公开(公告)号：US20130040862A1

公开(公告)日：2013-02-14

申请号：US13636799

申请日：2010-04-20

申请人： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu ,  R. Stanley Williams

发明人： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu ,  R. Stanley Williams

IPC分类号： C40B40/14 ,  C40B50/14 ,  C40B40/18 ,  C40B40/04 ,  B82Y15/00

CPC分类号： G01N21/658

摘要： A multi-pillar structure for molecular analysis is provided. The structure comprises at least two nanopoles, each nanopole attached at one end to a substrate and freely movable along its length. The opposite ends of the at least two nanopoles are each capable of movement toward each other to trap at least one analyte molecule at their opposite ends. Each nanopole is coated with a metal coating. An array of such multi-pillar structures is also provided. A method for preparing the multi-pillar structure is further provided.

摘要翻译： 提供了一种用于分子分析的多支柱结构。 该结构包括至少两个纳米微粒，每个纳米孔一端连接到基底上，并可沿其长度自由移动。 至少两个纳米球的相对端各自能够相互移动以在其相对端捕获至少一种分析物分子。 每个纳米孔涂有金属涂层。 还提供了这种多支柱结构的阵列。 还提供了一种制备多支柱结构的方法。

公开(公告)号：US08314932B2

公开(公告)日：2012-11-20

申请号：US12771440

申请日：2010-04-30

申请人： Fung Suong Ou ,  Zhiyong Li ,  Min Hu ,  Wei Wu

发明人： Fung Suong Ou ,  Zhiyong Li ,  Min Hu ,  Wei Wu

IPC分类号： G01J3/44

CPC分类号： G02B1/12 ,  G01N21/658

摘要： A surface-enhanced Raman spectroscopy device includes a substrate, and an ultraviolet cured resist disposed on the substrate. The ultraviolet cured resist has a pattern of cone-shaped protrusions, where each cone-shaped protrusion has a tip with a radius of curvature equal to or less than 10 nm. The ultraviolet cured resist is formed of a predetermined ratio of a photoinitiator, a cross-linking agent, and a siloxane based backbone chain. A Raman signal-enhancing material is disposed on each of the cone-shaped protrusions.

摘要翻译： 表面增强拉曼光谱装置包括基板和设置在基板上的紫外线固化抗蚀剂。 紫外线固化抗蚀剂具有锥形突起的图案，其中每个锥形突起具有等于或小于10nm的曲率半径的尖端。 紫外线固化的抗蚀剂由光引发剂，交联剂和基于硅氧烷的主链以预定比例形成。 拉曼信号增强材料设置在每个锥形突起上。

公开(公告)号：US20120220068A1

公开(公告)日：2012-08-30

申请号：US13450414

申请日：2012-04-18

申请人： Christopher J. Petti ,  Mohamed M. Hilali ,  Theodore Smick ,  Venkatesan Murali ,  Kathy J. Jackson ,  Zhiyong Li ,  Gopalakrishna Prabhu

发明人： Christopher J. Petti ,  Mohamed M. Hilali ,  Theodore Smick ,  Venkatesan Murali ,  Kathy J. Jackson ,  Zhiyong Li ,  Gopalakrishna Prabhu

IPC分类号： H01L31/0376 ,  H01L31/18

CPC分类号： H01L31/1892 ,  H01L31/0747 ,  H01L31/1864 ,  Y02E10/50

摘要： A semiconductor assembly is described in which a support element is constructed on a surface of a semiconductor lamina. Following formation of the thin lamina, which may have a thickness about 50 microns or less, the support element is formed, for example by plating, or by application of a precursor and curing in situ, resulting in a support element which may be, for example, metal, ceramic, polymer, etc. This is in contrast to pre-formed support element which is affixed to the lamina following its formation, or to a donor wafer from which the lamina is subsequently cleaved.Fabricating the support element in situ may avoid the use of adhesives to attach the lamina to a permanent support element. In some embodiments, this process flow allows the lamina to be annealed at high temperature, then to have an amorphous silicon layer formed on each face of the lamina following that anneal.

