公开(公告)号：US11877880B2

公开(公告)日：2024-01-23

申请号：US17293563

申请日：2019-11-07

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Dong Hyun Yang ,  June Goo Lee ,  Young-Hak Kim

IPC: A61B6/00 ,  G16H50/30 ,  G16H50/20 ,  G06T7/00

CPC classification number: A61B6/503 ,  A61B6/481 ,  A61B6/504 ,  A61B6/5217 ,  G06T7/0012 ,  G16H50/20 ,  G16H50/30 ,  G06T2207/10081 ,  G06T2207/30048 ,  G06T2207/30101

Abstract: A method for calculating a coronary artery calcium score, the method comprising acquiring a target image for a coronary artery and myocardium before contrast enhancement, identifying the coronary artery included in the target image by using an artificial neural network, calculating a coronary artery calcium score based on the identified coronary artery, wherein the artificial neural network is trained based on a training database generated via alignment between a pre-acquired image of a coronary artery and myocardium before contrast enhancement and a pre-acquired image of a coronary artery and myocardium after contrast enhancement.

公开(公告)号：US20230321160A1

公开(公告)日：2023-10-12

申请号：US17998537

申请日：2021-05-07

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Mi-Na KWEON ,  Seungil KIM

IPC: A61K35/741 ,  A61P1/04 ,  C12N1/20

CPC classification number: A61K35/741 ,  A61P1/04 ,  C12N1/205 ,  C12R2001/01

Abstract: An Akkermansia muciniphila AK32 (Accession No. KCTC 14172BP) strain. The Akkermansia muciniphila AK32 strain prevents or improves intestinal damage. A method for preventing, improving or treating intestinal damage, including administering to a subject an effective amount of the Akkermansia muciniphila AK32 strain or a culture thereof as an active ingredient.

公开(公告)号：US20230265174A1

公开(公告)日：2023-08-24

申请号：US18004029

申请日：2021-06-18

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Su Hwan CHANG ,  Song-Cheol KIM ,  Yeon Sook CHOI ,  Hyo Ri KIM

IPC: C07K16/18 ,  A61P35/04

CPC classification number: C07K16/18 ,  A61P35/04 ,  C07K2317/565 ,  C07K2317/24

Abstract: An antibody or antigen-binding fragment thereof specifically binding to galectin 3-binding protein (LGALS3BP), and a use thereof, is described. The antibody or antigen-binding fragment thereof may comprise heavy chain CDRs and light chain CDRs of specific sequences. The antibody specifically binding to LGALS3BP has been found to inhibit cancer growth and metastasis in an animal model with cancer and may be effective for alleviating or treating cancer.

公开(公告)号：US20230258954A1

公开(公告)日：2023-08-17

申请号：US18306309

申请日：2023-04-25

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Jun Ki KIM ,  Bjorn Rolf PAULSON ,  Bohlooli Darian SAEED

IPC: G02B27/64

CPC classification number: G02B27/644 ,  G02B23/2476

Abstract: Disclosed is a suction type stabilizer for a lens including a probe mount, in which a lens is disposed in an interior thereof and an opening that contacts a specimen is formed on one side thereof, an elastic body interposed between the lens and the probe mount, that elastically supports the lens, and defining a division space between the lens and the opening, and a negative pressure forming part forming a negative pressure while suctioning air accommodated in the division space and attaching and fixing the specimen to the opening.

公开(公告)号：US11723721B2

公开(公告)日：2023-08-15

申请号：US16470546

申请日：2016-12-16

Applicant: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Choung-Soo Kim ,  Nam Kug Kim ,  Yoon Soo Kyung ,  Guk Bae Kim

IPC: A61B17/3205 ,  A61B34/10 ,  B33Y30/00 ,  B33Y80/00 ,  G06T19/00 ,  A61B17/32 ,  A61B17/00 ,  A61B17/56 ,  A61B90/00

CPC classification number: A61B34/10 ,  A61B17/3205 ,  A61B2017/00743 ,  A61B2017/00867 ,  A61B2017/320052 ,  A61B2017/568 ,  A61B2034/108 ,  A61B2090/08021 ,  B33Y30/00 ,  B33Y80/00 ,  G06T19/00

Abstract: Provided is an apparatus for manufacturing a surgical guide that guides a cutting line formed to surround a tumor of an organ, the apparatus including: an organ modeling unit configured to model a 3-dimensional (3D) image of the organ, based on an image of a patient captured by an external imaging apparatus; a cutting line determining unit configured to determine, in the 3D image of the organ, the cutting line to correspond to a location of the tumor and an entry angle of a surgical instrument to the cutting line; and a guide manufacturing unit configured to manufacture a surgical guide that guides the surgical instrument to the cutting line in a slanting manner corresponding to the entry angle, based on the 3D image of the organ.

