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公开(公告)号：US20250128064A1
公开(公告)日：2025-04-24
申请号：US18930609
申请日：2024-10-29
Applicant: Galvani Bioelectronics Limited
Inventor： Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro-and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号：US20250128063A1
公开(公告)日：2025-04-24
申请号：US18682265
申请日：2022-08-09
Applicant: Galvani Bioelectronics Limited
Inventor： Margarita J. Vervoordeldonk , Misha Luyer
Abstract: Stimulation of the spleen and/or neural activity of one or more nerves supplying the spleen, such as a nerve associated with the splenic arterial neurovascular bundle, can decrease C-Reactive Protein (CRP) levels and post-operative surgical complications. The system for stimulating the spleen and/or neural activity of one or more nerves supplying the spleen for reducing post-operative surgical complications can include at least one transducer in signaling contact with the spleen and/or the one or more nerves; and at least one controller electrically coupled to the at least one transducer. The at least one controller can be configured to control the operation of the at least one transducer to apply a stimulating signal to the spleen and/or the one or more nerves. The stimulating signal may produce a change in a physiological parameter indicative of a target engagement of the nerves resulting in a reduction in C-reactive protein (CRP) plasma levels and/or Interleukin-6 (IL-6) plasma levels after surgery and reducing post-operative surgical complications and/or days in hospital.
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公开(公告)号：US20240390678A1
公开(公告)日：2024-11-28
申请号：US18790835
申请日：2024-07-31
Applicant: Galvani Bioelectronics Limited
Inventor： Matteo Donega , Daniel John Chew , Isha Gupta
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.
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公开(公告)号：US20240350809A1
公开(公告)日：2024-10-24
申请号：US18742863
申请日：2024-06-13
Applicant: Galvani Bioelectronics Limited
Inventor： David Karl Lee Peterson , Daniel John Chew , Matteo Donega , Xu Meng
CPC classification number: A61N1/36167 , A61N1/0551
Abstract: A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period.
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公开(公告)号：US12050253B2
公开(公告)日：2024-07-30
申请号：US17594924
申请日：2020-05-01
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Ellen Kaplan , Cindy Au , Pey-Jiun Ko
CPC classification number: G01R31/54 , G01R1/06705 , G01R1/06794 , A61N1/0553 , A61N1/0556
Abstract: A test fixture (20) for testing continuity in at least one electrode of a neuromodulation device. The test fixture may comprise a substrate (22), at least one electrically conductive pad (24a) disposed on the substrate for reducing pressure applied to the at least one electrode when the electrically conductive pad makes contact with an exposed surface of the electrode, and a wire (26a) extending from the at least one electrically conductive pad. The pad may be formed of a non-abrasive material, such as conductive foam or smooth metal. The substrate may be a probe formed with a number of slots for holding pads and routing wires, a mandrel with openings for holding pads and routing wires, and a flexible circuit with exposed smooth metal surfaces. The test fixture may be suitable for testing cuff-like and paddle-like devices.
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Patent Agency Ranking
公开(公告)号：US12023486B2
公开(公告)日：2024-07-02
申请号：US17690974
申请日：2022-03-09
Applicant: Galvani Bioelectronics Limited
Inventor： Brian Marc Pepin , Brian Otis
IPC: A61N1/05 , A61N1/36 , A61N1/372 , A61N1/378 , H02J7/02 , H02J7/34 , H02J50/10 , H02J50/20 , H02J50/80
CPC classification number: A61N1/0556 , A61N1/36139 , A61N1/3614 , A61N1/36178 , A61N1/36192 , A61N1/37229 , A61N1/3787 , H02J7/02 , H02J7/345 , H02J50/10 , H02J50/20 , H02J50/80
Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.
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公开(公告)号：USD1013324S1
公开(公告)日：2024-02-06
申请号：US29710834
申请日：2019-10-25
Applicant: Galvani Bioelectronics Limited
Designer： Morten Hansen , Jay Canham
Abstract: FIG. 1 is a perspective view of a charger positioning belt according to a first embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 2 is a front view of the charger positioning belt depicted in FIG. 1.
FIG. 3 is a back view of the charger positioning belt depicted in FIG. 1.
FIG. 4 is a right side view of the charger positioning belt depicted in FIG. 1.
FIG. 5 is a left side view of the charger positioning belt depicted in FIG. 1.
FIG. 6 is a top view of the charger positioning belt depicted in FIG. 1.
FIG. 7 is a bottom view of the charger positioning belt depicted in FIG. 1.
FIG. 8 is a perspective view of a charger positioning belt according to a second embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 9 is a front view of the charger positioning belt depicted in FIG. 8.
FIG. 10 is a back view of the charger positioning belt depicted in FIG. 8.
FIG. 11 is a right side view of the charger positioning belt depicted in FIG. 8.
FIG. 12 is a left side view of the charger positioning belt depicted in FIG. 8.
FIG. 13 is a top view of the charger positioning belt depicted in FIG. 8.
FIG. 14 is a bottom view of the charger positioning belt depicted in FIG. 8.
FIG. 15 is a perspective view of a charger positioning belt according to a third embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 16 is a front view of the charger positioning belt depicted in FIG. 15.
FIG. 17 is a back view of the charger positioning belt depicted in FIG. 15.