摘要翻译： 描述了半导体组件，其中在半导体层的表面上构造支撑元件。 形成厚度约为50微米或更小的薄层之后，例如通过镀覆或通过施加前体和原位固化来形成支撑元件，得到支撑元件，其可以用于 例如，金属，陶瓷，聚合物等。这与预先形成的支撑元件形成对比，该预制形成的支撑元件在其形成之后固定到层板上，或者与施加器晶片相接触，该晶片随后被切割。 原位制造支撑元件可以避免使用粘合剂将薄片附着到永久支撑元件上。 在一些实施例中，该工艺流程允许薄层在高温下退火，然后在该退火之后具有在层的每个表面上形成的非晶硅层。

公开(公告)号：US08183220B2

公开(公告)日：2012-05-22

申请号：US12577900

申请日：2009-10-13

申请人： Jixing Liu ,  Bin Yang ,  Xi Lan ,  Xiangping Yin ,  Yinmei Bai ,  Xiaorong Han ,  Xuerui Li ,  Baoyu Li ,  Yuping Fang ,  Zhiyong Li

发明人： Jixing Liu ,  Bin Yang ,  Xi Lan ,  Xiangping Yin ,  Yinmei Bai ,  Xiaorong Han ,  Xuerui Li ,  Baoyu Li ,  Yuping Fang ,  Zhiyong Li

IPC分类号： A61K48/00 ,  C12N15/113 ,  C12N15/42 ,  C12N15/85

CPC分类号： A61K39/135 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/552 ,  C12N15/1131 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2770/32134 ,  C12N2830/20 ,  C12N2840/203

摘要： A double-effective vaccine vector against foot-and-mouth disease virus having a bicistronic expression vector sequence, the bicistronic expression vector sequence is an antisense gene sequence capable of conjugating with 5′ UTR of RNA of the foot-and-mouth disease virus genome and an intact sequence of VP1 structural protein gene of the foot-and-mouth disease virus. Animal experiments show that the vaccine vector provides double effects in terms of gene therapy and gene immunization for the prevention and treatment of foot-and-mouth disease in animals. Also provided are construction methods and methods of use of the vaccine vector.

摘要翻译： 双顺反子表达载体序列是一种双重有效的口蹄疫病毒疫苗载体，双顺反子表达载体序列是能够与口蹄疫病毒基因组RNA的5'UTR共轭的反义基因序列 和口蹄疫病毒的VP1结构蛋白基因的完整序列。 动物实验表明疫苗载体在基因治疗和基因免疫方面提供了双重效果，用于预防和治疗动物口蹄疫。 还提供了疫苗载体的构建方法和使用方法。

公开(公告)号：US20120113418A1

公开(公告)日：2012-05-10

申请号：US13383078

申请日：2009-07-08

申请人： David A. Fattal ,  Jingjing Li ,  Zhiyong Li ,  Shih-Yuan Wang

发明人： David A. Fattal ,  Jingjing Li ,  Zhiyong Li ,  Shih-Yuan Wang

IPC分类号： G01J3/44 ,  H01L21/20 ,  H01L33/06 ,  B82Y40/00 ,  B82Y99/00

CPC分类号： G01N21/658 ,  B82Y20/00

摘要： A light amplifying device for surface enhanced Raman spectroscopy is disclosed herein. The device includes a dielectric layer having two opposed surfaces. A refractive index of the dielectric layer is higher than a refractive index of a material or environment directly adjacent thereto. At least one opening is formed in one of the two opposed surfaces of the dielectric layer, and at least one nano-antenna is established on the one of the two opposed surfaces of the dielectric layer. A gain region is positioned in the dielectric layer or adjacent to another of the two opposed surfaces of the dielectric layer.

摘要翻译： 本文公开了一种用于表面增强拉曼光谱的光放大装置。 该装置包括具有两个相对表面的电介质层。 电介质层的折射率高于与其直接相邻的材料或环境的折射率。 至少一个开口形成在电介质层的两个相对表面之一中，并且至少一个纳米天线被建立在电介质层的两个相对表面之一上。 增益区域位于电介质层中或邻近电介质层的两个相对表面中的另一个。

公开(公告)号：US08173452B1

公开(公告)日：2012-05-08

申请号：US12980424

申请日：2010-12-29

申请人： Christopher J. Petti ,  Mohamed M. Hilali ,  Theodore Smick ,  Venkatesan Murali ,  Kathy J. Jackson ,  Zhiyong Li ,  Gopalakrishna Prabhu

发明人： Christopher J. Petti ,  Mohamed M. Hilali ,  Theodore Smick ,  Venkatesan Murali ,  Kathy J. Jackson ,  Zhiyong Li ,  Gopalakrishna Prabhu

