公开(公告)号：US06650940B1

公开(公告)日：2003-11-18

申请号：US09496832

申请日：2000-02-02

申请人： Qingsheng Zhu ,  Julio C. Spinelli ,  Gerrard M. Carlson

发明人： Qingsheng Zhu ,  Julio C. Spinelli ,  Gerrard M. Carlson

IPC分类号： A61N1365

CPC分类号： A61N1/36542 ,  A61N1/3712

摘要： An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient's heart. The device operates in an automatic capture verification mode, wherein a global accelerometer signal is utilized to identify heart sounds (S1 and S2) of the patient's heart. The presence or absence of one or more of the heart sounds S1 and S2 in the accelerometer signal indicates whether a stimulation pulse evokes a response by the patient's heart. The device may automatically adjust the stimulation output in accordance with a step down stimulation protocol, wherein the presence of a predetermined heart sound indicates capture. Also, the device may suspend the automatic capture verification sequence if the patient's physical activity level exceeds a predetermined threshold.

摘要翻译： 一种能够自动检测患者心脏的内在和诱发反应的植入式心律管理装置。 该装置以自动捕获验证模式工作，其中使用全局加速度计信号来识别患者心脏的心音（S1和S2）。 加速度计信号中存在或不存在一个或多个心音S1和S2表示刺激脉冲是否引起患者心脏的反应。 设备可以根据降压刺激协议自动调节刺激输出，其中预定心音的存在指示捕获。 此外，如果患者的身体活动水平超过预定阈值，则设备可以暂停自动捕获验证序列。

公开(公告)号：US06427085B1

公开(公告)日：2002-07-30

申请号：US09309951

申请日：1999-05-11

申请人： Scot C. Boon ,  Mark Gryzwa ,  Michael Lyden ,  Qingsheng Zhu ,  Paul Haefner

发明人： Scot C. Boon ,  Mark Gryzwa ,  Michael Lyden ,  Qingsheng Zhu ,  Paul Haefner

IPC分类号： A61N137

CPC分类号： A61N1/3712

摘要： A cardiac rhythm management device having a capture verification sensing circuit for use in either a normal beat to beat pacing mode or an autothreshold mode. The cardiac rhythm management device is coupled to one or more pacing leads having pacing/sensing electrodes coupled thereto, and includes a sensing circuit for sensing electrical activity of the patient's heart, wherein the sensing circuit includes a dedicated evoked response sense amplifier and at least one high pass coupling capacitor electrically connected as a portion of a high pass network and between a pacing/sensing electrode and a blanking switch. A plurality of high pass coupling capacitors are coupled in parallel each having a separate blanking switch, thereby creating a differential network to offset imbalance sensed from the electrode due to extraneous factors.

摘要翻译： 一种具有捕获验证感测电路的心律管理装置，其用于正常搏动以节拍起搏模式或自阈值模式。 心律管理装置耦合到具有与之相连的起搏/感测电极的一个或多个起搏引线，并且包括用于感测患者心脏的电活动的感测电路，其中感测电路包括专用的诱发响应读出放大器和至少一个 高通耦合电容器作为高通网络的一部分并且在起搏/感测电极和消隐开关之间电连接。 多个高通耦合电容器并联耦合，每个具有单独的消隐开关，由此产生差分网络以抵消由于外部因素而从电极感测的不平衡。

公开(公告)号：US06363281B1

公开(公告)日：2002-03-26

申请号：US09571786

申请日：2000-05-16

申请人： Qingsheng Zhu ,  Avram Scheiner

发明人： Qingsheng Zhu ,  Avram Scheiner

IPC分类号： A61N137

CPC分类号： A61N1/3712

摘要： A system and method for cardiac rhythm management, which includes an electrode system having at least one electrode and control circuitry coupled to the electrode system from which a first cardiac signal is sensed. The control circuitry includes a pulse circuit to produce electrical pulses at a first value to be delivered to the electrode system in a first cardiac region. At least one cardiac signal is sensed from a second cardiac region, where the cardiac signal includes indications of cardiac depolarizations from the second cardiac region which occurs in direct reaction to the electrical pulses delivered to the first cardiac region. The first value of the electrical pulses are then modified by a pulse adjustment circuit when a cardiac depolarization which occurs in direct reaction to the electrical pulse delivered to the first cardiac region is detected from the second cardiac region.

摘要翻译： 一种用于心律管理的系统和方法，其包括具有耦合到所述电极系统的至少一个电极和控制电路的电极系统，从所述电极系统感测到第一心脏信号。 控制电路包括脉冲电路，以在第一心脏区域产生将被传送到电极系统的第一值的电脉冲。 从第二心脏区域感测至少一个心脏信号，其中心脏信号包括来自第二心脏区域的心脏去极化的指示，其发生在与递送至第一心脏区域的电脉冲直接反应中。 当从第二心脏区域检测到与传送到第一心脏区域的电脉冲直接反应发生的心脏去极化时，脉冲调节电路修改电脉冲的第一值。

公开(公告)号：US08880169B2

公开(公告)日：2014-11-04

申请号：US13216969

申请日：2011-08-24

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/362

CPC分类号： A61N1/3627

摘要： Various systems, methods and arrangements are implemented in connection with ventricular pacing. One such method relates to a method for use in connection with ventricular pacing of a left ventricle of a heart from a pacing lead located in the right ventricle. Ventricular function of the heart is sensed. The sensed ventricular function is used to determine whether a conduction abnormality exists. The ventricular pacing is provided in response to determining a conduction abnormality exists and the ventricular pacing is inhibited in response to determining a conduction abnormality does not exist.