FIG. 18 is a right side view of the charger positioning belt depicted in FIG. 15.
FIG. 19 is a left side view of the charger positioning belt depicted in FIG. 15.
FIG. 20 is a top view of the charger positioning belt depicted in FIG. 15.
FIG. 21 is a bottom view of the charger positioning belt depicted in FIG. 15.
FIG. 22 is a perspective view of a charger positioning belt according to a fourth embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 23 is a front view of the charger positioning belt depicted in FIG. 22.
FIG. 24 is a back view of the charger positioning belt depicted in FIG. 22.
FIG. 25 is a right side view of the charger positioning belt depicted in FIG. 22.
FIG. 26 is a left side view of the charger positioning belt depicted in FIG. 22.
FIG. 27 is a top view of the charger positioning belt depicted in FIG. 22.
FIG. 28 is a bottom view of the charger positioning belt depicted in FIG. 22.
FIG. 29 is a perspective view of a charger positioning belt according to a fifth embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 30 is a front view of the charger positioning belt depicted in FIG. 29.
FIG. 31 is a back view of the charger positioning belt depicted in FIG. 29.
FIG. 32 is a right side view of the charger positioning belt depicted in FIG. 29.
FIG. 33 is a left side view of the charger positioning belt depicted in FIG. 29.
FIG. 34 is a top view of the charger positioning belt depicted in FIG. 29.
FIG. 35 is a bottom view of the charger positioning belt depicted in FIG. 29.
FIG. 36 is a perspective view of a charger positioning belt according to a sixth embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 37 is a front view of the charger positioning belt depicted in FIG. 36.
FIG. 38 is a back view of the charger positioning belt depicted in FIG. 36.
FIG. 39 is a right side view of the charger positioning belt depicted in FIG. 36.
FIG. 40 is a left side view of the charger positioning belt depicted in FIG. 36.
FIG. 41 is a top view of the charger positioning belt depicted in FIG. 36.
FIG. 42 is a bottom view of the charger positioning belt depicted in FIG. 36.
FIG. 43 is a perspective view of a charger positioning belt according to a seventh embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 44 is a front view of the charger positioning belt depicted in FIG. 43.
FIG. 45 is a back view of the charger positioning belt depicted in FIG. 43.
FIG. 46 is a right side view of the charger positioning belt depicted in FIG. 43.
FIG. 47 is a left side view of the charger positioning belt depicted in FIG. 43.
FIG. 48 is a top view of the charger positioning belt depicted in FIG. 43.
FIG. 49 is a bottom view of the charger positioning belt depicted in FIG. 43.
FIG. 50 is a perspective view of a charger positioning belt according to an eighth embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 51 is a front view of the charger positioning belt depicted in FIG. 50.
FIG. 52 is a back view of the charger positioning belt depicted in FIG. 50.
FIG. 53 is a right side view of the charger positioning belt depicted in FIG. 50.
FIG. 54 is a left side view of the charger positioning belt depicted in FIG. 50.
FIG. 55 is a top view of the charger positioning belt depicted in FIG. 50.
FIG. 56 is a bottom view of the charger positioning belt depicted in FIG. 50.
FIG. 57 is a perspective view of a charger positioning belt according to a ninth embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 58 is a front view of the charger positioning belt depicted in FIG. 57.
FIG. 59 is a back view of the charger positioning belt depicted in FIG. 57.
FIG. 60 is a right side view of the charger positioning belt depicted in FIG. 57.
FIG. 61 is a left side view of the charger positioning belt depicted in FIG. 57.
FIG. 62 is a top view of the charger positioning belt depicted in FIG. 57; and,
FIG. 63 is a bottom view of the charger positioning belt depicted in FIG. 57.
The broken lines depict portions of the article that form no part of the claimed design.-
公开(公告)号：US20230285752A1
公开(公告)日：2023-09-14
申请号：US18141045
申请日：2023-04-28
Applicant: Galvani Bioelectronics Limited
Inventor： Daniel John Chew , Matteo Donega , Isha Gupta
CPC classification number: A61N1/36071 , A61N1/0553 , A61N1/0556 , A61N1/205 , A61N1/36135 , A61N1/3616 , A61N1/36171
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.
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公开(公告)号：US11745010B2
公开(公告)日：2023-09-05
申请号：US15733277
申请日：2018-12-11
Applicant: Galvani Bioelectronics Limited , UCL Business LTD
Inventor： Matteo Donega , Daniel Chew , David Holder , Kirill Aristovich
CPC classification number: A61N1/0556 , A61N1/36053 , A61N1/36135 , A61N1/36167 , A61N1/3611 , A61N1/36114
Abstract: A nerve stimulation system including at least one nerve interface device is disclosed. The device includes a cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the cuff portion, each ring of electrodes including a plurality of electrodes, and wherein each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The system includes a stimulation device in communication with the pairs of electrodes to generate different electrical signals for the pairs of electrodes and a control system that causes the different signals to causes different physiological responses.
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公开(公告)号：US11738196B2
公开(公告)日：2023-08-29
申请号：US17872432
申请日：2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor： Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
CPC classification number: A61N1/3606 , A61N1/0556 , A61N1/3614 , A61N1/36135 , A61N1/36139 , A61N1/36171 , A61N1/36178 , A61N2001/083
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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