公开(公告)号：US08583235B2

公开(公告)日：2013-11-12

申请号：US13494785

申请日：2012-06-12

申请人： Qingsheng Zhu ,  Avram Scheiner

发明人： Qingsheng Zhu ,  Avram Scheiner

IPC分类号： A61N1/00

CPC分类号： A61N1/3712

摘要： A system and method for cardiac rhythm management, which includes an electrode system having at least one electrode and control circuitry coupled to the electrode system from which a first cardiac signal is sensed. The control circuitry includes a pulse circuit to produce electrical pulses at a first value to be delivered to the electrode system in a first cardiac region. At least one cardiac signal is sensed from a second cardiac region, where the cardiac signal includes indications of cardiac depolarizations from the second cardiac region which occurs in direct reaction to the electrical pulses delivered to the first cardiac region. The first value of the electrical pulses are then modified by a pulse adjustment circuit when a cardiac depolarization which occurs in direct reaction to the electrical pulse delivered to the first cardiac region is detected from the second cardiac region.

公开(公告)号：US08204594B2

公开(公告)日：2012-06-19

申请号：US12974837

申请日：2010-12-21

申请人： Qingsheng Zhu ,  Avram Scheiner

发明人： Qingsheng Zhu ,  Avram Scheiner

IPC分类号： A61N1/00

CPC分类号： A61N1/3712

摘要： A system and method for cardiac rhythm management, which includes an electrode system having at least one electrode and control circuitry coupled to the electrode system from which a first cardiac signal is sensed. The control circuitry includes a pulse circuit to produce electrical pulses at a first value to be delivered to the electrode system in a first cardiac region. At least one cardiac signal is sensed from a second cardiac region, where the cardiac signal includes indications of cardiac depolarizations from the second cardiac region which occurs in direct reaction to the electrical pulses delivered to the first cardiac region. The first value of the electrical pulses are then modified by a pulse adjustment circuit when a cardiac depolarization which occurs in direct reaction to the electrical pulse delivered to the first cardiac region is detected from the second cardiac region.

摘要翻译： 一种用于心律管理的系统和方法，其包括具有耦合到所述电极系统的至少一个电极和控制电路的电极系统，从所述电极系统感测到第一心脏信号。 控制电路包括脉冲电路，以在第一心脏区域产生将被传送到电极系统的第一值的电脉冲。 从第二心脏区域感测至少一个心脏信号，其中心脏信号包括来自第二心脏区域的心脏去极化的指示，其发生在与递送至第一心脏区域的电脉冲直接反应中。 当从第二心脏区域检测到与传送到第一心脏区域的电脉冲直接反应发生的心脏去极化时，脉冲调节电路修改电脉冲的第一值。

公开(公告)号：US06928325B2

公开(公告)日：2005-08-09

申请号：US10059771

申请日：2002-01-28

申请人： Qingsheng Zhu ,  Avram Scheiner

发明人： Qingsheng Zhu ,  Avram Scheiner

IPC分类号： A61N1/37

CPC分类号： A61N1/3712

摘要： A system and method for cardiac rhythm management, which includes an electrode system having at least one electrode and control circuitry coupled to the electrode system from which a first cardiac signal is sensed. The control circuitry includes a pulse circuit to produce electrical pulses at a first value to be delivered to the electrode system in a first cardiac region. At least one cardiac signal is sensed from a second cardiac region, where the cardiac signal includes indications of cardiac depolarizations from the second cardiac region which occurs in direct reaction to the electrical pulses delivered to the first cardiac region. The first value of the electrical pulses are then modified by a pulse adjustment circuit when a cardiac depolarization which occurs in direct reaction to the electrical pulse delivered to the first cardiac region is detected from the second cardiac region.

摘要翻译： 一种用于心律管理的系统和方法，其包括具有耦合到所述电极系统的至少一个电极和控制电路的电极系统，从所述电极系统感测到第一心脏信号。 控制电路包括脉冲电路，以在第一心脏区域产生将被传送到电极系统的第一值的电脉冲。 从第二心脏区域感测至少一个心脏信号，其中心脏信号包括来自第二心脏区域的心脏去极化的指示，其发生在与递送至第一心脏区域的电脉冲直接反应中。 当从第二心脏区域检测到与传送到第一心脏区域的电脉冲直接反应发生的心脏去极化时，脉冲调节电路修改电脉冲的第一值。

公开(公告)号：US06212434B1

公开(公告)日：2001-04-03

申请号：US09120824

申请日：1998-07-22

申请人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W. Goebel ,  Douglas A. Heitkamp ,  Randall M. Peterfeso

发明人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W. Goebel ,  Douglas A. Heitkamp ,  Randall M. Peterfeso

IPC分类号： A61N105

CPC分类号： A61N1/0573 ,  A61N1/0563

摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

公开(公告)号：US6085119A

公开(公告)日：2000-07-04

申请号：US121019

申请日：1998-07-22

申请人： Avram Scheiner ,  Qingsheng Zhu

发明人： Avram Scheiner ,  Qingsheng Zhu

IPC分类号： A61N1/05

CPC分类号： A61N1/0573

摘要： A single-pass endocardial lead electrode is adapted for implantation within a single chamber of the heart. The lead includes a first electrode and a second electrode. The first and second electrodes are placed within the same chamber of the heart. In one embodiment, two electrodes are placed on a curved distal end of the lead. In another embodiment, the lead includes multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart.