摘要翻译： 与心室起搏有关的各种系统，方法和布置。 一种这样的方法涉及一种用于与位于右心室的起搏导管的心脏左心室起搏有关的方法。 检测心脏的心室功能。 感测到的心室功能用于确定是否存在传导异常。 响应于确定存在传导异常并且不存在响应于确定传导异常而抑制心室起搏而提供心室起搏。

公开(公告)号：US08792980B2

公开(公告)日：2014-07-29

申请号：US12980417

申请日：2010-12-29

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

摘要翻译： 公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。 可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。 加速度计响应于心室壁位置的运动产生信号。 然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。 可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。 可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

公开(公告)号：US08755897B2

公开(公告)日：2014-06-17

申请号：US11985995

申请日：2007-11-19

申请人： Julio C. Spinelli ,  Qingsheng Zhu

发明人： Julio C. Spinelli ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/37282 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G06Q50/22 ,  G16H40/40

摘要： One embodiment includes a system for prescribing therapeutic treatment for a patient via communications over a network, including an implantable medical device (IMD) to be implanted in the patient to record a patient characteristic, the implantable medical device being programmable and configured to communicate via wireless communications with the IMD and to communicate securely over the network, the medical device programming computer including a user interface. The embodiment includes a server to communicate securely over the network with the medical device programming computer, the server including at least a first expert prescription system comprising at least one physician's prescription and at least one expert-system to compare the at least one patient characteristic to the at least one physician's prescription to issue a parameter to be programmed into the IMD based on the comparison.

摘要翻译： 一个实施例包括一种用于通过网络进行通信来对患者进行治疗性治疗的系统，包括要植入患者中的可植入医疗装置（IMD）以记录患者特征，所述可植入医疗装置是可编程的并且经配置以经由无线 与IMD的通信并且通过网络安全地通信，医疗设备编程计算机包括用户界面。 该实施例包括通过网络与医疗设备编程计算机安全地通信的服务器，该服务器至少包括第一专家处方系统，该第一专家处方系统包括至少一个医师的处方和至少一个专家系统，以将至少一个患者特征与 所述至少一位医生处方根据比较发布要编程到IMD中的参数。

公开(公告)号：US08478397B2

公开(公告)日：2013-07-02

申请号：US12686704

申请日：2010-01-13

申请人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew P. Kramer ,  Ankur Garg ,  Kristofer J. James

发明人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew P. Kramer ,  Ankur Garg ,  Kristofer J. James

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/36128 ,  A61N1/3621 ,  A61N1/3627

摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面提供可植入装置。 在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。 所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到 电极。 刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。 感测和刺激电路适用于执行CRM功能。 该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。 本文提供了其它方面和实施例。

公开(公告)号：US08423139B2

公开(公告)日：2013-04-16

申请号：US12147376

申请日：2008-06-26

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/362

CPC分类号： A61N1/371 ,  A61N1/3627

摘要： Various embodiments of the present invention are directed to systems, methods and devices for cardiac applications. One such device is directed to a catheter, and uses thereof, for capturing myocardium of a heart by delivering pacing signals to a location in the heart. The location is near a His Bundle of the heart. The catheter has a proximal end for interfacing with an electrical pacing signal source and a distal end. The distal end includes a fixation mechanism that attaches the catheter to heart tissue. First and second electrodes are also located at the distal end. Each electrode is individually addressable for providing pacing signals to the heart tissue and also arranged to physically contact the heart tissue when the fixation mechanism is attached to the heart tissue.

公开(公告)号：US08219197B2

公开(公告)日：2012-07-10

申请号：US12852875

申请日：2010-08-09

申请人： Julio C. Spinelli ,  Qingsheng Zhu

发明人： Julio C. Spinelli ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/371

摘要： A system and method for measuring the capture threshold of a bipolar lead in order to determine an appropriate value for the stimulus pulse energy to be used with the lead by a cardiac rhythm management device. An appropriate bipolar stimulating configuration can also be determined. The method is particularly useful in testing bipolar leads used to excite the left ventricle such as when delivering cardiac resynchronization therapy.

摘要翻译： 一种用于测量双极引线的捕获阈值的系统和方法，以便确定由心律管理装置与引线一起使用的刺激脉冲能量的适当值。 也可以确定适当的双极刺激构型。 该方法在测试用于激发左心室的双极引线（例如递送心脏再同步治疗时）特别有用。

公开(公告)号：US20120010678A1

公开(公告)日：2012-01-12

申请号：US13235599

申请日：2011-09-19

申请人： Julio C. SPINELLI ,  Qingsheng Zhu

发明人： Julio C. SPINELLI ,  Qingsheng Zhu

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36564

摘要： A method and apparatus for treating or preventing neurocardiogenic syncope is disclosed. Upon detection of bradycardia or a drop in blood pressure indicating the onset of syncope, electrostimulation pulses are delivered during the heart's refractory period. The pulses are non-excitatory but increase myocardial contractility and thereby increase cardiac output.

摘要翻译： 公开了用于治疗或预防神经心源性晕厥的方法和装置。 一旦检测到心动过缓或血压下降，表明晕厥发作，电刺激脉搏在心脏不应期期间输送。 脉冲是非兴奋性的，但增加心肌收缩力，从而增加心输出量。