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![8-azabicyclo[3.2.1]oct-2-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2014/01/21/US08633218B2/abs.jpg.150x150.jpg)
111.发明授权8-azabicyclo[3.2.1]oct-2-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权8-氮杂双环[3.2.1]辛-2-烯衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US08633218B2
公开(公告)日：2014-01-21
申请号：US13129561
申请日：2009-11-16
CPC分类号： C07D409/04
摘要： The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂双环[3.2.1]辛-2-烯衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![8-AZABICYCLO[3.2.1]OCT-2-ENE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS](/abs-image/US/2011/10/27/US20110263640A1/abs.jpg.150x150.jpg)
112.发明申请8-AZABICYCLO[3.2.1]OCT-2-ENE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 有权8-AZABICYCLO [3.2.1] OCT-2-ENE衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20110263640A1
公开(公告)日：2011-10-27
申请号：US13129561
申请日：2009-11-16
IPC分类号： A61K31/46 , A61P25/00 , A61P25/24 , A61P25/34 , A61P25/36 , A61P25/32 , A61P25/30 , A61P15/00 , A61P13/00 , A61P25/28 , A61P15/10 , A61P25/04 , A61P25/18 , A61P25/22 , C07D451/02
CPC分类号： C07D409/04
摘要： The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂双环[3.2.1]辛-2-烯衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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113.发明申请NOVEL TETRAMETHYL SUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开新型四甲基取代的哌啶衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20110136862A1
公开(公告)日：2011-06-09
申请号：US13001079
申请日：2009-06-23
IPC分类号： A61K31/4709 , C07D401/12 , A61P25/00 , A61P25/24
CPC分类号： C07D401/12
摘要： This invention relates to novel tetramethyl substituted pipehdine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型四甲基取代哌啶衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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114.发明申请N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS 审中-公开N-ARYL-N-PIPERIDIN-4-YL-丙酰胺衍生物及其作为阿片受体配体的用途公开(公告)号：US20110046180A1
公开(公告)日：2011-02-24
申请号：US12809156
申请日：2008-12-18
IPC分类号： A61K31/445 , C07D211/56 , A61P17/00 , A61P25/36 , A61P25/00 , A61P25/04 , A61P25/32
CPC分类号： C07D211/58
摘要： This invention relates to novel N-aryl-N-piperidin-4-yl-propionamide derivatives useful as opioid receptor ligands.In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of pain, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作阿片受体配体的新型N-芳基-N-哌啶-4-基 - 丙酰胺衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途，例如用于治疗疼痛，以及包含本发明化合物的药物组合物。
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115.发明申请N-PIPERIDIN-4-YLMETHYL-AMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开N-哌啶-4-基甲基衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20100204275A1
公开(公告)日：2010-08-12
申请号：US12671317
申请日：2008-07-31
申请人： Dan Peters , Birgitte L. Eriksen , John Paul Redrobe , Gordon Munro , Elsebet Østergaard Nielsen
发明人： Dan Peters , Birgitte L. Eriksen , John Paul Redrobe , Gordon Munro , Elsebet Østergaard Nielsen
IPC分类号： A61K31/445 , C07D211/26 , C07D401/12 , A61K31/4545 , C07D211/34 , A61K31/4465 , A61P25/00 , A61P25/24 , A61P25/22 , A61P25/28 , A61P25/16 , A61P25/30 , A61P29/00 , A61P13/00
CPC分类号： C07D211/26 , C07D401/12
摘要： This invention relates to novel N-piperidin-4-ylmethyl amide derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型N-哌啶-4-基甲基酰胺衍生物。 在其他方面，本发明涉及这些化合物在治疗方法中的用途，以及包含本发明化合物的药物组合物。
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116.发明授权Substituted diazabicyclo derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效取代的二氮杂双环衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07704991B2
公开(公告)日：2010-04-27
申请号：US11887622
申请日：2006-04-03
IPC分类号： A61K31/55 , C07D487/08 , A61P25/00
CPC分类号： C07D487/08
摘要： This invention relates to novel substituted diazabicyclo derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型取代的二氮杂双环衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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公开(公告)号：US07521480B2
公开(公告)日：2009-04-21
申请号：US10535683
申请日：2003-11-10
IPC分类号： A61K31/135 , C07C273/00 , C07C275/00
CPC分类号： C07D213/75 , C07C275/42 , C07C309/51 , C07C2603/18 , C07D209/40 , C07D231/56 , C07D257/04 , C07D271/07 , C07D317/66 , C07D333/36
摘要： This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are considered useful for treating diseases that are responsive to modulation of an aspartate or a glutamate receptor. Moreover the invention provides chemical compounds for use according to the invention, as well as pharmaceutical compositions comprising the chemical compounds, and methods of treating diseases or disorders or conditions responsive to modulation of an aspartate or a glutamate receptor.
摘要翻译： 本发明涉及可用作离子型GluR5受体的选择性和非竞争性拮抗剂的新型芳基脲基苯甲酸衍生物。 由于其生物学活性，本发明的芳基脲基衍生物被认为可用于治疗对天冬氨酸或谷氨酸受体的调节有反应的疾病。 此外，本发明提供了根据本发明使用的化合物，以及包含化合物的药物组合物，以及治疗对天冬氨酸或谷氨酸受体的调节作用的疾病或病症或病症的方法。
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公开(公告)号：US06617459B2
公开(公告)日：2003-09-09
申请号：US09855630
申请日：2001-05-15
IPC分类号： C07D45104
CPC分类号： C07D451/14 , A61K51/0455 , C07D451/02
摘要： The present invention relates to 8-azabicyclo[3.2.1]oct-2-ene derivatives in their labelled form. Furthermore, the present invention relates to the use of said derivatives in their labelled or unlabelled form in diagnostic methods, in particular for in vivo receptor imaging (neuroimaging).
摘要翻译： 本发明涉及其标记形式的8-氮杂双环[3.2.1]辛-2-烯衍生物。 此外，本发明涉及所述衍生物在其标记或未标记形式的诊断方法中的用途，特别是用于体内受体成像（神经成像）。
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119.发明申请CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开CHROMEN-2-ONE衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20130040985A1
公开(公告)日：2013-02-14
申请号：US13575712
申请日：2011-01-14
CPC分类号： C07D451/06
摘要： The present application discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the application discloses the use of these compounds, a method for therapy and to pharmaceutical compositions comprising these compounds.
摘要翻译： 本申请公开了可用作单胺神经递质再摄取抑制剂的新颖的8-氮杂 - 双环[3.2.1]辛-3-基氧基） - 色烯-2-酮衍生物。 在其它方面，本申请公开了这些化合物的使用，治疗方法和包含这些化合物的药物组合物。
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120.发明申请PIPERAZINYL-ALKYL-BENZOIMIDAZOL-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开哌嗪 - 苯甲酰基苯甲酸-2-酮衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20120220604A1
公开(公告)日：2012-08-30
申请号：US13497005
申请日：2010-09-13
IPC分类号： A61K31/496 , A61P25/00 , A61P25/24 , C07D403/14
CPC分类号： C07D235/26
摘要： The present application discloses novel piperazinyl-alkyl-benzoimidazol-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention discloses the use of these compounds in a method for therapy, and pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本申请公开了可用作单胺神经递质再摄取抑制剂的新型哌嗪基 - 烷基 - 苯并咪唑-2-酮衍生物。 在其它方面，本发明公开了这些化合物在治疗方法中的用途，以及包含本发明化合物的药物组合物。
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