公开(公告)号：US20160136275A1

公开(公告)日：2016-05-19

申请号：US15007274

申请日：2016-01-27

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Takayuki MIYANO ,  Takahiro KUROSE

IPC: A61K47/02 ,  A61K9/00 ,  A61K31/121

CPC classification number: A61K47/02 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/121

Abstract: An ophthalmic composition comprising geranylgeranylacetone and a phosphate buffering agent has an advantage that the loss of the geranylgeranylacetone content during long-term storage is very little. This is because of reduced adsorption of geranylgeranylacetone to a wall of an ophthalmic container. The ophthalmic composition comprising geranylgeranylacetone and a phosphate buffering agent also has an advantage that adsorption of geranylgeranylacetone to a contact lens is little. Further, the ophthalmic composition comprising geranylgeranylacetone and a phosphate buffering agent hardly becomes white turbid even when stored at low temperature.

公开(公告)号：US20150093345A1

公开(公告)日：2015-04-02

申请号：US14389200

申请日：2013-03-27

Applicant: ROHTO Pharmaceutical Co., Ltd.

Inventor： Yuya Hayashi ,  Yoko Mizutare

IPC: A61K8/49 ,  C07D307/33 ,  A61Q19/08 ,  A61Q19/02

CPC classification number: A61K8/4973 ,  A61K31/365 ,  A61K2800/782 ,  A61Q19/02 ,  A61Q19/08 ,  C07D307/33

Abstract: An arctigenin derivative used for anti-aging treatment, including protection of the skin from the sun and recovery of skin elasticity. A variety of fatty acid ester derivatives, alcohol ether derivatives and alkylated derivatives are used as the arctigenin derivatives. Agents for controlling ET-1 production, elastase inhibitors, and anti-inflammatory agents are prepared. Such arctigenin derivatives are particularly useful as an external agent for the skin, such as an anti-inflammatory external agent, a sunscreen external agent, or an external agent for recovering elasticity.

Abstract translation: 用于抗衰老治疗的抗坏血酸衍生物衍生物，包括保护皮肤免受太阳和恢复皮肤弹性。 各种脂肪酸酯衍生物，醇醚衍生物和烷基化衍生物用作抗坏血酸生成素衍生物。 制备用于控制ET-1产生的药剂，弹性蛋白酶抑制剂和抗炎剂。 这样的抗坏血酸衍生物特别可用作皮肤的外用剂，例如抗炎外用剂，防晒外用剂或用于回收弹性的外用剂。

公开(公告)号：US20150025154A1

公开(公告)日：2015-01-22

申请号：US14506731

申请日：2014-10-06

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Takayuki MIYANO ,  Takahiro KUROSE

IPC: A61K47/10 ,  A61K9/00 ,  A61K47/14 ,  A61K9/06 ,  A61K47/44 ,  A61K31/121 ,  A61K9/08

CPC classification number: A61K47/10 ,  A61K9/0048 ,  A61K9/06 ,  A61K9/08 ,  A61K31/121 ,  A61K47/14 ,  A61K47/22 ,  A61K47/44

Abstract: An ophthalmic composition comprising geranylgeranylacetone and a fat-soluble antioxidant has an advantage that adsorption of geranylgeranylacetone to a wall of a container is remarkably reduced and thereby the loss of the geranylgeranylacetone content or decrease in the geranylgeranylacetone concentration in the composition is remarkably reduced. Adsorption of the fat-soluble antioxidant to a wall of a container is also reduced due to combination with geranylgeranylacetone.

