公开(公告)号：US20140178454A1

公开(公告)日：2014-06-26

申请号：US14109795

申请日：2013-12-17

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Florencia Lim ,  Mikael O. Trollsas ,  Syed F.A. Hossainy ,  Stephen D. Pacetti

IPC: A61L31/10 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/606 ,  Y10T24/258 ,  C08L67/04

Abstract: The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.

Abstract translation: 本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用该涂层的方法。

公开(公告)号：US20140147687A1

公开(公告)日：2014-05-29

申请号：US14168903

申请日：2014-01-30

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61L31/06 ,  Y10T428/31725 ,  C08L77/12

Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, and the coatings comprise biologically absorbable poly(ester amides).

Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，并且涂层包括生物可吸收的聚（酯酰胺）。

公开(公告)号：US20140072609A1

公开(公告)日：2014-03-13

申请号：US14081287

申请日：2013-11-15

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Mikael Trollsas

IPC: C08G81/00 ,  A61K31/436 ,  A61L31/06

CPC classification number: A61L31/10 ,  A61K31/436 ,  A61L29/041 ,  A61L29/16 ,  A61L31/048 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/606 ,  A61L2420/00 ,  C08G81/00

Abstract: The present invention is directed to polymeric materials made of biodegradable, bioabsorbable triblock copolymers and implantable devices (e.g., drug-delivery stents) containing such polymeric materials. The polymeric materials may also contain at least one therapeutic substance. The polymeric materials are formulated so as to improve the mechanical and adhesion properties, degradation, biocompatibility and drug permeability of such materials and, thus, implantable devices formed of such materials.

Abstract translation: 本发明涉及由可生物降解的，生物可吸收的三嵌段共聚物和含有这种聚合材料的可植入装置（例如药物递送支架）制成的聚合材料。 聚合物材料还可含有至少一种治疗物质。 配制聚合物材料以改善这些材料的机械和粘合性能，降解，生物相容性和药物渗透性，从而改善由这些材料形成的可植入装置。

公开(公告)号：US20140037833A1

公开(公告)日：2014-02-06

申请号：US14052986

申请日：2013-10-14

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Stephen D. Pacetti ,  Laura Melton Kalvass

IPC: A61F2/82

CPC classification number: B05C11/00 ,  A61F2/82 ,  A61L2420/02 ,  B05B13/0442 ,  B05D1/002

Abstract: A systems and method for reducing coating defects on a stent may involve a support apparatus comprising wire cage for carrying a stent. The support apparatus may have no structure that extends inside the stent. A support apparatus may include a plurality of wires that pass through the stent but do not pass through the midplane of the stent. A support apparatus may contact only the proximal ends of the stent. The method may involve keeping the stent in motion during a spray coating process to prevent the stent from having a point remain in continuous contact with a support apparatus.

Abstract translation: 用于减少支架上的涂层缺陷的系统和方法可以涉及包括用于承载支架的线架的支撑装置。 支撑装置可以没有在支架内延伸的结构。 支撑装置可以包括穿过支架但不穿过支架的中平面的多根线。 支撑装置可以仅接触支架的近端。 该方法可以包括在喷雾涂覆过程期间保持支架运动，以防止支架保持与支撑装置的连续接触。

公开(公告)号：US20140005334A1

公开(公告)日：2014-01-02

申请号：US13963792

申请日：2013-08-09

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: A61L31/10

CPC classification number: A61L31/048 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  C08F214/18 ,  C08F295/00 ,  C09D127/16 ,  C08L27/12 ,  A61K31/10

Abstract: It is provided a polymer blend that contains a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer.

Abstract translation: 提供了一种聚合物共混物，其包含由氟化单体和烃单体形成的聚合物和另一种生物相容性聚合物。

公开(公告)号：US20130324637A1

公开(公告)日：2013-12-05

申请号：US13963753

申请日：2013-08-09

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: A61L31/10

CPC classification number: A61L31/048 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  C08F214/18 ,  C08F295/00 ,  C09D127/16 ,  C08L27/12 ,  A61K31/10

Abstract: It is a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer.

Abstract translation: 它是由氟化单体和烃单体和另一种生物相容性聚合物形成的聚合物。

公开(公告)号：US20130287833A1

公开(公告)日：2013-10-31

申请号：US13923559

申请日：2013-06-21

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Thierry Glauser ,  Stephen D. Pacetti ,  Paul M. Consigny

IPC: A61L31/16 ,  A61L31/08

CPC classification number: A61K33/00 ,  A61K45/06 ,  A61L29/16 ,  A61L31/08 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/606

Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.

公开(公告)号：US20130129814A1

公开(公告)日：2013-05-23

申请号：US13725525

申请日：2012-12-21

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Stephen D. Pacetti ,  Paul M. Consigny ,  Ronald W. Heil, JR. ,  Florian Niklas Ludwig ,  Dariush Davalian ,  Li Zhao ,  Irina Astafieva ,  Jinping Wan ,  Fozan El-Nounou ,  Katsuyuki Murase ,  Syed F.A. Hossainy ,  Rachel Bright ,  Jeffrey Ellis

IPC: A61M25/10

CPC classification number: A61M25/1002 ,  A61F2/82 ,  A61F2250/0067 ,  A61K31/27 ,  A61K31/44 ,  A61K31/56 ,  A61K31/66 ,  A61K38/1709 ,  A61L29/08 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/112 ,  A61L2300/216 ,  A61L2300/252 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/62 ,  A61M25/10 ,  A61M37/0015 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2210/12

Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.

Abstract translation: 本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织 受影响组织的外围也是如此。

公开(公告)号：US20250114584A1

公开(公告)日：2025-04-10

申请号：US18985461

申请日：2024-12-18

Applicant: Abbott Cardiovascular Systems, Inc.

Inventor： Aaron M. Fortson ,  Stephen D. Pacetti

IPC: A61B17/00 ,  A61B17/12

Abstract: An access closure device for closing an opening in tissue is provided. The access closure device may comprise an implant delivery system and a sealant delivery mechanism. The implant delivery system may comprise a suture, a procedural sheath, a delivery tube, an deployable implant and a suture attached to the implant. The sealant delivery mechanism may comprise a sealant deliverable over a suture through the procedural sheath, configured to settle proximal an implant located in an access track.

公开(公告)号：US20220152372A1

公开(公告)日：2022-05-19

申请号：US17524889

申请日：2021-11-12

Applicant: Abbott Cardiovascular Systems, Inc.

Inventor： Aaron M. Fortson ,  Stephen D. Pacetti

IPC: A61M39/02

Abstract: An access closure device for closing an opening in tissue is provided. The access closure device may comprise a balloon delivery system and a sealant delivery system. The balloon delivery system may comprise a suture, a delivery shaft, an inflatable balloon, and a balloon segment releasably attached to the delivery shaft. The sealant delivery system may comprise a sealant delivery shaft, an ejection tube, and a snare wire configured to snare a suture of the delivery system.