The model is developed, at least partially, based upon operational data from a second engine having a rotatable crankshaft. A sensor is operable to determine values representative of the instantaneous crankshaft speed of the first engine, at a plurality of angular positions of the crankshaft of the first engine. A modifier is operable to modify at least some of the representative values to, at least partially, calibrate out differences between the first and second engines that may cause variations in instantaneous crankshaft speed. The modified values are input to the model.

Abstract translation: 提供一种用于估计第一发动机的操作参数的系统，所述第一发动机包括可旋转的曲轴。 该系统包括用于在第一发动机的曲轴的多个角位置处估计第一发动机的操作参数作为瞬时曲轴速度的函数的模型。 该模型至少部分地基于具有可旋转曲轴的第二发动机的操作数据而开发。 传感器可操作以在第一发动机的曲轴的多个角位置处确定表示第一发动机的瞬时曲轴速度的值。 修改器可操作以将至少一些代表值修改为至少部分地校准可能引起瞬时曲轴速度变化的第一和第二发动机之间的差异。 修改后的值被输入到模型中。

公开(公告)号：US5795713A

公开(公告)日：1998-08-18

申请号：US795470

申请日：1997-02-04

Applicant: Bernard Roizman ,  Bin He

Inventor： Bernard Roizman ,  Bin He

IPC: C12Q1/42 ,  C12Q1/48 ,  C12Q1/70

CPC classification number: C12Q1/42 ,  G01N2333/912 ,  G01N2333/916

Abstract: Methods for identifying inducers and inhibitors of programmed cell death in a cell-free system are described. The methods exploit the finding that programmed cell death is accompanied by shutdown of cellular protein synthesis and by phosphorylation of eIF-2.alpha. and that the dephosphorylation of eIF-2.alpha. prevents the shutdown of protein synthesis.

Abstract translation: 描述了在无细胞系统中鉴定诱导剂和程序性细胞死亡抑制剂的方法。 该方法利用程序性细胞死亡伴随着细胞蛋白质合成的停止和eIF-2α的磷酸化的发现，并且eIF-2α的去磷酸化阻止了蛋白质合成的停止。