Abstract translation: 包含香叶基香叶基丙酮和脂溶性抗氧化剂的眼用组合物具有显着降低香叶基香叶基丙酮吸附至容器壁的优点，从而显着降低了香叶基香叶基丙酮含量的丧失或香叶基香叶基丙酮浓度的降低。 由于与香叶基香叶基丙酮的组合，脂溶性抗氧化剂对容器壁的吸附也降低。

公开(公告)号：US20140350119A1

公开(公告)日：2014-11-27

申请号：US14460564

申请日：2014-08-15

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Takayuki MIYANO ,  Takahiro KUROSE ,  Mariyo KATO ,  Yoshihiro TAKAI

IPC: A61K31/121

CPC classification number: A61K31/121 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/26 ,  A61K47/44

Abstract: An ophthalmic composition comprising geranylgeranylacetone which (a) is a mixture of (5E,9E,13E)-geranylgeranylacetone and (5Z,9E,13E)-geranylgeranylacetone, the (5E,9E,13E)-geranylgeranylacetone content of the mixture being 80% by weight or more, (b) consists of (5E,9E,13E)-geranylgeranylacetone, or (c) consists of (5Z,9E,13E)-geranylgeranylacetone protects various types of retinal cells from degeneration, impairment or destruction, thereby remarkably promoting the survival. Consequently, the composition exhibits a remarkable effect of preventing, ameliorating or treating various retinal diseases. In addition, the composition hardly becomes white turbid during storage.

Abstract translation: （a）是（5E，9E，13E）ger anyl ger anyl anyl one one one and and ger ger ger ger ger ger ger ger ger ger ger An An An An An An An An ger ger％％％％％％％％％％％％％％％％％％％％％％％％％％ （5E，9E，13E） - ger ger ger ger anyl anyl anyl，，，，ger ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably 促进生存。 因此，该组合物显示出预防，改善或治疗各种视网膜疾病的显着效果。 此外，组合物在储存期间几乎不变成白色混浊。

公开(公告)号：US20130331458A1

公开(公告)日：2013-12-12

申请号：US13775547

申请日：2013-02-25

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Takayuki MIYANO ,  Takahiro KUROSE

IPC: A61K31/121

CPC classification number: A61K31/121 ,  A01N1/0226 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/24 ,  A61K47/26 ,  A61K47/44 ,  A61L12/12 ,  B65D65/38 ,  Y10T428/1397

Abstract: An ophthalmic composition kit comprising an ophthalmic container holding an ophthalmic composition comprising geranylgeranylacetone, the ophthalmic container having a surface in contact with the ophthalmic composition, the surface being at least partially or wholly made of a container material selected from the group consisting of a polyolefin, an acrylic acid resin, a terephthalic acid ester, a polycarbonate, a polymethylterpene, a fluorine resin and a glass,the ophthalmic composition kit having an advantage that the loss of the geranylgeranylacetone content or decrease in the geranylgeranylacetone concentration in the ophthalmic composition is very little.

Abstract translation: 一种眼用组合物试剂盒，其包含容纳含有香叶基香叶基丙酮的眼用组合物的眼用容器，所述眼用容器具有与所述眼用组合物接触的表面，所述表面至少部分或全部由选自以下的容器材料制成：聚烯烃， 丙烯酸树脂，对苯二甲酸酯，聚碳酸酯，聚甲基萜烯，氟树脂和玻璃，眼用组合物试剂盒具有以下优点，即眼用组合物中er牛ger牛儿基丙酮含量的损失或香叶基香叶基丙酮浓度的降低非常小 。

公开(公告)号：US20130303624A1

公开(公告)日：2013-11-14

申请号：US13775524

申请日：2013-02-25

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Takayuki MIYANO ,  Takahiro KUROSE ,  Mariyo KATO ,  Yoshihiro TAKAI

IPC: A61K31/121 ,  A61K9/00

CPC classification number: A61K31/121 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/26 ,  A61K47/44

Abstract: An ophthalmic composition comprising geranylgeranylacetone which (a) is a mixture of (5E,9E,13E)-geranylgeranylacetone and (5Z,9E,13E)-geranylgeranylacetone, the (5E,9E,13E)-geranylgeranylacetone content of the mixture being 80% by weight or more, (b) consists of (5E,9E,13E)-geranylgeranylacetone, or (c) consists of (5Z,9E,13E)-geranylgeranylacetone protects various types of retinal cells from degeneration, impairment or destruction, thereby remarkably promoting the survival. Consequently, the composition exhibits a remarkable effect of preventing, ameliorating or treating various retinal diseases. In addition, the composition hardly becomes white turbid during storage.

