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公开(公告)号：US20210238147A1
公开(公告)日：2021-08-05
申请号：US17238492
申请日：2021-04-23
申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT , The United States Government as Represented by the DEPARTMENT OF VETERANS AFFAIRS
IPC分类号： C07D239/47 , A61P13/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.
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公开(公告)号：US20200055827A1
公开(公告)日：2020-02-20
申请号：US16347163
申请日：2017-11-02
IPC分类号： C07D239/47 , A61P13/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.
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公开(公告)号：US20140024677A1
公开(公告)日：2014-01-23
申请号：US13859546
申请日：2013-04-09
IPC分类号： A61K31/4704 , A61K31/138 , A61K31/137
CPC分类号： A61K31/4704 , A61K31/137 , A61K31/138 , A61K31/167
摘要： Methods and compositions for inducing mitochondrial biogenesis are provided. In some aspects, methods for the treatment of diseases such as acute kidney disease (AKI) or a muscle wasting disease by administering tomoxetine, nisoxetine, fenoterol, formoterol, or procaterol to an individual are provided.
摘要翻译： 提供了诱导线粒体生物发生的方法和组合物。 在一些方面，提供了通过向个体施用托莫西汀，尼索西汀，非诺特罗，福莫特罗或丙卡特罗来治疗诸如急性肾脏疾病（AKI）或肌肉消瘦疾病的疾病的方法。
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