公开(公告)号：US20230181307A1

公开(公告)日：2023-06-15

申请号：US18166764

申请日：2023-02-09

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Jae Yong JEON ,  Hwayeong CHEON ,  Jung Hoon PARK

IPC: A61F2/07

CPC classification number: A61F2/07 ,  A61F2002/072 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2210/00

Abstract: Disclosed is a graft for a biological tube including a graft having a hollow of a specific length, having openings at opposite ends along a lengthwise direction thereof, and being contractible, and the graft is contracted to be adhered to outer peripheral surfaces of biological tubes when heat is applied to the graft in a state, in which portions of the biological tubes are inserted into the openings of the graft.

公开(公告)号：US20230017150A1

公开(公告)日：2023-01-19

申请号：US17812892

申请日：2022-07-15

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Deok Hee LEE ,  Seon Moon HWANG ,  Joon Ho CHOI

IPC: A61B17/12

Abstract: A hydrogel stent for cerebral aneurysm includes a hydrogel polymer, and a stent body wrapping at least a portion of the hydrogel polymer. The stent body is expandable in a cerebral aneurysm of a blood vessel. The stent body is provided in a mesh type surrounding at least a portion of the hydrogel polymers. An embolization device for cerebral aneurysm, includes a hydrogel stent for cerebral aneurysm; a micro-conduit providing a movement path for guiding the hydrogel stent to a cerebral aneurysm of a blood vessel; and a pusher wire connected to the hydrogel stent to be movable in the movement path.

公开(公告)号：US11439354B2

公开(公告)日：2022-09-13

申请号：US16483039

申请日：2018-02-05

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Chang Mo Hwang ,  Young Hak Kim ,  Gi Byoung Nam ,  Jae Soon Choi ,  Gi Seok Jeong

IPC: A61B5/00 ,  A61B5/287 ,  A61M25/01 ,  A61B34/20 ,  A61B5/339 ,  A61B18/14 ,  A61B18/00

Abstract: The present invention is a system for three-dimensionally mapping a heart, comprising: a mapping catheter including three or more optical cores each of which has a plurality of FBGs disposed in the lengthwise direction of a catheter body, and a plurality of electrodes disposed in the lengthwise direction of the catheter body and exposed on the outer circumferential surface of the catheter body, wherein the electrodes make contact with the inner wall of the heart; and a mapping processor for calculating coordinates of the FBGs by wavelength information of reflected light received from the three or more optical cores, and calculating coordinates of the electrodes from the coordinates of the FBGs so as to build a three-dimensional shape of the heart by using a sample point at which the plurality of electrodes make contact.

公开(公告)号：US20220252608A1

公开(公告)日：2022-08-11

申请号：US17621451

申请日：2020-06-22

Applicant: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  THE ASAN FOUNDATION

Inventor： Sung SHIN

IPC: G01N33/68 ,  C12Q1/68

Abstract: The present invention relates to a biomarker for the non-invasive diagnosis of kidney transplantation rejection and use thereof, and particularly to: a biomarker composition and kit for diagnosing antibody-mediated rejection after kidney transplantation or predicting the prognosis of a patient after kidney transplantation, comprising any one or more proteins selected from the group consisting of LBP and CST3, or gene(s) encoding for the same; a method for providing information required for diagnosing antibody-mediated rejection after kidney transplantation or predicting the prognosis of a patient after kidney transplantation, by using the marker composition; a method for providing information required for determining a therapy for rejection after kidney transplantation; a method for the diagnosis and treatment of antibody-mediated rejection after kidney transplantation; and a method for screening for a therapeutic agent for antibody-mediated rejection after kidney transplantation.

公开(公告)号：US20220089774A1

公开(公告)日：2022-03-24

申请号：US17310296

申请日：2020-01-29

Applicant: THE ASAN FOUNDATION ,  EDISBIOTECH CO., LTD. ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Seung-Jae MYUNG ,  Eun-Ju DO ,  Jayoung KANG ,  Hye-Nam SON ,  Hyori KIM ,  A-Neum LEE ,  Yeong Hui CHO

IPC: C07K16/32 ,  G01N33/574

Abstract: The present invention relates to a monoclonal antibody which specifically binds to an EGF2 domain of colon cancer secreted protein-2 (CCSP-2), or an antigen-binding fragment thereof. The monoclonal antibody or the antigen-binding fragment thereof of the present invention specifically binds to the EGF2 domain of CCSP-2, and thus has significantly increased affinity compared with existing peptides specifically binding to CCSP-2 and further increased specificity compared with existing antibodies to CCSP-2. Therefore, in future, accurate diagnosis can be achieved by specific detection of CCSP-2 in the protein level.