Abstract translation: （a）是（5E，9E，13E）ger anyl ger anyl anyl one one one and and ger ger ger ger ger ger ger ger ger ger ger An An An An An An An An ger ger％％％％％％％％％％％％％％％％％％％％％％％％％％ （5E，9E，13E） - ger ger ger ger anyl anyl anyl，，，，ger ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably ably 促进生存。 因此，该组合物显示出预防，改善或治疗各种视网膜疾病的显着效果。 此外，组合物在储存期间几乎不变成白色混浊。

公开(公告)号：US20130244978A1

公开(公告)日：2013-09-19

申请号：US13889576

申请日：2013-05-08

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yasuko MATSUMURA ,  Kazuhiro FUKUSHIMA

IPC: A61K31/721 ,  A61K31/045 ,  A61K31/08 ,  A61K31/717 ,  A61K31/4025

CPC classification number: A61K31/721 ,  A61K9/0048 ,  A61K31/045 ,  A61K31/08 ,  A61K31/125 ,  A61K31/4025 ,  A61K31/717 ,  A61K31/74 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

Abstract: The present invention provides an ophthalmic composition which stabilizes the tear film during wearing contact lens, prevents eye dryness, imparts a favorable sensation in using, is highly convenient with no risk of misuse and shows a high efficiency in the course from manufacturing to sales. More specifically, the present invention provides a wetting solution—eye drops for contact lenses or an ophthalmic composition/solution for contact lenses, which comprises (A) one or more member(s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and (B) a terpenoid.

Abstract translation: 本发明提供了一种眼用组合物，其在佩戴隐形眼镜期间稳定了泪膜，防止眼睛干涩，赋予使用感觉，非常方便，没有被误用的风险，并且在制造过程中显示出高效率。 更具体地，本发明提供了用于隐形眼镜的润湿溶液 - 滴眼剂或用于隐形眼镜的眼用组合物/溶液，其包含（A）一种或多种选自纤维素类聚合物， 乙烯基类聚合物，聚乙二醇和葡聚糖; 和（B）萜类化合物。

公开(公告)号：US20130210921A1

公开(公告)日：2013-08-15

申请号：US13767027

申请日：2013-02-14

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yoshiyuki Hirayama

IPC: A61K47/14

CPC classification number: A61K47/14 ,  A61F2013/00187 ,  A61F2013/00646 ,  A61F2013/00919 ,  A61K8/0208 ,  A61K8/347 ,  A61K8/375 ,  A61K8/42 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/7061 ,  A61K2800/242 ,  A61L15/20 ,  A61L15/44 ,  A61L2300/204 ,  A61L2300/216 ,  A61L2300/40 ,  A61L2300/45 ,  A61Q19/00

Abstract: A method for giving warmth to skin, wherein an external composition for skin is provided, which gives good warmth without inducing irritation or pain and whose sustainability of warmth is good. The external composition for skin contains (A) an agent for giving warmth and (B) at least one member selected from the group consisting of fatty acid esters of aliphatic polyhydric alcohols and aromatic carboxylic acid esters of lower alcohols or aliphatic polyhydric alcohols.

Abstract translation: 赋予皮肤温暖的方法，其中提供皮肤外用组合物，其不会引起刺激或疼痛而具有良好的温暖性，并且其温暖的可持续性良好。 皮肤外用组合物含有（A）赋予温度的试剂，（B）选自脂肪族多元醇的脂肪酸酯和低级醇或脂肪族多元醇的芳香族羧酸酯中的至少一种。