IPC分类号： H01L21/00

CPC分类号： H01L31/1892 ,  H01L31/0747 ,  H01L31/1864 ,  Y02E10/50

摘要： A semiconductor assembly is described in which a support element is constructed on a surface of a semiconductor lamina. Following formation of the thin lamina, which may have a thickness about 50 microns or less, the support element is formed, for example by plating, or by application of a precursor and curing in situ, resulting in a support element which may be, for example, metal, ceramic, polymer, etc. This is in contrast to a rigid or semi-rigid pre-formed support element which is affixed to the lamina following its formation, or to a donor wafer from which the lamina is subsequently cleaved. Fabricating the support element in situ may avoid the use of adhesives to attach the lamina to a permanent support element; such adhesives may be unable to tolerate processing temperatures and conditions required to complete the device. In some embodiments, this process flow allows the lamina to be annealed at high temperature, then to have an amorphous silicon layer formed on each face of the lamina following that anneal. A device may be formed which comprises the lamina, such as a photovoltaic cell.

摘要翻译： 描述了半导体组件，其中在半导体层的表面上构造支撑元件。 形成厚度约为50微米或更小的薄层之后，例如通过镀覆或通过施加前体和原位固化来形成支撑元件，得到支撑元件，其可以用于 例如，金属，陶瓷，聚合物等。这与刚性或半刚性的预成形支撑元件形成对比，该刚性或半刚性的预成型支撑元件在其形成之后固定到层板上，或者与施加器晶片相接触，其中层板随后被切割。 原位制造支撑元件可以避免使用粘合剂将薄片附着到永久支撑元件上; 这种粘合剂可能不能容忍完成装置所需的加工温度和条件。 在一些实施例中，该工艺流程允许薄层在高温下退火，然后在该退火之后具有在层的每个表面上形成的非晶硅层。 可以形成包括层的器件，例如光伏电池。

公开(公告)号：US08134702B1

公开(公告)日：2012-03-13

申请号：US12574379

申请日：2009-10-06

申请人： David A. Fattal ,  Zhiyong Li ,  Qiangfei Xia

发明人： David A. Fattal ,  Zhiyong Li ,  Qiangfei Xia

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01N21/658 ,  Y10T29/49865

摘要： An optical device for surface enhanced Raman spectroscopy includes a substrate, and at least one antenna established thereon. The at least one antenna including at least two segments, where each segment is formed of a metal having a predetermined volume and a predetermined contact angle with respect to the substrate. A gap is located between the two segments. The gap has a controllable size such that the at least one antenna resonates at a predetermined frequency that corresponds with the gap.

摘要翻译： 用于表面增强拉曼光谱的光学装置包括衬底和建立在其上的至少一个天线。 所述至少一个天线包括至少两个段，其中每个段由具有预定体积的金属和相对于衬底的预定接触角形成。 两个部分之间有间隙。 间隙具有可控制的尺寸，使得至少一个天线以与间隙对应的预定频率谐振。

公开(公告)号：US08111143B2

公开(公告)日：2012-02-07

申请号：US11117976

申请日：2005-04-29

申请人： William Tong ,  Geoffrey Lyon ,  Philip Kuekes ,  Zhiyong Li ,  Shih-Yuan Wang ,  R. Stanley Williams

发明人： William Tong ,  Geoffrey Lyon ,  Philip Kuekes ,  Zhiyong Li ,  Shih-Yuan Wang ,  R. Stanley Williams

IPC分类号： H04Q5/22

CPC分类号： G01D21/00 ,  H04Q9/00

摘要： An assembly for monitoring an environment includes a RFID tag and a sensing unit. The sensing unit is configured to be activated by a RF signal received by the RFID tag and to sense information regarding an environment.

摘要翻译： 用于监测环境的组件包括RFID标签和感测单元。 感测单元被配置为由RFID标签接收的RF信号激活并且感测关于环境的信息。

公开(公告)号：US20120013902A1

公开(公告)日：2012-01-19

申请号：US12836097

申请日：2010-07-14

申请人： Min Hu ,  Alexandre M. Bratkovski ,  Huel Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

发明人： Min Hu ,  Alexandre M. Bratkovski ,  Huel Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC分类号： G01J3/44

CPC分类号： G01J3/18 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/651

摘要： An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.

摘要翻译： 用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。 该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。 该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。

公开(公告)号：US20110188033A1

公开(公告)日：2011-08-04

申请号：US12696853

申请日：2010-01-29

申请人： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

发明人： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC分类号： G01J3/44

CPC分类号： G01J3/44

摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.

摘要翻译： 用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源， 以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光 以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。