公开(公告)号：US20220317479A1

公开(公告)日：2022-10-06

申请号：US17805832

申请日：2022-06-07

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Gordon Frederick MACCABEE ,  Ferry WIDJAJA ,  Amitava GUPTA

IPC: G02C11/00 ,  G02C7/04

Abstract: A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.

公开(公告)号：US20220299795A1

公开(公告)日：2022-09-22

申请号：US17806326

申请日：2022-06-10

Applicant: ACUCELA INC.

Inventor： Beat WYSS ,  Jean-Noël FEHR ,  Glenn NORONHA ,  Karim HAROUD ,  Julien SAUVET ,  Hans BERNHARD ,  Christian OGGENFUSS ,  Amitava GUPTA ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02C7/14 ,  G02C11/04

Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

公开(公告)号：US11358001B2

公开(公告)日：2022-06-14

申请号：US16947537

申请日：2020-08-05

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Karim Haroud ,  Beat Wyss ,  Hans Bernhard ,  Jean-Noël Fehr ,  Patrizia Weber ,  Moritz Haeberli ,  Amitava Gupta

IPC: A61N5/06 ,  G02B27/30 ,  G02B27/01

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US11357401B2

公开(公告)日：2022-06-14

申请号：US17247630

申请日：2020-12-18

Applicant: ACUCELA INC.

Inventor： Christian Oggenfuss ,  Karim Haroud ,  Lukas Scheibler ,  Matthias Pfister ,  Urban Schnell ,  Stefan Troller ,  Ryo Kubota ,  Philip M. Buscemi

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/13

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US20220155616A1

公开(公告)日：2022-05-19

申请号：US17650134

申请日：2022-02-07

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Nabin JOSHI ,  Arkady SELENOW ,  Steven ALI ,  Stefan BAUER ,  Jean-Noël FEHR ,  Moritz HAEBERLI ,  Patrizia WEBER ,  Julien SAUVET ,  Amitava GUPTA

IPC: G02C7/02 ,  G02C7/06 ,  G02C11/04 ,  A61F9/00 ,  G02C7/04 ,  A61B3/00

Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US20210387975A1

公开(公告)日：2021-12-16

申请号：US17279382

申请日：2019-09-27

Applicant: ACUCELA INC.

Inventor： Mark W. ORME ,  Edison S. ZUNIGA ,  Vladimir A. KUKSA ,  Russell Stuart CRAFT ,  Eduardo Moreno SAVEEDRA ,  Johannes Wilhelm Georg MEISSNER ,  Jacobus Antonius Joseph den HARTOG ,  Albert Cornelis DROS

IPC: C07D413/12 ,  C07D263/56 ,  C07D277/64 ,  C07D263/58 ,  C07D277/82 ,  C07D261/20 ,  C07D235/08 ,  C07D413/04 ,  C07D491/107 ,  C07D249/18

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

公开(公告)号：US20210263336A1

公开(公告)日：2021-08-26

申请号：US17250278

申请日：2019-07-03

Applicant: ACUCELA INC.

Inventor： Amitava GUPTA ,  Ryo KUBOTA

IPC: G02C7/02 ,  G02C7/04 ,  G02C11/04 ,  G02C11/00

Abstract: A contact lens configured to decrease dark adaptation comprises one or more LEDs and directs light from the LED away from the fovea and toward the parafovea or perifoveal regions of the retain. In some embodiments, soft contact lens embedded with one or more arrays of microLEDs and electronics operating the LEDs is configured to be worn at night in order to inhibit dark adaptation and reduce oxygen consumption by the rods. The contact lens may be made of a single layer of a contact lens material or multiple layers sandwiching a flexible transparent plastic layer comprising the electronics and the LED arrays. The contact lens may be made of a hydrophilic hydrogel material that is biocompatible to the human cornea, or a silicone hydrogel material. The contact lens may be spherical and may provide refractive correction to the eye of the wearer.

公开(公告)号：US20210235984A1

公开(公告)日：2021-08-05

申请号：US17248850

申请日：2021-02-10

Applicant: ACUCELA INC.

Inventor： Lukas SCHEIBLER ,  Matthias PFISTER ,  Urban SCHNELL ,  Stefan TROLLER ,  Ryo KUBOTA

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  G01B9/02

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US20210127969A1

公开(公告)日：2021-05-06

申请号：US17247630

申请日：2020-12-18

Applicant: ACUCELA INC.

Inventor： Christian OGGENFUSS ,  Karim HAROUD ,  Lukas SCHEIBLER ,  Matthias PFISTER ,  Urban SCHNELL ,  Stefan TROLLER ,  Ryo KUBOTA ,  Philip M. BUSCEMI

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/13

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US20210069524A1

公开(公告)日：2021-03-11

申请号：US17052906

申请日：2019-05-03

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Amitava GUPTA

IPC: A61N5/06 ,  G02C7/04

Abstract: A source of light energy such as a source of violet light energy is coupled to a structure configured to contact the eye. The light source and structure are arranged to provide therapeutic amounts of violet light energy to the eye in order to inhibit the progression of refractive error such as myopia. The light source can be configured in many ways and may comprise a radioisotope and a phosphorescent material. The structure configured to contact the eye may comprise a contact lens or an implant.