公开(公告)号：US20210369823A1

公开(公告)日：2021-12-02

申请号：US17320410

申请日：2021-05-14

Applicant: MUSC Foundation For Research Development ,  United States Government as Represented by the Department of Veteran Affairs

Inventor： Stephen Tomlinson ,  DeAnna Adkins ,  Ali Alawieh

IPC: A61K38/57 ,  C07K16/18 ,  A61K38/17 ,  A61K38/49 ,  A61P25/00

Abstract: The present invention describes compositions and method for improving outcomes after injury to the central nervous system wherein complement signaling is activated. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a therapeutic agent comprising a targeted inhibitor molecule comprising a targeting portion and an inhibitor portion, wherein the molecule inhibits complement, and wherein therapeutic agent is administered in combination with rehabilitation therapy or thrombolytic agent.

公开(公告)号：US20210325398A1

公开(公告)日：2021-10-21

申请号：US17231813

申请日：2021-04-15

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Richard R. DRAKE ,  Xiaowei LU

IPC: G01N33/58

Abstract: Described herein are compounds, compositions, and reagents capable of labeling a biomolecule. In some embodiments, the compounds, compositions, and reagents allow for labeling to occur using a bioorthagonal reaction outside of a living cell and without a glycosyltransferase enzyme. Also described herein are methods of using the compounds compositions and reagents described herein.

公开(公告)号：US20210238147A1

公开(公告)日：2021-08-05

申请号：US17238492

申请日：2021-04-23

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT ,  The United States Government as Represented by the DEPARTMENT OF VETERANS AFFAIRS

Inventor： Christopher C. LINDSEY ,  Craig C. BEESON ,  Yuri Karl PETERSON ,  Rick G. SCHNELLMANN

IPC: C07D239/47 ,  A61P13/12

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.

公开(公告)号：US11014892B2

公开(公告)日：2021-05-25

申请号：US16347163

申请日：2017-11-02

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT ,  The United States Government as Represented by the DEPARTMENT OF VETERANS AFFAIRS

Inventor： Christopher C. Lindsey ,  Craig C. Beeson ,  Yuri Karl Peterson ,  Rick G. Schnellmann

IPC: C07D239/47 ,  A61P13/12 ,  A61K45/06

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.

公开(公告)号：US20210145341A1

公开(公告)日：2021-05-20

申请号：US17158620

申请日：2021-01-26

Applicant: MUSC Foundation for Research Development

Inventor： Jonathan Edwards ,  Jessica Barley ,  Mark Semler

IPC: A61B5/24 ,  A61B5/00 ,  A61B5/296

Abstract: A needle electrode fixation device is configured to secure a transdermal needle electrode to a patient. The device includes a base having a body that defines a first portion and a second portion. The first and second portions are rotatable relative to each other. The first portion defines a channel configured to fit a portion of the transdermal needle electrode. The second portion defines a recess configured to fit a tip of the needle electrode. The device further includes an adhesive layer configured to affix the base to the patient.

公开(公告)号：US10988735B2

公开(公告)日：2021-04-27

申请号：US15543701

申请日：2016-01-15

Applicant: Clemson University Research Foundation ,  MUSC Foundation for Research Development ,  The University of Chicago

Inventor： Ying Mei ,  Tan Yu ,  Dylan Richards ,  Donald R. Menick ,  Bozhi Tian

IPC: C12N5/077 ,  G01N33/50 ,  A61K35/34 ,  A61L27/30 ,  A61L27/38

Abstract: Described herein are tissues containing semiconductor nanomaterials. In some embodiments, the tissues include vascular cells, cardiomyocytes, and/or cardiac fibroblasts. The tissue may be scaffold-free. In some embodiments, the tissue includes an electrically conductive network. The tissue may exhibit synchronized electrical signal propagation within the tissue. In some embodiments, the tissue exhibits increased functional assembly of cardiac cells and/or increased cardiac specific functions compared to a cardiac tissue prepared using a conventional tissue culture method. Methods of preparing and using such tissues are also described herein.

公开(公告)号：US20210000568A1

公开(公告)日：2021-01-07

申请号：US16469811

申请日：2019-03-12

Applicant: MUSC Foundation for Research Development

Inventor： Walter Renne ,  Zachary Evans

IPC: A61C1/00 ,  A61C1/08 ,  A61B17/17 ,  A61B18/20 ,  A61B34/10 ,  B33Y10/00 ,  B33Y50/02 ,  B33Y80/00 ,  B29C64/393

Abstract: Provided herein are surgical guides with internal channels for irrigation cooling. In one embodiment, an apparatus for guiding a surgical instrument includes a proximal side and a distal side. A first channel is configured to guide a material removal device, where the first channel extends from the proximal side of the apparatus to the distal side of the apparatus. A second channel configured to direct irrigation fluid, where the second channel extends from the proximal side of the of the apparatus to the distal side of the apparatus. The first channel is separate from the second channel. A method of performing a surgical procedure and a method of manufacturing a surgical guide are also disclosed. In certain embodiments, the surgical guides may be manufactured via additive manufacturing processes, including for example, three-dimensional printing processes.

公开(公告)号：US20200308295A1

公开(公告)日：2020-10-01

申请号：US16572260

申请日：2019-09-16

Applicant: MUSC Foundation for Research Development ,  Dept of Veterans Affairs ,  The Regents of the University of Colorado, a body corporate

Inventor： Stephen Tomlinson ,  V. Michael Holers

IPC: C07K16/28 ,  A61K49/16 ,  A61K49/00

Abstract: Provided herein, inter alia, are compositions and methods of using the same for detecting complement activation.

公开(公告)号：US10786283B2

公开(公告)日：2020-09-29

申请号：US13957190

申请日：2013-08-01

Applicant: MUSC Foundation for Research Development

Inventor： Bruce M. Frankel ,  Mark Evald Semler

IPC: A61B17/70 ,  A61B90/00

Abstract: A skeletal fixation apparatus may include two or more bodies that are attached to two or more screws that have been inserted into vertebral bodies associated with a patient. The apparatus may also include two or more cylindrical members that are attached to the bodies to control the movement or alignment of the bodies when the skeletal fixation apparatus is being installed in the patient. The apparatus may further include a rod that includes a first curvature and a second curvature. The first curvature may be different than the second curvature and may be based on a medical diagnosis associated with stabilizing the vertebral bodies. The second curvature may enable the bodies to be immovably fastened to the rod in a manner that precludes the cylindrical members from contacting each other or causing a false torque condition to exist when the skeletal fixation apparatus is installed in the patient.

公开(公告)号：US20190314170A1

公开(公告)日：2019-10-17

申请号：US16424455

申请日：2019-05-28

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Mark Evald SEMLER ,  Bruce FRANKEL ,  Joseph RUSCITO ,  Christopher HAPSTACK

IPC: A61F2/44 ,  A61F2/46

Abstract: Expandable vertebral body implants, systems, instruments, and methods of assembly and using the implants, systems, and instruments are disclosed. The vertebral body implant includes a body with a first end and a second end, a first rotating member rotatably coupled to the first end, wherein an end includes a plurality of first notches inset into the first rotating member, a second rotating member rotatably coupled to the second end, wherein an end includes a plurality of second notches inset into the second rotating member, a first extension member moveably coupled to the first end, and a second extension member moveably coupled to the second end. The expandable cage system comprises a vertebral body implant and an insertion instrument. Methods for assembling and using the vertebral body implants and instruments are also disclosed.