公开(公告)号：US11166938B2

公开(公告)日：2021-11-09

申请号：US16313876

申请日：2017-06-28

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Masatoshi Haga ,  Yuya Hayashi

IPC: A61K31/375 ,  A61K8/86 ,  A61P17/10 ,  A61P17/18 ,  A61K31/357 ,  A61P17/00 ,  A61K47/22 ,  A61K8/34 ,  A61K8/41 ,  A61K8/55 ,  A61K8/67 ,  A61K9/00 ,  A61K47/18 ,  A61K47/24 ,  A61Q19/02 ,  A61Q19/08 ,  A61K47/10

Abstract: Provided is an external composition excellent in stability and impression from use. An external composition containing (A) at least one member selected from the group consisting of ascorbic acid and salts of ascorbic acid, (B) at least one member selected from the group consisting of 3-O-ethylascorbic acid, salts of 3-O-ethylascorbic acid, and hydroxylated lecithin, and (C) polyethylene glycol is prepared.

公开(公告)号：US20170209522A1

公开(公告)日：2017-07-27

申请号：US15322779

申请日：2015-06-30

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Masatoshi Haga ,  Keiko Oyamada ,  Rumi Matsushita ,  Yuya Hayashi ,  Kyoko Nakajima ,  Yuko Kouda

IPC: A61K38/05 ,  A61K8/67 ,  A61K8/34 ,  A61Q19/08 ,  A61K47/10 ,  A61Q11/00 ,  A61K31/045 ,  A61K31/375 ,  A61K9/00 ,  A61K45/06 ,  A61K8/64 ,  A61Q15/00

CPC classification number: A61K38/05 ,  A61K8/34 ,  A61K8/44 ,  A61K8/4946 ,  A61K8/64 ,  A61K8/676 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/045 ,  A61K31/12 ,  A61K31/122 ,  A61K31/375 ,  A61K31/506 ,  A61K31/7034 ,  A61K45/06 ,  A61K47/10 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/08 ,  A61K2300/00

Abstract: An object of the present invention is to provide an external use composition having a novel composition that has a superior effect promoting collagen production and is able to suppress, prevent or improve wrinkles and sagging of the skin with aging.The present invention relates to an external use composition for anti-aging, comprising (A) a lipopeptide represented by the following formula (1), or a pharmaceutically acceptable salt thereof: (wherein, R1 represents a saturated aliphatic group, or aliphatic group having a single unsaturated bond, having 9 to 19 carbon atoms, and m represents 0 or 1).

公开(公告)号：US09675538B2

公开(公告)日：2017-06-13

申请号：US14389200

申请日：2013-03-27

Applicant: ROHTO Pharmaceutical Co., Ltd.

Inventor： Yuya Hayashi ,  Yoko Mizutare

IPC: A61K8/00 ,  A61K8/49 ,  A61Q19/02 ,  A61Q19/08 ,  A61K31/365 ,  C07D307/33

CPC classification number: A61K8/4973 ,  A61K31/365 ,  A61K2800/782 ,  A61Q19/02 ,  A61Q19/08 ,  C07D307/33

Abstract: An arctigenin derivative used for anti-aging treatment, including protection of the skin from the sun and recovery of skin elasticity. A variety of fatty acid ester derivatives, alcohol ether derivatives and alkylated derivatives are used as the arctigenin derivatives. Agents for controlling ET-1 production, elastase inhibitors, and anti-inflammatory agents are prepared. Such arctigenin derivatives are particularly useful as an external agent for the skin, such as an anti-inflammatory external agent, a sunscreen external agent, or an external agent for recovering elasticity.

公开(公告)号：US20150093345A1

公开(公告)日：2015-04-02

申请号：US14389200

申请日：2013-03-27

Applicant: ROHTO Pharmaceutical Co., Ltd.

Inventor： Yuya Hayashi ,  Yoko Mizutare

IPC: A61K8/49 ,  C07D307/33 ,  A61Q19/08 ,  A61Q19/02

CPC classification number: A61K8/4973 ,  A61K31/365 ,  A61K2800/782 ,  A61Q19/02 ,  A61Q19/08 ,  C07D307/33

Abstract: An arctigenin derivative used for anti-aging treatment, including protection of the skin from the sun and recovery of skin elasticity. A variety of fatty acid ester derivatives, alcohol ether derivatives and alkylated derivatives are used as the arctigenin derivatives. Agents for controlling ET-1 production, elastase inhibitors, and anti-inflammatory agents are prepared. Such arctigenin derivatives are particularly useful as an external agent for the skin, such as an anti-inflammatory external agent, a sunscreen external agent, or an external agent for recovering elasticity.

Abstract translation: 用于抗衰老治疗的抗坏血酸衍生物衍生物，包括保护皮肤免受太阳和恢复皮肤弹性。 各种脂肪酸酯衍生物，醇醚衍生物和烷基化衍生物用作抗坏血酸生成素衍生物。 制备用于控制ET-1产生的药剂，弹性蛋白酶抑制剂和抗炎剂。 这样的抗坏血酸衍生物特别可用作皮肤的外用剂，例如抗炎外用剂，防晒外用剂或用于回收弹性的外用剂。