摘要翻译： 单通道心内膜引线电极适于植入心脏的单个腔室内。 引线包括第一电极和第二电极。 第一和第二电极放置在心脏的相同的腔室内。 在一个实施例中，将两个电极放置在引线的弯曲远端上。 在另一个实施例中，引线包括多个支腿，每个支脚承载电极。 引线连接到脉冲发生器，用于向心脏内的多个位置产生脉冲。

公开(公告)号：US20120209130A1

公开(公告)日：2012-08-16

申请号：US13456795

申请日：2012-04-26

申请人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

发明人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

IPC分类号： A61B5/0402 ,  A61B7/00

CPC分类号： A61B7/04 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/04014 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/1118 ,  A61B5/742 ,  A61B7/023 ,  G06F19/00

摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

摘要翻译： 用于输出心音的装置包括可植入系统和外部系统。 可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。 外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。 可植入系统还可以包括用于检测心脏电信号的传感器。 在这种情况下，还输出表示心电信号的输出。

公开(公告)号：US07738953B2

公开(公告)日：2010-06-15

申请号：US11203756

申请日：2005-08-15

申请人： Qingsheng Zhu ,  Avram Scheiner ,  Julio C. Spinelli

发明人： Qingsheng Zhu ,  Avram Scheiner ,  Julio C. Spinelli

IPC分类号： A61N1/36

CPC分类号： A61N1/326 ,  A61N1/0587

摘要： A method and device for preventing plaque build-up in a coronary artery includes providing an electrical field generating device, and generating an electrical field in the coronary artery to prevent plaque build-up in the coronary artery. The method further includes sensing the heart rhythm and generating the electrical field after a depolarization wave in the heart. The electrical field is generated by circuitry, in one embodiment implanted circuitry, connected to leads which are epicardially or intracardially positioned on the heart.

摘要翻译： 用于防止冠状动脉斑块积聚的方法和装置包括提供电场产生装置，并且在冠状动脉中产生电场以防止冠状动脉中的斑块积聚。 该方法还包括感测心脏节律并在心脏中去极化波之后产生电场。 电场由电路产生，在一个实施例中，植入电路连接到心外膜或心内置于心脏上的引线。

公开(公告)号：US07328067B2

公开(公告)日：2008-02-05

申请号：US10858580

申请日：2004-06-02

申请人： Qingsheng Zhu ,  Avram Scheiner

发明人： Qingsheng Zhu ,  Avram Scheiner

IPC分类号： A61N1/00

CPC分类号： A61N1/3712

摘要： A system and method for cardiac rhythm management, which includes an electrode system having at least one electrode and control circuitry coupled to the electrode system from which a first cardiac signal is sensed. The control circuitry includes a pulse circuit to produce electrical pulses at a first value to be delivered to the electrode system in a first cardiac region. At least one cardiac signal is sensed from a second cardiac region, where the cardiac signal includes indications of cardiac depolarizations from the second cardiac region which occurs in direct reaction to the electrical pulses delivered to the first cardiac region. The first value of the electrical pulses are then modified by a pulse adjustment circuit when a cardiac depolarization which occurs in direct reaction to the electrical pulse delivered to the first cardiac region is detected from the second cardiac region.

公开(公告)号：US07101339B2

公开(公告)日：2006-09-05

申请号：US10319794

申请日：2002-12-13

申请人： Douglas R. Daum ,  Qingsheng Zhu ,  Avram Scheiner

发明人： Douglas R. Daum ,  Qingsheng Zhu ,  Avram Scheiner

IPC分类号： A61B5/08

CPC分类号： A61N1/36521

摘要： A cardiac rhythm management apparatus and system may include a first sensor to sense an atrial respiration signal, a second sensor to sense a ventricular respiration signal, and a measurement module capable of being communicatively coupled to the first and second sensors to monitor the atrial and ventricular respiration signals and to select a resulting signal as an indication of respiration. An article may cause a machine to implement a method which includes measuring a second signal responsive to a first signal, measuring a third signal responsive to a first signal, determining a respiration-to-cardiac ratio associated with each one of the second and third signals, and providing a resulting signal including a selected portion of a selected one of the second and third signals as an indication of respiration.

摘要翻译： 心律管理装置和系统可以包括用于感测心房呼吸信号的第一传感器，用于感测心室呼吸信号的第二传感器，以及能够通信地耦合到第一和第二传感器以监测心房和心室的测量模块 呼吸信号，并选择一个结果信号作为呼吸指示。 物品可以使机器实现一种方法，其包括响应于第一信号测量第二信号，响应于第一信号测量第三信号，确定与第二和第三信号中的每一个相关联的呼吸心脏比 并且提供包括所选择的第二和第三信号中的一个的选定部分的结果信号作为呼吸的指示。

公开(公告)号：US20050283099A1

公开(公告)日：2005-12-22

申请号：US11203756

申请日：2005-08-15

申请人： Qingsheng Zhu ,  Avram Scheiner ,  Julio Spinelli

发明人： Qingsheng Zhu ,  Avram Scheiner ,  Julio Spinelli

IPC分类号： A61N1/05 ,  A61N1/32 ,  A61H1/02

CPC分类号： A61N1/326 ,  A61N1/0587

摘要： A method and device for preventing plaque build-up in a coronary artery includes providing an electrical field generating device, and generating an electrical field in the coronary artery to prevent plaque build-up in the coronary artery. The method further includes sensing the heart rhythm and generating the electrical field after a depolarization wave in the heart. The electrical field is generated by circuitry, in one embodiment implanted circuitry, connected to leads which are epicardially or intracardially positioned on the heart.

摘要翻译： 用于防止冠状动脉斑块积聚的方法和装置包括提供电场产生装置，并且在冠状动脉中产生电场以防止冠状动脉中的斑块积聚。 该方法还包括感测心脏节律并在心脏中去极化波之后产生电场。 电场由电路产生，在一个实施例中，植入电路连接到心外膜或心内置于心脏上的引线。