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153 条记录 (耗时 0.042 秒)

    Rotary Valve Construction
    111.
    发明申请
    Rotary Valve Construction 审中-公开
    旋转阀结构

    公开(公告)号：US20070277770A1

    公开(公告)日：2007-12-06

    申请号：US11659693

    申请日：2005-08-31

    申请人： Anthony Wallis ,  Andrew Thomas ,  Klaus Roeske

    发明人： Anthony Wallis ,  Andrew Thomas ,  Klaus Roeske

    IPC分类号： F01L7/02

    CPC分类号： F01L7/023 ,  F01L7/024 ,  F01L7/16 ,  F01L2101/00 ,  F01L2101/02

    摘要： An axial flow rotary valve (1) for an internal combustion engine and method of manufacture thereof. The valve comprising a centre portion (5) having a cylindrical periphery, inlet and exhaust portions (9, 16) both smaller in diameter than the centre portion, and an inlet port (3) and an exhaust port (4) terminating respectively as an inlet opening (6) and an exhaust opening (7) in the periphery of the centre portion. The centre portion having at least one elongate passage (21) communicating between the inlet portion and the exhaust portion, the whole of the passage being disposed circumferentially outside the openings and radially outside at least one of the inlet and exhaust portions.

    摘要翻译： 一种用于内燃机的轴流式旋转阀（1）及其制造方法。 所述阀包括具有圆柱形周边的中心部分（5），直径小于所述中心部分的入口和排气部分（9,16）以及分别终止于所述中心部分的入口端口（3）和排气口（4） 入口开口（6）和排气口（7）。 中心部分具有在入口部分和排气部分之间连通的至少一个细长通道（21），整个通道周向地设置在开口的外侧，并且在入口部分和排气部分中的至少一个的径向外侧。

    Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives
    112.
    发明申请
    Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives 失效
    芳基异恶唑-4-基 - 咪唑并[1,2-a]吡啶衍生物

    公开(公告)号：US20070179178A1

    公开(公告)日：2007-08-02

    申请号：US11654183

    申请日：2007-01-16

    申请人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Andrew Thomas

    发明人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Andrew Thomas

    IPC分类号： A61K31/4745 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The present invention is concerned with aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives of formula I: wherein R1 to R5 are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

    摘要翻译： 本发明涉及式I的芳基 - 异恶唑-4-基 - 咪唑并[1,2-a]吡啶衍生物：其中R 1至R 5各自为 在本说明书中定义及其药学上可接受的酸加成盐。 这类化合物对GABA Aα5受体结合位点具有高亲和力和选择性，可用作认知增强剂或用于治疗认知障碍如阿尔茨海默病。

    3-aryl-isoxazole-4-carbonyl-indole derivatives
    113.
    发明申请
    3-aryl-isoxazole-4-carbonyl-indole derivatives 失效
    3-芳基 - 异恶唑-4-羰基 - 吲哚衍生物

    公开(公告)号：US20070105922A1

    公开(公告)日：2007-05-10

    申请号：US11590571

    申请日：2006-10-31

    申请人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Matthias Nettekoven ,  Andrew Thomas

    发明人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Matthias Nettekoven ,  Andrew Thomas

    IPC分类号： A61K31/42 ,  C07D413/02

    CPC分类号： C07D413/06 ,  C07D413/14

    摘要： The present invention is concerned with 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives of formula I wherein R1, R2, and R3 are as defined in the specification and claims and with their pharmaceutically acceptable acid addition salts. These compounds have a high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

    摘要翻译： 本发明涉及式I的3-芳基 - 异恶唑-4-羰基 - 苯并呋喃衍生物，其中R 1，R 2，R 3和R 3， SUP>如说明书和权利要求书及其药学上可接受的酸加成盐所定义。 这些化合物对GABA Aα5受体结合位点具有高亲和力和选择性，并且可用作认知增强剂或用于治疗诸如阿尔茨海默病的认知障碍。

    Ultrasonic fault detection system using a high dynamic range analog to digital conversion system
    114.
    发明申请
    Ultrasonic fault detection system using a high dynamic range analog to digital conversion system 失效
    超声波故障检测系统采用高动态范围的模数转换系统

    公开(公告)号：US20070084288A1

    公开(公告)日：2007-04-19

    申请号：US11489889

    申请日：2006-07-20

    申请人： Andrew Thomas

    发明人： Andrew Thomas

    IPC分类号： G01N29/00

    CPC分类号： G01N29/44 ,  G01N29/043 ,  G01N29/262 ,  G01N29/42 ,  G01N29/4463 ,  G01N2291/044 ,  G01N2291/102 ,  H03M1/188

    摘要： A method and apparatus for effecting ultrasonic flaw detection of an object processes an echo signal received from the object being tested in at least three signal channels, wherein the echo signal is scaled to different degrees along each channel to increase and extend the dynamic range of an associated A/D converter system, in a manner which dispenses with the need for using numerous analog high pass and low pass filters and a variable gain amplifier. This reduces complexity and avoids performance limitations. The digital to analog converters sample the differently scaled input signal and a selection circuit selects the output of the digital output obtained from that analog to digital converter which has the highest gain, but which has not overflowed. The digital outputs are seamlessly merged to produce an output that can be displayed as a scan display which shows the location of faults.

