摘要:
Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is and R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
摘要:
There is provided an organic light emitting diode having an anode, a hole transport layer containing a material having an ionization potential IPHTL, an emissive layer, an electron transport layer, and a cathode. The emissive layer contains: (a) a fluorinated hexacoordinate iridium complex emitter having an ionization potential IPemt; (b) an electron transport host material having an ionization potential IPHO; and (c) a recombination zone shifting additive having an ionization potential IPx. The weight ratio of host to zone shifting additive is at least 4 and the following energy relationships exist: (i) (IPHTL−IPemt)≧−0.1 eV; (ii) IPHO>IPHTL; and (iii) IPx≦IPHTL.
摘要:
Techniques for transmitting signals on shared resources in a manner to detect and/or combat collision are described. In an aspect, a terminal may transmit a signal on a subset of resource elements in a resource block, and at least one null resource element with no signal may be used to detect for collision of the signal. In another aspect, different terminals may simultaneously transmit their signals on different subsets of resource elements in a resource block. These different subsets of resource elements may be pseudo-randomly selected to randomize interference. In one design, a terminal may determine a resource block to use for transmission of a signal, select a subset of the resource elements in the resource block, and transmit the signal on the selected resource elements, e.g., to at least one other terminal for peer-to-peer communication. The signal may be a peer discovery signal, a paging signal, etc.
摘要:
Techniques for performing transmit power control based on receiver gain setting in a wireless communication network are described. In an aspect, a terminal A may estimate pathloss to another terminal B, e.g., based on a peer discovery signal received from terminal B. Terminal A may then determine a transmit power level for a peer-to-peer (PTP) signal (e.g., a paging signal) based on the estimated pathloss, a receiver gain setting at terminal B, and a target received power level for the PTP signal. Terminal A may send the PTP signal at the determined transmit power level to terminal B. In another aspect, terminal B may use different receiver gain settings in different time intervals to receive PTP signals from other terminals. Terminal A may then select a suitable time interval to send the PTP signal based on the pathloss and the different receiver gain settings used by terminal B.
摘要:
A method of synchronizing multi-carrier systems is provided, wherein the method comprises inserting a predefined frequency domain signal into a signal on a transmitter side of a multi-carrier system and multi-carrier modulating the signal. Furthermore, the method comprises transmitting the multi-carrier modulated signal via a carrier channel to a receiving side of the multi-carrier system, and synchronizing the multi-carrier modulated signal by using the predefined frequency domain signal portion of the multi-carrier modulated signal.
摘要:
The present invention provides a lubricating composition comprising: (a) an oil of lubricating viscosity; and (b) a crosslinked polymer derived from monomers comprising: (i) 0.001 wt % to 7 wt % of a di- or higher functional crosslinking monomer; (ii) 30 wt % or higher of a hydrocarbyl-substituted (meth)acrylic monomer, wherein each hydrocarbyl contains greater than 8 carbon atoms; and (iii) 0 wt % to 40 wt % of a hydrocarbyl-substituted (meth)acrylic monomer, wherein each hydrocarbyl contains 8 or fewer carbon atoms. The invention further provides a method of preparing the crosslinked polymer and its use in a lubricating composition for lubricating an internal combustion engine.
摘要:
High quality communications among a diverse set of cognitive radio (CR) nodes is permitted while minimizing interference to primary and other secondary users by employing Dynamic Spectrum Access (DSA) in a Dynamic Cellular Cognitive System (DCCS). Diverse device types interoperate, cooperate, and communicate with high spectrum efficiency and do not require infrastructure to form the network. The dynamic cellular cognitive system can expand to a wider geographical distribution via linking to existing infrastructure.
摘要:
Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR 119 G protein-coupled receptor modulator therapy. These novel compounds have the structure Formula I or Formula IA.
摘要:
The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
摘要:
Compounds of formula (I) wherein A is N or N+—O−; n is 0, 1, or 2; Y is O, S, —NH—, and —N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6-membered aromatic rings with a —NR8R9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
摘要翻译:式(I)的化合物,其中A是N或N +,-O - n为0,1或2; Y是O,S,-NH-和-N-烷基 - ; Ar 1是两个6元芳环; Ar 2是如本文所定义的具有-NR 8 R 9 R 9基团的5-或6-元芳环。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了具有式(I)化合物的药物组合物和使用这些化合物和组合物的方法。