    摘要翻译： 用于实现物体的超声波探伤的方法和装置处理在至少三个信号通道中从被测试对象接收的回波信号，其中回波信号沿着每个通道被缩放到不同程度，以增加和扩展一个 相关的A / D转换器系统，其不需要使用大量模拟高通和低通滤波器和可变增益放大器。 这降低了复杂性并避免了性能限制。 数模转换器对不同比例的输入信号进行采样，并且选择电路选择从具有最高增益但尚未溢出的模数转换器获得的数字输出的输出。 数字输出无缝合并，产生可显示为显示故障位置的扫描显示的输出。

    Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives
    115.
    发明申请
    Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives 失效
    取代的咪唑并[1,5-a] [1,2,4]三唑并[1,5-d] [1,4]苯并二氮杂衍生物

    公开(公告)号：US20070082890A1

    公开(公告)日：2007-04-12

    申请号：US11542944

    申请日：2006-10-04

    申请人： Bernd Buettelmann ,  Henner Knust ,  Andrew Thomas

    发明人： Bernd Buettelmann ,  Henner Knust ,  Andrew Thomas

    IPC分类号： A61K31/551 ,  C07D487/14

    CPC分类号： C07D487/14

    摘要： The present invention is concerned with substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives of the following formula wherein the definition of substituents is described in the claims. This class of compounds shows high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as a cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

    摘要翻译： 本发明涉及下式的取代咪唑并[1,5-a] [1,2,4]三唑并[1,5-d] [1,4]苯并二氮杂衍生物，其中取代基的定义描述于 声称。 这类化合物对GABA Aα5受体结合位点显示出高亲和力和选择性，可能作为认知增强剂或治疗阿尔茨海默病等认知障碍。

    2-Anilino-4-(imidazol-5-yl)-pyrimidine derivatives and their use as cdk(cdk2) inhibitors
    117.
    发明申请
    2-Anilino-4-(imidazol-5-yl)-pyrimidine derivatives and their use as cdk(cdk2) inhibitors 失效
    2-苯胺基-4-（咪唑-5-基） - 嘧啶衍生物及其作为cdk（cdk2）抑制剂的用途

    公开(公告)号：US20070037839A1

    公开(公告)日：2007-02-15

    申请号：US10556561

    申请日：2004-05-12

    申请人： Andrew Thomas

    发明人： Andrew Thomas

    IPC分类号： A61K31/506 ,  C07D403/04

    CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D409/14

    摘要： Compounds of the formula (I), and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are desc ribed. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti cell proliferation) effect in a warm blooded animal, such as man.

    摘要翻译： 式（I）的化合物及其药学上可接受的盐和体内可水解的酯被降解。 还描述了其制备方法及其作为药物的用途，特别是用于在温血动物如人中产生细胞周期抑制（抗细胞增殖）作用的药物。

    Deriving location information about a communicating entity
    119.
    发明授权
    Deriving location information about a communicating entity 有权
    导出有关通信实体的位置信息

    公开(公告)号：US07050815B2

    公开(公告)日：2006-05-23

    申请号：US09821143

    申请日：2001-03-29

    申请人： Colin I'Anson ,  Rycharde Jeffery Hawkes ,  James Thomas Edward McDonnell ,  Andrew Thomas ,  John Deryk Waters ,  Simon Edwin Crouch

    发明人： Colin I'Anson ,  Rycharde Jeffery Hawkes ,  James Thomas Edward McDonnell ,  Andrew Thomas ,  John Deryk Waters ,  Simon Edwin Crouch

    IPC分类号： H04Q7/20

    CPC分类号： H04W64/00

    摘要： Location information about a communicating entity (41), in particular a mobile entity, is derived by identifying intermediate nodes (42) along the communication path being used by the entity, and then looking up, in a database (44), the geographic significance of at least one of these nodes when considered in a direction along the communication path towards the entity of interest. Preferably, account is taken of any identified downstream/upstream nodes to refine the geographic significance of a node. The geographic significance information can be compiled by taking location fixes at a plurality of endpoint locations and associating the location data thus obtained with the intermediate nodes traversed when communication is effected from the corresponding endpoint locations.

    摘要翻译： 通过识别实体所使用的通信路径的中间节点（42），然后在数据库（44）中查找地理意义（44）来获得关于通信实体（41）特别是移动实体的位置信息 当沿着朝向感兴趣的实体的通信路径的方向被考虑时，这些节点中的至少一个。 优选地，考虑任何所识别的下游/上游节点以改善节点的地理意义。 可以通过在多个端点位置处进行位置定位来编译地理有意义信息，并且将由此获得的位置数据与从相应的端点位置进行通信时所经过的中间节点相关联。